Cohen, MD
Cyrille J. Cohen, Rockville, MD US
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20090304657 | CHIMERIC T CELL RECEPTORS AND RELATED MATERIALS AND METHODS OF USE - The invention provides a chimeric T cell receptor (TCR) comprising a variable region of a human TCR and a constant region comprising at least an extracellular domain of a constant region of a non-human TCR, as well as functional variants thereof. The invention also provides polypeptides and proteins related to the inventive TCRs, as well as nucleic acids encoding the TCRs, polypeptides, or proteins, recombinant expression vectors, and host cells. Further provided are pharmaceutical compositions related to the inventive TCRs and methods of preventing or treating a disease, e.g., an infectious disease, cancer, in a host, methods of detecting a diseased cell in a host, and methods of improving the biological activity of a TCR. | 12-10-2009 |
Daniel S. Cohen, Baltimore, MD US
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20090122913 | System and method for controlling modulation - A system and method for controlling modulation. The system includes a plurality of modulators and a transmitting unit. The plurality of modulators decodes data from a data signal and also encodes the data into a clock signal. The transmitting unit transmits the encoded clock signal. According to the system and method disclosed herein, the present invention provides optimized coding efficiency while minimizing overall power consumption. | 05-14-2009 |
Daniel Scott Cohen, Baltimore, MD US
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20100017563 | MICROCONTROLLER BASED FLASH MEMORY DIGITAL CONTROLLER SYSTEM - Some embodiments includes a digital control system having a microcontroller for handling timed events, a command decoder for interpreting user commands, a separate burst controller for handling burst reads of the Flash memory, a program buffer for handling page writes to the Flash memory, a page transfer controller for handling data transfers from the Flash core to the program buffer as well as address control for page writes from the program buffer to the Flash memory, a memory control register block for storing and adjusting memory control, and memory test mode signals, a memory plane interface for multiplexing addresses into the Flash memory and accelerating program, erase, and recovery verification, and an I/O Mux module for multiplexing data out of the system, and a general purpose I/O port (GPIO) that can be read and written by the microcontroller for use in test and debug. Other embodiments are described. | 01-21-2010 |
20100122097 | COMMAND DECODER FOR MICROCONTROLLER BASED FLASH MEMORY DIGITAL CONTROLLER SYSTEM - A command decoder used for a microcontroller based Flash memory digital controller system includes multiple subsystems, including the command decoder, which serves as the main user interface for interpreting commands from a user and managing the priority of commands and command modes. The command decoder also stores crucial information including address, data, opcodes, and various flags registers that are used by other subsystems including the program buffer, burst read module, register block, and microcontroller. In addition, the command decoder contains clock synchronization logic, controls the sleep function of the microcontroller and serves as a test mode controller. | 05-13-2010 |
Gary A. Cohen, Baltimore, MD US
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20140064598 | MOBILE AND DESKTOP APPLICATION FOR EXTRACTING GEOMETRIC ELEMENTS AND MAPPING TO A MASTER KEY-CODE DATABASE - A method and application provide a universal key code for use when a key is lost. The code can be taken to a locksmith or retailer for duplication. The user can obtain a digital image of their key and a software application can extract unique key geometries from the key, via, for example, edge detection technology and/or other mathematical methods, digital image processing methods and standard image processing methods. A key code can be determined from this extracted information and mapped to a known key code database. The software application can output, from a digital image of an original key, the key blank and key cut code to allow a consumer to simply and conveniently obtain a duplicate key. | 03-06-2014 |
Gary Arnold Cohen, Baltimore, MD US
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20140064597 | MOBILE APPLICATION FOR EXTRACTING GEOMETRIC ELEMENTS AND MAPPING TO A MASTER KEY-CODE DATABASE - A method and application provide a universal key code for use when a key is lost. The code can be taken to a locksmith or retailer for duplication. The user can take a picture of their key and a software application can extract unique key geometries from the key, via, for example, edge detection technology and/or other mathematical methods, digital image processing methods and standard image processing methods. A key code can be determined from this extracted information and mapped to a known key code database. The software application can output, from a picture of an original key, the key blank and key cut code to allow a consumer to simply and conveniently obtain a duplicate key. | 03-06-2014 |
Ian R. Cohen, Eldersburg, MD US
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20090278736 | METHOD AND APPARATUS FOR RELATIVE NAVIGATION USING REFLECTED GPS SIGNALS - A method and system to passively navigate an orbiting moving body towards an orbiting target using reflected GPS signals. A pair of antennas is employed to receive both direct signals from a plurality of GPS satellites and a second antenna to receive GPS signals reflected off an orbiting target. The direct and reflected signals are processed and compared to determine the relative distance and position of the orbiting moving body relative to the orbiting target. | 11-12-2009 |
Jeffrey C. Cohen, Rockville, MD US
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20090089747 | METHOD AND SYSTEM FOR MANAGING CONFIGURATION INFORMATION - An approach is provided for managing a software environment. A system file that includes information of a software environment is built. The system file is validated against one or more rules. A script is output and used to generate standardized configuration information for the software environment. | 04-02-2009 |
Jeffrey I. Cohen, Silver Spring, MD US
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20080279886 | Safer Attenuated Virus Vaccines With Missing Or Diminished Latency Of Infection - Viruses having weakened ability to establish and/or maintain latency and their use as live vaccines are described. The vaccines have one or more alterations in genes that provide continued virus replication but that inhibit latency. The vaccine materials and methods for their construction are exemplified with the varicella zoster virus. Deletion of a significant portion from both copies of the varicella zoster gene ORF63 was shown to inhibit establishment of a latent infection from a live vaccine form of the virus. Insertion of an additional ORF62 gene which is partially truncated with the ORF63 deletion inhibited establishment of latency and allowed normal growth of the virus. Other desirable viral antigen encoding sequence(s) and/or cytokine genes advantageously may replace deleted genetic material to enhance a desired immunological response. Aspects of the discovery pertain to live vaccines of other viruses, and can provide a variety of vaccines having greater safety. | 11-13-2008 |
20130209506 | Recombinant Virus with Diminished Latency and Methods of Using Same - The disclosure provides recombinant herpes virus with diminished latency. In embodiments, the recombinant herpes virus comprises a latency gene or transcript linked to an altered or heterologous promoter. The disclosure also provides compositions and methods for inducing immunity in animals using the recombinant herpes viruses. | 08-15-2013 |
Jonathan Cohen, Potomac, MD US
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20140378500 | METHODS FOR PREDICTING TUMOR REPONSE TO TARGETED THERAPIES - A method for identifying cancer patients that are likely to be responders or non-responders to a signal transduction pathway inhibitor is described. | 12-25-2014 |
Jonathan D. Cohen, Glenwood, MD US
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20140068768 | Apparatus and Method for Identifying Related Code Variants in Binaries - An apparatus for identifying related code variants may include processing circuitry configured to execute instructions for receiving query binary code, processing the query binary code to generate one or more query code fingerprints comprising compressed representations of respective functional components of the query binary code, comparing the one or more query code fingerprints to at least some reference code fingerprints stored in a database to determine a similarity measure between the one or more query code fingerprints and at least some of the reference code fingerprints, and preparing at least one report based on the similarity measure. | 03-06-2014 |
20140223565 | Apparatus And Method For Identifying Similarity Via Dynamic Decimation Of Token Sequence N-Grams - An apparatus for identifying related code variants or text samples includes processing circuitry configured to execute instructions for receiving query binary code, processing the query binary code to generate one or more query code fingerprints comprising compressed representations of respective functional components of the query binary code, generating token sequence n-grams of the fingerprints, hashing the n-grams, partitioning samples by length to compare selected samples based on length, and identifying similarity via dynamic decimation of token sequence n-grams. | 08-07-2014 |
Kenneth J. Cohen, Silver Spring, MD US
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20090322098 | INTEGRATED COMBUSTION AND ELECTRIC HYBRID ENGINES AND METHODS OF MAKING AND USE THEREOF - A new approach to achieving greater fuel efficiencies in the design and implementation of hybrid automotive vehicles. Efficiency and power benefits accrue from the integration of electric motor components into various components of combustion-fueled engines, thus obviating the need for much separate equipment, such as discrete electric motor(s) and gear arrangements in order to obtain hybrid operation. Among other things, a significant savings of weight in the vehicle and increased control of the coordination between combustion-fueled and electric motor propulsion of the vehicle is obtained. | 12-31-2009 |
20120223529 | INTEGRATED COMBUSTION AND ELECTRIC HYBRID ENGINES AND METHODS OF MAKING AND USE THEREOF - A new approach to achieving greater fuel efficiencies in the design and implementation of hybrid automotive vehicles. Efficiency and power benefits accrue from the integration of electric motor components into various components of combustion-fueled engines, thus obviating the need for much separate equipment, such as discrete electric motors) and gear arrangements in order to obtain hybrid operation. Among other things, a significant savings of weight in the vehicle and increased control of the coordination between combustion-fueled and electric motor propulsion of the vehicle is obtained. | 09-06-2012 |
20140306453 | INTEGRATED COMBUSTION AND ELECTRIC HYBRID ENGINES AND METHODS OF MAKING AND USE THEREOF - A new approach to achieving greater fuel efficiencies in the design and implementation of hybrid automotive vehicles. Efficiency and power benefits accrue from the integration of electric motor components into various components of combustion-fueled engines, thus obviating the need for much separate equipment, such as discrete electric motor(s) and gear arrangements in order to obtain hybrid operation. Among other things, a significant savings of weight in the vehicle and increased control of the coordination between combustion-fueled and electric motor propulsion of the vehicle is obtained. | 10-16-2014 |
Larry Cohen, Silver Spring, MD US
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20090213435 | Certified inbound facsimile service - Method for monitoring delivery of e-mail messages includes delivering an e-mail message to a primary, recipient, determining the time at which the e-mail message was delivered to the primary recipient, and determining whether the primary recipient reads the e-mail message within a primary maximum time frame. When the primary recipient does not read the e-mail message within the primary maximum time frame, delivering a copy of the e-mail message to a secondary recipient, determining the time at which the e-mail message was delivered to the secondary recipient, and determining whether the secondary recipient reads the e-mail message within a secondary maximum time frame. When both the primary and secondary recipients do not read the e-mail message within the secondary maximum time frame, appropriate action is taken such as notifying a predesignated available recipient to enable the available recipient to attend to facilitating a response to the e-mail message. | 08-27-2009 |
Marc H. Cohen, Silver Spring, MD US
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20090020609 | SENSOR-EMBEDDED BARCODES - A barcode includes sensors or actuators in selected modules whereby its code changes to indicate exposure to, or change in, one or more properties of interest. Prior to exposure, the barcode displays a first code. After exposure, the barcode displays a different code. The displayed code conveys qualitative or quantitative information about one or more chosen properties of interest. This dynamic barcode can be configured as a standalone device or as a label that can be affixed to an object. Data coded by the dynamic barcode is machine-readable or visible to the naked eye, and can be autonomously conveyed to a database to facilitate analysis or prognostics. | 01-22-2009 |
20100041571 | Multiplexed Lateral Flow Assay Arrays - A diagnostic test device comprising at least one membrane disposed in any of one, two, and three dimensions; at least one test sample fluid input port that receives and transfers at least one test sample fluid and onto the at least one membrane; at least one contiguous fluid flow manifold within the at least one membrane to multiplex or distribute the at least one test sample fluid; at least one contiguous fluid flow channel that operatively connects the at least one membrane to the at least one contiguous fluid flow manifold; at least one analyte assay test zone disposed within the at least one contiguous fluid flow channel; and at least one chemical capturing reagent disposed within the at least one analyte assay test zone, wherein multiple analyte assay test results are simultaneously obtained and in parallel in the diagnostic test device. | 02-18-2010 |
Rob Cohen, Kensington, MD US
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20090021752 | Orientation Sensing Of A Rod - A laparoscopy simulator includes two rods and an orientation sensor that determines the orientation of the rods. An optical sensor is used to determine measurements of each rod based on the rotation of the rod around a central axis of the rod and a sliding of the rod along the central axis. An accelerometer is used to determine additional measurements of each rod based on a rotation of the rod around two additional rotation axes of the simulator. The measurements are used to determine the overall orientation of the rods. | 01-22-2009 |
Robert E. Cohen, Baltimore, MD US
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20110250613 | Arrayed Multiple Ubiquitin Binding Domains as Linkage-specific Polyubiquitin Affinity Reagents - Linkage-specific polyubiquitin recognition is thought to make possible the diverse set of functional outcomes associated with ubiquitination. Thus far, mechanistic insight into this selectivity has been largely limited to single domains that preferentially bind to lysine 48-linked polyubiquitin (K48-polyUb) in isolation. A mechanism is proposed herein, linkage-specific avidity, in which multiple ubiquitin-binding domains are arranged in space so that simultaneous, high-affinity interactions are optimum with one polyUb linkage but unfavorable or impossible with other polyUb topologies and monoUb. The model used herein is human Rap80, which contains tandem ubiquitin interacting motifs (UIMs) that bind to K63-polyUb at DNA doublestrand breaks. The sequence between the Rap80 UIMs positions the domains for efficient avid binding across a single K63 linkage, thus defining selectivity. K48-specific avidity is also demonstrated in a different protein, ataxin-3. Using tandem UIMs, the general principles governing polyUb linkage selectivity and affinity in multivalent ubiquitin receptors are established. | 10-13-2011 |
Robert F. Cohen, Kensington, MD US
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20080287824 | Systems and Methods for Locating A Blood Vessel - Systems and methods for locating a blood vessel are described. One described method includes receiving a first temperature measure associated with a first point on a surface of a skin; receiving a second temperature measure associated with a second point on the surface of the skin, and determining a differential between the first temperature measure and the second temperature measure. The method further includes generating an output signal indicating the presence of a blood vessel if the differential exceeds a threshold. | 11-20-2008 |
20090053683 | Flexible Member Based Simulator - A simulator includes a motor and a flexible member coupled to the motor. The simulator further includes a processor that is coupled to the motor and controls the motor to vary the tension of the flexible member. | 02-26-2009 |
20090245601 | Locating Blood Vessels - Several systems and methods for locating blood vessels are described in the present disclosure. One of the implementations of a blood vessel locating system comprises an image capture device and processing circuitry. The image capture device is configured to capture a first image of a region of the skin of a subject when the region is illuminated by a first light and to capture a second image of the region of the skin when the region is illuminated by a second light. The processing circuitry is configured to calculate the difference between the first image and the second image to obtain a differential image. The processing circuitry is further configured to enhance the differential image to obtain an enhanced image of blood vessels located under the surface of the skin of the subject. | 10-01-2009 |
20090320227 | Apparatus and Method for Providing Condition-Based Vibrotactile Feedback - Systems and methods for monitoring motion parameters of an object are described in the present disclosure. In one embodiment among many, a sensor, coupled to a housing, senses motion associated with the housing and provides a sensor output based on the sensed motion. A processing device receives the sensor output, accumulates counts associated with the sensor output, and provides an output once a threshold associated with the accumulated counts is reached. A vibrotactile device, that receives the output from the processing device, provides a haptic output in response to the output from the processing device. In one embodiment among many, a toothbrush is described as a monitoring mechanism for monitoring a plurality of brush strokes that a user executes with the toothbrush. The monitoring mechanism is incorporated in the handle of the toothbrush. The monitoring mechanism may be used to provide an alert once a sufficient number of brush strokes is achieved. | 12-31-2009 |
20100069941 | Systems and Methods For Sensing Hand Motion By Measuring Remote Displacement - Systems and methods for sensing hand motion by measuring remote displacement are disclosed. For example, one disclosed apparatus includes a first surface configured to engage a first distal member of a surgical tool and a second surface configured to engage a second distal member of the surgical tool, the second surface coupled to the first surface at a pivot point. The apparatus further includes a sensor configured to detect a relative movement of the first surface and the second surface about the pivot point and to generate a signal based at least in part on the relative movement. | 03-18-2010 |
20110148794 | Haptic Interface for Palpation Simulation - A method for interfacing a user with a computer running an application program, the computer generating a graphical environment comprising a graphical object and a graphical representation of at least a portion of a living body, comprises providing an object in communication with the computer, controlling the graphical object in relation to manipulation of at least a portion of the object by the user, and outputting a haptic sensation to the user when the graphical object interacts with a region within the graphical representation to provide the user with haptic feedback related to a simulated palpation of the region. | 06-23-2011 |
20130120153 | Apparatus for Providing Condition-Based Vibrotactile Feedback - Systems and methods for monitoring motion parameters of an object are described in the present disclosure. In an embodiment, a sensor, coupled to a housing, senses motion associated with the housing and provides a sensor output based on the sensed motion. A processing device receives the sensor output, accumulates counts associated with the sensor output, and provides an output once a threshold associated with the accumulated counts is reached. A vibrotactile device, that receives the output from the processing device, provides a haptic output in response to the output from the processing device. | 05-16-2013 |
20140149067 | IMPACT AND ACCELERATION DETECTION - An sensor system measures acceleration and detects impacts. According one embodiment of the present invention, an impact sensor system attaches to a helmet, detects impacts, and displays indications of single and cumulative impacts. Identifying impacts when they occur can help identify players to be screened for concussion or taken out of action before they show symptoms. This can help prevent concussions that result from cumulative hits, which are often more dangerous than those that result from a single hit. The system serves as a continue-to-play decision support aid. | 05-29-2014 |
Ronald Cohen, Silver Spring, MD US
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20100284883 | Ordered Oxynitride Perovskites - This invention relates to partially ordered and ordered oxynitride perovskites of the general formula ABO | 11-11-2010 |
20130071312 | Ordered Oxynitride Perovskites - This invention relates to partially ordered and ordered oxynitride perovskites of the general formula ABO | 03-21-2013 |
Shane Perry Cohen, Potomac, MD US
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20080196367 | METHOD AND APPARATUS FOR DETECTING AND REMOVING AIRBORNE IMPURITIES WITHIN AN ENCLOSED CHAMBER - An apparatus for detecting and removing airborne impurities within an enclosed chamber is provided according to an embodiment of the invention. The enclosed chamber includes a chamber housing and an opening in the chamber housing for introducing airborne impurities. The enclosed chamber also includes a meter for detecting the airborne impurity level within the enclosed chamber. At least one air cleaner located within the chamber housing is provided for removal of airborne impurities. | 08-21-2008 |
20080264257 | METHOD AND APPARATUS FOR ILLUMINATING AND REMOVING AIRBORNE IMPURITIES WITHIN AN ENCLOSED CHAMBER - An enclosed chamber for illuminating and removing airborne impurities includes at least one air cleaner for removing airborne impurities. The enclosed chamber also includes a means for illuminating the airborne impurities. Airborne impurities can be introduced into the enclosed chamber through an aperture in a chamber housing of the enclosed chamber. | 10-30-2008 |