Patent application number | Description | Published |
20100274346 | MULTI-SECTION FILAMENTARY ENDOLUMINAL STENT - A multi-section filamentary stent comprises a braided section, which is a cylindrical mesh of a first set of filaments, connected to at least one wound section comprising a second set of one or more filaments having a repeating configuration with a bent portion. The two sections are preferably connected by at least one continuous filament extending into both sections. The two sections may be connected by a weld, a suture, a common graft, an overlapping portion of the two sections, or one or more filaments of one section looping through portions of the other section. The stent may comprise a first section, having a braided first stent architecture with a first flexibility and a first radial force, and a second section, having a non-braided second stent architecture with a second flexibility less than the first flexibility and a second radial force greater than the first radial force, in which at least one continuous filament is integral to both the first and second sections. The stent may have a radially compressed configuration and a radially expanded configuration, in which the first section has a first shortening ratio, and the second section has a second shortening ratio less than the first shortening ratio. Such multi-section stents may comprise modular components of a modular stent, such as a bifurcated modular stent, adapted for joining together in situ. The multi-section stent may comprise a first section having a first percentage of open area and a second section having a second percentage of open area. The stent may also comprise a first section having a first stent architecture with an end effect wherein the radial strength at the end is less than elsewhere in the stent, and a second section having a second stent architecture to counteract the end effect. Methods for treating body lumen by implanting the stents as described herein are also disclosed, as is a method for counteracting a stent architecture end effect. | 10-28-2010 |
Patent application number | Description | Published |
20080221671 | BRAIDED ENDOLUMINAL DEVICE HAVING TAPERED FILAMENTS - A stent comprising a plurality of continuous filaments braided together, at least one filament comprising a tapered filament having at least one first region having a first, relatively-larger cross-sectional area and at least one second region having a second, relatively-smaller cross-sectional area. The stent itself may have a tapered diameter, such as from one end to the other. A method for treating a lumen with the stent is also claimed | 09-11-2008 |
20080288046 | Method of Attaching Radiopaque Markers to Intraluminal Medical Devices, and Devices Formed Using the Same - A method of attaching radiopaque markers to an intraluminal medical device frame formed from a shape memory metal or alloy thereof, the process conducted during the shape recovery process of said shape memory metal or alloy thereof. | 11-20-2008 |
20100137974 | Stent with Graduated Stiffness - Disclosed herein is a stent having a generally tubular stent body with a first end region, a second end region, and a third region therebetween. The stent has a plurality of circumferential serpentine bands and a plurality of connector columns. Each connector column is located between two immediately adjacent serpentine bands, with each connector column having at least one connector. Connectors are connected at one end to one serpentine band and at the other end to an immediately adjacent serpentine band. The connectors of the first and second end regions have a first length which is substantially parallel to the longitudinal axis, and the connectors of the third region have a length greater than the first length and form an oblique angle relative to the longitudinal axis. | 06-03-2010 |
20110276126 | Longitudinally Flexible Expandable Stent - In at least one embodiment, a stent comprises a plurality of serpentine bands and a plurality of connector columns. Each serpentine band comprises a plurality of alternating straight band struts and turns. Adjacent serpentine bands are connected across a connector column by a plurality of connector struts. Each connector strut is connected at one end to a turn of one serpentine band and connected at the other end to a turn of another serpentine band. The turns of a serpentine band comprise connected turns that connect to a connector strut and unconnected turns that do not connect to a connector strut. At least one serpentine band comprises a repeating pattern of three band struts and then five band struts extending between connected turns as the serpentine band is traversed. At least one serpentine band comprises a repeating pattern of three band struts and then one band strut extending between connected turns as the serpentine band is traversed. | 11-10-2011 |
20120130471 | Venous Valve Apparatus, System, and Method - A venous valve with a tubular frame that includes an outer surface and an inner surface opposite the outer surface and defining a lumen, and a cover over at least the outer surface of the tubular frame, where the cover includes surfaces defining a reversibly sealable opening for unidirectional flow of a liquid through the lumen. A system with the venous valve and a catheter including a proximal end and a distal end, the venous valve located between the proximal end and distal end of the catheter. A method including forming the venous valve and reversibly joining the venous valve and a catheter. A method including positioning at least part of the catheter including the venous valve at a predetermined location and deploying the venous valve from the catheter at the predetermined location. | 05-24-2012 |
20130050830 | Stent Inspection Mandrel - A covered mandrel that includes a mandrel and a covering. The mandrel has an outer surface and comprises a first material. The covering is engaged to the outer surface of the mandrel and comprises a second material different than the first material. At least a portion of the covered mandrel is configured to scatter light. | 02-28-2013 |
20130095264 | Composite ePTFE/Textile Prosthesis - A composite intraluminal prosthesis which is preferably used as a vascular prothesis includes a layer of ePTFE and a layer of textile material which are secured together by an elastomeric bonding agent. The ePTFE layer includes a porous microstructure defined by nodes interconnected by fibrils. The adhesive bonding agent is preferably applied in solution so that the bonding agent enters the pores of the microstructure of the ePTFE. This helps secure the textile layer to the ePTFE layer. | 04-18-2013 |
20130116618 | CATHETER INCLUDING A BARE METAL HYPOTUBE - Catheter and methods for designing, making, and using catheters are disclosed. An example catheter is a balloon catheter. The balloon catheter may include a proximal shaft. The proximal shaft may be a bare metal hypotube having a skew value of −1.0 to −2.5. A midshaft may be attached to the proximal shaft. A distal shaft may be attached to the midshaft. A balloon may be coupled to the distal shaft. An inflation lumen may be defined that extends from the proximal shaft, through the midshaft, and into the distal shaft. The inflation lumen may be in fluid communication with the balloon. | 05-09-2013 |
20140207229 | Venous Valve Apparatus, System, and Method - A venous valve with a tubular frame that includes an outer surface and an inner surface opposite the outer surface and defining a lumen, and a cover over at least the outer surface of the tubular frame, where the cover includes surfaces defining a reversibly sealable opening for unidirectional flow of a liquid through the lumen. A system with the venous valve and a catheter including a proximal end and a distal end, the venous valve located between the proximal end and distal end of the catheter. A method including forming the venous valve and reversibly joining the venous valve and a catheter. A method including positioning at least part of the catheter including the venous valve at a predetermined location and deploying the venous valve from the catheter at the predetermined location. | 07-24-2014 |
20150088065 | CATHETER INCLUDING A BARE METAL HYPOTUBE - Catheter and methods for designing, making, and using catheters are disclosed. An example catheter is a balloon catheter. The balloon catheter may include a proximal shaft. The proximal shaft may be a bare metal hypotube having a skew value of −1.0 to −2.5. A midshaft may be attached to the proximal shaft. A distal shaft may be attached to the midshaft. A balloon may be coupled to the distal shaft. An inflation lumen may be defined that extends from the proximal shaft, through the midshaft, and into the distal shaft. The inflation lumen may be in fluid communication with the balloon. | 03-26-2015 |
Patent application number | Description | Published |
20100152833 | STENT-GRAFT WITH BIOABORBABLE STRUCTURAL SUPPORT - The invention relates to a stent-graft with a bioabsorbable structure and a permanent graft for luminal support and ‘treatment of arterial fistulas, occlusive disease, and aneurysms. The bioabsorbable structure is formed from braided filaments of materials such as PLA, PLLA, PDLA, and PGA and the graft is formed from materials such as PET, ePTFE, PCU or PU. | 06-17-2010 |
20120029614 | Stent-Graft with Bioabsorbable Structural Support - The invention relates to a stent-graft with a bioabsorbable structure and a permanent graft for luminal support and ‘treatment of arterial fistulas, occlusive disease, and aneurysms. The bioabsorbable structure is formed from braided filaments of materials such as PLA, PLLA, PDLA, and PGA and the graft is formed from materials such as PET, ePTFE, PCU or PU. | 02-02-2012 |
Patent application number | Description | Published |
20110046045 | Method of treating obesity and metabolic disorders related to excess adipose tissue by administration of sFRP-5 peptide - Disclosed is a method of reducing the amount of adipose tissue in a subject comprising administering to the subject an amount of an sFRP-5 peptide effective to reduce the amount of adipose tissue, or an amount of a molecule effective to stimulate expression of the sFRP-5 peptide in the subject. Also disclosed is a screen for molecules that can reduce the amount of adipose tissue in a subject. | 02-24-2011 |
20110288034 | Methods of identifying adipocyte specific genes, the genes identified, and their uses - Disclosed is a method of identifying genes that are over-expressed in adipose tissue as compared to pre-adipocyte tissue or other tissues comprising performing differential gene expression analysis between the white adipose tissue (WAT) or stromal vascular tissue (SVT) from any two different mice selected from the group consisting of wild-type, HMGI-C−/−, ob/ob, and HMGI-C−/− ob/ob genotype mice. Based on this method a number of nucleotide sequences are identified whose expression is adipocyte specific. The identified nucleotide sequences and their corresponding polypeptides are then used to prevent adipogenesis, to treat diabetes, and to screen for small-molecules that can modulate or prevent adipogenesis and to treat diabetes. | 11-24-2011 |
20130165369 | METHOD OF TREATING OBESITY AND METABOLIC DISORDERS RELATED TO EXCESS ADIPOSE TISSUE BY ADMINISTRATION OF sFRP-- PEPTIDE - Disclosed is a method of reducing the amount of adipose tissue in a subject comprising administering to the subject an amount of an sFRP-5 peptide effective to reduce the amount of adipose tissue, or an amount of a molecule effective to stimulate expression of the sFRP-5 peptide in the subject. Also disclosed is a screen for molecules that can reduce the amount of adipose tissue in a subject. | 06-27-2013 |
20160024162 | Promoting Apoptosis Of Differentiated Adipocytes And Increasing Endogenous Expression Of sFRP-5 Peptide By Adipocytes By Administration Of sFRP-5 Peptide - Disclosed is a method of reducing the amount of adipose tissue in a subject comprising administering to the subject an amount of an sFRP-5 peptide effective to reduce the amount of adipose tissue, or an amount of a molecule effective to stimulate expression of the sFRP-5 peptide in the subject. Also disclosed is a screen for molecules that can reduce the amount of adipose tissue in a subject. | 01-28-2016 |
Patent application number | Description | Published |
20100212029 | NOVEL ASSAYS UTILIZING NICOTINIC ACETYLCHOLINE RECEPTOR SUBUNITS - The present invention is in the field of identification and characterization of novel insecticidal target sites and, in particular, relates to host cells, assays and antibodies thereto. | 08-19-2010 |
20100233696 | METHODS, FLOW CELLS AND SYSTEMS FOR SINGLE CELL ANALYSIS - A method, flow cell and/or device for increasing the recovery of a limiting analyte in a sample, e.g., for single molecule analysis is disclosed. Methods for preparing a nucleic acid sample from a single cell and capturing nucleic acids on a surface configured for use in or with single molecule analysis are also provided. | 09-16-2010 |
20120028822 | METHODS, FLOW CELLS AND SYSTEMS FOR SINGLE CELL ANALYSIS - A method, flow cell and/or device for increasing the recovery of a limiting analyte in a sample, e.g., for single molecule analysis is disclosed. Methods for preparing a nucleic acid sample from a single cell and capturing nucleic acids on a surface configured for use in or with single molecule analysis are also provided. | 02-02-2012 |