Patent application number | Description | Published |
20090240923 | Computing Device with Entry Authentication into Trusted Execution Environment and Method Therefor - A computing device ( | 09-24-2009 |
20100199077 | AUTHENTICATED DEBUG ACCESS FOR FIELD RETURNS - Under the direction of a first party, an integrated circuit (IC) device is configured to temporarily enable access to a debug interface of the IC device via authentication of the first party by a challenge/response process using a key of the IC device and a challenge value generated at the IC device. The first party then may conduct a software evaluation of the IC device via the debug interface. In response to failing to identify an issue with the IC device from the software evaluation, the first party can permanently enable open access to the debug interface while authenticated and provide the IC device to a second party. Under the direction of the second party, a hardware evaluation of the IC device is conducted via the debug interface that was permanently opened by the first party. | 08-05-2010 |
20140006804 | VIRTUALIZED TRUSTED DESCRIPTORS | 01-02-2014 |
20140064480 | SECURE PROVISIONING IN AN UNTRUSTED ENVIRONMENT - Embodiments of methods of provisioning an electronic circuit enable security of sensitive data in a design and manufacturing process that includes multiple parties. In an illustrative embodiment, a method of provisioning an electronic circuit includes generating at least one secret value, embedding the at least one secret value into the electronic circuit, programming into the electronic circuit a private key derivation function that derives the private key from the at least one secret value and a trust anchor, and programming into the electronic circuit a public key generation function that generates a public key matching the private key. The method can further include receiving for execution trust anchor-authenticated logic that contacts a predetermined actor of the plurality of distinct actors and communicates to the predetermined actor a message signed with the private key. | 03-06-2014 |
20140068133 | VIRTUALIZED LOCAL STORAGE - Embodiments of electronic circuits, computer systems, and associated methods include a module that accesses memory using virtual addressing, the memory including local memory that is local to the module and nonlocal memory that is accessible via a system bus coupled to the module, the module including logic coupled to the local memory via a local bus. The logic is configured to receive a memory access specified to a virtual address, determine whether the virtual address is within the local memory, and direct the memory access either to the local memory via the local bus or to the nonlocal memory via the system bus based on the determination. | 03-06-2014 |
20140068246 | CIRCUIT FOR SECURE PROVISIONING IN AN UNTRUSTED ENVIRONMENT - Embodiments of electronic circuits enable security of sensitive data in a design and manufacturing process that includes multiple parties. An embodiment of an electronic circuit can include a private key embedded within the electronic circuit that is derived from a plurality of components including at least one component known only to the electronic circuit and at least one immutable value cryptographically bound into messages and residing on the electronic circuit, public key generation logic that generates a public key to match the private key, and message signing logic that signs messages with the private key. | 03-06-2014 |
20140164779 | SECURE PROVISIONING IN AN UNTRUSTED ENVIRONMENT - Embodiments include methods for securely provisioning copies of an electronic circuit. A first entity (e.g., a chip manufacturer) embeds one or more secret values into copies of the electronic circuit. A second entity (e.g., an OEM): 1) embeds a trust anchor in a first copy of the electronic circuit; 2) causes the electronic circuit to generate a message signing key pair using the trust anchor and the embedded secret value(s); 3) signs provisioning code using a code signing private key; and 4) sends a corresponding code signing public key, the trust anchor, and the signed provisioning code to a third entity (e.g., a product manufacturer). The third entity embeds the trust anchor in a second copy of the electronic circuit and causes the electronic circuit to: 1) generate the message signing private key; 2) verify the signature of the signed provisioning code using the code signing public key; and 3) launch the provisioning code on the electronic circuit. The electronic circuit can authenticate itself to the OEM using the message signing key pair. | 06-12-2014 |
20140205092 | SECURE PROVISIONING IN AN UNTRUSTED ENVIRONMENT - Embodiments include methods for securely provisioning copies of an electronic circuit. A first entity (e.g., a chip manufacturer) embeds one or more secret values into copies of the electronic circuit. A second entity (e.g., an OEM): 1) embeds a trust anchor in a first copy of the electronic circuit; 2) causes the electronic circuit to generate a message signing key pair using the trust anchor and the embedded secret value(s); 3) signs provisioning code using a code signing private key; and 4) sends a corresponding code signing public key, the trust anchor, and the signed provisioning code to a third entity (e.g., a product manufacturer). The third entity embeds the trust anchor in a second copy of the electronic circuit and causes the electronic circuit to: 1) generate the message signing private key; 2) verify the signature of the signed provisioning code using the code signing public key; and 3) launch the provisioning code on the electronic circuit. The electronic circuit can authenticate itself to the OEM using the message signing key pair. | 07-24-2014 |
20140281354 | CONTINUOUS RUN-TIME INTEGRITY CHECKING FOR VIRTUAL MEMORY - A run-time integrity checking (RTIC) method compatible with memory having at least portions that store data that is changed over time or at least portions configured as virtual memory is provided. For example, the method may comprise storing a table of page entries and accessing the table of page entries by, as an example, an operating system or, as another example, a hypervisor to perform RTIC on memory in which, as an example, an operating system, as another example, a hypervisor, or, as yet another example, application software is stored. The table may, for example, be stored in secure memory or in external memory. The page entry comprises a hash value for the page and a hash valid indicator indicating the validity status of the hash value. The page entry may further comprise a residency indicator indicating a residency status of the memory page. | 09-18-2014 |
Patent application number | Description | Published |
20100263980 | ANNULARLY MOUNTED MULTIPLE FRICTION MEMBER SYNCHRONIZING AND ENGAGING CLUTCH - A gear synchronizing system having a component carrier, wherein the component carrier accepts a splined shaft therethrough and interact with the splined shaft to allow transfer of rotation between the splined shaft and the component carrier while also allowing the component carrier to slide axially along the splined shaft relative to an associated friction plate. The component carrier includes a plurality of friction members pivotably coupled within walled recesses of the component carrier, such that when the component carrier is urged toward the associated friction plate, at least a portion of the contact surface of the friction members initially contacts a surface of the friction plate and, as the component carrier continues to be urged toward the associated friction plate, each friction member is rotated, such that at least a portion of the contact surface of each friction member continues to contact a surface of the friction plate. | 10-21-2010 |
20110240435 | MULTIPLE FRICTION MEMBER SYNCHRONIZING CLUTCH - A synchronizing clutch having a component carrier, wherein the component carrier accepts a splined shaft therethrough and interact with the splined shaft to allow transfer of rotation between the splined shaft and the component carrier while also allowing the component carrier to slide axially along the splined shaft relative to an associated friction plate. The component carrier includes a plurality of friction members pivotably coupled within walled recesses of the component carrier, such If that when the component carrier is urged toward the associated friction plate, at least a portion of the contact surface of the friction members initially contacts a surface of the friction plate and, as the component carrier continues to be urged toward the associated friction plate, each friction member is rotated, such that at least a portion of the contact surface of each friction member continues to contact a surface of the friction plate. | 10-06-2011 |
Patent application number | Description | Published |
20140235600 | NEUROACTIVE 19-ALKOXY-17-SUBSTITUTED STEROIDS, PRODRUGS THEREOF, AND METHODS OF TREATMENT USING SAME - The present disclosure is generally directed to neuroactive 19-alkoxy-17-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorders relating to GABA function and activity. The present disclosure is further directed to pharmaceutical compositions comprising such compounds. | 08-21-2014 |
20140249120 | NEUROACTIVE 13, 17-SUBSTITUTED STEROIDS AS MODULATORS FOR GABA TYPE-A RECEPTORS - The present disclosure is generally directed to neuroactive 13,17-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorders relating to GABA function and activity. The present disclosure is further directed to pharmaceutical compositions comprising such compounds. | 09-04-2014 |
20140256805 | NEUROACTIVE SUBSTITUTED CYCLOPENTA[b]PHENANTHRENES AS MODULATORS FOR GABA TYPE-A RECEPTORS - The present disclosure is generally directed to neuroactive substituted cyclopenta[b]phenanthrenes as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorders relating to GABA function and activity. The present disclosure is further directed to pharmaceutical compositions comprising such compounds. | 09-11-2014 |
20140275241 | NEUROACTIVE SUBSTITUTED CYCLOPENT[a]ANTHRACENES AS MODULATORS FOR GABA TYPE-A RECEPTORS - The present disclosure is generally directed to neuroactive substituted cyclopent[a]anthracenes as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorders relating to GABA function and activity. The present disclosure is further directed to pharmaceutical compositions comprising such compounds. | 09-18-2014 |
20140309443 | NEUROACTIVE 17(20)-Z-VINYLCYANO-SUBSTITUTED STEROIDS, PRODRUGS THEREOF, AND METHODS OF TREATMENT USING SAME - The present disclosure is generally directed to neuroactive 17(20)-Z-vinylcyano-substituted compound of Formula (I) and (II), as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorders relating to GABA function and activity. The present disclosure is further directed to pharmaceutical compositions comprising such compounds. | 10-16-2014 |
Patent application number | Description | Published |
20100317638 | Neuroactive 13,24-Cyclo-18,21-Dinorcholanes and Structurally Related Pentacylic Steroids - Novel pentacyclic steroids and pentacyclic D-homosteroids comprising: (i) the tetracyclic steroid ring system or tetracyclic D-homosteroid ring system, respectively; (ii) a C(3) substituent selected from the group consisting of (a) a hydroxyl or carboxyl in the α-configuration and (b) a sulfate or other negatively charged moiety; and (iii) a fused fifth ring, the fused fifth ring comprising a hydrogen bond acceptor, and (a) in the case of the pentacyclic steroid the C(13) and C(17) carbons, or (b) in the case of the pentacyclic D-homosteroid the C(13) and C(17a) carbons, having utility as anesthetics and in the treatment of disorders relating to GABA function and activity. | 12-16-2010 |
20110015165 | MODIFIED, HYDROXY-SUBSTITUTED AROMATIC STRUCTURES HAVING CYTOPROTECTIVE ACTIVITY - The present invention is directed to a process for conferring cytoprotection on a population of cells which comprises administering to that population of cells a compound comprising a hydroxy-substituted aromatic ring structure and a non-fused polycyclic, hydrophobic substituent attached thereto. In particular, the present invention is directed to such a process wherein the administered compound is phenolic, such as a steriod (e.g., estrogen), and has a non-fused polycyclic, hydrophobic substituent attached to the hydroxy-substituted A-ring thereof. | 01-20-2011 |
Patent application number | Description | Published |
20120171407 | MULTI-LOBED POROUS CERAMIC BODY AND PROCESS FOR MAKING THE SAME - A carrier having at least three lobes, a first end, a second end, a wall between the ends and a non-uniform radius of transition at the intersection of an end and the wall is disclosed. A catalyst comprising the carrier, silver and promoters deposited on the carrier and useful for the epoxidation of olefins is also disclosed. A method for making the carrier, a method for making the catalyst and a process for epoxidation of an olefin with the catalyst are also disclosed. | 07-05-2012 |
20150045565 | PROCESS FOR PREPARING AN OLEFIN OXIDE USING A MULTI-LOBED POROUS CERAMIC BODY - A carrier having at least three lobes, a first end, a second end, a wall between the ends and a non-uniform radius of transition at the intersection of an end and the wall is disclosed. A catalyst comprising the carrier, silver and promoters deposited on the carrier and useful for the epoxidation of olefins is also disclosed. A method for making the carrier, a method for making the catalyst and a process for epoxidation of an olefin with the catalyst are also disclosed. | 02-12-2015 |
20150209774 | MULTI-LOBED POROUS CERAMIC BODY AND PROCESS FOR MAKING THE SAME - A carrier having at least three lobes, a first end, a second end, a wall between the ends and a non-uniform radius of transition at the intersection of an end and the wall is disclosed. A catalyst comprising the carrier, silver and promoters deposited on the carrier and useful for the epoxidation of olefins is also disclosed. A method for making the carrier, a method for making the catalyst and a process for epoxidation of an olefin with the catalyst are also disclosed. | 07-30-2015 |
Patent application number | Description | Published |
20080205834 | ALL-OPTICAL LOGIC GATES USING NONLINEAR ELEMENTS - CLAIM SET IV - An all-optical logic gates comprises a nonlinear element such as an optical resonator configured to receive optical input signals, at least one of which is amplitude-modulated to include data. The nonlinear element is configured in relation to the carrier frequency of the optical input signals to perform a logic operation based on the resonant frequency of the nonlinear element in relation to the carrier frequency. Based on the optical input signals, the nonlinear element generates an optical output signal having a binary logic level. A combining medium can be used to combine the optical input signals for discrimination by the nonlinear element to generate the optical output signal. Various embodiments include all-optical AND, NOT, NAND, NOR, OR, XOR, and XNOR gates and memory latch. | 08-28-2008 |
20080225362 | ALL-OPTICAL LOGIC GATES USING NONLINEAR ELEMENTS CLAIM - SET V - An all-optical logic gates comprises a nonlinear element such as an optical resonator configured to receive optical input signals, at least one of which is amplitude-modulated to include data. The nonlinear element is configured in relation to the carrier frequency of the optical input signals to perform a logic operation based on the resonant frequency of the nonlinear element in relation to the carrier frequency. Based on the optical input signals, the nonlinear element generates an optical output signal having a binary logic level. A combining medium can be used to combine the optical input signals for discrimination by the nonlinear element to generate the optical output signal. Various embodiments include all-optical AND, NOT, NAND, NOR, OR, XOR, and XNOR gates and memory latch. | 09-18-2008 |
20080273848 | ALL-OPTICAL LOGIC GATES USING NONLINEAR ELEMENTS CLAIM SET V - An all-optical logic gates comprises a nonlinear element such as an optical resonator configured to receive optical input signals, at least one of which is amplitude-modulated to include data. The nonlinear element is configured in relation to the carrier frequency of the optical input signals to perform a logic operation based on the resonant frequency of the nonlinear element in relation to the carrier frequency. Based on the optical input signals, the nonlinear element generates an optical output signal having a binary logic level. A combining medium can be used to combine the optical input signals for discrimination by the nonlinear element to generate the optical output signal. Various embodiments include all-optical AND, NOT, NAND, NOR, OR, XOR, and XNOR gates and memory latch. | 11-06-2008 |
20090154887 | ALL-OPTICAL LOGIC GATES USING NONLINEAR ELEMENTS - CLAIM SET V - An all-optical logic gates comprises a nonlinear element such as an optical resonator configured to receive optical input signals, at least one of which is amplitude-modulated to include data. The nonlinear element is configured in relation to the carrier frequency of the optical input signals to perform a logic operation based on the resonant frequency of the nonlinear element in relation to the carrier frequency. Based on the optical input signals, the nonlinear element generates an optical output signal having a binary logic level. A combining medium can be used to combine the optical input signals for discrimination by the nonlinear element to generate the optical output signal. Various embodiments include all-optical AND, NOT, NAND, NOR, OR, XOR, and XNOR gates and memory latch. | 06-18-2009 |
20100182665 | ALL-OPTICAL LOGIC GATES USING NONLINEAR ELEMENTS - CLAIM SET V - An all-optical logic gates comprises a nonlinear element such as an optical resonator configured to receive optical input signals, at least one of which is amplitude-modulated to include data. The nonlinear element is configured in relation to the carrier frequency of the optical input signals to perform a logic operation based on the resonant frequency of the nonlinear element in relation to the carrier frequency. Based on the optical input signals, the nonlinear element generates an optical output signal having a binary logic level. A combining medium can be used to combine the optical input signals for discrimination by the nonlinear element to generate the optical output signal. Various embodiments include all-optical AND, NOT, NAND, NOR, OR, XOR, and XNOR gates and memory latch. | 07-22-2010 |
20100290749 | ALL-OPTICAL LOGIC GATES USING NONLINEAR ELEMENTS CLAIM SET V - An all-optical logic gates comprises a nonlinear element such as an optical resonator configured to receive optical input signals, at least one of which is amplitude-modulated to include data. The nonlinear element is configured in relation to the carrier frequency of the optical input signals to perform a logic operation based on the resonant frequency of the nonlinear element in relation to the carrier frequency. Based on the optical input signals, the nonlinear element generates an optical output signal having a binary logic level. A combining medium can be used to combine the optical input signals for discrimination by the nonlinear element to generate the optical output signal. Various embodiments include all-optical AND, NOT, NAND, NOR, OR, XOR, and XNOR gates and memory latch. | 11-18-2010 |
Patent application number | Description | Published |
20090269800 | DEVICE AND METHOD FOR PROCESSING CELL SAMPLES - A cell analysis device and method is described which enables the user to efficiently treat cells in a sample. The cells can be treated with reagents at a time and place proximate to collection and may be handled in a automated or semi automated fashion. | 10-29-2009 |
20100105074 | HIGH THROUGHPUT FLOW CYTOMETRY SYSTEM AND METHOD - The invention provides systems, compositions, kits and methods for automated processing of biological samples and analysis using a flow cytometer. | 04-29-2010 |
20100209929 | MULTIPLE MECHANISMS FOR MODULATION OF JAK/STAT ACTIVITY - An embodiment of the present invention is a method for subjecting a hematopoetic cell to a JAK/STAT inhibitor, determining the activity of gain-of-function mutations of a Jak family kinase, determining the expression levels and activity of JAK/STAT regulatory proteins, correlating the expression levels and the activity of JAK/STAT regulatory proteins with the activity of gain-of-function mutations of a Jak family kinase and with a response to the JAK/STAT inhibitor, and then classifying the cells. A further embodiment of the invention includes determining the clinical outcome based on the cell classification, determining a method of treatment, determining dosing and scheduling of at least one of the JAK/STAT inhibitors or other compounds. | 08-19-2010 |
20100240542 | KITS FOR MULTIPARAMETRIC PHOSPHO ANALYSIS - As disclosed herein, the present invention provides for kits and a composition for diagnosis, prognosis, drug discovery, drug development, and patient stratification. The kits can comprise a plurality of binding elements for cell surface markers, and a plurality of binding elements for state-specific intracellular markers. The kits can further comprise a plurality of modulators directed for the particular cell function or signaling pathways. The kits can further include fixatives, permeabilizing agent, buffers, containers, instructions, and software for data analysis/compilation. | 09-23-2010 |
20120276558 | KITS FOR MULTIPARAMETRIC PHOSPHO ANALYSIS - As disclosed herein, the present invention provides for kits and a composition for diagnosis, prognosis, drug discovery, drug development, and patient stratification. The kits can comprise a plurality of binding elements for cell surface markers, and a plurality of binding elements for state-specific intracellular markers. The kits can further comprise a plurality of modulators directed for the particular cell function or signaling pathways. The kits can further include fixatives, permeabilizing agent, buffers, containers, instructions, and software for data analysis/compilation. | 11-01-2012 |
20130129681 | METHODS FOR DIAGNOSING SOLID TUMORS - An embodiment of the present invention is useful for identifying tumor cells in bladder cancer washes, pleural effusions, biliary tumor cells and circulating tumor cells in whole blood. Subsequent analysis may identify therapeutic treatments based on a single cell analysis of activatable elements in cell signaling pathways. This analysis can be useful for diagnosis, prognosis, therapy selection and monitoring of solid tumor diseases. | 05-23-2013 |
20140065633 | METHODS FOR DETERMINING THE EFFECTS OF COMPOUNDS ON JAK/STAT ACTIVITY - An embodiment of the present invention is a method for subjecting a hematopoetic cell to a JAK/STAT inhibitor, determining the activity of gain-of-function mutations of a Jak family kinase, determining the expression levels and activity of JAK/STAT regulatory proteins, correlating the expression levels and the activity of JAK/STAT regulatory proteins with the activity of gain-of-function mutations of a Jak family kinase and with a response to the JAK/STAT inhibitor, and then classifying the cells. A further embodiment of the invention includes determining the clinical outcome based on the cell classification, determining a method of treatment, determining dosing and scheduling of at least one of the JAK/STAT inhibitors or other compounds. | 03-06-2014 |
20150110736 | METHODS FOR DETERMINING THE EFFECTS OF COMPOUNDS ON JAK/STAT ACTIVITY - An embodiment of the present invention is a method for subjecting a hematopoetic cell to a JAK/STAT inhibitor, determining the activity of gain-of-function mutations of a Jak family kinase, determining the expression levels and activity of JAK/STAT regulatory proteins, correlating the expression levels and the activity of JAK/STAT regulatory proteins with the activity of gain-of-function mutations of a Jak family kinase and with a response to the JAK/STAT inhibitor, and then classifying the cells. A further embodiment of the invention includes determining the clinical outcome based on the cell classification, determining a method of treatment, determining dosing and scheduling of at least one of the JAK/STAT inhibitors or other compounds. | 04-23-2015 |
Patent application number | Description | Published |
20100030719 | METHODS AND APPARATUS RELATED TO BIOINFORMATICS DATA ANALYSIS - In one embodiment, one or more processor-readable media can be configured to store code representing instructions that when executed by one or more processors can cause the one or more processors to select a first relationship rule based on a first combination of parameters including a first parameter, and based on a hierarchical position of the first parameter within a hierarchical structure of a set of parameters from a biological category. A first statistical value can be defined based on a plurality of test values and based on the first relationship rule. A second statistical value can be defined based on a second relationship rule and based on a second combination of parameters. The second relationship rule can be selected based on a hierarchical position of the second parameter within the hierarchical structure of the set of parameters. | 02-04-2010 |
20100042351 | METHODS AND APPARATUS RELATED TO MANAGEMENT OF EXPERIMENTS - In one embodiment, a method includes sending an indicator of an availability of a sample from a sample pool stored in a physical inventory. The sample being included in the sample pool based on an attribute of the sample satisfying a condition associated with the sample pool. An indicator that the sample has been selected from the sample pool for analysis at a first test site included in an array of test sites is received. A rule is retrieved from a rule database based on an experimental parameter value associated with the first test site. At least one of the experimental parameter value associated with the first test site or an experimental parameter value associated with a second test site is modified based on a condition within the rule being satisfied. | 02-18-2010 |
20120215481 | METHODS AND APPARATUS RELATED TO MANAGEMENT OF EXPERIMENTS - In one embodiment, a method includes sending an indicator of an availability of a sample from a sample pool stored in a physical inventory. The sample being included in the sample pool based on an attribute of the sample satisfying a condition associated with the sample pool. An indicator that the sample has been selected from the sample pool for analysis at a first test site included in an array of test sites is received. A rule is retrieved from a rule database based on an experimental parameter value associated with the first test site. At least one of the experimental parameter value associated with the first test site or an experimental parameter value associated with a second test site is modified based on a condition within the rule being satisfied. | 08-23-2012 |
20140031308 | BENCHMARKS FOR NORMAL CELL IDENTIFICATION - Provided herein are methods, compositions, and kits for determining cell signaling profiles in normal cells and comparing the cell signaling profiles of normal cells to cell signaling profiles from a test sample. | 01-30-2014 |
20150119288 | KITS FOR MULTIPARAMETRIC PHOSPHO ANALYSIS - As disclosed herein, the present invention provides for kits and a composition for diagnosis, prognosis, drug discovery, drug development, and patient stratification. The kits can comprise a plurality of binding elements for cell surface markers, and a plurality of binding elements for state-specific intracellular markers. The kits can further comprise a plurality of modulators directed for the particular cell function or signaling pathways. The kits can further include fixatives, permeabilizing agent, buffers, containers, instructions, and software for data analysis/compilation. | 04-30-2015 |