Patent application number | Description | Published |
20120078357 | Prosthetic Heart Valve Frame With Flexible Commissures - A prosthetic heart valve can include a valve frame having a wireform portion and a stent portion. The wireform and stent portions can be undetachably coupled together via a plurality of upright struts so as to form a one-piece prosthetic heart valve frame. Alternatively, a self-expanding wireform portion and a balloon-expandable stent portion can be coupled together via one or more leaflets and a subassembly having a flexible leaflet support stent and a sealing ring. The wireform portion can include cusps and commissures configured to support a plurality of leaflets. The prosthetic valve can be radially collapsible for minimally invasive and/or transcatheter delivery techniques. Disclosed embodiments can also provide flexion of the wireform portion (e.g., of the commissures) in response to physiologic pulsatile loading when the valve is implanted in a patient's native valve annulus. Methods of making and using prosthetic heart valves are also disclosed. | 03-29-2012 |
20130023984 | COMMISSURE MODIFICATION OF PROSTHETIC HEART VALVE FRAME FOR IMPROVED LEAFLET ATTACHMENT - Embodiments of the present disclosure provide an improved support frame for a prosthetic heart valve. The support frame can include a plurality of diamond-shaped cells arranged in a plurality of circumferential rows. Three cells corresponding to the leaflet commissures can be configured as commissure tip cells, with elongated rounded portions rather than a diamond shape. The commissure tip cells can allow for insertion of leaflet tabs, thereby allowing the leaflets to be sutured outside of the valve. In this manner, the leaflet sutures can be removed from areas of high stress during physiologic loading. Thus, currently disclosed embodiments of a support frame can allow for use of thinner leaflet materials than possible with conventional prosthetic heart valves, without sacrificing valve durability in some embodiments. | 01-24-2013 |
20130150869 | SELF-CINCHING SURGICAL CLIPS AND DELIVERY SYSTEM - A device and method for deploying self-cinching surgical clips. The device accesses at least two layers of tissue or material from only one side of the tissue or material and punctures through the two layers of tissue or material. The various configurations of clips disclosed herein are made of a superelastic material such as Nitinol, and have a constrained and a relaxed state, and no sharp edges or tips so as to reduce tissue irritation following deployment. The clip is disposed within the housing of the delivery device and held in a constrained state by a tube assembly until deployment wherein the clip assumes its relaxed state, where the ends of the clip are brought into close approximation, thereby securing the layers of tissue or material together. | 06-13-2013 |
20130150954 | FORCE-BASED HEART VALVE SIZER - A valve sizer for determining an appropriate replacement valve size when performing a heart valve replacement procedure is provided. In one version the valve sizer has a hollow shaft with proximal and distal ends. A movable sizing element couples to the distal end of the shaft and is radially expandable between first, contracted and second, expanded positions. An actuator assembly on a handle includes an actuator coupled to a clutch member via a ball-spring-detent clutch. A rod extends through the shaft and maintains a fixed distance between the handle and a distal hub in the sizing element. Movement of the actuator causes axial movement of the shaft, thereby causing radial expansion of sizing petals relative to the hub. The clutch slips when a predetermined reaction force from the surrounding valve annulus is met by the petals. | 06-13-2013 |
20130158600 | KNOTLESS SUTURE ANCHORING DEVICES AND TOOLS FOR IMPLANTS - Devices for securing prostheses such as heart valves or annuloplasty rings with sutures and without using knots are disclosed. The devices are particularly well suited for traditional surgery or minimally invasive surgery, and improve the ease of implantation by eliminating surgical knots a clinician would normally tie in the limited space in and around the implant site. The devices have opposed the clamp halves surrounded by a coil spring. Sutures pass between the clamp halves and the coil spring has an inner coil diameter sufficient to compress the sutures between the clamp. A retention member positioned between the clamp halves maintains a minimum space and therebetween to enable the locking device to be slid along the sutures into position, and to adjust the tension of the sutures therethrough. A delivery tool may be used to deliver and deploy the locking devices. | 06-20-2013 |
20130166022 | ANCHORING DEVICE AND METHOD FOR REPLACING OR REPAIRING A HEART VALVE - A device for anchoring a prosthetic heart valve or annuloplasty ring to a valve annulus in a heart and a method of implanting same is disclosed. The device can include a prosthetic valve or annuloplasty ring with one or more anchors configured to be threaded or otherwise passed underneath a native leaflet and/or subvalvular tissue to secure the device at the native annulus. | 06-27-2013 |
20130282028 | SIDE-ENTRY KNOTLESS SUTURE ANCHORING CLAMPS AND DEPLOYMENT TOOLS - Suture locking clamps for securing prostheses such as heart valves or annuloplasty rings with sutures and without knots improve the ease of implantation. The clamps have opposed clamp halves separated by a slot opening to one side and surrounded by a biasing member such as one or more C-clip springs. Sutures pass laterally into the slot which is held open by a retention member positioned between the clamp halves. The locking clamp slides along the sutures into position, the tension of the sutures is adjusted, and the retention member removed to allow the biasing member to clamp the sutures between the clamp halves. A delivery tool used to deliver and deploy the locking clamps contains a number of clamps within a delivery tube in a stack and bonded together for safety and a common retention member. The tool has a longitudinal channel on one side for entry of sutures. | 10-24-2013 |
20130345801 | FORCE-BASED HEART VALVE SIZER - A valve sizer for determining an appropriate replacement valve size when performing a heart valve replacement procedure is provided. In one version the valve sizer has a hollow shaft with proximal and distal ends. A movable sizing element couples to the distal end of the shaft and is radially expandable between first, contracted and second, expanded positions. An actuator assembly on a handle includes an actuator coupled to a clutch member via a ball-spring-detent clutch. A rod extends through the shaft and maintains a fixed distance between the handle and a distal hub in the sizing element. Movement of the actuator causes axial movement of the shaft, thereby causing radial expansion of sizing petals relative to the hub. The clutch slips when a predetermined reaction force from the surrounding valve annulus is met by the petals. | 12-26-2013 |
20140188219 | POST-IMPLANT EXPANDABLE SURGICAL HEART VALVE CONFIGURATIONS - Disclosed herein is a prosthetic heart valve, and associated methods therefore, configured to replace a native heart valve, and having a support frame configured to be reshaped into an expanded form in order to receive and/or support an expandable prosthetic heart valve therein. The prosthetic heart valve is configured to have an expansion-resistant configuration when initially implanted to replace a native valve (or other prosthetic heart valve), but to assume a generally expanded form when subjected to an outward force such as that provided by a dilation balloon or other mechanical expander. | 07-03-2014 |
20140188221 | SURGICAL HEART VALVES ADAPTED FOR POST-IMPLANT EXPANSION - A prosthetic heart valve configured to replace a native heart valve and having a support frame configured to be reshaped into an expanded form in order to receive and/or support an expandable prosthetic heart valve therein is disclosed, together with methods of using same. The prosthetic heart valve may be configured to have a generally rigid and/or expansion-resistant configuration when initially implanted to replace a native valve (or other prosthetic heart valve), but to assume a generally expanded form when subjected to an outward force such as that provided by a dilation balloon or other mechanical expander. | 07-03-2014 |
20140277421 | DYNAMIC ANNULOPLASTY RING SIZER - A dynamic, adjustable annuloplasty ring sizer can include an adjustable ring replica, which can be adjusted through a range of sizes corresponding to available prosthetic annuloplasty repair ring sizes. Actuation of an adjustment trigger on a handle portion of the ring sizer can displace tension wires that extend through a malleable shaft and through a plurality of articulating segments that form the ring replica. Displacement of the tension wires causes flexion of the joints between adjacent articulating segments, thereby reducing the overall size of the ring replica. Releasing the tension wires can allow an elastic extension wire to act on the ring replica, enlarging the ring replica to its maximum, at-rest size. In this manner, the appropriate size of annuloplasty ring prosthesis can be determined with a single device, without requiring a plurality of static ring sizers that require individual insertion and placement for the conventional trial-and-error sizing methods. | 09-18-2014 |
20140364943 | METHODS OF DELIVERY OF FLEXIBLE HEART VALVES - A prosthetic heart valve can include a valve frame having a wireform portion and a stent portion. The wireform and stent portions can be undetachably coupled together via a plurality of upright struts so as to form a one-piece prosthetic heart valve frame. Alternatively, a self-expanding wireform portion and a balloon-expandable stent portion can be coupled together via one or more leaflets and a subassembly having a flexible leaflet support stent and a sealing ring. The wireform portion can include cusps and commissures configured to support a plurality of leaflets. The prosthetic valve can be radially collapsible for minimally invasive and/or transcatheter delivery techniques. Disclosed embodiments can also provide flexion of the wireform portion (e.g., of the commissures) in response to physiologic pulsatile loading when the valve is implanted in a patient's native valve annulus. Methods of making and using prosthetic heart valves are also disclosed. | 12-11-2014 |
20140371842 | CARDIAC IMPLANT WITH INTEGRATED SUTURE FASTENERS - A cardiac implant system including a cardiac implant such as an annuloplasty ring, a prosthetic heart valve, or a valved conduit pre-assembled at the time of manufacture with devices for securing the implant to a heart valve annulus using knotless suture fasteners. The knotless suture fasteners may be embedded within a pliant sealing edge of the cardiac implant, or they may be positioned adjacent to the sealing edge. The knotless suture fasteners are spring-biased so as to grip onto annulus anchoring sutures pass to therethrough upon removal of a restraining device, such as a hypotube inserted within the suture fasteners. Guide tubes are assembled in line with the suture fasteners to permit introduction of suture snares that pass through the suture fasteners and through the sealing edge to facilitate capture of the pre-installed annulus anchoring sutures. | 12-18-2014 |
Patent application number | Description | Published |
20090070797 | METHODS, SYSTEMS, AND APPARATUS FOR MULTI-PURPOSE METERING - Methods and apparatus for multi-purpose metering are disclosed. An example method includes acquiring a rate of data transfer to/from the monitored location and comparing the acquired rate of data transfer to a threshold. The example method also includes setting at least one media monitoring device in a first bandwidth mode when the acquired rate of data transfer exceeds the threshold, and setting the at least one media monitoring device in a second bandwidth mode when the acquired rate of data transfer is below the threshold. | 03-12-2009 |
20130174190 | METHODS, SYSTEMS AND APPARATUS FOR MULTI-PURPOSE METERING - Methods and apparatus for multi-purpose metering are disclosed. An example method includes acquiring a rate of data transfer to/from the monitored location and comparing the acquired rate of data transfer to a threshold. The example method also includes setting at least one media monitoring device in a first bandwidth mode when the acquired rate of data transfer exceeds the threshold, and setting the at least one media monitoring device in a second bandwidth mode when the acquired rate of data transfer is below the threshold. | 07-04-2013 |
20140259033 | METHODS, SYSTEMS AND APPARATUS FOR MULTI-PURPOSE METERING - Methods and apparatus for multi-purpose metering are disclosed. An example method includes transmitting a first discovery inquiry message in response to a wakeup timer expiration signal, disabling a media detection circuit of the portable device when a base unit responds to the discovery inquiry message, and enabling the media detection circuit of the portable device when the base unit response to the discovery inquiry message is absent. | 09-11-2014 |
Patent application number | Description | Published |
20080253748 | APPARATUS AND METHODS FOR TRACKING AND ANALYZING DIGITAL RECORDING DEVICE EVENT SEQUENCES - Methods and apparatus for tracking a sequence of events associated with a digital recording device are disclosed. An example method involves monitoring data conveyed via a data bus communicatively coupled to a processor and a data storage device associated with the digital media device. The example method also involves identifying event information associated with the digital media device based on the data and identifying the viewing information based on the event information. | 10-16-2008 |
20080263579 | METHODS AND APPARATUS FOR METERING PORTABLE MEDIA PLAYERS - Example methods, apparatus, and articles of manufacture to collect metering information associated with media presented by portable and computer media presentation devices are disclosed. A disclosed example method accesses a first data structure including metering information generated by at least one of first media presentation software executed by a personal computer or second media presentation software executed by a portable media presentation device. The metering information is associated with media presented by at least one of the first or second media presentation software. At least some of the metering information is then extracted from the first data structure and stored in a second data structure. The at least some of the metering information is then communicated from the second data structure to a data collection facility. | 10-23-2008 |
20090201132 | METHODS AND APPARATUS FOR METERING PRINTED MEDIA - Methods and apparatus for metering printed media are disclosed. A disclosed example apparatus comprises a first radio frequency identification (RFID) tag to adhere to a first leaflet of a printed media at a first location; a second RFID tag to adhere to a second leaflet of the printed media at a second location of the second leaflet, the first and second locations being substantially a same location; and a first RFID absorber to adhere to a third leaflet of the printed media such that, when the printed media is positioned to expose the first and the third leaflets, the second RFID tag is inactive, and such that, when the printed media is positioned to expose the second and the third leaflets, the first RFID tag is inactive. | 08-13-2009 |
20100079597 | Methods and Apparatus for Determining the Operating State of Audio-Video Devices - Methods and apparatus for identifying the operating state of an audio-video (AV) device are described. Example methods and apparatus include monitoring messages transmitted via a data bus in a first AV device, wherein the data bus is communicatively coupled to a processor and an AV network controller of the first AV device, and wherein the AV network controller is further communicatively coupled to a second AV device external to the first AV device. The example method also involves extracting messages associated with an operation of the second AV device from the monitored messages, analyzing the extracted messages for data associated with an operating state of the second AV device, and sending a command to the AV network controller to request data missing from the extracted messages and associated with the operating state of the second AV device. Additionally, the example methods and apparatus include identifying the operating state of the second AV device by analyzing the extracted messages and a response from the second AV device associated with the command. | 04-01-2010 |
20120311620 | POWER MANAGEMENT FOR AUDIENCE MEASUREMENT METERS - Power management methods, apparatus and articles of manufacture for audience measurement meters are disclosed. An example method disclosed herein comprises determining an activation state of a media presentation device, and controlling activation of an audience measurement meter based on the activation state of the media presentation device, the audience measurement meter to monitor the media presentation device when the activation state is an active state. Another example method disclosed herein comprises obtaining presentation device state data representing an activation state of a media presentation device to be monitored by an audience measurement meter, the presentation device state data including time information, and determining whether to fault audience measurement data reported by the audience measurement meter based on the presentation device state data and outage information determined from the audience measurement data. | 12-06-2012 |
20130215006 | METHODS AND APPARATUS FOR AUTOMATIC TV ON/OFF DETECTION - Methods and apparatus are disclosed for automatic TV ON/OFF detection. An example method includes detecting a power state of an information presentation device. The method includes comparing, using a processor, a measurement indicative of an amount of power drawn by the information presentation device to a first threshold. The method also includes comparing the measurement to a second threshold. The method also includes storing an indication that the information presentation device is in an indeterminate state if the measurement is greater than the first threshold and less than the second threshold. | 08-22-2013 |
20150089525 | POWER MANAGEMENT FOR AUDIENCE MEASUREMENT METERS - Power management methods, apparatus and articles of manufacture for audience measurement meters are disclosed. Example methods disclosed herein include obtaining presentation device state data representing an activation state of a media presentation device that is to present received media and is monitored by an audience measurement meter, the presentation device state data including time information. Such disclosed example methods also include determining whether to fault audience measurement data reported by the audience measurement meter based on the presentation device state data and power outage information determined from the audience measurement data. | 03-26-2015 |
20150143400 | Methods and Apparatus for Determining the Operating State of Audio-Video Devices - Methods and apparatus for identifying an operating state of an AV device are described. An example method includes extracting, at a first AV device, data communicated via a data bus coupling a processor of the first AV device to a HDMI interface, the HDMI interface coupled to a second AV device different than the first AV device; analyzing a temporal sequence of the extracted data to determine if additional information is needed from the second AV device to identify a current operating state of the second AV device; when the temporal sequence is missing an expected message related to the current operating state of the second AV device, causing an AV network controller of the first AV device to request information from the second AV device; and analyzing a response from the second AV device including the requested information to identify the current operating state of the second AV device. | 05-21-2015 |
Patent application number | Description | Published |
20090001082 | Recessed Wall Housing For Concealing Wall Mounted Electrical Devices - An enclosure adapted to be recessed into a wall is disclosed. The enclosure may include an access frame or base to which an access door or lid is hinged or otherwise movable. The access frame is adapted to be secured to a stud of the wall. The door, in a closed configuration, is adapted to be substantially flush with the wall itself. Accordingly, in a closed configuration, the housing substantially conceals or hides the contents of the enclosure. In certain embodiments, the contents could be wall-mounted electrical devices such as power outlets, thermostats, switches, alarm key pads or audio/visual controls, but in alternative embodiments, the contents can be ordinary objects such as keys, wallets, or the like. In any embodiment set forth herein, a recessed housing is provided to provide for storage space to the user while not substantially disturbing the overall appearance or aesthetics of the room. | 01-01-2009 |
20140213295 | SYSTEMS AND METHODS FOR LOCATION-BASED GROUP TRACKING AND NOTIFICATIONS - Systems and methods are provided for creating and associating notification groups, such as affinity groups, and assigned locations, such as associated social hubs. The locations of group members at the assigned locations are tracked and notifications to the notification group are transmitted when group members are at the assigned locations. Group creation requests, location assignment requests, and association requests are received that respectively create generic groups, assigned locations, and notification groups. Invitations can be transmitted to group members to join the notification groups. When an electronic device associated with a group member is at an assigned location, notifications that the group member is at the assigned location are transmitted to other group members. Information is also transmitted to group members when a trigger event occurs. A user can advantageously create and control both the broadcasting of the location of the user and the audience that can see that location. | 07-31-2014 |
Patent application number | Description | Published |
20110107624 | Wear Assembly - A wear assembly for excavating equipment which includes a wear member and a base each with upper and lower stabilizing surfaces that are offset and at overlapping depths to reduce the overall depth of the assembly while maintaining high strength and a stable coupling. The nose and socket each includes a generally triangular-shaped front stabilizing end to provide a highly stable front connection between the nose and wear member for both vertical and side loading. The lock is movable between hold and release positions to accommodate replacing of the wear member when needed, and secured to the wear member for shipping and storage purposes. | 05-12-2011 |
20120137493 | Method Of Shipping A Wear Assembly - A wear assembly for excavating equipment which includes a wear member and a base each with upper and lower stabilizing surfaces that are offset and at overlapping depths to reduce the overall depth of the assembly while maintaining high strength and a stable coupling. The nose and socket each includes a generally triangular-shaped front stabilizing end to provide a highly stable front connection between the nose and wear member for both vertical and side loading. The lock is movable between hold and release positions to accommodate replacing of the wear member when needed, and secured to the wear member for shipping and storage purposes. | 06-07-2012 |
20130091684 | Method Of Shipping A Wear Assembly - A method of shipping a wear assembly for excavating equipment which includes securing a lock to a wear member, and shipping the product as a single integral component. The lock is secured to the wear member for movement between a hold position and a release position. | 04-18-2013 |
20130091746 | Wear Assembly - A wear assembly for excavating equipment which includes a wear member and a base each with upper and lower stabilizing surfaces that are offset and at overlapping depths to reduce the overall depth of the assembly while maintaining high strength and a stable coupling. The nose and socket each includes a generally triangular-shaped front stabilizing end to provide a highly stable front connection between the nose and wear member for both vertical and side loading. The lock is movable between hold and release positions to accommodate replacing of the wear member when needed, and secured to the wear member for shipping and storage purposes. | 04-18-2013 |
20130097895 | Wear Assembly - A wear assembly for excavating equipment which includes a wear member and a base each with upper and lower stabilizing surfaces that are offset and at overlapping depths to reduce the overall depth of the assembly while maintaining high strength and a stable coupling. The nose and socket each includes a generally triangular-shaped front stabilizing end to provide a highly stable front connection between the nose and wear member for both vertical and side loading. The lock is movable between hold and release positions to accommodate replacing of the wear member when needed, and secured to the wear member for shipping and storage purposes. | 04-25-2013 |
20130174453 | WEAR ASSEMBLY - A wear assembly for use on various kinds of earth working equipment that includes a base with a supporting portion, a wear member with a cavity into which the supporting portion is received, and a lock to releasably secure the wear member to the base. The supporting portion is formed with top and bottom recesses that receive complementary projections of the wear member. These recesses and projections include aligned holes so as to receive and position the lock centrally within the wear assembly and remote from the wear surface. The lock includes a mounting component that defines a threaded opening for receiving a threaded pin that is used to releasably hold the wear member to the base. The separate mounting component can be easily manufactured and secured within the wear member for less expense and higher quality than forming the threads directly in the wear member. | 07-11-2013 |
20140196324 | LOCK FOR SECURING A WEAR ASSEMBLY TO EXCAVATING EQUIPMENT - A wear assembly for excavating equipment which includes a wear member and a base each with upper and lower stabilizing surfaces that are offset and at overlapping depths to reduce the overall depth of the assembly while maintaining high strength and a stable coupling. The nose and socket each includes a generally triangular-shaped front stabilizing end to provide a highly stable front connection between the nose and wear member for both vertical and side loading. The lock is movable between hold and release positions to accommodate replacing of the wear member when needed, and secured to the wear member for shipping and storage purposes. | 07-17-2014 |
20140215868 | WEAR ASSEMBLY - Wear members for wear assemblies include a lock configured to secure the wear member to a base, where the lock has two engagement positions, namely: (a) a first position that secures the lock to the wear member, and (b) a second position that secures the wear member to the base. The locks are further configured to be unlatched and removed from the wear member in two phases, a first retraction of the latching mechanism, followed by a rotation of the lock itself with removal from the wear member. | 08-07-2014 |
Patent application number | Description | Published |
20100261776 | BRUTON'S TYROSINE KINASE AS ANTI-CANCER DRUG TARGET - Receptor protein tyrosine kinases (RPTKs) transmit extracellular signals across the plasma membrane to cytosolic proteins, stimulating the formation of complexes that regulate key cellular functions. Over half of the 90 tyrosine kinases have been implicated in human cancers and are for this reason considered highly promising drug targets. To gain insight into the tyrosine kinases that contribute to breast cancer related cellular mechanisms, we carried out a large-scale loss-of-function analysis of the tyrosine kinases, using RNA interference, in the clinically relevant Erb-B2 positive, BT474 breast cancer cell line. The cytosolic, non-receptor tyrosine kinase Bruton's tyrosine kinase (BTK), which has been extensively studied for its role in B cell development, was among those tyrosine kinase genes required for BT474 breast cancer cell survival. The BTK protein identified was an alternative form containing an amino-terminal extension. This alternative form of the Btk message is also present in tumorigenic breast cells at significantly higher levels than in normal breast cells. | 10-14-2010 |
20100267803 | Regulators Of Fat Metabolism As Anti-Cancer Targets - Embodiments of the invention provide methods of identifying agents that reduce or prevent the proliferation of breast cancer cells, or kill them, in particular by interfering with the expression of the transcription factors NR1D1 and PPARγ or the expression of genes whose transcription they activate or the activity of the proteins translated from those transcripts. | 10-21-2010 |
20120165395 | Bruton's Tyrosine Kinase As Anti-Cancer Drug Target - Receptor protein tyrosine kinases (RPTKs) transmit extracellular signals across the plasma membrane to cytosolic proteins, stimulating formation of complexes that regulate key cellular functions. Over half of the known tyrosine kinases are implicated in human cancers and are therefore highly promising drug targets. A large-scale loss-of-function analysis of the tyrosine kinases using RNA interference in the clinically relevant Erb-B2 positive, BT474 breast cancer cell line showed that Bruton's tyrosine kinase (BTK), a cytosolic, non-receptor tyrosine kinase that has been extensively studied for its role in B cell development, is required, in altered form, for BT474 breast cancer cell survival. This alternative form contains an amino-terminal extension that is also present in tumorigenic breast cells at significantly higher levels than in normal breast cells. | 06-28-2012 |
20140073593 | BRUTON'S TYROSINE KINASE AS ANTI-CANCER DRUG TARGET - Receptor protein kinases (RPTKs) transmit extracellular signals across the plasma membrane to cytosolic proteins, stimulating formation of complexes that regulate key cellular functions. Over half of the known tyrosine kinases are implicated in human cancers and are therefore highly promising drug targets. A large-scale loss-of-function analysis of tyrosine kinases using RNA interference in the clinically relevant Erb-B2 positive, BT474 breast cancer cell line showed that Bruton's tyrosine kinase (BTK), a cytosolic, non-receptor tyrosine kinase that has been extensively studied for its role in B cell development, is required, in altered form, for BT474 breast cancer survival. This alternative form contains an amino-terminal extension that is also present in tumorigenic breast cells at significantly higher levels than in normal breast cells. | 03-13-2014 |
20140288098 | Bruton's Tyrosine Kinase As Anti-Cancer Drug Target - Receptor protein kinases (RPTKs) transmit extracellular signals across the plasma membrane to cytosolic proteins, stimulating formation of complexes that regulate key cellular functions. Over half of the known tyrosine kinases are implicated in human cancers and are therefore highly promising drug targets. A large-scale loss-of-function analysis of tyrosine kinases using RNA interference in the clinically relevant Erb-B2 positive, BT474 breast cancer cell line showed that Bruton's tyrosine kinase (BTK), a cytosolic, non-receptor tyrosine kinase that has been extensively studied for its role in B cell development, is required, in altered form, for BT474 breast cancer survival. This alternative form contains an amino-terminal extension that is also present in tumorigenic breast cells at significantly higher levels than in normal breast cells. | 09-25-2014 |
Patent application number | Description | Published |
20090132001 | USE OF ELECTRICAL STIMULATION OF THE LOWER ESOPHAGEAL SPHINCTER TO MODULATE LOWER ESOPHAGEAL SPHINCTER PRESSURE - The present invention describes methods and devices using low frequency electrical stimulation or neural high frequency stimulation to modulate lower esophageal sphincter (LES) pressure. The electrical stimulation may be delivered to the LES via one or more electrodes that is placed in contact with the LES tissue. The methods and devices are useful to treat a number of conditions or disease conditions, including for example, gastroesophageal reflux disease (GERD). | 05-21-2009 |
20100137212 | USE OF GLP-1 RECEPTOR AGONISTS FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS - The present invention describes the methods of using incretin mimetics such as GLP-1 receptor agonists, particularly exenatide, to treat short bowel syndrome and spastic or hyperactive esophageal motor disorders. | 06-03-2010 |
20120232610 | Systems and Methods for Electrically Stimulating the Lower Esophageal Sphincter to Treat Gastroesophageal Reflux Disease - The present specification describes methods and devices using electrical stimulation to modulate lower esophageal sphincter (LES) pressure. The electrical stimulation may be delivered to the LES via one or more electrodes that is placed in contact with the LES tissue. The methods and devices are useful to treat a number of conditions or disease conditions, including for example, gastroesophageal reflux disease (GERD). | 09-13-2012 |
20120295849 | USE OF GLP-1 RECEPTOR AGONISTS FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS - The present invention describes the methods of using incretin mimetics such as GLP-1 receptor agonists, particularly exenatide, to treat short bowel syndrome and spastic or hyperactive esophageal motor disorders. | 11-22-2012 |
20140221963 | USE OF EATING DETECTION TO CONTROL THE RELEASE OF BIOLOGICALLY ACTIVE AGENTS - Systems, apparatuses, and methods for delivery of an active agent in response to the changes in electrical activity of a subject's lower esophageal sphincter. Changes in electrical activity can be monitored by a monitoring unit containing a microprocessor. A reservoir and pump can be used to store and release the active agent. The active agent can be cholecystokinin, peptide YY, glucagon-like peptide 1 or 2, and ghrelin, or a combination thereof. | 08-07-2014 |
Patent application number | Description | Published |
20100294211 | Nocturnal Pet Toys - A simulated mouse toy having a prerecorded sound chip therein is provided which emits a prerecorded sound upon physical movement, such as when swatted, rolled or carried, to encourage pets to continue to play. An illumination device, such as luminescent or chemiluminescent coatings or light emitting diodes (LED's) are operatively connected in conjunction the prerecorded sound chip to simultaneously provide a blinking visual stimulation. | 11-25-2010 |
20110259282 | Transformable, Dual Element Pet Toy - A pet toy is provided having multiple elements interconnected or intertwined in a manner that the elements, combined, function as a single toy unit, and when the members are pulled apart or disconnected then each separable element functions similarly on its own. Each toy member is formed as a separate component and forms a generally helical body member terminating at least one end by a thematic caricature formed as a plush doll or plush toy element. The body member is formed of a outer covering having an otherwise generally elongated outer shell adapted such as to create arcuate or compound arcuate centerline such as to urge the body member to wrap about itself or other similar structure. The friction of the outer surfaces provide a fictional, torsion, compression or other non-magnetic or non-adhesive attachment, cling or connection between the toys. The instant abstract is neither intended to define the invention disclosed in this specification nor intended to limit the scope of the invention in any way. | 10-27-2011 |
Patent application number | Description | Published |
20090018003 | ROLLING PIN - Rolling pins of the present invention generally have a core, a rolling surface disposed on the outer surface of the core, a shaft that extends through the core, a first handle, and a second handle. The shaft has a first handle section, a second handle section, and a central section, and also has a shaft length greater than the core length. The handles are removably connected to the handle sections of the shaft. Preferably, the handle sections of the rolling pin shaft have locking features, and the handles have catches that releasably engage the locking features. The rolling surface is made from, or contains, thermoplastic elastomer. In at least some embodiments, the rolling surface can be a sleeve that slides onto the outer surface of the core and is secured to the ends of the core by end caps. | 01-15-2009 |
20090056440 | ADJUSTABLE MEASURING CUP - Adjustable measuring cups include a housing having a peripheral wall having an open upper end, an outer surface, an inner surface, and a bottom surface. The adjustable measuring cups also include a platform slidably movable within the housing, and an adjustment wheel rotatably connected to the bottom surface of the housing. The platform has an upper surface and a lower surface. A plurality of connecting rods can be connected to the adjustment wheel, and can also be connected to the lower surface of the platform. The measuring volume of an adjustable measuring cup can be defined by the open upper end, the inner surface of the housing and the upper surface of the platform. The platform slidably moves when the adjustment wheel is rotated, thereby adjusting the measuring volume of the measuring cup. | 03-05-2009 |
20090059715 | PASTRY BLENDER - A pastry blender that includes a handle, a plurality of arcuate cutting wires attached to the handle, and a plurality of arcuate blending wires that are also attached to the handle. The pastry blender can also include a scraper that removably connects to the cutting wires and the blending wires. | 03-05-2009 |
20090166230 | Pencil box - A portable supply container with a concave upwardly open bottom shell, a cover hinged to one side of the bottom shell and adapted to selectively cover the opening the bottom shell, and a downwardly facing concave top shell. The top shell has a first portion secured to the cover along one end and two sides, and a second portion connected to the first portion by a transverse hinge between the two sides. A first releasable connection is provided between the cover and the bottom shell on the other side of the bottom shell, and a second releasable connection is provided between the top shell second portion and the cover on the other end. The outer surface of the bottom shell has a non-slip surface having a different tactile feel than the outer surface of the top shell. | 07-02-2009 |
Patent application number | Description | Published |
20120261023 | APPARATUS FOR RECEIVING INSULATION - A conduit for facilitating the installation of insulation is disclosed. In one embodiment, the conduit comprises a body having one or more ribs and a collar having a forward end taper. In another embodiment, two or more pieces of conduit are joined to form a conduit network, with at least one piece of conduit comprising a body having one or more ribs and a collar having a forward end taper. | 10-18-2012 |
20130292937 | U-BEND FITTING - A U-bend fitting having a flow path chamber and a flow transition chamber is disclosed. In one embodiment, the U-bend fitting is designed with its maximum outer diameter to be substantially equal to the maximum combined outer diameter of the pipes which are fused to the flow path chamber. The flow transition chamber is designed to provide a larger flow path between the two pipes without any sharp turns. | 11-07-2013 |
20130313821 | U-BEND FITTING - A U-bend fitting for connecting a first pipe and a second pipe, e.g., in cooling pipe system for an ice rink, is disclosed. The U-bend fitting includes a first collar, a second collar, and a curved hollow body forming a fluid path configured to allow fluid to flow from the first pipe to the second pipe. In one embodiment, the U-bend fitting includes a brace extending transversely between the first collar and the second collar, the brace configured to resist movement of the first collar toward the second collar. In another embodiment, the U-bend fitting includes a concave channel extending longitudinally along at least a portion of the outer surface of the curved hollow body. The concave channel is configured for receiving a curved surface of a support to which the outer surface of the curved hollow body can be tied. | 11-28-2013 |
Patent application number | Description | Published |
20110262128 | MESH RESTORATION IN OPTICAL TRANSPORT NETWORKS - The present disclosure provides mesh restoration systems and methods with Optical Transport Network (OTN) links using a signaling and routing protocol, such as Optical Signaling and Routing Protocol (OSRP), Automatically Switched Optical Network (ASON), Generalized Multi Protocol Label Switching (GMPLS), and the like. The present invention includes an optical node, network, and method using the signaling and routing protocol for OTN lines of differing bandwidth granularities. The present invention utilizes OTN overhead for in-band signaling and may include capability for supporting SONET/SDH lines as well as OTN lines in the same system using the signaling and routing protocol. | 10-27-2011 |
20110274427 | DYNAMIC TRAIL TERMINATION POINT CREATION FOR OPTICAL TRANSPORT NETWORKS - The present disclosure provides dynamic service provisioning by creating embedded Optical Transport Network (OTN) ports on the fly during mesh restoration or circuit provisioning. These dynamically provisioned ports are referred to herein as “fast paths” with all the management objects created in a “slow path” so that they do not interfere with mesh restoration performance. During network failures, these dynamically created objects are deleted via the “slow path” and a new mesh path supports “fast path” creation of these objects. This results in substantial increase in mesh performance and also provides enhancements for operators allowing a “Click and Go” model to provision circuits across a network. This also reduces routing scaling issue as the routing itself is against the OTU level and not against the embedded lines. | 11-10-2011 |
20120106950 | METHOD AND SYSTEM FOR OPTICAL NETWORK SMART TIMER MANAGEMENT VIA DELAY MEASUREMENT BETWEEN SPANS - A method and system for determining timers in an High Level Data Link Control (HDLC) Traffic Manager (HTM) state machine are disclosed. According to one aspect, the invention provides for determining a transit delay between two nodes by sending a first packet having a delay measurement byte to a second node that is on a link between the first node and the second node. The method also includes receiving a second packet with the delay measurement byte from the second node. The delay measurement byte sent by the second node is adjusted by the second node to indicate its receipt by the second node. A measured delay value is determined. The measured delay value is the delay between a time of sending the first packet to the second node and receiving the second packet from the second node. The measured delay value is determined by the hardware of the first node. Upon determining the measured delay value, timer values of the HTM state machine are set based on the measured delay value. | 05-03-2012 |
Patent application number | Description | Published |
20120089313 | SYSTEM AND METHOD FOR REDUCING BRAKE FADE - A vehicle braking control system includes a vehicle brake associated with a wheel on the vehicle. A pedal activated by an operator of the vehicle controls application of the brake. An electronic control unit determines a grade mode of the vehicle and controls application of the brake independent of the operator activating the pedal while in an automatic braking mode. The electronic control unit sends a control signal to apply the brake in a manner to reduce brake fade while controlling a speed of the vehicle when the electronic control unit is in the automatic braking mode and the vehicle is in a downhill grade mode. | 04-12-2012 |
20120296543 | AUTOMATIC WORK BRAKE - A vehicle, air brake system is presented with an improved service work brake arrangement. The arrangement may provide a service work brake function or both a service work brake function and a parking brake function for the vehicle. The arrangement may provide an improved service work brake arrangement disposed within a housing for reducing the number of components and plumbing required to achieve this functionality versus prior known systems. The arrangement may utilizes a pneumatic latching valve to deliver pressurized air for applying a vehicle's service brakes. The pneumatic latching valve opens upon receiving a pneumatic control signal from an electronically controlled valve and closes upon receiving a pneumatic control signal from another source. In addition, a controller and control logic may be provided for controlling the arrangement. | 11-22-2012 |
20120312645 | MULTI-PRESSURE VALVE CONTROLLER AND METHOD FOR A VEHICLE BRAKING SYSTEM - A vehicle braking system includes a brake associated with a respective wheel of the vehicle, a multi-pressure valve associated with the brake, and a controller electrically communicating with the multi-pressure valve. The multi-pressure valve receives fluid at a first pressure at a supply port and is capable of delivering the fluid at a delivery port at a plurality of pressure profiles. A control signal is transmitted to the multi-pressure valve. The multi-pressure valve delivers the pressurized fluid to the brake, via the delivery port, at one of the plurality of delivery pressure profiles based on the control signal. | 12-13-2012 |
20130319232 | PURGE EXHAUST PROCESSOR - A purge exhaust processor includes an inlet chamber, a sump chamber, a selectively charged surface in the inlet chamber, and an orifice. The inlet chamber receives purge exhaust including at least one of air, water vapor, oil aerosol, and water aerosol. The selectively charged surface agglomerates at least one of the oil aerosol and water aerosol into a liquid. The orifice is sized for passing the agglomerated liquid from the inlet chamber to the sump chamber. | 12-05-2013 |
20150094905 | VEHICLE INSPECTION VERIFICATION AND DIAGNOSTIC UNIT - A diagnostic display device is coupled to a vehicle data bus and receives vehicle identification information which is used to identify one or more expected onboard systems installed on the vehicle. Expected systems are queried to determine that they are present and operating properly. Presence and operation status information are stored and/or presented to a user to facilitate automated vehicle system inspection. | 04-02-2015 |
Patent application number | Description | Published |
20100272438 | SYSTEMS AND METHODS FOR RAPID OPTICAL TRANSPORT NETWORK CIRCUIT PROVISIONING - The present disclosure provides systems and methods for rapid circuit provisioning in Optical Transport Networks (OTN) using signaling and routing protocols thereby enabling fast mesh restoration. The present invention utilizes a shim layer between OTN messaging (e.g., GCC or High-Level Data Link Control (HDLC)) and the associated signaling and routing protocol (e.g., OSRP, GMPLS, etc.). If an ODUk Connection CTP or TTP needs to be created, the shim layer runs a fast “OTN Setup” protocol, while buffering out going OTN messages. Incoming messages are still processed and do not require additional buffering. The purpose of the OTN Setup protocol is to allow the OTUk to re-frame on its client ODUk, while buffering out-going messages. When re-framing completes, buffers are released and the OTN messaging resumes without dropping any of the signaling frames. | 10-28-2010 |
20110170859 | OPTICAL NETWORK REAL TIME LATENCY MEASUREMENT SYSTEMS AND METHODS - The present disclosure provides systems and methods for real-time, in-service latency measurements over optical links that may be further integrated within various optical control planes. The present invention may utilize minimal unused overhead to calculate latency of an optical line through a transport network. The present invention utilizes timers at two end-point nodes associated with the optical line, and includes a mechanism to filter out frame skew between the nodes. Advantageously, the present invention provides a highly accurate latency measurement that may calculate latency on links as small as one meter, an in-service algorithm operable without network impact, and may be integrated with an optical control plane to automatically provide administrative weight variables associated with link costs. | 07-14-2011 |
20110170860 | SYSTEMS AND METHODS OF MEASURING LATENCY AND ROUTING THEREON IN OPTICAL NETWORKS - The present disclosure provides systems and methods for making latency measurements and using these measurements in routing in optical networks. In an exemplary embodiment, a method is defined whereby two nodes sharing a line automatically determine whether both nodes are capable of making a latency measurement and then which node will initiate and which node participates in making the latency measurement. In another exemplary embodiment, an on-demand latency measurement may be made between any two arbitrary nodes within a domain. Routing messages may be used to disseminate the latency of links via a signaling and routing protocol. Advantageously, the present invention provides measurement of latency and latency variation of customer circuits (i.e., SNCs) using an in-band, non-intrusive calculation with a high-degree of accuracy. Furthermore, the present invention may consider these calculations for circuit routing based on the latency and circuit acceptance based on maximum latency restrictions. | 07-14-2011 |
20130142509 | OPTICAL TRANSPORT NETWORK LINE MANAGEMENT SYSTEM AND METHODS - An Optical Transport Network (OTN) mode management system includes a controller communicatively coupled to at least one OTN port. The controller is configured to operate an OTN line Optical channel Data Unit level k (ODUk) mode management system for the at least one OTN port, and the OTN line ODUk mode management system is configured to support different multiplexing scenarios on the OTN port with no loss of control plane packets on aggregated links. A network element includes at least one port with a plurality of lines associated therewith, a controller communicatively coupled to the at least one port, and an OTN line ODUk mode management system executed on the controller for managing the plurality of lines on the at least one port. A method includes configuring and dynamically managing modes of a plurality of OTN lines in a link. | 06-06-2013 |
Patent application number | Description | Published |
20090047021 | Integrated overlay card, optical line terminal and system with integrated overlay card, and methods for operating the system and terminal - An integrated overlay card, an optical line terminal with an integrated overlay card, and a method for operating an optical network. The integrated overlay card may fit at least partially within the optical line terminal. The integrated overlay card includes a wavelength dimension multiplexer/demultiplexer that overlays first signals at a first wavelength onto second signals at a second wavelength, so as to combine signals. The combined signals may be routed to an optical network. In example embodiments, the invention may be used to provide an IP television service. | 02-19-2009 |
20090180782 | APPARATUS, SYSTEM, COMPUTER PROGRAM, AND METHOD FOR PROVIDING A MULTIMEDIA-OVER-COAX-ALLIANCE NETWORK IN CONJUNCTION WITH AN OPTICAL NETWORK - An apparatus, system, computer program, and method for providing a Multimedia over Coax Alliance (MoCA) (or other multimedia-over-coaxial cable technology) network in conjunction with an optical network. In example embodiments, MoCA data is communicated between network nodes in an optical signal. In other example embodiments, MoCA data, or other data, is transmitted in optical frequencies above 860 MHz. | 07-16-2009 |
20090324228 | ONT TEST UNIT - An Optical Network Terminal (ONT) simulator is provided. The ONT simulator includes one or more partially functional ONTs coupled to an Optical Line Termination (OLT) and an ONT/Optical network termination Management and Control Interface (ONT/OMCI) simulation utility. The ONTs receive test network traffic from the OLT and forward any OMCI traffic contained in the network traffic to the ONT/OMCI simulation utility. The ONT/OMCI simulation utility in turn simulates the operation of field-deployable ONT using the OMCI traffic. | 12-31-2009 |
Patent application number | Description | Published |
20130276135 | FILTERING ACCESS TO NETWORK CONTENT - A system receives a request to filter access by a client device to content over a network and causes access to network content by said client device to be filtered. | 10-17-2013 |
20150046507 | Secure Network Data - Disclosed herein are a system, non-transitofy computer readable medium, and method to secure network data. It is determined whether an application can execute in a first network based on information associated with the first network. The application is transferred to a second network, if it is determined that the application cannot execute in the first network. A secure connection is established between the application transferred to the second network and the data residing in the first network. | 02-12-2015 |
20150058844 | VIRTUAL COMPUTING RESOURCE ORCHESTRATION - According to an example, a method for virtual computing resource orchestration includes receiving environmental data related to an operational characteristic of a compute resource for hosting a virtual machine (VM), receiving VM data related to an operational characteristic of the VM, and determining if the environmental data or the VM data violate predetermined threshold values respectively related to the environmental data and the VM data. The method further includes generating an event based on violation of one of the threshold values by the environmental data or the VM data, evaluating, by a processor, a rule to determine an action based on the violation of one of the threshold values, and executing the action to modify the operational characteristic of the compute resource or the operational characteristic of the VM. | 02-26-2015 |
Patent application number | Description | Published |
20100160400 | TREATMENT USING DANTROLENE - Provided are low-volume, safe for injection formulations of dantrolene yielding significant advantages over the currently approved and marketed dantrolene for malignant hyperthermia (MH) threatening anesthetic crisis. Once dantrolene can be made immediately available to patients triggered of MH, the anesthesiologist will be able to focus exclusively on the management of the patient's physiologic status in this complex and evolving crisis, not on the laborious and time consuming reconstitution process of the rescue agent. The low volume, safe for injection formulations of dantrolene have significant advantages over currently used approaches to the prevention and treatment of pumphead, and other neurological, cognitive and motor dysfunction incident to iatrogenically or trauma induced situations of altered blood flow, including those incurred during surgical procedures involving CPB or related procedures, as well as those incurred during non-normothermic episodes caused iatrogenically or by disease. | 06-24-2010 |
20120121662 | TREATMENT USING DANTROLENE - Provided are low-volume, safe for injection formulations of dantrolene yielding significant advantages over the currently approved and marketed dantrolene for malignant hyperthermia (MH) threatening anesthetic crisis. Once dantrolene can be made immediately available to patients triggered of MH, the anesthesiologist will be able to focus exclusively on the management of the patient's physiologic status in this complex and evolving crisis, not on the laborious and time consuming reconstitution process of the rescue agent. The low volume, safe for injection formulations of dantrolene have significant advantages over currently used approaches to the prevention and treatment of pumphead, and other neurological, cognitive and motor dysfunction incident to iatrogenically or trauma induced situations of altered blood flow, including those incurred during surgical procedures involving CPB or related procedures, as well as those incurred during non-normothermic episodes caused iatrogenically or by disease. | 05-17-2012 |
20120121663 | TREATMENT USING DANTROLENE - Provided are low-volume, safe for injection formulations of dantrolene yielding significant advantages over the currently approved and marketed dantrolene for malignant hyperthermia (MH) threatening anesthetic crisis. Once dantrolene can be made immediately available to patients triggered of MH, the anesthesiologist will be able to focus exclusively on the management of the patient's physiologic status in this complex and evolving crisis, not on the laborious and time consuming reconstitution process of the rescue agent. The low volume, safe for injection formulations of dantrolene have significant advantages over currently used approaches to the prevention and treatment of pumphead, and other neurological, cognitive and motor dysfunction incident to iatrogenically or trauma induced situations of altered blood flow, including those incurred during surgical procedures involving CPB or related procedures, as well as those incurred during non-normothermic episodes caused iatrogenically or by disease. | 05-17-2012 |
20140099382 | TREATMENT USING DANTROLENE - Provided are low-volume, safe for injection formulations of dantrolene yielding significant advantages over the currently approved and marketed dantrolene for malignant hyperthermia (MH) threatening anesthetic crisis. Once dantrolene can be made immediately available to patients triggered of MH, the anesthesiologist will be able to focus exclusively on the management of the patient's physiologic status in this complex and evolving crisis, not on the laborious and time consuming reconstitution process of the rescue agent. The low volume, safe for injection formulations of dantrolene have significant advantages over currently used approaches to the prevention and treatment of pumphead, and other neurological, cognitive and motor dysfunction incident to iatrogenically or trauma induced situations of altered blood flow, including those incurred during surgical procedures involving CPB or related procedures, as well as those incurred during non-normothermic episodes caused iatrogenically or by disease. | 04-10-2014 |