Cochran, CA
Alex Cochran, Los Angeles, CA US
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20140304582 | MOBILE REPORTS - A mobile data analysis system is provided that enables mobile device location tracking, secure messaging, and real-time sharing of intelligence information, among other features. In one embodiment, a mobile data analysis system includes functionality for generating mobile reports. In this context, a mobile report represents information collected by a mobile device user and provided as input to a report form displayed by an associated mobile device. The collected information may, for example, include information relating to an activity or event, information relating to a particular person, entity, or location, or any combination thereof. A mobile report may be based on a report template. A report template defines one or more data fields and other property information to be included in a mobile report based on the report template. A mobile report may be sent to a server that generates one or more data objects, and one or more data object links between the data objects, based on input data contained in a mobile report. | 10-09-2014 |
Andrea Cochran, San Francisco, CA US
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20110256127 | ANTI-LRP6 ANTIBODIES - The invention provides anti-LRP6 antibodies and methods of using the same. A particular aspect of the invention provides for bispecific anti-LRP6 antibodies that inhibit signaling by multiple Wnt isoforms. | 10-20-2011 |
20120100562 | METHODS AND COMPOSITIONS FOR MODULATING THE WNT PATHWAY - The invention provides methods and compositions for modulating the Wnt signaling pathway, in particular by interfering with binding of Dkk1 or SOST with LRP5 and/or LRP6. | 04-26-2012 |
20140235820 | METHODS AND COMPOSITIONS FOR MODULATING THE Wnt PATHWAY - The invention provides methods and compositions for modulating the Wnt signaling pathway, in particular by interfering with binding of Dkk1 or SOST with LRP5 and/or LRP6. | 08-21-2014 |
20140363439 | ANTI-LRP6 ANTIBODIES - The invention provides anti-LRP6 antibodies and methods of using the same. A particular aspect of the invention provides for bispecific anti-LRP6 antibodies that inhibit signaling by multiple Wnt isoforms. | 12-11-2014 |
Andrea G. Cochran, San Francisco, CA US
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20090011988 | METHOD FOR TREATING CARTILAGE DISORDERS - The present invention relates to a method for the treatment of a cartilage disorder, including cartilage damaged by injury or degenerative cartilagenous disorders. The method involves contacting the cartilage with an IGF-1 analog with altered affinity for IGF-binding proteins (IGFBPs) or an IGFBP displacer peptide that prevents the interaction of an IGF with an IGFBP and does not bind to a human IGF receptor. | 01-08-2009 |
20100130411 | METHOD FOR TREATING CARTILAGE DISORDERS - The present invention relates to a method for the treatment of a cartilage disorder, including cartilage damaged by injury or degenerative cartilagenous disorders. The method involves contacting the cartilage with an IGF-1 analog with altered affinity for IGF-binding proteins (IGFBPs) or an IGFBP displacer peptide that prevents the interaction of an IGF with an IGFBP and does not bind to a human IGF receptor. | 05-27-2010 |
Benjamin D. Cochran, Corte Madera, CA US
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20100031196 | METHOD AND APPARATUS FOR SELECTING AND HIGHLIGHTING OBJECTS IN A CLIENT BROWSER - A computer implemented method, apparatus, article of manufacture and storage medium, provide the ability to select and highlight objects. A rendered image (containing one or more rendered objects) is displayed in a client browser on a client computer. A run length encoded (RLE) selection buffer is received, from a server across a network, into the client browser. The selection buffer provides a mapping of each pixel from the rendered image to rendered objects. User input is accepted that identifies a location of a cursor with respect to the rendered image. A determination is made, on the client computer, regarding which of the rendered objects has been selected based on the user input and the RLE selection buffer. The selected rendered object is then displayed in a visually distinguishable manner. | 02-04-2010 |
20130268927 | PROCESS FOR COMPRESSING APPLICATION DEPLOYMENTS - A method, apparatus, article of manufacture, and computer readable storage medium provide the ability to compress an application deployment. A master application to be deployed that has two or more files is obtained. The files in the master application are inventoried and two file instances that are identical are identified. An application deployment, based on the master application, is written by writing the first file instance and replacing additional identical file instances with links to the first file instance. | 10-10-2013 |
Benjamin David Cochran, Corte Madera, CA US
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20090109217 | Pre-Computing Image Manipulations - The present disclosure includes, among other things, systems, methods and program products for pre-computing image manipulations. | 04-30-2009 |
20150287247 | INTEGRATING COMPONENTS INTO 3D PRINTED OBJECTS - Methods, systems, and apparatus, including computer programs encoded on a storage medium, for integrating components into objects that are to be 3D printed. One of the methods includes obtaining a three-dimensional model of a first object; receiving an input identifying an additional component; generating a digital representation of the additional component; integrating the digital representation of the additional component with the three-dimensional model; and providing the three-dimensional model with the integrated digital representation to a 3D printer for fabrication. | 10-08-2015 |
Brian Cochran, Thousand Oaks, CA US
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20140364455 | PROCESSES OF MAKING AND CRYSTALLINE FORMS OF A MDM2 INHIBITOR - The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates. | 12-11-2014 |
Brooks B. Cochran, Northridge, CA US
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20110152654 | ANALYTE SENSORS COMPRISING BLENDED MEMBRANE COMPOSITIONS AND METHODS FOR MAKING AND USING THEM - Embodiments of the invention provide analyte sensors having elements designed to modulate their chemical reactions as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes an analyte modulating membrane that comprises a blended mixture of a linear polyurethane/polyurea polymer, and a branched acrylate polymer. | 06-23-2011 |
20130178726 | STABILIZED POLYMERS FOR USE WITH ANALYTE SENSORS AND METHODS FOR MAKING AND USING THEM - Embodiments of the invention provide analyte sensors having elements designed to modulate their chemical reactions as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes an analyte modulating membrane that comprises a linear polyurethane/polyurea polymer comprising one or more agents selected for their ability to stabilize the polymers against thermal and/or oxidative degradation. | 07-11-2013 |
Diane Cochran, Mission Veijo, CA US
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20090319879 | Double click inline edit / single click action - A system, method and prepaid payment card configured to enable web-browser behavior for double-click in-line edit and single click action fields. | 12-24-2009 |
Dougals R. Cochran, Novato, CA US
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20150355822 | METHOD FOR FINE-TUNING THE PHYSICAL POSITION AND ORIENTATION ON AN ELECTRONIC DEVICE - An electronic data device programmed with a position and orientation calibration and adjustment program to visually display a two- or three-dimensional virtual representation of a user-selected physical space on the electronic visual display and to display a position indicator corresponding to an estimated initial location and orientation of the electronic data device in the user-selected physical space, and thereafter when a user makes a manual adjustment to the indicated location, the program causes the electronic data device to automatically adjust and correct the indicated location. | 12-10-2015 |
Douglas R. Cochran, Novato, CA US
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20150260544 | METHOD FOR CALIBRATING THE PHYSICAL POSITION AND ORIENTATION OF AN ELECTRONIC DEVICE USING DEVICE SENSORS - A system for calibrating physical position and orientation of an electronic device, including an electronic data device with core processor, permanent memory for storing a program, temporary memory for running a program, an electronic visual display, a display subsystem, a user input device, a motion detection subsystem, and an orientation detection subsystem; and a program with instructions that, when executed by the core processor, cause the electronic data device to visually display a two- or three-dimensional virtual representation of a user-selected physical space on the electronic visual display and to display a prompt for a user to mark initial calibration points in the displayed virtual representation of the physical space, wherein after a user marks at least one calibration point, the program causes the electronic data device to adjust and update the location and orientation of the electronic data device as it is moved within the physical space. | 09-17-2015 |
20150269134 | METHOD OF ANNOTATING A DOCUMENT DISPLAYED ON AN ELECTRONIC DEVICE - A system and method for creating a location tag and attaching and linking multiple attributes to that tag, including such attributes as digital audio files, video files, text and photographs, thereby facilitating subsequent finding of the location in an electronic document or display. In this way, the same or a different user can proceed directly to a location of interest to view and inspect the features identified in the linked attributes. | 09-24-2015 |
20150289113 | METHOD FOR CALIBRATING THE PHYSICAL POSITION AND ORIENTATION OF AN ELECTRONIC DEVICE - A system and method for calibrating the location and orientation of an electronic device, including an electronic data device having a processor, permanent memory, temporary memory, program loading means, a visual display and display subsystem, user input devices, a motion detection subsystem, an orientation detection subsystem, and a geolocation subsystem. The electronic device is programmed with instructions that, when executed, cause the electronic device to visually display a virtual representation of a user-selected physical space on the electronic visual display and to display a position indicator corresponding to an initial location and orientation of the electronic data device in the user-selected physical space, and thereafter to adjust and correct the location according to either user manual inputs or movement of the electronic data device in the physical space. | 10-08-2015 |
20150355822 | METHOD FOR FINE-TUNING THE PHYSICAL POSITION AND ORIENTATION ON AN ELECTRONIC DEVICE - An electronic data device programmed with a position and orientation calibration and adjustment program to visually display a two- or three-dimensional virtual representation of a user-selected physical space on the electronic visual display and to display a position indicator corresponding to an estimated initial location and orientation of the electronic data device in the user-selected physical space, and thereafter when a user makes a manual adjustment to the indicated location, the program causes the electronic data device to automatically adjust and correct the indicated location. | 12-10-2015 |
Dustin Cochran, Aptos, CA US
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20140169027 | MECHANICAL ATTACHMENT SYSTEM FOR LINEAR LIGHT MODULES - A lighting system comprising multiple linear lighting module building blocks is described. A lighting module is designed to emit light in a linear configuration, and multiple lighting modules are concatenated to emit light in a single linear configuration. A mechanical coupling system allows the lighting modules to be inserted into the linear configuration from a direction perpendicular to the linear configuration. The housing of the lighting modules is designed to allow the module to be clipped together in the linear configuration. | 06-19-2014 |
Dustin Cochran, Boulder Creek, CA US
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20110134645 | LED LAMP ASSEMBLY WITH THERMAL MANAGEMENT SYSTEM - A lighting system is described. The lighting system includes a lamp and a first container including a first phase change material thermally connected to the lamp. Heat generated by the lamp during operation is conducted to the first phase change material. The system also includes a second container including a second phase change material thermally connected to the lamp. Heat generated by the lamp during operation is also conducted to the second phase change material, and the second phase change material has a transition point temperature lower than the transition point temperature of the first phase change material of the first container to account for a temperature drop between the second container and the first container. The lighting system also includes a temperature sensor for reducing lamp power if the lamp becomes too hot, and a mounting bracket which may also conduct heat away from the lamp. | 06-09-2011 |
20120307500 | LED LAMP ASSEMBLY WITH THERMAL MANAGEMENT SYSTEM - A lighting system is described. The lighting system includes a lamp and a first container including a first phase change material thermally connected to the lamp. Heat generated by the lamp during operation is conducted to the first phase change material. The system also includes a second container including a second phase change material thermally connected to the lamp. Heat generated by the lamp during operation is also conducted to the second phase change material, and the second phase change material has a transition point temperature lower than the transition point temperature of the first phase change material of the first container to account for a temperature drop between the second container and the first container. The lighting system also includes a temperature sensor for reducing lamp power if the lamp becomes too hot, and a mounting bracket which may also conduct heat away from the lamp. | 12-06-2012 |
20130234602 | SYSTEM AND METHOD FOR COLOR TUNING LIGHT OUTPUT FROM AN LED-BASED LAMP - Systems and methods for using an LED-based lamp for reproducing a target light are disclosed. A color-space searching technique is introduced here that enables the LED-based lamp to be tuned to generate light at a specific CCT by adjusting the amount of light contributed by each of the LED strings in the lamp. The target light is decomposed into different wavelength bands, and light generated by the LED-based lamp is also decomposed into the same wavelength bands and compared. The color-searching techniques allow the LED-based lamp to closely emulate a black body radiator given the limitations of the physical specification of color string in the LED strings. | 09-12-2013 |
20140167617 | SYSTEM AND METHOD FOR COMMUNICATION AMONG LINEAR LIGHT MODULES IN A LIGHTING SYSTEM - Light source systems and methods of operating the light source systems are disclosed. A light source system may include a combination of two lighting modules in communication with each other. The lighting modules can operate in concert, in parallel, or as master or slave. A printed circuit board assembly (PCBA) of the light source system includes electrical circuitry to drive a set of light emitting diodes (LEDs). The PCBA can include a communication interface for communication amongst the lighting modules. The PCBA can also include an optical sensor to provide color spectrum feedback to a controller module for self calibration. A master PCBA can receive sensor feedbacks, such as thermal and optical feedbacks from a slave PCBA. The sensor feedbacks can then be used to tune a color spectrum of a slave lighting module including calibrating the slave lighting module. | 06-19-2014 |
20140168777 | LIGHT DIFFUSERS AND METHODS FOR MANUFACTURING - A linear light module having an optical coupling element and a light pipe is described. The optical coupling element receives light emitted by multiple light emitting diodes (LEDs) having different emission wavelengths and couples the light efficiently to a linear light pipe. The light from the LEDs is efficiently mixed by the optical coupling element and the light pipe to produce a linear light output that is uniform in color and intensity. Light diffusers can be used with the optical coupling element and light pipe at various locations to further enhance the uniformity of the emitted light. Novel techniques for manufacturing the light diffusers that use patterning of a suspension solution or injection molding are described. | 06-19-2014 |
20140169025 | SYSTEM AND METHOD FOR MIXING AND GUIDING LIGHT EMITTED FROM LIGHT EMITTING DIODES TO A LIGHT PIPE FOR EMISSION IN A LINEAR CONFIGURATION - A linear light module having an optical coupling element and a light pipe is described. The optical coupling element receives light emitted by multiple light emitting diodes (LEDs) having different emission wavelengths and couples the light efficiently to a linear light pipe. The light from the LEDs is efficiently mixed by the optical coupling element and the light pipe to produce a linear light output that is uniform in color and intensity. Diffusers can be used with the optical coupling element and light pipe at various locations to further enhance the uniformity of the emitted light. | 06-19-2014 |
20140169026 | THERMAL PATH FOR HEAT DISSIPATION IN A LINEAR LIGHT MODULE - A linear light module that uses a thermally conductive housing for dissipating heat generated by a lighting source within the housing is described. Light is thermally coupled away from the lighting source via a thermally conductive heating block. The heating block is thermally coupled to a thermally conductive heat pipe that runs along the length of the housing, where the length of the housing is substantially the same length as the linear light module. The housing is extruded to include a channel that runs the length of the housing for holding the heat pipe. Because the housing is long, the heat is easily conducted from the housing. | 06-19-2014 |
Frank V. Cochran, Stanford, CA US
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20150266936 | CONJUGATED KNOTTIN MINI-PROTEINS CONTAINING NON-NATURAL AMINO ACIDS - Disclosed are knottin peptides containing non-natural amino acids so that they can be formed by chemical conjugation into two or more knottin monomers. The knottin monomers comprise a non-natural amino acid such as an aminooxy residue within the polypeptide sequence. The exemplified dimers were produced by oxime formation between two aldehyde groups present on a polyether linker and an aminooxy functional group that was site-specifically incorporated the knottin. Knottins variants based on EETI ( | 09-24-2015 |
Gene Paul Cochran, Long Beach, CA US
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20110127411 | System and Method for Using an Optical Isolator in Laser Testing - According to one embodiment, a method includes receiving a first optical signal at a pulse detector. An electronic pulse of the first optical signal is received at an optical module. A second optical signal is generated at the optical module based on the electronic pulse. At least a portion of the first optical signal is received in a reverse direction at an optical isolator and the second optical signal is received in a forward direction at the optical isolator. The optical isolator substantially transmits the second optical signal to a target in the forward direction. The optical isolator substantially attenuates at least a portion of the first optical signal in the reverse direction. | 06-02-2011 |
Glenn C. Cochran, Roseville, CA US
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20140212147 | OPTICAL TRANSMITTER AND RECEIVER CIRCUIT ARRANGEMENT - A system includes an optical transmitter package comprising an optical transmitter to generate optical transmission signals based on electrical transmission signals. The system also includes an optical receiver package comprising an optical receiver to generate electrical reception signals based on optical reception signals. The system further includes a printed circuit board (PCB) on which the optical transmitter package and the optical receiver package are mounted. The PCB includes a heat generating circuit component. The optical transmitter package can be mounted to the PCB to subjected to less heat from the heat generating circuit component than the optical receiver package. | 07-31-2014 |
Jennifer R. Cochran, Stanford, CA US
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20080249008 | Mutant epidermal growth factor polypeptides, nucleic acids, and uses therefor - The present invention is based, in part, on our discovery that EGF can be engineered to generate mutants that bind to the EGF receptor (EGFR) of a cell and that have a desirable effect on the activity of the cell. For example, the mutants can agonize the receptor (i.e., increase a biological activity of the receptor), or antagonize the receptor (i.e., decrease or inhibit a biological activity of the receptor). In turn, the rate at which the cell proliferates, for example, can be changed. Moreover, some of these mutants bind EGFR with a higher affinity than wild-type EGF exhibits. The affinity may increase by about, for example, 2-, 5-, 10-, 15-, 20-, 25-, 30-, 50-, or 100-fold relative to wild-type EGF. | 10-09-2008 |
20090117166 | Sequential coupling of biomolecule layers to polymers - A bio-mimetic or bio-implantable material based on a sequential process of coupling biomolecule layers to a polymer layer is provided. In general, the material could be based on two or more biomolecule layers starting with one of the layers covalently linked to the polymer layer via cross-linkers and the other layers sequentially and covalently linked using cross-linkers to the previously added layer. The polymer layer could be a hydrogel or an interpenetrating polymer network hydrogel. The first layer of biomolecules could be a collagen type, fibronectin, laminin, extracellular matrix protein, or any combinations thereof. The second layer of biomolecules typically is a growth factor, protein or stimulant. The cross-linkers are either water soluble or insoluble bifunctional cross-linkers or azide-active-ester crosslinkers. The material and process as taught in this invention are useful in the field of tissue engineering and wound healing. | 05-07-2009 |
20090257952 | Engineered Integrin Binding Peptides - Engineered peptides that bind with high affinity (low equilibrium dissociation constant (Kd)) to the cell surface receptors of fibronectin (α | 10-15-2009 |
20090280182 | Devices for the treatment of wounds and methods and kits therefor - Interpenetrating network hydrogels are described that may be incorporated into wound dressings and/or in implants. The properties of the interpenetrating network hydrogel may be tuned to control an amount of moisture in a wound environment. The devices, methods, and kits described herein may be adapted to treat a variety of wound types at a variety of healing stages over a range of time scales. Some hydrogels may be configured to deliver one or more vulnerary agents to a wound. The interpenetrating network hydrogels may also be adapted to control a rate and/or amount of moisture uptake so that the hydrogels may be used as expandable implants to expand tissue. | 11-12-2009 |
20100113708 | Surface modification of interpenetrating polymer networks - Surface modification methods for an interpenetrating polymer network (IPN) hydrogel to provide a basis for cell or tissue attachment are provided. The method involves the activation of functional groups on the surface of the IPN hydrogel. The activated functional groups are then reacted with amine-containing molecules or hydroxyl-containing molecules. The methods (i) can be performed in an aqueous environment and do not require the use of any organic solvent, (ii) do not require UV treatment, thereby avoiding denaturation of the IPN hydrogel or proteins, and/or (iii) can be performed as a one pot reaction. | 05-06-2010 |
20110136740 | CYSTINE KNOT PEPTIDES BINDING TO ALPHA IIb BETA 3 INTEGRINS AND METHODS OF USE - Disclosed are peptides having a cystine knot structural motif and comprising a sequence engineered for specificity against α | 06-09-2011 |
20120020889 | Polypeptides Targeting Vascular Endothelial Growth Factor Receptor-2 and Alpha V Beta 3 Integrin - Polypeptides comprising variant vascular endothelial growth factor sequences are provided. The polypeptides are useful in cancer imaging, cancer diagnosis, monitoring and treatment as well as treatment of diseases characterized by excessive neovascularization. | 01-26-2012 |
20130017205 | Inhibition of AXL Signaling in Anti-Metastatic Therapy - Compositions and methods are provided for alleviating cancer in a mammal by administering a therapeutic dose of a pharmaceutical composition that inhibits activity of AXL protein activity, for example by competitive or non-competitive inhibition of the binding interaction between AXL and its ligand GAS6. | 01-17-2013 |
20130053314 | Mutant Epidermal Growth Factor Polypeptides with Improved Biological Activity and Methods of Their Making and Use - Compositions that are EGF polypeptides that possess improved biological activity as compared to the biological activity exhibited by wild-type EGF are provided. Also provided are methods for the preparation of these mutants, methods for the use of these mutants, methods for rationally designing new polypeptide mutants, and methods for screening mutants polypeptides to identify novel EGF mutants with desirable biological activities. | 02-28-2013 |
20130108644 | Inhibition of AXL Signaling in Anti-Metastatic Therapy | 05-02-2013 |
20130171068 | HEPATOCYTE GROWTH FACTOR FRAGMENTS THAT FUNCTION AS POTENT MET RECEPTOR AGONISTS AND ANTAGONISTS - The NK1 fragment of hepatocyte growth factor (HGF) binds to and activates the Met receptor, a transmembrane receptor tyrosine kinase that plays a critical role in embryonic development and organ formation. The instant application discloses NK1 variant polypeptides which act as agonists or antagonists of HGF. Further disclosed are covalently linked NK1 variant polypeptides. Many of the disclosed variant polypeptides possess improved stability characteristics. | 07-04-2013 |
20130189254 | Inhibition of AXL/GAS6 Signaling in the Treatment of Disease - Compositions and methods are provided for alleviating endometriosis, kidney disease, inflammatory disease and/or transplant rejection in a mammal by administering a therapeutic dose of a pharmaceutical composition that inhibits AXL, MER or Tyro3 protein activity, for example by competitive or non-competitive inhibition of the binding interaction between AXL, MER or Tyro3 and its ligand GAS6. | 07-25-2013 |
20140010757 | IMAGING METHODS USING ENGINEERED INTEGRIN BINDING PEPTIDES - Engineered peptides that bind with high affinity (low equilibrium dissociation constant (Kd)) to the cell surface receptors of fibronectin (α | 01-09-2014 |
20140065143 | Inhibition of AXL Signaling in Anti-Metastatic Therapy - Compositions and methods are provided for alleviating cancer in a mammal by administering a therapeutic dose of a pharmaceutical composition that inhibits activity of AXL protein activity, for example by competitive or non-competitive inhibition of the binding interaction between AXL and its ligand GAS6. | 03-06-2014 |
20140073518 | FUSION PROTEINS COMPRISING AN ENGINEERED KNOTTIN PEPTIDE AND USES THEREOF - The present disclosure presents a general approach to engineering existing protein-protein interactions through domain addition and evolution. The disclosure teaches the creation of novel fusion proteins that include knottin peptides where a portion of the knottin peptide is replaced with a sequence that has been created for binding to a particular target. Such fusion proteins can also be bispecific or multi specific in that they can bind to and/or inhibit two or more receptors or receptor ligands. Knottins may be fused with an existing ligand (or receptor) as a general platform for increasing the affinity of a ligand-receptor interaction or for creating a multi specific protein. In addition, the fusion proteins may comprise a knottin peptide fused to another protein where the other protein facilitates proper expression and folding of the knottin. | 03-13-2014 |
20140356286 | Polypeptides Targeting Vascular Endothelial Growth Factor Receptor-2 and Alpha V Beta 3 Integrin - Polypeptides comprising variant vascular endothelial growth factor sequences are provided. The polypeptides are useful in cancer imaging, cancer diagnosis, monitoring and treatment as well as treatment of diseases characterized by excessive neovascularization. | 12-04-2014 |
20150037888 | Polypeptides Targeting Vascular Endothelial Growth Factor Receptor-2 and Alpha V Beta 3 Integrin - Polypeptides comprising variant vascular endothelial growth factor sequences are provided. The polypeptides are useful in cancer imaging, cancer diagnosis, monitoring and treatment as well as treatment of diseases characterized by excessive neovascularization. | 02-05-2015 |
20150037889 | Polypeptides Targeting Vascular Endothelial Growth Factor Receptor-2 and Alpha V Beta 3 Integrin - Polypeptides comprising variant vascular endothelial growth factor sequences are provided. The polypeptides are useful in cancer imaging, cancer diagnosis, monitoring and treatment as well as treatment of diseases characterized by excessive neovascularization. | 02-05-2015 |
20150266936 | CONJUGATED KNOTTIN MINI-PROTEINS CONTAINING NON-NATURAL AMINO ACIDS - Disclosed are knottin peptides containing non-natural amino acids so that they can be formed by chemical conjugation into two or more knottin monomers. The knottin monomers comprise a non-natural amino acid such as an aminooxy residue within the polypeptide sequence. The exemplified dimers were produced by oxime formation between two aldehyde groups present on a polyether linker and an aminooxy functional group that was site-specifically incorporated the knottin. Knottins variants based on EETI ( | 09-24-2015 |
20150315552 | Inhibition of AXL Signaling in Primary Tumor Therapy - Compositions and methods are provided for alleviating cancer in a mammal by administering a therapeutic dose of a pharmaceutical composition that inhibits activity of AXL, MER or Tyro3 protein activity, for example by competitive or non-competitive inhibition of the binding interaction between AXL, MER or Tyro3 and its ligand GAS6. | 11-05-2015 |
20150315553 | Modified AXL Peptides and Their Use in Inhibition of AXL Signaling in Anti-Metastatic Therapy - Compositions and methods are provided for alleviating cancer in a mammal by administering a therapeutic dose of a pharmaceutical composition that inhibits activity of AXL, MER or Tyro3 protein activity, for example by competitive or non-competitive inhibition of the binding interaction between AXL, MER or Tyro3 and its ligand GAS6. | 11-05-2015 |
20160039895 | POLYPEPTIDES TARGETING VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 AND ALPHA V BETA 3 INTEGRIN - Polypeptides comprising variant vascular endothelial growth factor sequences are provided. The polypeptides are useful in cancer imaging, cancer diagnosis, monitoring and treatment as well as treatment of diseases characterized by excessive neovascularization. | 02-11-2016 |
20160039896 | POLYPEPTIDES TARGETING VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 AND ALPHA V BETA 3 INTEGRIN - Polypeptides comprising variant vascular endothelial growth factor sequences are provided. The polypeptides are useful in cancer imaging, cancer diagnosis, monitoring and treatment as well as treatment of diseases characterized by excessive neovascularization. | 02-11-2016 |
Jonas Dean Cochran, La Jolla, CA US
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20150190613 | MANUALLY POSITIONED ARMATURE SYSTEM AND METHOD OF USE - A manually positionable armature system including a flexible semi-rigid housing including an inner wall, a connecter coupled to the housing to connect the housing to a holding structure, a holder coupled to the housing to hold an instrument in place during a procedure, a compressible media disposed within the flexible semi-rigid housing, an adjustable volume member disposed within the compressible media within the flexible semi-rigid housing, the adjustable volume member adjustable between at least a first volume state where the compressible media is less compressed against the inner wall of the housing and the flexible semi-rigid housing is freely positionable and a second volume state where the compressible media is more compacted against the inner wall of the housing, rigidizing and fixing the flexible semi-rigid housing in a desired orientation. | 07-09-2015 |
Jonas Dean Cochran, San Diego, CA US
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20140216325 | Undersea Free Vehicle and Components - A free vehicle suitable to serve as a platform to carry a variety of equipment to the ocean floor, actuate devices at the floor and at intermediate points on the way to and returning from the ocean floor is described. The free vehicle includes standardized power, control electronics, navigation equipment and mechanical release mechanisms that can be used in conjunction with custom experiments. Exemplary experiments include sensors and sampling equipment used for deep-sea exploration. The free vehicle platform provides for scalable designs to meet scientific needs and surface vessel constraints. | 08-07-2014 |
20150231552 | Portable Purge System - A purge system and methods are described. The system allows purging of closed vessels in a precise and reproducible manner under microprocessor and sensor control. The process includes automated valves that allow repeated purge cycles with little or no operator attention. The purge parameters may be stored in memory for recall at a later time to repeat the purge process on the same or a different vessel. In a preferred embodiment the equipment and process allows for purging and desiccation of deep-sea vehicles without the need to carry compressed gas cylinders out to sea. | 08-20-2015 |
Joseph R. Cochran, Grass Valley, CA US
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20100117273 | PROCESS FOR HOT-FORGING SYNTHETIC CERAMIC - The embodiments of the invention are directed to a synthetic ceramic comprising pyroxene-containing crystalline phase, a clast, and a glass phase, wherein at least a portion of the synthetic ceramic is plastically deformable in a certain temperature range. Other embodiments of the invention relate to a method of making a synthetic ceramic, comprising heating a green ceramic material to 900-1400° C., to a temperature sufficient to initiate partial melting of at least a portion of the green ceramic material, transferring the heated green ceramic material to a press, pressing the heated green ceramic material in a die at 1,000 to 10,000 psi, and transferring the heated, pressed green ceramic material to a furnace for cooling to form the synthetic ceramic. | 05-13-2010 |
Kyle Cochran, San Diego, CA US
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20150220908 | SYSTEM AND METHOD FOR DETERMINING APPROPRIATE REDEMPTION PRESENTATIONS FOR A VIRTUAL TOKEN ASSOCIATED WITH A STORED VALUE ACCOUNT - A method for determining an appropriate redemption presentation for a virtual token associated with a stored value account is disclosed. The method may include receiving a request for presenting a redemption presentation of a virtual token and obtaining a merchant identifier associated with the request. The method may further include determining if the request is for one of an on-line transaction and a transaction with a point-of-sale terminal, and if the request is for a transaction with a point-of-sale terminal, then searching a database using the merchant identifier to find one or more redemption presentations of virtual token preferred by a merchant. Subsequently, the one or more redemption presentations of the virtual token may be transmitted over a computer network to a client device. | 08-06-2015 |
Laura Cochran, San Diego, CA US
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20120259683 | METHODS AND APPARATUS TO GENERATE AND UTILIZE VENUE PROFILES - Methods and apparatus to generate and utilize venue profiles are disclosed. An example method includes selecting an attribute for a non-residential-based venue indicative of a type of person likely to attend the non-residential-based venue; obtaining at least one of demographic data or psychographic data associated with the attribute; and generating, using a processor, a venue profile for the non-residential-based venue using the at least one of the demographic data or psychographic data associated with the attribute. | 10-11-2012 |
20150127427 | METHODS, SYSTEMS AND APPARATUS TO GENERATE MARKET SEGMENTATION DATA WITH ANONYMOUS LOCATION DATA - Methods and apparatus are disclosed to determine a consumer classification segment. A disclosed example method involves generating, with a processor, a list of consumer classification segments based on geographic indicators associated with a mobile device, associating, with the processor, the mobile device with a first consumer classification segment of the list of consumer classification segments if the geographic indicators were retrieved while a first application was executed, and associating, with the processor, the mobile device with a second consumer classification segment of the list of consumer classification segments if the geographic indicators were retrieved while a second application was executed. | 05-07-2015 |
Michael Cochran, Aliso Viejo, CA US
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20110043492 | INPUT DEVICE AND DISPLAY SYSTEM HAVING THE SAME - An input device capable of optically communicating with an electronic apparatus is provided. The input device includes a light source, a force sensor, and a controller. The force sensor is configured to sense a force applied to a tip of the input device and generate a first sensing signal corresponding to the sensed force. The controller is electrically connected to the light source and the force sensor, and configured to receive the first sensing signal and control the light source to generate light pulses in response to the first sensing signal according to a predefined protocol. | 02-24-2011 |
20130197941 | EMERGENCY RESPONSE HEALTH INFORMATION SYSTEM, ACCESS DEVICE, PATIENT TAG AND METHOD FOR SECURE ACCESS OF HEALTH INFORMATION - In one embodiment, an emergency response health information system includes: (a) a patient tag; (b) an access device; and (c) an information processing system. In one embodiment, the patient tag includes: (a) an indicia; and (b) a unique patient identifier. In one embodiment, the access device is configured to read the indicia and transmit the indicia to the information processing system. After a secure connection is established between the access device and the information processing system, the access device enables a user to enter a unique patient identifier and transmits the entered unique patient identifier to the information processing system. In one embodiment, the information processing system is configured to, after the entered unique patient identifier has been transmitted, transmit, to the access device, a first health information component. | 08-01-2013 |
Monroe Adler Cochran, Ojai, CA US
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20160073766 | Cosmetic Applicator - A cosmetic applicator includes a tubular neck and hollow head, preferably constructed of an elastomeric material. By providing a hollow applicator made of the elastomeric material, flexibility is improved compared to existing applicators which use rigid materials for construction. A number of variations are possible beyond the basic construction; some variations include the use of curved faces, planar faces, or both for an applicator surface of the hollow head. Other variations include the addition of clamp-receiving grooves that make it easier for a person to secure the applicator to a tool via clamping action. It is also possible to combine variations, for example using the clamp-receiving groove along with curved faces and planar faces. The tubular neck allows the applicator to be secured to existing tools while the hollow head provides an improved surface for application and adjustment of cosmetics. A variety of shapes, materials, and surface finishes are possible. | 03-17-2016 |
Monroe Adler Cochran, Oxnard, CA US
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20140130297 | Insert Assembly for an Applicator - An insert assembly for an applicator is built from two semi-cylindrical retention jaws connected by a living hinge. Each of the semi-cylindrical retention jaws has a plurality of stake pins, while the first semi-cylindrical retention jaw has a locator receptacle and the second semi-cylindrical retention jaw has a locator insert. An insert is placed between the two retention jaws, which then close to secure the insert between the retention jaws. The locator receptacle receives the locator insert from the second semi-cylindrical retention jaw, helping to align the two retention jaws. The plurality of stake pins impale the insert, holding it in place. In addition to being secured by the stake pins, the insert is supported by an interior ridge. The insert assembly can then be slid into a barrel sleeve, held in place by a press fit or by a removable mounting system, such as a lug mount. | 05-15-2014 |
Robert A. Cochran, Sacramento, CA US
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20080270692 | Enabling and disabling cache in storage systems - Embodiments include methods, apparatus, and systems for enabling and disabling cache in storage systems. One embodiment includes a method that changes a time period for delaying host requests received at a cache of a storage device and converts the storage device from a cache enabled state to a cache disabled state while the storage device is online. | 10-30-2008 |
20080270719 | Method and system for efficient snapshot operations in mass-storage arrays - Embodiments of the present invention are directed to efficient snapshot operations that produce multiple, useable snapshot logical units when successively directed to a logical unit, and to mass-storage arrays that support such efficient snapshot operations. In one embodiment of the present invention, allocate-on-write techniques are employed for handling WRITE access operations directed to storage-allocation units not yet overwritten following a snapshot operation. The allocate-on-WRITE technique is enhanced by a background process that continuously defragments the logical-storage-allocation-unit address space referenced by the original logical unit. | 10-30-2008 |
20090193195 | CACHE THAT STORES DATA ITEMS ASSOCIATED WITH STICKY INDICATORS - Data items are stored in a cache of the storage system, where the data items are for a snapshot volume. Sticky indicators are associated with the data items in the cache, where the sticky indicators delay removal of corresponding data items from the cache. Data items of the cache are sacrificed according to a replacement algorithm that takes into account the sticky indicators associated with the data items. | 07-30-2009 |
20120026863 | LINK THROUGHPUT ENHANCER - A communication method comprises communicating information on a standardized link compliant with a published standard and communicating information on a private link capable of operation at a throughput higher than maximum throughput of the published standard. The method further comprises monitoring private link performance and increasing information throughput on the private link above the maximum standard throughput by an amount determined by the monitored private link performance. | 02-02-2012 |
Scot Cochran, San Diego, CA US
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20100122781 | ACTUATOR FOR OPERATING A SLIDING CURTAIN - This electro-mechanical actuator is used to operate a curtain mounted to slide along an axis. It comprises a motor ( | 05-20-2010 |
20120011681 | DRIVE CARRIAGE FOR DRIVING A SLIDABLY MOUNTED CURTAIN - The invention relates to a drive carriage ( | 01-19-2012 |
Travis Cochran, Fountain Valley, CA US
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20130282170 | AUTOMATIC PILL DISPENSER - A pill dispensing device includes a base with a top surface and a bottom surface, a transfer tray assembly coupled to the top surface of the base, a controller, and a plurality of vibrating tray assemblies. Each vibrating tray assembly couples to the top surface of the base and includes a pill tray, at least one spring support, a pill tray electric motor, and at least one optical sensor. The pill tray has an open end which is positioned above the transfer tray assembly. The at least one spring support is coupled between the top surface of the base and the pill tray. The pill tray electric motor couples to the pill tray and an offset weight. Each pill tray electric motor electrically couples to the controller. An optical sensor couples to the pill tray. | 10-24-2013 |
Travis Cochran, Costa Mesa, CA US
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20130075349 | ORGANIZER - An adjustable organizer that includes a plurality of spaced apart vertically oriented dividers and a plurality of selectively stackable platforms extending from the dividers. The platforms increase in height from a foremost platform to a rearmost platform. Adjacent dividers together with a platform extending between the adjacent dividers define a compartment. A connector assembly is operatively associated with one of the dividers and platforms. The connector assembly is configured to allow for independent adjustment of spacing between adjacent dividers to selectively adjust a size of a compartment and to allow a forward platform to slide beneath a platform rearward of the forward platform. | 03-28-2013 |