Cima
Igor Cima, Torre-Blenio CH
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20110065605 | METHOD FOR BIOMARKER AND DRUG-TARGET DISCOVERY FOR PROSTATE CANCER DIAGNOSIS AND TREATMENT AS WELL AS BIOMARKER ASSAYS DETERMINED THEREWITH - The invention relates to a method for the determination of a cancer diagnostic/therapeutic biomarker assay and drug-targets including the following steps: (a) identification of potential candidate protein/peptide biomarkers and drug-targets based on the measurement of protein/peptide constituent concentrations in tissue sample proteomes as well as serum, plasma or any other derivatives of blood, or blood itself sample proteomes derived from healthy non-human mammalian individuals as well as from cancerous non-human mammalian individuals and qualitatively selecting as potential candidate protein/peptide biomarkers those which show a pronounced differential behaviour between healthy and cancerous sample proteomes; (b) optional verification of the potential candidate protein/peptide biomarkers as identified in step (a) by quantitative mass spectrometric measurement of the potential candidate protein biomarkers in serum, plasma or any other derivatives of blood, or blood itself sample proteomes derived from healthy non-human mammalian individuals as well as from cancerous non-human mammalian individuals and selecting as candidate protein/peptide biomarkers those which show a mass-spectrometrically measurable quantitative differential behaviour between healthy and cancerous sample proteomes; (c) validation of the candidate protein/peptide biomarkers as identified in step (a), or as optionally verified in step (b), by mass spectrometric measurement and/or antibody-based assays such as an Enzyme-Linked Immunosorbent Assay (ELISA) determination of the candidate protein biomarkers in serum, plasma or any other derivatives of blood, or blood itself sample proteomes derived from healthy human individuals as well as from cancerous human individuals and selecting as protein/peptide biomarkers those which show a mass-spectrometrically measurable and/or antibody-based assay detectable differential behaviour between healthy and cancerous sample proteomes; (d) application of statistical methods to uncover single or groups of protein/peptide biomarkers as validated in step (c) as signatures for the detection of patients with cancer. The invention furthermore relates to specific biomarker assays for the highly reliable diagnosis of cancer, specifically of localized or non-localized prostate cancer, using human serum, plasma or any other derivatives of blood, or blood itself. | 03-17-2011 |
20140322732 | METHOD FOR BIOMARKER AND DRUG-TARGET DISCOVERY FOR PROSTATE CANCER DIAGNOSIS AND TREATMENT AS WELL AS BIOMARKER ASSAYS DETERMINED THEREWITH - The invention relates to a method for the determination of a cancer diagnostic/therapeutic biomarker assay and drug-targets including the following steps: (a) identification of potential candidate protein/peptide biomarkers and drug-targets based on the measurement of protein/peptide constituent concentrations in tissue sample proteomes as well as serum, plasma or any other derivatives of blood, or blood itself sample proteomes derived from healthy non-human mammalian individuals as well as from cancerous non-human mammalian individuals and qualitatively selecting as potential candidate protein/peptide biomarkers those which show a pronounced differential behaviour between healthy and cancerous sample proteomes; (b) optional verification of the potential candidate protein/peptide biomarkers as identified in step (a) by quantitative mass spectrometric measurement of the potential candidate protein biomarkers in serum, plasma or any other derivatives of blood, or blood itself sample proteomes derived from healthy non-human mammalian individuals as well as from cancerous non-human mammalian individuals and selecting as candidate protein/peptide biomarkers those which show a mass-spectrometrically measurable quantitative differential behaviour between healthy and cancerous sample proteomes; (c) validation of the candidate protein/peptide biomarkers as identified in step (a), or as optionally verified in step (b), by mass spectrometric measurement and/or antibody-based assays such as an Enzyme-Linked Immunosorbent Assay (ELISA) determination of the candidate protein biomarkers in serum, plasma or any other derivatives of blood, or blood itself sample proteomes derived from healthy human individuals as well as from cancerous human individuals and selecting as protein/peptide biomarkers those which show a mass-spectrometrically measurable and/or antibody-based assay detectable differential behaviour between healthy and cancerous sample proteomes; (d) application of statistical methods to uncover single or groups of protein/peptide biomarkers as validated in step (c) as signatures for the detection of patients with cancer. The invention furthermore relates to specific biomarker assays for the highly reliable diagnosis of cancer, specifically of localized or non-localized prostate cancer, using human serum, plasma or any other derivatives of blood, or blood itself. | 10-30-2014 |
Jarrid Cima, Evansville, IN US
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20110118927 | SYSTEMS AND METHODS FOR CONTROLLING POSITIONS AND ORIENTATIONS OF AUTONOMOUS VEHICLES - A method for controlling an autonomous vehicle includes: Receiving data relating to a plurality of proposed vehicle locations; generating a simulated vehicle path based on the received data; determining a simulated vehicle orientation for at least one point on the simulated vehicle path; presenting at least the simulated vehicle orientation in a user-discernable form; receiving a user verification of the simulated vehicle orientation for at least one point on the simulated vehicle path; and producing approved vehicle control commands from the simulated vehicle path and simulated vehicle orientation, the approved vehicle control commands controlling the autonomous vehicle to follow the simulated vehicle path and the simulated vehicle orientation. | 05-19-2011 |
20140288759 | SYSTEMS AND METHODS FOR CONTROLLING POSITIONS AND ORIENTATIONS OF AUTONOMOUS VEHICLES - A method for controlling an autonomous vehicle includes: Receiving data relating to a plurality of proposed vehicle locations; generating a simulated vehicle path based on the received data; determining a simulated vehicle orientation for at least one point on the simulated vehicle path; presenting at least the simulated vehicle orientation in a user-discernable form; receiving a user verification of the simulated vehicle orientation for at least one point on the simulated vehicle path; and producing approved vehicle control commands from the simulated vehicle path and simulated vehicle orientation, the approved vehicle control commands controlling the autonomous vehicle to follow the simulated vehicle path and the simulated vehicle orientation. | 09-25-2014 |
Lionel Cima, Chatenay-Malabry FR
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20110140694 | PERMANENT OR VARIABLE ALTERNATING MAGNETIC FIELD CIRCULATION SENSOR, AND CURRENT SENSOR IMPLEMENTING SUCH A SENSOR - A permanent or variable magnetic field circulation sensor including apparatus for magnetic excitation further including at least one elongated excitation coil extending around an elongated supple magnetic core and including a supple magnetic material with low relative magnetic permeability having a supple or flexible matrix in which magnetic particles are dispersed, an excitation current generation unit coupled to the excitation coil to generate an excitation magnetic field in the core over substantially the entire length of the coil, apparatus for measurement including: at least one magnetic measuring transducer magnetically coupled to the apparatus for magnetic excitation, a measuring unit connected to the magnetic measuring transducer and suitable for providing a measurement of magnetic field circulation in the core. | 06-16-2011 |
Maria Grazia Cima, Pomezia (rome) IT
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20080293812 | Use of pamoic acid or one of its derivatives, or one of its analogues, for the preparation of a medicament for the treatment of diseases characterised by deposits of amyloid aggregates - Pamoic acid or its derivatives of formula (I) are used to treat diseases characterized by deposits of amyloid aggregates. | 11-27-2008 |
Michael Cima, Winchester, MA US
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20080253935 | METHODS OF MANIPULATING SMALL AMOUNTS OF SOLIDS - The invention relates to methods and apparatuses for manipulating small amounts of solids. Specific embodiments of the invention are particularly suited for the automated transfer of small amounts of solids. In one embodiment, a uniform powder bed is lightly compressed into plugs of powder and dispensed. In another embodiment, the solid is placed in a liquid carrier to form a slurry, dispensed, and the liquid component is subsequently removed. In yet another embodiment, solids are manipulated using adhesive surfaces. | 10-16-2008 |
Michael D. Cima, Churchill, PA US
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20110074120 | Rotary centrifuge seal with a phenolic overmold component and method of manufacture - A rotary centrifuge seal consisting of a silicone rubber ring-shaped diaphragm secured to a phenolic ring member is manufactured by inserting the preformed phenolic compound element into a mold cavity of an injection compression mold with precise fit. The phenolic element is then covered with an overmold cavity and silicone rubber is injected into the overmold cavity by runnerless injection techniques in contact with exposed bonding surfaces of the phenolic compound element and the silicone rubber molding components and the phenolic compound element are compressed together to form a strong molecular bond with the application of heat and without the required use of primers, adhesives, bonding agents or mechanical bonding. The phenolic compound element is shaped in the form of a ring having external and internal peripheral surfaces whereby the exposed bonding surfaces include these internal and external peripheral surfaces to provide a more secure bond. | 03-31-2011 |
Michael J. Cima, Medford, MA US
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20080257718 | Electrochemical actuator - The present invention provides systems, devices, and related methods, involving electrochemical actuation. In some cases, application of a voltage or current to a system or device of the invention may generate a volumetric or dimensional change, which may produce mechanical work. For example, at least a portion of the system may be constructed and arranged to be displaced from a first orientation to a second orientation. Systems such as these may be useful in various applications, including pumps (e.g., infusion pumps) and drug delivery devices, for example. | 10-23-2008 |
Stephen Anthony Cima, San Antonio, TX US
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20080258064 | RADIATION RATE METER DISPLAYING REMAINING TIME PARAMETERS - A dosimeter includes a radiation detector and a display. The radiation detector outputs a signal indicative of an instantaneous radiation level. The dosimeter determines and displays a percent of limit (POL) value and/or a time to limit (TTL) value. The POL value indicates a ratio of an accumulated exposure to an exposure threshold. The TTL value indicates an amount of time estimated until the accumulated exposure exceeds the exposure threshold. The display may includes information indicative of both the POL parameter and the TTL parameter. The display may also display the instantaneous radiation level and/or a graphical representation of the instantaneous exposure level. The graphical representation might include a set of LED's arranged in a line wherein the number of activated LED's indicates the instantaneous exposure level. The display might also indicate a scale associated with the set of LED's. The dosimeter might include a switch to select one of multiple operational modes where the POL parameter and the TTL parameter are determined in part by the operational mode. | 10-23-2008 |