Cox, NC
Adrienne D. Cox, Chapel Hill, NC US
Patent application number | Description | Published |
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20110027806 | FARNESYLTRANSFERASE INHIBITORS FOR TREATMENT OF LAMINOPATHIES, CELLULAR AGING AND ATHEROSCLEROSIS - Although it can be farnesylated, the mutant lamin A protein expressed in Hutchinson Gilford Progeria Syndrome (HGPS) cannot be defarnesylated because the characteristic mutation causes deletion of a cleavage site necessary for binding the protease ZMPSTE24 and effecting defarnesylation. The result is an aberrant farnesylated protein (called “progerin”) that alters normal lamin A function as a dominant negative, as well as assuming its own aberrant function through its association with the nuclear membrane. The retention of farnesylation, and potentially other abnormal properties of progerin and other abnormal lamin gene protein products, produces disease. Farnesyltransferase inhibitors (FTIs) (both direct effectors and indirect inhibitors) will inhibit the formation of progerin, cause a decrease in lamin A protein, and/or an increase prelamin A protein. Decreasing the amount of aberrant protein improves cellular effects caused by and progerin expression. Similarly, treatment with FTIs should improve disease status in progeria and other laminopathies. In addition, elements of atherosclerosis and aging in non-laminopathy individuals will improve after treatment with farnesyltransferase inhibitors. | 02-03-2011 |
20120329066 | FARNESYLTRANSFERASE INHIBITORS FOR TREATMENT OF LAMINOPATHIES, CELLULAR AGING AND ATHEROSCLEROSIS - Although it can be farnesylated, mutant lamin A expressed in Hutchinson Gilford Progeria Syndrome cannot be defarnesylated; the characteristic mutation causes deletion of a cleavage site necessary for binding the protease ZMPSTE24 and effecting defarnesylation. The result is an aberrant farnesylated protein (“progerin”) that alters normal lamin A function as a dominant negative, and assumes its own aberrant function through its association with the nuclear membrane. Retention of farnesylation, and potentially other abnormal properties of progerin and other abnormal lamin gene protein products, produces disease. Farnesyltransferase inhibitors (FTIs) will inhibit formation of progerin, cause a decrease in lamin A protein, and/or an increase prelamin A protein. Decreasing the amount of aberrant protein improves cellular effects caused by and progerin expression. Similarly, treatment with FTIs should improve disease status in progeria and other laminopathies. In addition, elements of atherosclerosis and aging in non-laminopathy individuals will improve after treatment with FTIs. | 12-27-2012 |
20130203799 | FARNESYLTRANSFERASE INHIBITORS FOR TREATMENT OF LAMINOPATHIES, CELLULAR AGING AND ATHEROSCLEROSIS - Although it can be farnesylated, the mutant lamin A protein expressed in Hutchinson Gilford Progeria Syndrome (HGPS) cannot be defarnesylated because the characteristic mutation causes deletion of a cleavage site necessary for binding the protease ZMPSTE24 and effecting defarnesylation. The result is an aberrant farnesylated protein (called “progerin”) that alters normal lamin A function as a dominant negative, as well as assuming its own aberrant function through its association with the nuclear membrane. The retention of farnesylation, and potentially other abnormal properties of progerin and other abnormal lamin gene protein products, produces disease. Farnesyltransferase inhibitors (FTIs) (both direct effectors and indirect inhibitors) will inhibit the formation of progerin, cause a decrease in lamin A protein, and/or an increase prelamin A protein. Decreasing the amount of aberrant protein improves cellular effects caused by and progerin expression. Similarly, treatment with FTIs should improve disease status in progeria and other laminopathies. In addition, elements of atherosclerosis and aging in non-laminopathy individuals will improve after treatment with farnesyltransferase inhibitors. | 08-08-2013 |
20150018381 | FARNESYLTRANSFERASE INHIBITORS FOR TREATMENT OF LAMINOPATHIES, CELLULAR AGING AND ATHEROSCLEROSIS - Although it can be farnesylated, the mutant lamin A protein expressed in Hutchinson Gilford Progeria Syndrome (HGPS) cannot be defarnesylated because the characteristic mutation causes deletion of a cleavage site necessary for binding the protease ZMPSTE24 and effecting defarnesylation. The result is an aberrant farnesylated protein (called “progerin”) that alters normal lamin A function as a dominant negative, as well as assuming its own aberrant function through its association with the nuclear membrane. The retention of farnesylation, and potentially other abnormal properties of progerin and other abnormal lamin gene protein products, produces disease. Farnesyltransferase inhibitors (FTIs) (both direct effectors and indirect inhibitors) will inhibit the formation of progerin, cause a decrease in lamin A protein, and/or an increase prelamin A protein. Decreasing the amount of aberrant protein improves cellular effects caused by and progerin expression. Similarly, treatment with FTIs should improve disease status in progeria and other laminopathies. In addition, elements of atherosclerosis and aging in non-laminopathy individuals will improve after treatment with farnesyltransferase inhibitors. | 01-15-2015 |
Adrienne Deich Cox, Chapel Hill, NC US
Patent application number | Description | Published |
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20090170837 | METHODS FOR TREATING RAS DRIVEN CANCER IN A SUBJECT - The invention relates to the discovery that the dibenzodiazepinone analogues have growth inhibiting activities on tumorigenic cells that are driven by expression of RAS or mutated RAS. Thus the invention includes methods for inhibiting the activity of RAS using dibenzodiazepinone analogues; methods for inhibiting the growth of a RAS driven cancer cell using dibenzodiazepinone analogues; methods for inhibiting the growth of a RAS driven cancer using dibenzodiazepinone analogues; and methods for treating a subject having a RAS driven cancer using dibenzodiazepinone analogues. | 07-02-2009 |
Brian C. Cox, Durham, NC US
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20080252983 | METHODS AND APPARATUS FOR CREATING APERTURES THROUGH MICROLENS ARRAYS USING CURVED CRADLES - Methods for creating apertures in a layer on a back side of a substrate that includes a microlens array on a front side thereof include curving the substrate into a cylindrical surface segment that defines an axis, so that the microlens array on the front side of the substrate faces the axis. A pulsed laser beam is scanned from the axis circumferentially along the cylindrical surface segment, to pass through the microlens array on the front side of the substrate and into the layer on the back side of the substrate to create the apertures, while simultaneously translating the substrate and/or the scanned pulsed laser beam axially relative to one another. Related apparatus and microlens array products are also disclosed. | 10-16-2008 |
20110057941 | SYSTEM AND METHOD FOR INSERTING CONTENT INTO AN IMAGE SEQUENCE - Systems and methods for augmenting an image sequence with content are disclosed. A system may include a character generator, a graphics frame buffer and a graphics insertion system. The character generator may generate pixel block content. The graphics frame buffer may be in communication with the character generator and store the pixel block content. The graphics insertion system may be in communication with the first graphics frame buffer. The graphics insertion system may be used to retrieve the pixel block content from the first graphics frame buffer and modify an image sequence with an insert graphic based on the pixel block content. | 03-10-2011 |
Brian E. Cox, Charlotte, NC US
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20090095177 | KIT FOR CREATING ARTISTIC WORK ON LAWN - Components of a kit for creating an artistic work on a lawn include: a container of aerosol paint; a plurality of stakes for anchoring a lawn stencil to a lawn; and a sheet of flexible material in which is defined one or more openings used to apply one or more design elements of the artistic work to the lawn by spraying the aerosol paint through the one or more openings in the lawn stencil when the lawn stencil is anchored to the lawn with the stakes. The components are held in a container having a relatively small form factor that readily accommodates point-of-sale display and purchase at retail stores by consumers. | 04-16-2009 |
20100319557 | LAWN LOGOS - A combination for creating artwork such as a sports logo on a lawn includes a lawn stencil having one or more openings configured to facilitate creation of a portion of the artwork. The combination further includes a container of spray paint and elongate members each having an elongate shaft with proximal and distal portions. The distal portion of each elongate shaft is pointed and includes a shape for accommodating insertion of the distal portion into the lawn. A container holds the lawn stencil, the container of paint, and the plurality of elongate members. The lawn stencil further comprises a connecting member that extends across a said opening of the lawn stencil for maintaining structural integrity of the lawn stencil and for distributing tension in the lawn stencil when the lawn stencil is laid upon the ground with the plurality of elongate members extending through the lawn stencil into the lawn. | 12-23-2010 |
Brian Everett Cox, Sanford, NC US
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20150174515 | Diatomaceous Earth Filter Apparatus and Method - A method for removing diatomaceous earth and contaminants from a filter, and for filtering liquid using diatomaceous earth is provided. Embodiments of the method can include a washdown process, a backwash process, and a filtering process. Some embodiments can include one or more filter cartridges with cartridge tubes to increase flow during the backwash process. Some embodiments can also include a backwash sprayer to disturb contaminants during the backwash process. | 06-25-2015 |
Carrie E. Cox, Apex, NC US
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20080204137 | DESIGN STRUCTURE FOR A SERIAL LINK OUTPUT STAGE DIFFERENTIAL AMPLIFIER - A design structure embodied in a machine readable storage medium for designing, manufacturing, and/or testing a design for protection for the transmission of higher amplitude outputs required of differential amplifiers formed by thin oxide transistors with limited maximum voltage tolerance used where compliance with communication protocol standards requires handling voltages which may, in transition, exceed desirable levels is provided by limiting the voltage across any two device terminals under power down conditions. | 08-28-2008 |
20120153910 | DUAL-LOOP VOLTAGE REGULATOR ARCHITECTURE WITH HIGH DC ACCURACY AND FAST RESPONSE TIME - Dual-loop voltage regulator circuits and methods in which a dual-loop voltage regulation framework is implemented with a first inner loop having a bang-bang voltage regulator to achieve nearly instantaneous response time, and a second outer loop, which is slower in operating speed than the first inner loop, to controllably adjust a trip point of the bang-bang voltage regulator to achieve high DC accuracy. | 06-21-2012 |
20130335120 | SOURCE SERIES TERMINATED DRIVER CIRCUIT WITH PROGRAMMABLE OUTPUT RESISTANCE, AMPLITUDE REDUCTION, AND EQUALIZATION - A source-series terminated (‘SST’) driver circuit that includes: one or more data signal inputs; one or more control signal inputs; a driver output; and a plurality of driver cells, the driver cells coupled in parallel to one another, outputs of the driver cells coupled together to form the driver output of the SST driver circuit, where output resistance of the SST driver circuit varies in dependence upon activation of one or more of the parallel driver cells, activation of each driver cell controlled by control signals received at the control signal inputs. | 12-19-2013 |
20140211350 | ESD PROTECTION DEVICE FOR SST TRANSMITTER - Aspects of the invention provide for an ESD protection device for an SST transmitter. In one embodiment, the ESD protection device includes: a primary ESD protection structure at an output of the SST transmitter; and an additional protection ESD structure in parallel with a slice of the SST transmitter, the additional ESD protection structure including: a first device in parallel with a pull-up transistor network within the slice; and a second device in parallel with a pull-down transistor network within the slice. | 07-31-2014 |
20140254650 | ADAPTABLE RECEIVER DETECTION - Methods and apparatuses for adaptable receiver detection are provided. Embodiments include providing, by receiver detection circuitry at a transmitter coupled to a communication link, a voltage to the communication link; determining, by the receiver detection circuitry, a rise time corresponding to a rising edge change of the voltage on the communication link; determining, by the receiver detection circuitry, a fall time corresponding to a falling edge change of the voltage on the communication link; and determining, by the receiver detection circuitry, whether the rise time and the fall time are consistent with the transmitter being coupled through the communication link to a remote receiver. | 09-11-2014 |
20140355661 | DECISION FEEDBACK EQUALIZER ('DFE') WITH A PLURALITY OF INDEPENDENTLY-CONTROLLED ISOLATED POWER DOMAINS - A Decision Feedback Equalizer (DFE) that includes: a plurality of input signal lines comprising at least one data signal line and a plurality of power control signal lines; at least one output signal line; and a plurality of independently-controlled isolated power domains, where each independently-controlled isolated power domain is coupled to a corresponding one of the power control signal lines, each of the power control signal lines configured to transmit a power control signal to the independently-controlled isolated power domain dynamically, and each independently-controlled isolated power domain selectively consumes power in response to the power control signal, each independently-controlled isolated power domain configured to be dynamically powered up or powered down without impacting signal processing operations. | 12-04-2014 |
20150160920 | ALIGNING FIFO POINTERS IN A DATA COMMUNICATIONS LANE OF A SERIAL LINK - Aligning FIFO pointers includes resetting, by a write control block coupled to a write side of the FIFO, write pointers to an initial value. Then, iteratively, until one or more bits retrieved from the write side match one or more bits of an alignment bit pattern: providing, by the write side to the read side, the alignment bit pattern; retrieving, by the read side, one or more bits from the write side; providing, by the read side through a read control block, the retrieved one or more bits to the write control block; determining, by the write control block, whether the retrieved one or more bits match one or more bits of the alignment bit pattern; and, if the retrieved one or more bits do not match one or more bits of the alignment bit pattern, suppressing the read pointer from incrementing for a predetermined period of time. | 06-11-2015 |
Carrie E. Cox, Cary, NC US
Patent application number | Description | Published |
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20080238554 | Serial Link Output Stage Differential Amplifier and Method - Protection for the transmission of higher amplitude outputs required of differential amplifiers formed by thin oxide transistors with limited maximum voltage tolerance used where compliance with communication protocol standards requires handling voltages which may, in transition, exceed desirable levels is provided by limiting the voltage across any two device terminals under power down conditions. | 10-02-2008 |
20080285661 | HIGH SPEED SERIAL LINK OUTPUT STAGE HAVING SELF ADAPTATION FOR VARIOUS IMPAIRMENTS - A high speed serial link structure and method are provided, comprising a data driver and a replica driver structure, the replica driver structure comprising a replica driver, a calibration engine and a peak level detector. The calibration engine compares a peak level detector output to a reference value and responsively performs a data driver adjustment, wherein the data driver adjustment comprises at least one of a driver biasing adjustment, a driver intermediate stage bandwidth adjustment and a driver equalization setting adjustment. In some embodiments, the calibration engine incorporates a comparator and a digital state machine; in other embodiments, it incorporates an analog operational amplifier. | 11-20-2008 |
20090110084 | RECEIVER TERMINATION CIRCUIT FOR A HIGH SPEED DIRECT CURRENT (DC) SERIAL LINK - A method for matching receiver and transmitter common-mode voltages for a high-speed direct current (DC) serial connection between the receiver and the transmitter includes measuring, at the receiver, a common-mode voltage of the transmitter. The common-mode voltage of the transmitter is an average of a voltage signal transmitted by the transmitter and received by the receiver. The method further includes comparing the common-mode voltage of the transmitter with a common-mode voltage of the receiver. The method further includes maintaining the common-mode voltage of the receiver at a first level at which the common-mode voltage of the receiver substantially matches the common-mode voltage of the transmitter. | 04-30-2009 |
Carrie Ellen Cox, Cary, NC US
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20090091375 | SYSTEM AND METHOD TO MINIMIZE TRANSITION TIME BETWEEN CIRCUIT OPERATING MODES - A system is disclosed. The system includes a first circuit, the first circuit includes a bias device for allowing the first circuit to transition between a first mode and a second mode. The system further includes a second circuit which controls the bias device. The second circuit provides a bias voltage at a sub-threshold voltage level to the bias device when the first device is in one of the first and the second mode. The second circuit provides a bias voltage at a threshold voltage level or higher when the first device is in one of the first and the second mode. Accordingly, the transition time between modes of the first circuit is minimized. | 04-09-2009 |
Chris Gregory Cox, Columbus, NC US
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20130297325 | PHARMACEUTICAL WILL CALL SYSTEM AND METHOD - A wireless computerized will call system is provided for filling prescriptions and then locating specific prescriptions that have been filled when the customer arrives to pick up the prescription. The system includes a computer workstation or network, a wireless transmitter, and hanger bags for temporarily storing prescriptions awaiting customer pick up. The hanger bags are equipped with wireless receivers and transducers. When a pharmacy worker commands the computer system to locate a specific prescription, the specific hanger bag containing that prescription receives a wireless signal from the computer system and activates the transducer on the hanger bag to alert the pharmacy worker to the location of the prescription. | 11-07-2013 |
Christopher Alan Cox, Raleigh, NC US
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20110071096 | Macrolides Having Antibiotic Activity - The present invention relates to a semi-synthetic macrolide having antimicrobial activity, in particular antibacterial activity; pharmaceutical compositions comprising the macrolide; and methods of using the macrolide to treat or prevent an infection. | 03-24-2011 |
Christopher J. Cox, Raleigh, NC US
Daniel Cox, Elon, NC US
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20100132515 | Shingle Removing Tool - A shingle removing tool includes, among other possible things, a handle, a shaft connected to the handle, and a base connected to the shaft. A length of the shaft is adjustable. The base includes a blade portion that is configured to separate one or more shingles from a support structure to which the shingles are affixed. | 06-03-2010 |
20100260862 | TIME RELEASE FORMULATIONS AND METHODS OF MAKING SAME - Time release repellent formulations and methods of making formulations, comprising a natural repellent, alum in an amount effective to keep microbial count below a pre-determined level and a natural binder. The natural repellent may be animal urine or a natural oil. The natural binder is selected from the group consisting of: rice, pearlite, polymer, peat moss, clay and foam. The pH level of the formulation is maintained within a pre-determined range by adding a natural acid to lower the pH level or adding a natural base to raise the pH level. | 10-14-2010 |
Daniel S. Cox, Gibsonville, NC US
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20140318820 | Motors with Magnetic Components - Disclosed are methods and devices utilizing magnetized components to assist operation of an internal mechanism of a tool. Magnetic fields can assist a power tool comprising internal mechanisms that cycle very quickly. Magnetized components can assist in a load/reset action relative to internal components of the power tool. In one example, one or more hammers of a hammer drill/driver can be reset more efficiently when various magnetized elements are oriented in certain ways relative to one another. Additionally, friction between components can be reduced by repulsive magnetic fields between two or more components. Utilizing the magnetic fields can improve the overall function of internal components of the tool. In another example, a tool such as a nailer or stapler can utilize magnetism to assist its internal components. In a nailer or stapler the magnetism can assist, for example, acceleration and deceleration of components utilized to drive the nail/staple. | 10-30-2014 |
20150071806 | Rotary Vane Air Motor with Improved Vanes and Other Improvements - A rotary vane air motor comprises a rotor, stator and vanes. The rotor has slots for the vanes, and the vanes may move between a retracted position and a contact position in which the vanes contact the cylinder. Each vane may have a longitudinal portion whose shape conforms generally to the slot, and a transverse portion that is radially outside of the slot and extends at least in part in a direction that is transverse to the longitudinal portion and that may be tangential to the perimeter of the rotor at the slot. The shape of the perimeter may be a polygon with rounded corners. The vanes may also include a magnetic portion or a rotating portion. | 03-12-2015 |
Daniel S. Cox, Elon, NC US
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20130202470 | Rotary Vane Air Motor with Improved Vanes and Other Improvements - A rotary vane air motor comprises a rotor, stator and vanes. The rotor has slots for the vanes, and the vanes may move between a retracted position and a contact position in which the vanes contact the cylinder. Each vane may have a longitudinal portion whose shape conforms generally to the slot, and a transverse portion that is radially outside of the slot and extends at least in part in a direction that is transverse to the longitudinal portion and that may be tangential to the perimeter of the rotor at the slot. The shape of the perimeter may be a polygon with rounded corners. The vanes may also include a magnetic portion or a rotating portion. | 08-08-2013 |
20140208648 | Agricultural Systems and Methods - An agricultural system includes a container containing a medium and a plant source. The medium may be a binder, and the container may further contain an additive bound to the binder. The medium may be pollen. Agricultural methods are also included. | 07-31-2014 |
David Alan Cox, Raeford, NC US
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20100313320 | BODY ARMOR - A body armor accessory adds protection to unguarded areas of conventional body armor. The removable accessory comprises an axillary panel having a coverage area and is made of material that impedes the penetration of a foreign object. The accessory can be worn on either the left or right side of the wearer. The coverage area to the deltoid and flank areas of the wearer provided by the axillary panel is greater than that provided by the vest without the panel. A deltoid panel provides added protection to the deltoid area of the wearer. | 12-16-2010 |
David E. Cox, Raleigh, NC US
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20090172012 | Methodology to derive enterprise relationships for generating a topology view in a SOA environment - A method for generating a topology of a service oriented architecture (SOA) environment comprises associating a unique identifier with each entity within the SOA environment. The unique identifier summarizes attribute data of a respective entity. The relationships between the unique identifiers are used to derive a topology of the SOA environment. | 07-02-2009 |
20130159390 | Information Caching System - A method, data processing system, and computer program product for caching information. A computer determines whether at least one of a client data processing system and a hardware device in a plurality of hardware devices has performed a number of operations that have been identified as being associated with a request that is sent to a first hardware device in the plurality of hardware devices. The first hardware device is configured to obtain information from a second hardware device in the plurality of hardware devices for use in generating a response to the request. The computer caches the information in a cache for the plurality of hardware devices prior to a subsequent request for the information being sent to the first hardware device in response to a determination that the at least one of the client data processing system and the hardware device has performed the number of operations. | 06-20-2013 |
David Eugene Cox, Raleigh, NC US
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20100030805 | PROPAGATING INFORMATION FROM A TRUST CHAIN PROCESSING - A method, system, and computer usable program product for propagating information in a trust chain processing are provided in the illustrative embodiments. Upon a trust client invoking the trust chain processing, a mapped security information is received, the mapped security information being stored in a memory or a data storage associated with a data processing system. A set of security information attributes are located from the mapped security information according to a configuration. The set of security information attributes are packaged to form a packaged security information. The packaged security information is issued to a target system, the target system being distinct from the trust client that invoked the trust chain processing. The locating, the packaging, and the issuing collectively form monitoring the trust chain processing. A next component in the trust chain processing may be invoked. The invoking may occur before, after, or during the monitoring. | 02-04-2010 |
David Neil Cox, Raleigh, NC US
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20140317113 | TABULAR DATA PARSING IN DOCUMENT(S) - One or more techniques and/or systems are provided for parsing tabular data of a document. That is, a document may comprise arbitrarily formatted content (e.g., an equipment inspection report generated by an engineer). Respective rows of the document may be clustered into one or more row clusters based upon row proximity and/or numeric content (e.g., rows having similar numeric content may comprise logically related information). One or more vertical clusters may be generated within respective row clusters based upon vertical overlap. In this way, row clusters and/or vertical clusters may be searched for one or more values that may be assigned to a search term. For example, a row cluster may comprise a search term “Average temp”. One or more vertical clusters within the row cluster may be searched for a word that matches a pattern criteria (e.g., a two digit number), which may be assigned to the search term. | 10-23-2014 |
Edwin B. Cox, Chapel Hill, NC US
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20090223511 | Unglazed photovoltaic and thermal apparatus and method - A photovoltaic/thermal solar panel is presented which contains no glazing above the photovoltaic array. The absence of glazing allows the photovoltaic cells to operate at a lower temperature and therefore at a higher efficiency. In addition, the absence of glazing allows the present invention PV/T panel to be used to provide nighttime cooling for a building. The panel is constructed by adhering an aluminum heat transfer plate to the rear of the PV array in the panel using a silicone adhesive. PEX tubing is inserted into channels integrally formed into the back of the heat transfer plate again using silicone or other heat-conductive compound. | 09-10-2009 |
Edwin G. Cox, Jamestown, NC US
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20130234686 | SYSTEM AND METHOD FOR PROVIDING A HIGH EFFICIENCY BYPASS CIRCUIT FOR MULTI-STAGE DC-DC CONVERTERS USED IN BATTERY POWERED SYSTEMS - A system and method are disclosed for providing a high efficiency bypass circuit for multi-stage direct current to direct current (DC-DC) converters used in battery powered systems. When the system is operating in a battery mode, the vehicle power source is unplugged from the power supply input connector and the external battery is connected in its place. The system uses a relay to bypass the flyback converter so as to connect the boost converter output directly to the output terminals. The system uses a single control signal to: 1) energize the relay connecting the boost converter output directly to the output terminals, 2) adjust the boost converter circuit to cause the boost converter to deliver a voltage equal to what the flyback converter would have delivered, and 3) disable the flyback converter. | 09-12-2013 |
Everett Cox, Sanford, NC US
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20120063921 | Control Algorithm of Variable Speed Pumping System - A pumping system includes a pump for moving water. In one aspect, this is in connection with performance of an operation. The system includes a variable speed motor operatively connected to drive the pump. A value indicative of flow rate of water is determined and the motor is controlled to adjust the flow rate indicative value toward a constant. A value indicative of flow pressure is determined and the motor is controlled to adjust the flow pressure indicative value toward a constant. A selection is made between flow rate control and flow pressure control. In another aspect, the pump is controlled to perform a first operation, and is operated to perform a second water operation. Control of operation of the pump to perform the first water operation is altered in response to operation of the pump to perform the second operation. | 03-15-2012 |
20140322030 | Control Algorithm of Variable Speed Pumping System - A pumping system includes a pump for moving water. In one aspect, this is in connection with performance of an operation. The system includes a variable speed motor operatively connected to drive the pump. A value indicative of flow rate of water is determined and the motor is controlled to adjust the flow rate indicative value toward a constant. A value indicative of flow pressure is determined and the motor is controlled to adjust the flow pressure indicative value toward a constant. A selection is made between flow rate control and flow pressure control. In another aspect, the pump is controlled to perform a first operation, and is operated to perform a second water operation. Control of operation of the pump to perform the first water operation is altered in response to operation of the pump to perform the second operation. | 10-30-2014 |
Gregory K. Cox, Snow Hill, NC US
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20110100403 | Gutter Cleaning Device - A gutter cleaning device comprising a nozzle body preferably detachably coupled to a wand in fluid communication with a pressurized water source, the nozzle body having a fluid passage means providing fluid communication to a first nozzle obtusely offset from a coplanar, simultaneously operating, second nozzle. | 05-05-2011 |
G. Sidney Cox, Durham, NC US
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20080297274 | CAPACITIVE/RESISTIVE DEVICES, ORGANIC DIELECTRIC LAMINATES AND PRINTED WIRING BOARDS INCORPORATING SUCH DEVICES, AND METHODS OF MAKING THEREOF - This invention relates to a capacitive/resistive device, which may be embedded within a layer of a printed wiring board. Embedding the device conserves board surface real estate, and reduces the number of solder connections, thereby increasing reliability. More specifically, the device, comprises a first metallic foil; a second metallic foil; a first electrode formed from the first metallic foil; a dielectric disposed over the first electrode; a resistor element formed on and adjacent to the dielectric; a conductive trace; and a second electrode formed from the second metallic foil and disposed over the dielectric and in electrical contact with the resistor element, wherein the dielectric is disposed between the first electrode and the second electrode and wherein said dielectric comprises an unfilled polymer of dielectric constant less than 4.0. | 12-04-2008 |
20090118408 | Dielectric compositions containing coated filler and methods relating thereto - The present disclosure relates to a dielectric composition having a resin and a filler. The filler is used to raise the dielectric and has a passivating surface coating thereon. | 05-07-2009 |
20150197073 | POLYIMIDE METAL CLAD LAMINATE - The present disclosure is directed to a polyimide metal clad laminate. The metal clad laminate has a metal foil and a polyimide layer. The polyimide layer having a polyimide derived from 100 mole % 3,3′,4,4′-biphenyl tetracarboxylic dianhydride, and 100 mole % 2,2′-bis(trifluoromethyl)benzidine. The polyimide metal clad laminate does not have an adhesive layer between the metal foil and the polyimide layer. | 07-16-2015 |
20150201490 | CIRCUIT BOARD - The present disclosure is directed to a circuit board having a first imaged metal layer, a first electrically insulating layer, a second imaged metal layer, a polyimide bondply derived from 100 mole % 3,3′,4,4′-biphenyl tetracarboxylic dianhydride, 20 to 90 mole % 2,2′-bis(trifluoromethyl)benzidine, and 10 to 80 mole % 4,4′-oxydianiline, a third imaged metal layer, a second electrically insulating layer and a forth imaged metal layer. The circuit board does not have an adhesive layer between the second imaged metal layer and the polyimide bondply or the third imaged layer and the polyimide bondply. | 07-16-2015 |
Herman Cox, Pinetops, NC US
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20150101178 | UNIVERSAL CLAMPING ASSEMBLY FOR KEY DUPLICATING MACHINE - A universal clamping assembly for a key duplicating machine is described. The clamping assembly comprises a housing having a pair of opposed flat guide rail support surfaces and a sliding tip clamp is guidingly displaceable along each of the guide rail support surfaces and are urged against the tip of the key and key blank blades which are positioned on the guide rails. A pivoting clamp is displaceably engageable on a forward top edge of the respective key blades to apply a downward force on the key blades to ensure that the lower edge of the key blades is firmly resting against the guide rail support surfaces. A pair of cam operated side clamps is actuable to further clamp the blade on their sides at two distinct areas. The universal clamping assembly is capable of accommodating different key and key blank lengths, widths and thicknesses. The method of clamping the key and key blank is also described. | 04-16-2015 |
James Cox, Cary, NC US
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20140059073 | Systems and Methods for Providing a Unified Variable Selection Approach Based on Variance Preservation - This disclosure describes a method, system and computer-program product for parallelized feature selection. The method, system and computer-program product may be used to access a first set of features, wherein the first set of features includes multiple features, wherein the features are characterized by a variance measure, and wherein accessing the first set of features includes using a computing system to access the features, determine components of a covariance matrix, the components of the covariance matrix indicating a covariance with respect to pairs of features in the first set, and select multiple features from the first set, wherein selecting is based on the determined components of the covariance matrix and an amount of the variance measure attributable to the selected multiple features, and wherein selecting the multiple features includes executing a greedy search performed using parallelized computation. | 02-27-2014 |
James Allen Cox, Cary, NC US
Patent application number | Description | Published |
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20140089247 | Fast Binary Rule Extraction for Large Scale Text Data - Systems and methods for identifying data files that have a common characteristic are provided. A plurality of data files including one or more data files having a common characteristic are received. A potential rule is generated by selecting key terms from a list that satisfy a term evaluation metric, and the potential rule is evaluated using a rule evaluation metric. The potential rule is added to the rule set if the rule evaluation metric is satisfied. Based upon the potential rule being added to the rule set, data files covered by the potential rule are removed from the plurality of data files. The potential rule generation and evaluation steps are repeated until a stopping criterion is met. After the stopping criterion has been met, the rule set is used to identify other data files having the common characteristic. | 03-27-2014 |
20140337271 | SYSTEM FOR EFFICIENTLY GENERATING K-MAXIMALLY PREDICTIVE ASSOCIATION RULES WITH A GIVEN CONSEQUENT - This disclosure provides a computer-program product, system, method and apparatus for accessing a representation of a category or item and accessing a set of multiple transactions. The transactions are processed to identify items found amongst the transactions, and the items are ordered based on an information-gain heuristic. A depth-first search for a group of best association rules is then conducted using a best-first heuristic and constraints that make the search efficient. The best rules found during the search can then be displayed to a user, along with accompanying statistics. The user can then select rules that appear to be most relevant, and further analytics can be applied to the selected rules to obtain further information about the information provided by these rules. | 11-13-2014 |
20140337272 | SYSTEMS AND METHODS FOR INTERACTIVE DISPLAYS BASED ON ASSOCIATIONS FOR MACHINE-GUIDED RULE CREATION - This disclosure provides a computer-program product, system, method and apparatus for accessing a representation of a category or item and accessing a set of multiple transactions. The transactions are processed to identify items found amongst the transactions, and the items are ordered based on an information-gain heuristic. A depth-first search for a group of best association rules is then conducted using a best-first heuristic and constraints that make the search efficient. The best rules found during the search can then be displayed to a user, along with accompanying statistics. The user can then select rules that appear to be most relevant, and further analytics can be applied to the selected rules to obtain further information about the information provided by these rules. | 11-13-2014 |
20150193523 | SYSTEM AND METHODS FOR INTERACTIVE DISPLAYS BASED ON ASSOCIATIONS FOR MACHINE-GUIDED RULE CREATION - This disclosure provides a computer-program product, system, method and apparatus for accessing a representation of a category or item and accessing a set of multiple transactions. The transactions are processed to identify items found amongst the transactions, and the items are ordered based on an information-gain heuristic. A depth-first search for a group of best association rules is then conducted using a best-first heuristic and constraints that make the search efficient. The best rules found during the search can then be displayed to a user, along with accompanying statistics. The user can then select rules that appear to be most relevant, and further analytics can be applied to the selected rules to obtain further information about the information provided by these rules. | 07-09-2015 |
Jason A. Cox, Raleigh, NC US
Patent application number | Description | Published |
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20080288720 | MULTI-WAFER 3D CAM CELL - A multi-wafer CAM cell in which the negative effects of increased travel distance have been substantially reduced is provided. The multi-wafer CAM cell is achieved in the present invention by utilizing three-dimensional integration in which multiple active circuit layers are vertically stack and vertically aligned interconnects are employed to connect a device from one of the stacked layers to another device in another stack layer. By vertically stacking multiple active circuit layers with vertically aligned interconnects, each compare port of the inventive CAM cell can be implemented on a separate layer above or below the primary data storage cell. This allows the multi-wafer CAM structure to be implemented within the same area footprint as a standard Random Access Memory (RAM) cell, minimizing data access and match compare delays. | 11-20-2008 |
20080288752 | DESIGN STRUCTURE FOR FORWARDING STORE DATA TO LOADS IN A PIPELINED PROCESSOR - A design structure embodied in a machine readable storage medium for designing, manufacturing, and/or testing a design for forwarding store data to loads in a pipelined processor is provided. In one implementation, a processor is provided that includes a decoder operable to decode an instruction, and a plurality of execution units operable to respectively execute a decoded instruction from the decoder. The plurality of execution units include a load/store execution unit operable to execute decoded load instructions and decoded store instructions and generate corresponding load memory operations and store memory operations. The store queue is operable to buffer one or more store memory operations prior to the one or more memory operations being completed, and the store queue is operable to forward store data of the one or more store memory operations buffered in the store queue to a load memory operation on a byte-by-byte basis. | 11-20-2008 |
20090286598 | System And Method Of Deterministic Teleportation Within A Virtual World - A method for deterministic teleportation within a virtual world, comprising creating and storing an association between a set of user conditions and a set of teleporter exit destinations. When a user engages the teleporter entrance, a user condition set is retrieved from the incoming user. The set of retrieved incoming user conditions is stored and compared to the association. A correct teleporter exit destination is selected from the set of teleporter exit destinations corresponding to a data match between the set of retrieved incoming user conditions and the set of user conditions associated with the exit destination. | 11-19-2009 |
20100036936 | MODIFICATION OF SOCIAL NETWORKS VIA DESIGN CODES - A method including receiving an update to at least one social network map encoded in a design code, modifying the social network map by inserting or deleting social contact data, and regenerating the design code to include the modified social network map. | 02-11-2010 |
20100037288 | Inherited Access Authorization to a Social Network - A method for access authorization via inheritance to information of a first registered user on a social network comprises defining authorization criteria for the first registered user; receiving first verification data from a requester, wherein the requester comprises one of a second registered user or a non-registered user; determining if the first verification data satisfies the authorization criteria, and in the event the first verification data satisfies the authorization criteria, extending inherited access authorization to the requester in the event the requester is the non-registered user, and extending inherited access authorization to a contact of the requestor in the event the requestor is the second registered user. | 02-11-2010 |
20100088744 | System For Online Compromise Tool - An Activity Access Control (AAC) utility controls access to applications and devices by allowing an administrator to set terms of use/access regarding a applications and/or devices for a group of users, whose activity are monitored. The AAC utility also enables administrator and user access to a compromise facility via a centralized access point to establish or request changes to the terms of use/access. The AAC utility allows the administrator to dynamically update information and set terms based on real-time information collected during activity monitoring. Dynamic updates may also occur based on the monitored user's request, the priority of the requesting user(s), historical data, occurrence of a special event, completion of other internal or/external tasks, and/or pre-set limitations or thresholds. In addition, the AAC utility facilitates the real-time display or publishing of the terms of use, status information, and statistical information to users and the administrator. | 04-08-2010 |
20120127771 | MULTI-WAFER 3D CAM CELL - A multi-wafer CAM cell in which the negative effects of increased travel distance have been substantially reduced is provided. The multi-wafer CAM cell is achieved in the present invention by utilizing three-dimensional integration in which multiple active circuit layers are vertically stack and vertically aligned interconnects are employed to connect a device from one of the stacked layers to another device in another stack layer. By vertically stacking multiple active circuit layers with vertically aligned interconnects, each compare port of the inventive CAM cell can be implemented on a separate layer above or below the primary data storage cell. This allows the multi-wafer CAM structure to be implemented within the same area footprint as a standard Random Access Memory (RAM) cell, minimizing data access and match compare delays. | 05-24-2012 |
20120151142 | TRANSFER OF BUS-BASED OPERATIONS TO DEMAND-SIDE MACHINES - An L2 cache, method and computer program product for transferring an inbound bus operation to a processor side handling machine. The method includes a bus operation handling machine accepting the inbound bus operation received over a system interconnect, the bus operation handling machine identifying a demand operation of the processor side handling machine that will complete the bus operation, the bus operation handling machine sending the identified demand operation to the processor side handling machine, and the processor side handling machine performing the identified demand operation. | 06-14-2012 |
20120159082 | Direct Access To Cache Memory - Methods and apparatuses are disclosed for direct access to cache memory. Embodiments include receiving, by a direct access manager that is coupled to a cache controller for a cache memory, a region scope zero command describing a region scope zero operation to be performed on the cache memory; in response to receiving the region scope zero command, generating a direct memory access region scope zero command, the direct memory access region scope zero command having an operation code and an identification of the physical addresses of the cache memory on which the operation is to be performed; sending the direct memory access region scope zero command to the cache controller for the cache memory; and performing, by the cache controller, the direct memory access region scope zero operation in dependence upon the operation code and the identification of the physical addresses of the cache memory. | 06-21-2012 |
20120159086 | Cache Management - Methods, apparatuses, and computer program products are disclosed for cache management. Embodiments include receiving, by a cache controller, a request to insert a new cache line into a cache; determining, by the cache controller, whether the new cache line is associated with a forced injection; in response to determining that the new cache line is associated with a forced injection, accepting, by the cache controller, the insertion of the new cache line into the cache; and in response to determining that the new cache line is not associated with a forced injection, determining, by the cache controller, whether to accept the insertion of the new cache line based on a comparison of an address of the new cache line to a predefined range of addresses. | 06-21-2012 |
20120159087 | Ensuring Forward Progress of Token-Required Cache Operations In A Shared Cache - Ensuring forward progress of token-required cache operations in a shared cache, including: snooping an instruction to execute a token-required cache operation; determining if a snoop machine is available and if the snoop machine is set to a reservation state; if the snoop machine is available and the snoop machine is in the reservation state, determining whether the instruction to execute the token-required cache operation owns a token or is a joint instruction; if the instruction is a joint instruction, instructing the operation to retry; if the instruction to execute the token-required cache operation owns a token, dispatching a cache controller; determining whether all required cache controllers of relevant compute nodes are available to execute the instruction; executing the instruction if the required cache controllers are available otherwise not executing the instruction. | 06-21-2012 |
20120159640 | Acquiring Access To A Token Controlled System Resource - Acquiring access to a token controlled system resource, including: receiving, by a token broker, a command that requires access to the token controlled system resource, where the token broker is automated computing machinery for acquiring tokens and distributing the command to the token controlled system resource for execution; identifying, by the token broker, a first need state, the first need state indicating that the token broker requires access to the token controlled system resource to which the token broker does not possess a token; requesting, by the token broker, a configurable number of tokens to gain access to the token controlled system resource, without dispatching an operation handler for executing the command until at least one token is acquired; assigning, by the token broker, an acquired token to the operation handler; and dispatching, by the token broker, the operation handler and its assigned token for executing the command. | 06-21-2012 |
20120198178 | ADDRESS-BASED HAZARD RESOLUTION FOR MANAGING READ/WRITE OPERATIONS IN A MEMORY CACHE - One embodiment provides a cached memory system including a memory cache and a plurality of read-claim (RC) machines configured for performing read and write operations dispatched from a processor. According to control logic provided with the cached memory system, a hazard is detected between first and second read or write operations being handled by first and second RC machines. The second RC machine is suspended and a subset of the address bits of the second operation at specific bit positions are recorded. The subset of address bits of the first operation at the specific bit positions are broadcast in response to the first operation being completed. The second operation is then re-requested. | 08-02-2012 |
20120278867 | SYSTEM FOR ONLINE COMPROMISE TOOL - An Activity Access Control (AAC) utility controls access to applications and devices by allowing an administrator to set terms of use/access regarding a applications and/or devices for a group of users, whose activity are monitored. The AAC utility also enables administrator and user access to a compromise facility via a centralized access point to establish or request changes to the terms of use/access. The AAC utility allows the administrator to dynamically update information and set terms based on real-time information collected during activity monitoring. Dynamic updates may also occur based on the monitored user's request, the priority of the requesting user(s), historical data, occurrence of a special event, completion of other internal or/external tasks, and/or pre-set limitations or thresholds. In addition, the AAC utility facilitates the real-time display or publishing of the terms of use, status information, and statistical information to users and the administrator. | 11-01-2012 |
20140237186 | FILTERING SNOOP TRAFFIC IN A MULTIPROCESSOR COMPUTING SYSTEM - Filtering snoop traffic in a multiprocessor computing system, each processor in the multiprocessor computing system coupled to a high level cache and a low level cache, the including: receiving a snoop message that identifies an address in shared memory targeted by a write operation; identifying a set in the high level cache that maps to the address in shared memory; determining whether the high level cache includes an entry associated with the address in shared memory; responsive to determining that the high level cache does not include an entry corresponding to the address in shared memory: determining whether the set in the high level cache has been bypassed by an entry in the low level cache; and responsive to determining that the set in the high level cache has not been bypassed by an entry in the low level cache, discarding the snoop message. | 08-21-2014 |
Jeffrey Neal Cox, Asheboro, NC US
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20150204618 | THERMAL ENERGY STORAGE SYSTEMS - In one aspect, thermal energy storage systems are described herein. In some embodiments, a thermal energy storage system comprises a thermal energy storage system comprising a container and a heat exchange apparatus disposed within the container. The heat exchange apparatus comprises a tank, a manifold at least partially disposed within the tank, and a phase change material disposed within the tank and in thermal contact with the manifold. | 07-23-2015 |
Jesse Barton Cox, Fairview, NC US
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20120031025 | INSULATED NATURAL LOG CABIN - Interior insulation slots cut vertically through natural logs align to form a full wall interior insulation space within the stacked natural log wall. A plank cut out of the interior of each log is used in the interior structure of the building. Solid ends of the logs form corners with intersecting walls. Structural metal posts within the interior insulation space bind the logs together. Foam and vapor barrier insulation fill the interior insulation space. Only the curved natural log surfaces are exposed on the exterior and interior walls. | 02-09-2012 |
John S. Cox, Apex, NC US
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20140129666 | PREEMPTIVE CACHING OF DATA - A first computing device receives a first request from a client computing device, wherein the first request includes a markup language request. The first computing device transmits the first request to a second computing device, wherein the second computing device services the first request. The first computing device receives the serviced first request, wherein the serviced first request includes a manifest tag. The first computing device caches the serviced first request. The first computing device transmits the serviced first request to the client computing device. | 05-08-2014 |
20140189044 | PREEMPTIVE CACHING OF DATA - A first computing device receives a first request from a client computing device, wherein the first request includes a markup language request. The first computing device transmits the first request to a second computing device, wherein the second computing device services the first request. The first computing device receives the serviced first request, wherein the serviced first request includes a manifest tag. The first computing device caches the serviced first request. The first computing device transmits the serviced first request to the client computing device. | 07-03-2014 |
Kenneth R. Cox, Mooresville, NC US
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20140095379 | Payments Perfection And Processing System - Data associated with a payment may be perfected before additional processing. An image file is received during a first time period, and a processor determines, during the first time period, data associated with the image file. The processor automatically determines, during the first time period, one or more exceptions associated with the data by evaluating if the data meets one or more exception rules. The processor performs, during the first time period, one or more data perfection procedures triggered by the one or more exceptions to obtain perfected data. The processor sends, during the first time period, the perfected data to a posting application. | 04-03-2014 |
20150066750 | Payments Perfection and Processing System - Data associated with a payment may be perfected before additional processing. An image file is received during a first time period, and a processor determines, during the first time period, data associated with the image file. The processor automatically determines, during the first time period, one or more exceptions associated with the data by evaluating if the data meets one or more exception rules. The processor performs, during the first time period, one or more data perfection procedures triggered by the one or more exceptions to obtain perfected data. The processor sends, during the first time period, the perfected data to a posting application. | 03-05-2015 |
Kevin Cox, Raleigh, NC US
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20110236416 | FOOT AND MOUTH DISEASE VIRUS RECOMBINANT VACCINES AND USES THEREOF - The present invention encompasses FMDV vaccines or compositions. The vaccine or composition may be a vaccine or composition containing FMDV antigens. The invention also encompasses recombinant vectors encoding and expressing FMDV antigens, epitopes or immunogens which can be used to protect animals, in particular ovines, bovines, caprines, or porcines, against FMDV. | 09-29-2011 |
20110236420 | BLUETONGUE VIRUS RECOMBINANT VACCINES AND USES THEREOF - The present invention encompasses BTV vaccines or compositions. The vaccine or composition may be a vaccine or composition containing BTV antigens. The invention also encompasses recombinant vectors encoding and expressing BTV antigens, epitopes or immunogens which can be used to protect animals, such as ovines, bovines, or caprines, against BTV. | 09-29-2011 |
20110250177 | ALPHA INTERFERON VARIANTS - The present invention provides biologically active variants of human α-2b-interferon. The variants contain carboxy terminus truncations when compared with the amino acid sequence of full-length human α-2b-interferon. It is the novel finding of the present invention that these truncated variants have the biological activity of full-length human α-2b-interferon. The invention encompasses these biologically active variant α-interferons, as well as polynucleotides encoding these interferons. Expression cassettes comprising these polynucleotides and host cells comprising the expression cassettes are also provided. The invention also provides compositions comprising variant α-interferon polypeptides and a pharmaceutically acceptable carrier. | 10-13-2011 |
Kevin M. Cox, Raleigh, NC US
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20090060921 | GLYCAN-OPTIMIZED ANTI-CD20 ANTIBODIES - Glycan-optimized monoclonal antibodies that specifically bind CD20 antigen and which have improved effector function are provided. The anti-CD20 antibodies of the invention have a glycosylation pattern that results in an antibody composition having predominately the G0 glycoform, and thus comprise N-glycans that lack fucose (i.e., afucosylated) and galactose residues attached thereto. In some embodiments, these anti-CD20 antibodies comprise the light chain and heavy chain sequences of the rituximab anti-CD20 antibody, and thus represent afucosylated rituximab. Methods for producing these glycan-optimized anti-CD20 antibodies are also provided. | 03-05-2009 |
20090175886 | MONOCLONAL ANTIBODIES AGAINST CD30 LACKING IN FUCOSYL AND XYLOSYL RESIDUES - The invention pertains to anti-CD30 antibodies that lack fucosyl and xylosyl residues. The antibodies of the invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity, including the ability to lyse CD30-expressing cell lines that are not lysed by the fucosylated and xylosylated form of the antibodies. The invention also provides host cells that express the anti-CD30 antibodies that lack fucosyl and xylosyl residues, wherein the host cells are deficient for a fucosyltransferase and a xylosyltransferase. Methods of using the antibodies to inhibit the growth of CD30 cells, such as tumor cells, are also provided. | 07-09-2009 |
20100043099 | EXPRESSION CONTROL ELEMENTS FROM THE LEMNACEAE FAMILY - Compositions and methods for regulating expression of nucleotide sequences of interest in a plant are provided. Compositions include novel nucleic acid molecules, and variants and fragments thereof, for expression control elements isolated from the Lemnaceae ubiquitin, r-histone and chitinase genes. A method for expressing a nucleotide sequence of interest in a plant using the expression control elements disclosed herein is further provided. The method includes introducing into a plant or plant cell or nodule an expression construct comprising an expression control element of the present invention operably linked to a nucleotide sequence of interest. In particular, the compositions and methods find use in enhancing expression of nucleotide sequences of interest in duckweed. Also provided is a novel Lemnaceae signal peptide-encoding sequence and the signal peptide encoded thereby. Where an expression construct of the invention is designed to express a polypeptide of interest, this novel signal peptide-encoding sequence can be included within the expression construct of the invention to provide for extracellular secretion of the encoded polypeptide of interest. | 02-18-2010 |
20100186126 | EXPRESSION OF PLASMINOGEN AND MICROPLASMINOGEN IN DUCKWEED - The present invention provides methods and compositions for the production of recombinant plasminogen, microplasminogen, and fragments thereof in a duckweed expression system. It is the novel finding of the present invention that a duckweed expression system may be used to produce high levels of plasminogen and microplasminogen. The duckweed-produced plasminogen and microplasminogen can be activated to produce a polypeptide having protease activity. Thus, the invention encompasses methods for the expression of plasminogen, microplasminogen, and fragments thereof in duckweed, duckweed plants that are transformed with expression cassettes for the expression of plasminogen, microplasminogen, and fragments thereof, and nucleic acids comprising nucleotide sequences encoding plasminogen, microplasminogen, and fragments thereof, where these nucleotide sequences are modified to enhance their expression in duckweed. | 07-22-2010 |
20110144308 | COMPOSITIONS AND METHODS FOR HUMANIZATION AND OPTIMIZATION OF N-GLYCANS IN PLANTS - Methods for altering the N-glycosylation pattern of proteins in higher plants are provided. The methods comprise introducing into the plant a recombinant construct that provides for the inhibition of expression of α1,3-fucosyltransferase (FucT) and β1,2-xylosyltransferase (XylT) in a plant. Use of these constructs to inhibit or suppress expression of both of these enzymes, and isoforms thereof, advantageously provides for the production of endogenous and heterologous proteins having a “humanized” N-glycosylation pattern without impacting plant growth and development. Stably transformed higher plants having this protein N-glycosylation pattern are provided. Glycoprotein compositions, including monoclonal antibody compositions, having substantially homogeneous glycosylation profiles, and which are substantially homogeneous for the G0 glycoform, are also provided. | 06-16-2011 |
20120220015 | COMPOSITIONS AND METHODS FOR PRODUCTION OF AGLYCOSYLATED PLASMINOGEN - Compositions and methods for producing aglycosylated plasminogen (PLG) polypeptides and fragments and variants thereof are provided. Compositions of the invention include isolated nucleic acid molecules encoding aglycosylated PLG polypeptides in which the asparagine (Asn) residue corresponding to residue Asn-289 of the mature human PLG polypeptide has been substituted with an amino acid residue that does not support N-linked glycosylation at that position of the PLG polypeptide, as well as the aglycosylated PLG polypeptides encoded thereby. Expression constructs comprising these PLG-encoding nucleic acid molecules and transgenic plants comprising these expression constructs are also provided. Methods of the invention comprise introducing a PLG-encoding nucleic acid molecule of the invention into a plant of interest and culturing the plant under conditions to produce the aglycosylated PLG polypeptide. The aglycosylated PLG polypeptide allows for significant increases in production and yield of PLG from a plant-based expression system without comprising the ability of the PLG product to be activated to a polypeptide capable of binding fibrin and having serine protease activity, including biologically active plasmin that is also glycosylated. The activated aglycosylated plasmin is useful to treat diseases or conditions associated with a thrombus. | 08-30-2012 |
20120276086 | MONOCLONAL ANTIBODIES AGAINST CD30 LACKING IN FUCOSYL AND XYLOSYL RESIDUES - The invention pertains to anti-CD30 antibodies that lack fucosyl and xylosyl residues. The antibodies of the invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity, including the ability to lyse CD30-expressing cell lines that are not lysed by the fucosylated and xylosylated form of the antibodies. The invention also provides host cells that express the anti-CD30 antibodies that lack fucosyl and xylosyl residues, wherein the host cells are deficient for a fucosyltransferase and a xylosyltransferase. Methods of using the antibodies to inhibit the grown of CD30 | 11-01-2012 |
20140216118 | Compositions and Methods for Making and Biocontaining Auxotrophic Transgenic Plants - Compositions and methods are described for making and using transgenic plants and plant parts having at least one auxotrophic requirement for an essential compound such as an amino acid, carbohydrate, fatty acid, nucleic acid, vitamin, plant hormone, or precursor thereof. Transgenic plants and plants parts having at least one auxotrophic requirement can be effectively biocontained by withdrawal of the essential compound. | 08-07-2014 |
Landon Cox, Durham, NC US
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20110116493 | METHOD AND APPARATUS FOR PROVIDING MOBILE AND SOCIAL SERVICES VIA VIRTUAL INDIVIDUAL SERVERS - A method, computer readable medium and apparatus for providing a virtual individual server service within a communications network are disclosed. For example, the method receives a request from a subscriber of the communications network to subscribe to the virtual individual server service, provides a virtual individual server to the subscriber in response to the request and executes at least one application via the virtual individual server using at least one piece of personal information associated with the subscriber. | 05-19-2011 |
20130247141 | METHOD AND APPARATUS FOR PROVIDING MOBILE AND SOCIAL SERVICES VIA VIRTUAL INDIVIDUAL SERVERS - A method, computer readable medium and apparatus for providing a virtual individual server service within a communications network are disclosed. For example, the method receives a request from a subscriber of the communications network to subscribe to the virtual individual server service, provides a virtual individual server to the subscriber in response to the request and executes at least one application via the virtual individual server using at least one piece of personal information associated with the subscriber. | 09-19-2013 |
Marilyn Cox, Chapel Hill, NC US
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20100104666 | Animal Repellant & Method of Use Thereof - A new Animal Repellent & Method of Use Thereof which generally comprises a composition of materials or ingredients that combine to create a new and novel animal repellant that is embodied in liquid or granular form, and can be applied as a spray directly to plant parts or sprinkled on or combined with the soil or mulch bed as a granule to discourage activities such as browsing and eating, burrowing and or digging, or general consumption or disruption of a potted plants, planting beds, landscape, garden, or other foliage environment, by animals including but not limited to, squirrels, chipmunks, prairie dogs, gophers, woodchucks, and other members of the order rodentia family not referred to herein, as well as other types of animals such as raccoons, that would otherwise destroy or damage plant material and the surrounding region or soil. | 04-29-2010 |
Mary Llewellyn Cox, Charlotte, NC US
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20100217681 | Shopping Cart Planogram Ordering System - A method for providing remote ordering of products and configuring of individualized shelf configurations on a computer network, where the method comprises the steps of presenting an adjustable shelving plan having a shelving space; presenting a list of products or groups of products wherein each product or group of products has a cost; allowing a customer to adjust the shelving plan to reflect the customer's shelf space; allowing the customer to place products or groups of products on empty space in the shelving plan; showing the shelving plan with the products or groups of products placed on the shelving plan and showing the remaining empty space on the shelving plan; calculating the cost of the products or groups of products on the shelving plan; allowing the customer to order a set of products on the shelving plan; and receiving an order for the set of products on the shelving plan. | 08-26-2010 |
Mary M. Cox, Raleigh, NC US
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20100124913 | EMBEDDED ADS IN MMS STATIONARY - An electronic device includes a communication circuit configured to establish a communication over a wireless network, and a messaging circuit operative to create messages for transmission to other devices via said communication circuit. The messaging circuit is configured to automatically include into a user-composed message multimedia data that corresponds to an entity subsidizing the electronic device. | 05-20-2010 |
Michael Wayne Cox, Trinity, NC US
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20130292439 | Themed Slip On Cover For A GPS Unit - Disclosed is a single layer, light weight, themed slip on cover for a GPS “unit” that allows the “end user” the ability to display an expression of individual style, character, belief and/or personal concepts. The slip on cover offers the “end user” the ability to theme and cover an existing GPS “unit”. The single layer, light weight, themed slip on cover fits tightly over the existing GPS “unit”, allowing the “end user” unobstructed access to the interactive features and controls of the GPS “unit”. The single layer, light weight, themed slip on cover offers no claimed protection from shock and or impact damage to a GPS “unit”, and is merely a “novelty” cover intended for purposes of display. | 11-07-2013 |
Nathan M. Cox, Raleigh, NC US
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20140046257 | RAPID FLUID COOLING DEVICES AND METHODS FOR COOLING FLUIDS - A cooling device includes a target fluid inlet, a target fluid outlet, an inner conduit, and a chamber surrounding the inner conduit. The inner conduit communicates with the target fluid inlet and the target fluid outlet, and provides a flow path for a target fluid to be cooled. The chamber contains a first endothermic reactant and includes a reactant inlet selectively alterable from a closed state to an open state. When the reactant inlet is in the closed state, the first endothermic reactant is isolated from a second endothermic reactant and no endothermic reaction occurs. When the reactant inlet is in the open state, the reactant inlet provides a flow path for enabling the second endothermic reactant to come into contact with the first endothermic reactant in the chamber for initiating the endothermic reaction and cooling the target fluid in the inner conduit. | 02-13-2014 |
20140364806 | RAPID FLUID COOLING DEVICES AND METHODS FOR COOLING FLUIDS - A cooling device includes a target fluid inlet, a target fluid outlet, an inner conduit, and a chamber surrounding the inner conduit. The inner conduit communicates with the target fluid inlet and the target fluid outlet, and provides a flow path for a target fluid to be cooled. The chamber contains a first endothermic reactant and includes a reactant inlet selectively alterable from a closed state to an open state. When the reactant inlet is in the closed state, the first endothermic reactant is isolated from a second endothermic reactant and no endothermic reaction occurs. When the reactant inlet is in the open state, the reactant inlet provides a flow path for enabling the second endothermic reactant to come into contact with the first endothermic reactant in the chamber for initiating the endothermic reaction and cooling the target fluid in the inner conduit. | 12-11-2014 |
Patrick Herbert Cox, Raleigh, NC US
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20080244011 | System and Method for providing instant messaging session backups - A system, method, and program product are provided that receives an instant messaging request from a sender over a network, such as the Internet. The instant messaging request is directed to requesting an instant messaging session with a primary recipient. The system determines whether the primary recipient is available. If the primary recipient is available, the system sets up the instant messaging session with the primary recipient. On the other hand, if the primary recipient is unavailable, the system identifies a backup recipient. This is accomplished by retrieving stored backup recipient identifiers that correspond to one or more backup recipients associated with the primary recipient. At least one available backup recipient identifier from the one or more stored backup recipient identifiers is identified, and the instant messaging session is set up with the identified (available) backup recipient. | 10-02-2008 |
Robert Cox, Charlotte, NC US
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20120031451 | HIGH TEMPERATURE THERMOELECTRIC GENERATOR - The present invention relates to a high temperature thermoelectric generator. The generator includes at least one thermocouple thermally connected to a high temperature surface, a power management circuit adapted to receive electric power from the at least one thermocouple and provide a regulated output voltage, and a storage device adapted to receive the regulated output voltage from the power management circuit such that the output voltage charges the storage device. | 02-09-2012 |
Sidney G. Cox, Durham, NC US
Patent application number | Description | Published |
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20150147567 | POLYIMIDE METAL CLAD LAMINATE - The present disclosure is directed to a polyimide metal clad laminate. The metal clad laminate has a metal foil and a polyimide layer. The polyimide layer having a polyimide derived from 80 to 90 mole % 3,3′,4,4′-biphenyl tetracarboxylic dianhydride, 10 to 20 mole % 4,4′-oxydiphthalic anhydride and 100 mole % 2,2′-bis(trifluoromethyl)benzidine. The polyimide metal clad laminate does not have an adhesive layer between the metal foil and the polyimide layer. | 05-28-2015 |
Steve Cox, Durham, NC US
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20100185512 | SYSTEMS, METHODS AND COMPUTER PROGRAM PRODUCTS FOR INTEGRATING ADVERTISING WITHIN WEB CONTENT - Systems, methods, and computer program products that facilitate the integration and accounting of advertising within audio Web content requested by users via telephone devices are provided. Upon receiving a request from a user for Web content via a telephone device, a Web server retrieves an advertisement from an advertisement server, inserts the retrieved advertisement within the user requested Web content, and forwards the user requested Web content and advertisement to a text-to-speech transcoder for conversion to an audio format. The text-to-speech transcoder converts the Web content and advertisement from a text-based format to an audio format and serves the Web content and advertisement in the audio format to the user client device via a telephone link established with the user client device. If an advertisement is interactive, a text-to-speech transcoder may be configured to notify an advertisement server of user interaction with the advertisement. Information such as an identification of a requesting client device, user, as well as time and date information, may be recorded by an advertisement server for use in measuring effectiveness of a particular marketing and/or advertising campaign. Information associated with providing a user with additional information associated with an advertisement may also be stored. | 07-22-2010 |
20140372206 | SYSTEMS, METHODS AND COMPUTER PROGRAM PRODUCTS FOR FACILITATING DISPLAY OF CONTENT WITHIN APPLICATION PROGRAMS EXECUTING ON ELECTRONIC DEVICES - An application program interface (API) is operably associated with application programs executing on an electronic device and enables the application programs to retrieve, store, and display content. The API enables application programs to communicate with other application programs and to send/retrieve content to/from other application programs. In addition, the API is configured to perform various event accounting functions. A gateway communicates with an electronic device application program via the API and is configured to retrieve content from a content server in response to receiving requests from the application programs. The gateway is configured to serve content retrieved from the content server to the electronic device, as well as to other servers and/or devices. Methods, apparatus, and computer program products are provided for dynamically selecting advertisements for use within user-requested content wherein the advertisements are stored locally within a user client device. | 12-18-2014 |
Susan Gabriel Cox, Greensboro, NC US
Patent application number | Description | Published |
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20110088133 | Bib-scarf system - A bib-scarf system which is simple to manufacture and creates an adjustable, nonplanar bib. The system incorporates a piece of fabric, a horizontal opening in the fabric, and a horizontal strap. The fabric is cut to a predetermined rectangular size. Then a horizontal opening is created in the center of the fabric. The fabric at the top of the newly created horizontal opening is folded over and pulled through the opening. A strap is then run through the horizontal opening and fold in the top half of the fabric. This process creates an adjustable nonplanar bib which can be attached to the wearer with the strap either worn around the neck or secured to a garment which receives the strap. | 04-21-2011 |
Thomas Warren Cox, Holly Springs, NC US
Patent application number | Description | Published |
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20100185702 | Computer-Implemented System And Method For Tagged And Rectangular Data Processing - A computer-implemented system and method for tagged data and rectangular data conversions. The system and method receive tagged input data that is in a non-rectangular format and that uses a hierarchical arrangement of tags to indicate data relationships. The tagged input data is displayed in a graphical interface, and the graphical interface is used to create a mapping specification from the tagged input data. | 07-22-2010 |
William D. Cox, Chapel Hill, NC US
Patent application number | Description | Published |
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20090032968 | VIA CONFIGURABLE ARCHITECTURE FOR CUSTOMIZATION OF ANALOG CIRCUITRY IN A SEMICONDUCTOR DEVICE - A semiconductor device having a plurality of layers and a plurality of circuit elements arranged in tiles. At least one of the plurality of layers in the semiconductor device may be a via layer configured to determine the connections of the plurality of circuit elements. The semiconductor device may include an interconnection quilt having a plurality of metal layers disposed to interconnect the plurality of circuit elements. The plurality of circuit elements may be analog circuit element and/or digital circuit elements. The tiles may be analog tiles and digital tiles that form a mixed signal structured array. | 02-05-2009 |
20090061567 | VIA CONFIGURABLE ARCHITECTURE FOR CUSTOMIZATION OF ANALOG CIRCUITRY IN A SEMICONDUCTOR DEVICE - A semiconductor device having a plurality of layers and a plurality of circuit elements arranged in tiles. At least one of the plurality of layers in the semiconductor device may be a via layer configured to determine the connections of the plurality of circuit elements. The semiconductor device may include an interconnection quilt having a plurality of metal layers disposed to interconnect the plurality of circuit elements. The plurality of circuit elements may be analog circuit element and/or digital circuit elements. The tiles may be analog tiles and digital tiles that form a mixed signal structured array. | 03-05-2009 |
20090065813 | CONFIGURING STRUCTURED ASIC FABRIC USING TWO NON-ADJACENT VIA LAYERS - An application-specific integrated circuit (ASIC) is customized using two non-adjacent via layers. An array of logic cells, each including a plurality of logic devices, are arranged in a plurality of non-customized base layers. A first routing grid, which includes a first non-customized metal routing layer, a customized via layer, and a second non-customized metal routing layer, is disposed on top of the plurality of non-customized layers. A second routing grid, which includes a third non-customized metal routing layer, another customized via layer, and a fourth non-customized metal routing layer, is disposed above the first routing grid. A non-customized via layer is disposed above the first routing grid and beneath the second routing grid. The routing grids and the non-customized via layer collectively facilitate routing connections to and from the logic cells. | 03-12-2009 |
20090210848 | LOGIC ARRAY DEVICES HAVING COMPLEX MACRO-CELL ARCHITECTURE AND METHODS FACILITATING USE OF SAME - Logic array devices having complex macro-cell architecture and methods facilitating use of same. A semiconductor device comprising an array of logic cells and programmable metal includes gate structures that are pre-wired, where, inputs and/or outputs are available for routing in programmable metal, possibly as part of a hybrid process. The device can also include selectable, in-line inverters, which can share the input/output tracks with logic inputs. A bubble-pushing algorithm can take advantage of the selectable in-line inverters to reduce the number of inverters in a design. In some embodiments, an embedded clock line is common to a plurality of logic cells. The clock line is terminated in a clock cell, which can include test logic, so that a clock group is formed. Flexibility to power down cells, or groups of cells can be provided by power traces with programmable connections. | 08-20-2009 |