Christopher J. Chang, Berkeley US
Christopher J. Chang, Berkeley, CA US
|Patent application number
|PRO-FLUORESCENT PROBES - The present invention provides a novel class of pro-fluorescent probes for reactive oxygen species (ROS). One exemplary probe is mitochondria peroxy yellow 1 (MitoPY1), a new type of flurophore for imaging mitochondrial H
|METAL RESPONSIVE MRI-AGENTS - The present invention provides compositions comprising an MRI contrast agent and methods of their use.
|Molecular Molybdenum Persulfide and Related Catalysts for Generating Hydrogen from Water - New metal persulfido compositions of matter are described. :In one embodiment the metal is molybdenum and the metal persulfido complex mimics the structure and function of the triangular active edge site fragments of MoS
|Molecular Metal-Oxo Catalysts for Generating Hydrogen from Water - A composition of matter suitable for the generation of hydrogen from water is described, the positively charged cation of the composition having the general formula [(PY5W
|Molecular Cobalt Pentapyridine Catalysts for Generating Hydrogen from Water - A composition of matter suitable for the generation of hydrogen from water is described, the positively charged cation of the composition including the moiety of the general formula. [(PY5Me
|FLUORESCENT PROBES FOR REACTIVE SULFUR SPECIES - The invention provides reaction-based fluorescent probes for selective imaging of hydrogen sulfide in living cells.
|Compositions and Methods for Imaging - The present disclosure provides compositions for in vivo imaging of hydrogen peroxide; and methods for detecting hydrogen peroxide in vivo. The compositions and methods find use in various diagnostic applications, which are also provided.
|Luciferin Derivatives from Bicyclic Reactants and Aminothiol Derivatives and Methods of Use Thereof - The present disclosure features a condensation reaction and a luciferin-unmasking reaction that can be carried out under physiological conditions. In general, the condensation reaction involves reacting a bicyclic reactant with an aminothiol derivative, generating a luciferin or luciferin derivative. A luciferin can provide detectable luminescence. A luciferin derivative can be unmasked to provide detectable luminescence in a luciferin-unmasking reaction. The present disclosure provides bicyclic reactants and aminothiol derivatives suitable for use in the condensation reaction. The condensation and luciferin-unmasking reactions find use in a variety of applications, which are also provided.
|Compounds and Methods for Detecting Reactive Oxygen Species - The present disclosure provides compounds that detect reactive oxygen species in a living cell, in a multicellular organism, or in a cell-free sample. The compounds find use in a variety of applications, which are also provided. The present disclosure provides compositions comprising a subject compound.
|FLUORESCENT PROBES FOR DETECTION OF COPPER - The invention provides fluorescent sensors for the selective detection of a metal such as copper. The sensors may be considered to be derivatives of cyanine, fluorescein, rhodamine, rhodol, Tokyo green, or BODIPY. The sensors find particular use in detecting copper in cells and living animals.
|REACTION-BASED FLUORESCENT PROBE FOR SELECTIVE DETECTION OF CARBON MONOXIDE USING METAL-MEDIATED CARBONYLATION - Carbon monoxide (CO) is a member of the gasotransmitter family that includes NO and H
Patent applications by Christopher J. Chang, Berkeley, CA US