Cobb, GB
Andre Cobb, Reading GB
Patent application number | Description | Published |
---|---|---|
20150328109 | DERMAL COMPOSITIONS CONTAINING UNNATURAL HYGROSCOPIC AMINO ACIDS - Unnatural, hygroscopic amino acids are useful to enhance the moisture retention and uptake properties of skin. In particular, such amino acids are N-hydroxyserine, N-hydroxyglycine, L-homoserine, alpha-hydroxyglycine, 2-(aminooxy)-2-hydroxyacetic acid, 2-hydroxy-2-(hydroxyamino) acetic acid, 2-(aininooxy)acetic acid, and combinations thereof. | 11-19-2015 |
Andy Cobb, Shropshire GB
Patent application number | Description | Published |
---|---|---|
20100173776 | METHOD FOR ENHANCING PLANT TOLERANCE - A method of increasing functional protein activity in a plant comprising applying to the plant, part of the plant, the plant propagation material thereof and/or a surrounding area thereof an effective amount of one or more neonicotinoid compounds selected from thianicotinyl compounds and tetrahydrofuranyl compounds. | 07-08-2010 |
Ben Cobb, Wiltshire GB
Patent application number | Description | Published |
---|---|---|
20120200396 | GENEDRIVE RFID - The present invention provides a method of operating a thermal cycler using readable tags (for example, Radio Frequency Identification (RFID)) to simplify the operation and to reduce user interaction requirements. The RFID tag is used to program the thermal cycler unit. This automates process flow and allows single button operation. In general terms, the invention uses RFID tags provided on reaction vessels to identify a particular vessel; while a readable program card contains data associating reaction vessel identities with specific operations (eg, thermal cycling program, detection steps) to be performed on that vessel. The thermal cycler detects the reaction vessel RFID tag, and selects an appropriate operation to perform. | 08-09-2012 |
20120214158 | MUTATIONAL ANALYSIS - A method for analysing genetic mutations, and in particular single nucleotide polymorphisms (SNPs) and/or somatic mutations, is described, as well as methods for preferentially amplifying one allelic form compared with another form. The methods use an oligonucleotide probe which hybridises to a first allele with a lower melting temperature (Tm) than that with which it hybridises to a second allele, together with amplification primers which flank the oligonucleotide probe binding site and which bind to the sample with a higher Tm than that of the probe and the first allele. An amplification reaction may be carried out at a temperature such that the probe is preferentially hybridised to the second allele, thereby amplifying the first allele. The amplified sequences may be detected using the same probe as acted as the blocking probe during amplification. | 08-23-2012 |
20140255937 | MUTATIONAL ANALYSIS OF JAK2 - An assay for mutations in JAK2 is described. The assay uses selective amplification of mutant alleles with a blocker probe which preferentially hybridises to wild type alleles. The same probe is then used to detect presence or absence of wild type sequences. It is not necessary to know the specific mutant sequence beforehand. | 09-11-2014 |
20140315325 | ASSEMBLY COMPRISING A REACTION VESSEL AND A SAMPLE MATRIX, SAMPLE MATRIX COMPRISING AN UPPER ADSORBENT LAYER AND A LOWER LATERAL FLOW LAYER - An assembly and related methods are described for the preparation and processing of samples in molecular biology assays and nucleic acid amplification reactions. The assembly allows rapid and easy processing with reduced sample handling compared to known sample preparation apparatus and methods. The assembly comprises a reaction vessel, a sample matrix and a lid. The invention further provides an integrated punch to punch out discs of the sample matrix into the reaction vessel (without handling); thereby reducing the sample handling required to generate the final amplified nucleic acid product. | 10-23-2014 |
20150344870 | NUCLEIC ACID EXTRACTION - A method and device for extracting nucleic acids from a biological sample is described. The device includes a substrate, such as a cellulose filter, functionalised with a biocidal agent having multiple functional groups including a binding moiety, which is involved in binding the agent to the substrate; a hydrophobic moiety; and a charged moiety. The various functional groups serve to bind the agent to the substrate, weaken or lyse the cell wall or membrane of the sample, and retain nucleic acids on the substrate. A preferred biocidal agent is a silylated quaternary ammonium compound (SiQAC), for example 3-(trimethoxysilyl) propyldimethyloctadecyl ammonium chloride. | 12-03-2015 |
Ben Cobb, Leatherhead GB
Ben Cobb, North Wraxal GB
Patent application number | Description | Published |
---|---|---|
20120077259 | EPISTEM GENEDRIVE - We describe a thermal cycler comprising a Peltier-type thermoelectric element used for cooling a sample block, and a non-Peltier-type heating device for heating the sample block. The cycler also includes a heat sink connected to the Peltier-type element by a heat pipe, which permits thermal energy to transfer from the Peltier-type element to the heat sink. This configuration operates more efficiently than conventional thermal cyclers which use Peltier-type elements for heating and cooling, and allows a more rapid cycling time as well as operation in a wider range of ambient temperatures. Certain embodiments utilise the Peltier-type element as a thermal gate to reduce thermal loss during heating when the Peltier-type element is switched off. | 03-29-2012 |
Ben Cobb, North Wraxall Wiltshire GB
Patent application number | Description | Published |
---|---|---|
20080268506 | Reaction Vessel - A reaction vessel for use in thermal cycling reactions is disclosed. The vessel has a width greater than its depth, to give the vessel a flattened profile. The side walls of the vessel extending across the width of the vessel are generally flat, and have a lesser thickness than the side walls extending across the depth of the vessel, This conformation allows rapid heat transfer into the vessel during thermal cycling, while the flattened profile allows optical detection techniques to be used on the contents of the vessel. The tubes may be provided singly or in an array or multiwell formal. Also described is a carousel for holding the tubes for use in a thermal cycler. | 10-30-2008 |
Ben Cobb, North Wraxall GB
Patent application number | Description | Published |
---|---|---|
20120220024 | REACTION VESSEL - A reaction vessel assembly for use with thermal cyclers is described. The assembly includes a reaction vessel and a casing defining a cavity. In a first configuration, the casing receives the reaction vessel within the cavity, to act as a protective casing for the reaction vessel. In a second configuration, the casing engages with a mouth of the reaction vessel, to close the vessel. In this configuration, the casing may also act as a handle. In preferred embodiments, the reaction vessel is in the form of a capillary tube, and/or may include an integrated collimating lens. Certain embodiments also include an RFID tag. | 08-30-2012 |
Benjamin Cobb, North Wraxall, Wiltshire GB
Patent application number | Description | Published |
---|---|---|
20160030939 | SAMPLE PREPARATION PAPER CARTRIDGE - A sample preparation cartridge is described having a lower portion having four integrally-formed leaf springs, and a raised lower base part which is slightly below the level of the leaf springs. An upper portion of the cartridge engages with the lower portion, via four paired pins and holes formed in the lower and upper portions. The upper portion includes three well-shaped openings formed in the central region of the upper portion. Between the upper and lower portions is placed a sheet of sample preparation paper, resting on the leaf springs, which raise the lower face of the paper away from the raised lower base part, leaving a small air gap between the base and the paper. The upper face of the paper is in contact with the well-shaped openings of the upper portion. The user loads a liquid sample into the openings, and the paper wicks the liquid sample away from the loading location, leaving cellular debris in the place of application. Applying pressure to the upper portion of the cartridge urges the paper into contact with the raised base portion, so providing a firm base which allows the user to remove sections of the paper, using for example a biopsy needle, for further processing. | 02-04-2016 |
Benjamin David Cobb, North Wraxall GB
Patent application number | Description | Published |
---|---|---|
20160040156 | METHOD OF DNA/RNA EXTRACTION USING SILYATED QUATERNARY AMMONIUM COMPOUNDS (SIQAC) - There is described a method of extracting DNA and/or RNA from a cell or capsid, the method comprising contacting the cell or capsid with a composition comprising a quaternary ammonium compound including a silicon-containing functional group. The quaternary ammonium compound may be of general formula (I) or a derivative salt thereof wherein L is a linking group; each of R | 02-11-2016 |
Benjamin David Cobb, Wiltshire GB
Patent application number | Description | Published |
---|---|---|
20150248524 | OPTICAL PROCESSING - We describe a quantitative PCR (qPCR) instrument for combined qPCR and melt curve (dissociation and/or association curve) analysis. The instrument has at least one optical channel; a fluorescence excitation source; a fluorescence detector; an electronic analogue signal amplifier having an input coupled to an output of the fluorescence detector; and an analogue-to-digital converter (ADC) having analogue input coupled to an output of the analogue signal amplifier. The instrument further comprises a quantified automatic gain control (AGC) loop coupled between the signal output of the fluorescence detector and the analogue input of the ADC. The AGC loop is configured to apply a determined, numerical gain value to a fluorescence signal for the analogue input of the ADC. The instrument also includes a system to scale a digital output of the ADC responsive to the numerical gain value and to provide a digital fluorescence level signal from the scaled digital output. | 09-03-2015 |
Gary Raymond Cobb, Hampshire GB
Patent application number | Description | Published |
---|---|---|
20080218256 | Channel Filtering in Radio Communications Systems - A system which provides frequency conversion and continuously variable bandwidth control is implemented using first and second filter networks that exhibit a generalised Chebyshev transfer function. The first and second filter networks may comprise a pseudo-high-pass type filter in combination with a pseudo-low-pass type filter, or in a particularly efficient embodiment, a pseudo-high-pass type filter in combination with an elliptic low pass type filter. | 09-11-2008 |
Jamie Cobb, London GB
Patent application number | Description | Published |
---|---|---|
20150112238 | NECK BRACES - A neck brace comprises a frame, which includes a support section for supporting a user's lower jaw and a brace section for bracing the support section. The brace section comprises a sternum rest and a strut that joins the sternum rest to the remainder of the frame, and is shaped to avoid contact with the user's clavicle region. | 04-23-2015 |
John Laurence Cobb, Berkshire GB
Patent application number | Description | Published |
---|---|---|
20110082889 | ONLINE DATABASE MODELING - Aspects of the present invention relate to methods and system of implementing online database modeling. The method includes providing an database modeling diagram framework. The framework is in communication with an online database, and the online database provides access to live data. The method further includes providing online access to the online database for the database modeling diagram framework via an intermediary API, representing a database structure of the online database in a database model within an interface of the database modeling diagram framework, and populating the database model with live data from the online database. Further, the method includes displaying the database model with the live data from the online database within the database modeling diagram framework interface. | 04-07-2011 |
Justin Cobb, London GB
Patent application number | Description | Published |
---|---|---|
20090149966 | TRANSCUTANEOUS PROSTHESIS - A transcutaneous prosthesis includes a first component configured for attachment to a bone, the first component including flutes or grooves on a surface thereof for deterring rotation of the prosthesis within a bone; a second component adapted for location between the bone and the skin, the second component having a surface treatment for stimulation of fibroblastic cell proliferation and attachment of epithelial cells; and a third component adapted for location to extend from the skin surface and is adapted to extend directly from the skin surface in use, the third component having a coating of a non-stick material on an outer surface thereof, the coating having a surface energy that is lower than a surface energy of the first and second components and which is low enough to deter bacterial adhesion. | 06-11-2009 |
20100331996 | METHOD OF INSTALLING A TRANSCUTANEOUS PROSTHESIS - A method of installing a transcutaneous prosthesis which includes a first component, a second component adapted for location between the bone and the skin, the second component having a surface treatment for stimulation of fibroblastic cell proliferation and attachment of epithelial cells and a third component adapted for location to extend from the skin surface and the third component having an outer surface. The outer surface of the third component has a surface energy that is lower than a surface energy of at least the first component and which is low enough to deter bacterial adhesion. The method includes attaching the first component to a bone such that a transition from the second component to the third component is essentially at the surface of the skin and the third component extends from the skin surface when the first component is attached to a bone | 12-30-2010 |
20110301654 | HIP RESURFACING - A method of locating an acetabular cup implant ( | 12-08-2011 |
20140107806 | TRANSCUTANEOUS PROSTHESIS - A transcutaneous prosthesis which includes a first component shaped for implantation into a bone, a second component intended for location between the bone and the skin, the second component having a surface treatment for stimulation of fibroblastic cell proliferation and attachment of epithelial cells, and a third component intended for location exterior to the skin surface having a low surface energy which deters bacterial adhesion. | 04-17-2014 |
Justin P. Cobb, London GB
Patent application number | Description | Published |
---|---|---|
20150105783 | DEVICE FOR USE IN FACILITATING ALIGNMENT OF AN ACETABULAR COMPONENT - A device for use in facilitating alignment of an acetabular component relative to the pelvis of a subject, the device having a device body and at least a first locator for placement on a first predetermined mounting location on the acetabular rim of a subject, the device defining an orientation and/or position with respect to said subject when installed for facilitating alignment of an acetabular component. | 04-16-2015 |
Justin Peter Cobb, London GB
Patent application number | Description | Published |
---|---|---|
20110218635 | MODULAR KNEE IMPLANTS - An implant for bone re-surfacing in a joint, the implant having a bearing platform having a front surface which forms a bearing surface and a back surface, and securing apparatus projecting from the back surface, the securing apparatus having a locking surface arranged to bear against an undercut surface of the bone to secure the implant against the bone. | 09-08-2011 |
20140222149 | Implant and Implant System - An implant system for implantation at a joint, the implant system including an implant device ( | 08-07-2014 |
20150297353 | MODULAR KNEE IMPLANTS - An implant for bone re-surfacing in a joint, the implant having a bearing platform having a front surface which forms a bearing surface and a back surface, and securing apparatus projecting from the back surface, the securing apparatus having a locking surface arranged to bear against an undercut surface of the bone to secure the implant against the bone. | 10-22-2015 |
Victoria H Cobb, Hukk GB
Patent application number | Description | Published |
---|---|---|
20090038082 | Device and Method for Applying a Treatment Agent to a Surface - A device for treating a surface to give a cleaning benefit comprises one or more containers ( | 02-12-2009 |
Victoria Heather Cobb, Hull GB
Patent application number | Description | Published |
---|---|---|
20110112006 | IMPROVEMENTS IN ACIDIC HARD SURFACE CLEANING COMPOSITIONS - Provided are an acidic hard surface cleaning composition which includes: a surfactant system which includes one or more of anionic, cationic, nonionic, amphoteric or zwitterionic surfactants in amounts of at least 0.01% wt, preferably in amounts of between in excess of 1% wt, to 30% wt., with the proviso that if a cationic surfactant is present, is it present in an amount of in excess of 1% wt, more preferably in an amount of at least 1.1% wt; a volatile hydrocarbon having a volatility greater than that of water, and preferably wherein the volatile hydrocarbon has a vapor pressure of 0.2 mniHg or more at 20° C. in amount effective to impart motility when the composition is applied as a film or laminar layer to a hard surface at normal atmospheric conditions (‘sea level’) and at ambient temperature (approx. 20° C.); an acid constituent which includes one or more acids, including one or more organic or inorganic acids in an amount effective to impart an acidic pH to the composition; optionally, when the compositions of the invention comprise more than 1% wt. of a cationic surfactant, and/or when the compositions of the invention comprise one or more anionic, amphoteric or zwitterionic surfactants in amount of at least 0.01% wt, the compositions of the invention may include an amphiphilic solvent constituent; further optionally, one or more further constituents including coloring agents, fragrances and fragrance solubilizers, viscosity modifying agents including one or more thickeners, pH adjusting agents and pH buffers including organic and inorganic salts, optical brighteners, organic solvents, opacifying agents, hydrotropes, abrasives, and preservatives, as well as other optional constituents known to the art; and water in an amount of at least 80% wt, preferably in an amount of at least 85% wt. based on the total weight of the composition of which it forms a pan. wherein the composition exhibits self-induced movement when the composition is applied as a film or laminar layer onto a hard surface. | 05-12-2011 |