Patent application number | Description | Published |
20100004165 | Novel Protein Transduction Domains and Uses Therefor - The present invention provides novel transduction domains, compositions comprising such transduction domains, and their use for in vivo molecular delivery. | 01-07-2010 |
20110288036 | Methods for Treating or Preventing Vascular Graft Failure - The described invention provides pharmaceutical compositions and methods for treating or preventing vascular graft failure in a subject in need of such treatment, the method comprising administering a therapeutically effective amount of a composition comprising a polypeptide of amino acid sequence YARAAARQARAKALARQLGVAA (SEQ ID NO: 1) or a functional equivalent thereof, and a pharmaceutically acceptable carrier. The methods also are clinically useful for treating a pre-atherosclerotic intimal hyperplasia condition. | 11-24-2011 |
20120263680 | Compositions And Methods For Preventing Or Treating Diseases, Conditions, Or Processes Characterized By Aberrant Fibroblast Proliferation And Extracellular Matrix Deposition - The described invention provides compositions and methods for preventing or treating a disease, condition, or pathologic process characterized by aberrant fibroblast proliferation and extracellular matrix deposition in a tissue of a subject. The method includes administering a therapeutic amount of a pharmaceutical composition comprising a polypeptide having the amino acid sequence YARAAARQARAKALARQLGVAA (SEQ ID NO: 1) or functional equivalent thereof, and a pharmaceutically acceptable carrier. | 10-18-2012 |
20130115256 | METHODS FOR TREATING OR PREVENTING VASCULAR GRAFT FAILURE - The described invention provides pharmaceutical compositions and methods for treating or preventing vascular graft failure in a subject in need of such treatment, the method comprising administering a therapeutically effective amount of a composition comprising a polypeptide of amino acid sequence YARAAARQARAKALARQLGVAA (SEQ ID NO: 1) or a functional equivalent thereof, and a pharmaceutically acceptable carrier. The methods also are clinically useful for treating a pre-atherosclerotic intimal hyperplasia condition. | 05-09-2013 |
20140072613 | Compositions and Methods for Treating Cutaneous Scarring - The described invention provides compositions, dressings and methods for treating a cutaneous scar in a subject. The compositions of the derived invention contains a pharmaceutical composition comprising a therapeutic amount of a Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK2) inhibitor comprising an MK2 polypeptide inhibitor or a functional equivalent thereof, and a pharmaceutically acceptable carrier. | 03-13-2014 |
20140073973 | INTRAVENOUS ACCESS DEVICE HAVING INTEGRATED HEMODYNAMIC RESUSCITATION SYSTEM AND RELATED METHODS - One aspect of the present disclosure is a system for hemodynamic resuscitation. The system includes an intravenous access device having a pressure sensor element configured to detect a peripheral venous pressure value in response to an occlusion of a peripheral vein. The system also includes a controller device that is configured to receive a signal from the pressure sensor comprising the peripheral venous pressure value, to process the signal to determine a hemodynamic parameter based on the peripheral venous pressure value, and to generate a resuscitation score based on the hemodynamic parameter. | 03-13-2014 |
20140207062 | APPARATUS AND METHODS FOR MEASURING PERIPHERAL VENOUS PRESSURE AND APPLICATIONS OF SAME - In one aspect, an apparatus for measuring peripheral venous pressure includes a tubing having two ends with one end connectable to a fluid source and the other end connectable to a vein, a fluid controlling device configured to have an on position and an off position, and at least one pressure sensor configured to measure fluid pressures therein. When the fluid controlling device is in the on position, fluid flow in the tubing is allowed to pass through the fluid controlling device, such that the at least one pressure sensor measures both a fluid pressure from the fluid source and a distal venous pressure from the vein. When the fluid controlling device is in the off position, no fluid flow in the tubing is allowed to pass through the fluid controlling device, such that the at least one pressure sensor measures the distal venous pressure from the vein only. | 07-24-2014 |
20150064134 | COMPOSITIONS AND METHODS FOR PREVENTING OR TREATING DISEASES, CONDITIONS, OR PROCESSES CHARACTERIZED BY ABERRANT FIBROBLAST PROLIFERATION AND EXTRACELLULAR MATRIX DEPOSITION - The described invention provides compositions and methods for treating asthma, a disease, condition or pathologic process whose progression is characterized by one or more of aberrant fibroblast proliferation and extracellular matrix deposition producing constriction in an airway, airway remodeling, and airway obstruction in lung tissue. The method includes administering a pharmaceutical composition comprising a therapeutic amount of a polypeptide having the amino acid sequence YARAAARQARAKALARQLGVAA (SEQ ID NO: 1) or functional equivalent thereof, and a pharmaceutically acceptable carrier, wherein the therapeutic amount of the polypeptide is effective to reduce the constriction of small airway dimensions and airway obstruction, treat airway remodeling, or a combination thereof. | 03-05-2015 |