Clifford M.
Clifford M. Babbey, Indianapolis, IN US
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20140335516 | INDUCIBLE CELL-BASED MODEL FOR THE STUDY OF FRIEDREICH'S ATAXIA - Isolated transduced cells exhibiting FRDA characteristics in an inducible fashion are disclosed. Isolated transduced cells comprise an expression vector having a nucleic acid sequence encoding an shRNA for frataxin protein knockdown and a heterologous expression control sequence. Additionally, methods of screening for a candidate therapeutic agent for treating Friedreich's Ataxia using isolated transduced cells are disclosed. Further, a recombinant nucleic acid construct for frataxin knockdown is disclosed that comprises a nucleic acid encoding an shRNA operably linked to a heterologous expression control sequence and expressing an shRNA molecule in a dose-responsive fashion. | 11-13-2014 |
20140336128 | GIGAXONIN FUSION PROTEIN AND METHODS FOR TREATING GIANT AXONAL NEUROPATHY - The present disclosure relates generally to fusion proteins including gigaxonin coupled to a cell penetrant peptide. These fusion proteins can be used to treat GAN in a subject in need thereof. Administration of the fusion proteins allows for control of at least one of Galectin-1 (GAL-1) levels and phosphorylated vimentin protein levels, thereby mediating aggregation of vimentin and the formation of vimentin-free zones in cells. | 11-13-2014 |
Clifford M. Behel, Florence, AL US
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20090057639 | FENCE TERMINATION BRACKET - A termination bracket that can be used with a wire and polymer composite ribbon fencing has a longitudinal channel member including a first main surface and a pair of outwardly protruding sides extending along opposite edges. A clasp member extends laterally at least part way between the two sides. The clasp member defines at least one opening, each opening receiving a vice element adapted to capture an end of a longitudinally extending polymer composite fencing element. The wire and polymer composite ribbon has a width substantially equal to the spacing between the outwardly protruding sides. | 03-05-2009 |
Clifford M. Fortgang, Los Alamos, NM US
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20120236905 | REMOTE DETECTION OF ELECTRONIC DEVICES - An apparatus and method for detecting solid-state electronic devices are described. Non-linear junction detection techniques are combined with spread-spectrum encoding and cross correlation to increase the range and sensitivity of the non-linear junction detection and to permit the determination of the distances of the detected electronics. Nonlinear elements are detected by transmitting a signal at a chosen frequency and detecting higher harmonic signals that are returned from responding devices. | 09-20-2012 |
Clifford M. Les, Birmingham, MI US
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20110189716 | METHOD FOR ANALYZING COLLAGENOUS TISSUES FOR THE DETECTION AND DIAGNOSIS OF BONE DISEASE - Methods and systems for diagnosing a bone disease related to collagen pathology in a subject are provided. These include providing a bone sample from the subject and determining a quantitative collagen morphology value of the bone sample. A reference value is provided from a non-affected control subject where the reference value is a quantitative collagen morphology value from the same type of bone sample obtained from a population of non-affected control subjects. The quantitative collagen morphology value of the subject's bone sample is compared to the reference value. If the collagen morphology value is altered versus the reference value, the subject is diagnosed as having a collagen related bone disease. The collagen morphology value can include mean fibril spacings and distributions of the fibril spacings taken from a subject's bone sample. | 08-04-2011 |
Clifford M. Liu, Randolph, MA US
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20090149777 | High performance coil wire - A high performance coil over-core guide wire. The guide wire incorporates a nickel-titanium core with a stainless steel coil to provide a wire with improved kink resistance and good pushability. | 06-11-2009 |
20090264770 | Medical Systems and Related Methods - This disclosure relates to medical systems and related methods. In some embodiments, the medical systems include a catheter having a coiled section that is radially displaceable relative to a waveguide. | 10-22-2009 |
20090275926 | Medical suction device - A medical device for fragmenting objects and aspirating remaining debris enables a physician or other medical personnel quickly and easily remove objects, such as kidney stones, from a patient. The medical device can include a dual-lumen elongated member and a handle coupled to the elongated member. A first one of the lumens provides a suction passageway, and a second one of the lumens receives a laser fiber for delivering laser energy to an object, such as a kidney stone, within the patient. The handle can include a positioning mechanism to enable the physician by manual manipulation to move and hold in place the laser fiber longitudinally within the second lumen. | 11-05-2009 |
20100121279 | Apparatus and Method for Establishing Access to the Body - An apparatus and method for access to the inside of a body includes a transparent sheath with a radiopaque marking and fastener for securing a guidewire or catheter. The transparent sheath permits objects located within and near the sheath to be visualized with an external imaging system. Objects located near the sheath can also be observed with an imaging device disposed inside the sheath. The radiopaque marker permits accurate positioning of the sheath in the body. The sheath can be inserted into the body over an interventional device. A fastener prevents migration of a guidewire or catheter during the procedure. | 05-13-2010 |
20120157980 | MEDICAL SUCTION DEVICE - A medical device for fragmenting objects and aspirating remaining debris enables a physician or other medical personnel quickly and easily remove objects, such as kidney stones, from a patient. The medical device can include a dual-lumen elongated member and a handle coupled to the elongated member. A first one of the lumens provides a suction passageway, and a second one of the lumens receives a laser fiber for delivering laser energy to an object, such as a kidney stone, within the patient. The handle can include a positioning mechanism to enable the physician by manual manipulation to move and hold in place the laser fiber longitudinally within the second lumen. | 06-21-2012 |
20140257458 | EXPANDABLE STENT DELIVERY SYSTEM WITH OUTER SHEATH - According to aspects described herein, there is disclosed an improved hot balloon catheter delivery system for shape memory tubular stents. An outer sheath is provided on the delivery system that facilitates stent placement on a balloon during delivery through an endoscope. In one embodiment, the stent may be positioned between radiopaque markers/electrodes and the balloon may be heated. The stent may be prevented from moving proximally relative to the catheter as the delivery system is tracked through the patient's anatomical passageways. The outer sheath may be positioned to ride over the proximal cone of the hot balloon catheter and abut the proximal end of the stent to facilitate proper alignment of the balloon for deployment. Upon deployment of the stent in an appropriate position, the sheath may be pulled away from the stent to expose the proximal cone of the balloon and thereby allow balloon and stent expansion. | 09-11-2014 |
Clifford M. Rhee, Mississauga CA
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20130076633 | INTEGRATED, PORTABLE COMPUTING AND ENTERTAINMENT DEVICE - A portable, integrated computing device, includes a PC board within a housing and a projector assembly. An input/output port is provided on the housing and operatively connected to the PC board. A display is located on a top portion of the housing. A virtual keyboard module projects an image of a keyboard on a surface. The unit can be turned on with a selectable actuator for turning on the device, to selectively operate the device as a projector, by connecting a source component to one of the at least one output port on the housing, and bypassing the PC board, in order to project an image through the lens of the projector assembly or to operate the device as a computing device, by powering the PC board, and by using either the projector for displaying images or using the display for displaying images, or both. | 03-28-2013 |
Clifford M. Risher-Kelly, Wells, ME US
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20140286361 | SYSTEMS AND METHODS OF CABLE MANAGEMENT - A device for consolidating cables is provided, along with a method of consolidating Other embodiments are also described herein. | 09-25-2014 |
Clifford M. Snapper, Potomac, MD US
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20130052204 | (POLY)-GLYCEROLPHOSPHATE-BASED ANTI-GRAM POSITIVE BACTERIAL VACCINE - Provided are an immunogenic composition comprising polyglycerol phosphate (PGP) and methods for using the composition for treating or preventing staphylococcal infections. The PGP may be conjugated to a T-cell dependent antigen. Also provided are methods for synthesizing PGP and methods for conjugating PGP to a T-cell dependent antigen. | 02-28-2013 |
Clifford M. Stupfel, Kirkland, WA US
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20090053473 | SURFACE-COVERING SYSTEM AND METHODS FOR MAKING AND USING THE SAME - A surface-covering system and methods for making and using the same. The system includes a plurality of components each being a substantially planar portion having plurality of edges and an upper surface and an under surface. A second portion is attached to the under surface of the planar portion along a predetermined one of the edges, forming a thickened edge that has a predetermined cross-section. The plurality of components are placed edge-to-edge to cover a surface. If desired, the edges can be straight and/or the upper and lower surfaces of the components can be rectangular. Also, the cross-section of the thickened edge can be an arc of a circle. The second portion can be attached to the under surface of the planar portion by an adhesive such as an epoxy adhesive. The component can be made from a quarry material such as granite. | 02-26-2009 |