Patent application number | Description | Published |
20090117125 | SYNTHESIS OF 8H-3A-AZA-CYCLOPENTA[A]INDENES AND 5,10-DIHYDROPYRROLO[1,2-B]ISOQUINOLINES DERIVATIVES AND THEIR USE AS ANTITUMOR THERAPEUTIC AGENTS - The present disclosure relates to a series of bis(hydroxymethyl) and its bis(carbamate) of 8H-3a-azacyclopenta[a]indene-1-yl and 5,10-dihydropyrrolo-[1,2-b]isoquinolines derivatives (Formula I-Formula IV) as DNA di-alkylating agents. The preliminary antitumor studies indicated that compounds disclosed herein could exhibit potent cytotoxicity in vitro and antitumor therapeutic efficacy in human tumor xenografts and could have little or no cross-resistance to either Taxol or Vinblastine. The results demonstrated that compounds disclosed herein possess potent antitumor therapeutic efficacy and are expected to have potential for clinical applications. | 05-07-2009 |
20090149516 | Synthesis of Epothilones, Intermediates Thereto, Analogues and Uses Thereof - The present invention provides compounds of formula (I): | 06-11-2009 |
20100197746 | SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO AND ANALOGUES THEREOF - The present invention provides compounds of formula (I): | 08-05-2010 |
20100240721 | SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO, ANALOGUES AND USES THEREOF - The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype. | 09-23-2010 |
20110124690 | COMPOSITIONS AND METHODS FOR TREATING CANCER OR A NEUROTROPHIC DISORDER - The present invention relates to compositions comprising an effective amount of a Panaxytriol Compound and a tubulin-binding drug, methods for treating or preventing cancer or a neurotrophic disorder comprising administering to a subject in need thereof an effective amount of a Panaxytriol Compound and a tubulin-binding drug, and methods for making a Panaxytriol Compound. | 05-26-2011 |
20110263663 | SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO, ANALOGUES AND USES THEREOF - The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype. | 10-27-2011 |
20110312904 | COMPOUNDS, COMPOSITIONS AND METHODS FOR REDUCING TOXICITY AND TREATING OR PREVENTING DISEASES - The present invention provides compounds of Formula (I), compositions comprising an effective amount of a compound of Formula (I), optionally with chemotherapeutic drugs such as a tubulin-binding drug, and methods of their use for reducing the toxicity of cytotoxic agents, treating or preventing cancer or a neuropathic disorder, inducing a chemoprotective phase II enzyme, DNA, or protein synthesis, enhancing the immune system, treating inflammation, improving and enhancing general health or well-being, and methods for making compounds of Formula (I). | 12-22-2011 |
20120316348 | SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO AND ANALOGUES THEREOF - The present invention provides compounds of formula (I): | 12-13-2012 |
20130178494 | PHENYL N-MUSTARD LINKED TO DNA-AFFINIC MOLECULES OR WATER-SOLUBLE ARYL RINGS, METHOD AND THEIR USE AS CANCER THERAPEUTIC AGENTS - The present disclosure relates to new DNA-directed alkylating agents and water-soluble N-mustard agents with improved chemical stability and anti-tumor therapeutic efficacy. | 07-11-2013 |
20130178629 | SYNTHESIS OF 4H-BENZO[D]PYRROLO[1,2-A]THIAZOLES AND INDOLIZINO[6,7-b]INDOLE DERIVATIVES AND THEIR USE AS ANTITUMOR THERAPEUTIC AGENTS - The present invention provides a series of 2,3-bis(hydroxymethyl)-4H-benzo[d]pyrrolo-[1,2-a]thiazoles and 1,2-bis(hydroxymethyl)indolizino[6,7-b]indole derivatives and their bis(alkylcarbamates) derivatives. These derivatives were designed as bi-functional DNA cross-linking agents. The in vitro cytotoxicity study of these compounds revealed that they exhibit significant anti-proliferative activity in inhibiting human lymphoblastic leukemia and various solid tumor cell growth. The compounds also exhibit therapeutic efficacy against human breast carcinoma and lung cancer in xenograft model. The compounds generally possess potent antitumor activity to kill various human solid tumors and have high potential for clinical applications. | 07-11-2013 |
20140213618 | SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO AND ANALOGUES THEREOF - The present invention provides compounds of formula (I): | 07-31-2014 |
Patent application number | Description | Published |
20080208972 | APPARATUS AND METHOD FOR STATEFUL WEB SERVICES ENABLEMENT - A web services enablement system includes a computer adapted to send and receive information to and from a first service, to send and receive information to and from a second service, which may not be a web service, to manage a connection with a third, stateful, service and to send and receive information via the stateful service based on information received from the first service or the second service. Also a method of enabling two-way web services and stateful transactions that includes steps of providing an architecture of base services and meta-services, defining a first base service comprising a core component and an extension component, combining the first base service and a meta-service to create a first usable service, managing a relationship between the first usable service and a second service through dependency or binding or utility, and performing a stateful transaction using the first usable service. | 08-28-2008 |
20090300750 | Proxy Based Two-Way Web-Service Router Gateway - A system for providing two-way Web services is disclosed that enables the client and server to be in different enterprise domains—behind firewalls—with few or no changes to the firewalls. In accordance with the illustrative embodiment, a “tunnel hub” is deployed in the public domain and “tunnel gateways” are deployed behind the firewalls where the clients request two-way services and the servers provide two-way services. Each tunnel gateway initiates a secure tunnel out through the firewall to the target hub. Thereafter, a request for service enters the tunnel gateway, travels to the tunnel hub and to the appropriate tunnel gateway where the server is that provides the service. When the server provides the service, it enters the tunnel gateway, travels to the tunnel hub and to the appropriate tunnel gateway where the client is that requested the service. | 12-03-2009 |
20110078781 | Framework for Communicating Across a Firewall - A system for enabling communication between a first domain and a second domain is disclosed. At least the first domain is protected by a firewall. A first data-processing system is provided in the first domain and a second data-processing system provided in second domain. The second domain hosts an application that the first domain desires to access. To enable the communication between the two domains a tunnel is established through the firewall. The tunnel runs from the first data-processing system to the second data-processing system. The second data-processing system provides a web-proxy interface to interface to the application and also acts as a tunnel gateway. | 03-31-2011 |
20110208908 | METHOD AND APPARATUS FOR HIGH AVAILABILITY (HA) PROTECTION OF A RUNNING VIRTUAL MACHINE (VM) - High availability (HA) protection is provided for an executing virtual machine. A standby server provides a disk buffer that stores disk writes associated with a virtual machine executing on an active server. At a checkpoint in the HA process, the active server suspends the virtual machine; the standby server creates a checkpoint barrier at the last disk write received in the disk buffer; and the active server copies dirty memory pages to a buffer. After the completion of these steps, the active server resumes execution of the virtual machine; the buffered dirty memory pages are sent to and stored by the standby server. Then, the standby server flushes the disk writes up to the checkpoint barrier into disk storage and writes newly received disk writes into the disk buffer after the checkpoint barrier. | 08-25-2011 |
20110302316 | METHOD AND SYSTEM FOR MANAGING AND USING SESSIONS AS RESTful WEB SERVICES - Disclosed herein are systems, methods, and non-transitory computer-readable storage media for managing and using sessions as RESTful web services. A session is exposed as a resource having an associated Uniform Resource Identifier (URI), and the session is composed with other services. For example, a client sends an HTTP POST request to a web server to create a session, an HTTP GET request to retrieve a representation of the session, an HTTP PUT request to update the representation of the session, and an HTTP DELETE request to delete the session so that resources within the session are reclaimed. Since the sessions are resources, the resources can be shared among clients, and the web servers knows the client states while still being stateless, making them robust and scalable. Composing web services with the common RESTful session service reduces complexity and enhances interoperability. | 12-08-2011 |
20110302499 | Generation of Macros - A method and apparatus that learns and generates procedures for machine-to-machine interactions by monitoring user browser interactions with the server. Based on an action by a user of the web browser, a communication is sent from the web browser to the server, which is recorded by a macro recorder. The communication is in a first format such as HTML, which contains human-readable API documentation for a user's interactions with the server. The web browser receives a response to the communication which contains a response in the first format and a response in a second format. The second format is parsed to produce a normalized representation. The normalized representation describes the machine-readable API and the service invocation flow that can be interpreted by a particular programming language to generate service macros to invoke the services programmatically from a remote client to a server that supports the same services for machine-to-machine interaction. | 12-08-2011 |
20120079066 | SYSTEM AND METHOD TO CREATE BI-DIRECTIONAL EVENT SUBSCRIPTIONS - System and method to create a bi-directional event subscription. The method includes responding to a request by providing a URI of the subscription factory of the first topic; receiving a request to create a bidirectional subscription; creating a first subscription resource to represent an outbound event flow from a first topic to a second topic; sending a discovery request to a remote host for a URI of a subscription factory of the second topic; receiving the URI of the subscription factory of the second topic; requesting creation of a second subscription resource, to represent an outbound event flow from the second topic to the first topic; receiving from the remote host a URI of the second subscription resource; entangling the first subscription resource with the second subscription to form the bi-directional event subscription; and providing to the web browser a URI of the first subscription. | 03-29-2012 |
20120084520 | Method and Apparatus for Efficient Memory Replication for High Availability (HA) Protection of a Virtual Machine (VM) - High availability (HA) protection is provided for an executing virtual machine. At a checkpoint in the HA process, the active server suspends the virtual machine; and the active server copies dirty memory pages to a buffer. During the suspension of the virtual machine on the active host server, dirty memory pages are copied to a ring buffer. A copy process copies the dirty pages to a first location in the buffer. At a predetermined benchmark or threshold, a transmission process can begin. The transmission process can read data out of the buffer at a second location to send to the standby host. Both the copy and transmission processes can operate asynchronously on the ring buffer. The ring buffer cannot overflow because the transmission process continues to empty the ring buffer as the copy process continues. This arrangement allows for using smaller buffers and prevents buffer overflows, and thereby, it reduces the VM suspension time and improves the system efficiency. | 04-05-2012 |
20120084782 | Method and Apparatus for Efficient Memory Replication for High Availability (HA) Protection of a Virtual Machine (VM) - High availability (HA) protection is provided for an executing virtual machine. At a checkpoint in the HA process, the active server suspends the virtual machine; and the active server copies dirty memory pages to a buffer. During the suspension of the virtual machine on the active host server, dirty memory pages are copied to a ring buffer. A copy process copies the dirty pages to a first location in the buffer. At a predetermined benchmark or threshold, a transmission process can begin. The transmission process can read data out of the buffer at a second location to send to the standby host. Both the copy and transmission processes can operate substantially simultaneously on the ring buffer. As such, the ring buffer cannot overflow because the transmission process continues to empty the ring buffer as the copy process continues. This arrangement allows for smaller buffers and prevents buffer overflows. | 04-05-2012 |
20120254102 | SYSTEM AND METHOD TO CALCULATE TIME WEIGHT IN RDF GRAPHS - Method to calculate time weight in an RDF graph, including: providing one or more triples of the RDF graph to an inference engine module, the one or more triples comprising a time information; providing a reference time to the inference engine; calculating an elapsed time from the reference time to the time value; and inversely weighting the time information by the elapsed time to provide a calculated time weight. Another embodiment may provide a method to update a time weight of a relation when an RDF graph has been added to or deleted from the relation. Another embodiment may provide a method to update a time weight of a relation represented by an RDF graph, when a new reference timestamp is provided. Another embodiment may provide a system to calculate time weight in an RDF graph. | 10-04-2012 |
20120254362 | SYSTEM AND METHOD TO TRANSPORT HTPP OVER XMPP - Method to transport HTPP over XMPP, including: forming a first two-level URI template to identify web resources accessible by use of HTTP in an XMPP network, wherein a first level is XMPP-formatted and a second level is HTTP-formatted; binding HTTP to XMPP and stanzas; transmitting the HTTP messages in those stanzas; receiving a HTTP messages in those stanzas; and a XMPP mechanism to discover if an XMPP entity supports transporting HTTP over XMPP. | 10-04-2012 |
20120254407 | SYSTEM AND METHOD TO MONITOR AND TRANSFER HYPERLINK PRESENCE - Method to monitor and transfer hyperlink presence information, including: transmitting a hyperlink presence monitor request to a web server; receiving an hyperlink presence information; and rendering a hyperlink based upon the hyperlink presence information. Optionally, the hyperlink presence information is represented as one of: attributes of a hyperlink element; HTML5 microdata; RDFa data; and XHTML message data. Optionally, the hyperlink presence information includes: a last-update information to indicate when the hyperlink presence was last updated; a last-status information to indicate a latest hyperlink presence status; a monitor information to indicate a URI that points to a resource to monitor for hyperlink presence; a status-list information to indicate a list of hyperlink presence status values; and a target information to indicate the hyperlink to be monitored. | 10-04-2012 |
20130014032 | SYSTEM AND METHOD OF ENHANCED COLLABORATION THROUGH TELEPORTATION - Embodiments of the present invention generally relate to a system and method enhanced collaboration through teleportation. In one or more embodiments, there is provided a system for moderating an enhanced collaboration environment for at least a set of participants, comprising a server for facilitating a 2-D federated collaboration environment for the at least one set of participants; a server for facilitating a 3-D virtual collaboration environment for the at least one set of participants; and a gateway server for facilitating teleportation of at least two participants of the at least one set of participants from the 2-D federated collaboration environment to form a teleported collaboration group in the 3-D virtual collaboration environment. | 01-10-2013 |
20130085993 | SYSTEM AND METHOD TO JOIN AND CUT TWO-WAY REST OVERLAY TREES FOR DISTRIBUTED KNOWLEDGE BASES - System and method of event-driven synchronization of a database distributed among servers connected in a tree topology, including: transmitting, from a root server, a composition request to a first level of child servers of the root server; recursively transmitting, from each child server of a first level, a composition request to child servers at a second level, wherein the second level is lower than the first level; recursively transmitting, from each child server of the second level, a notification message to child servers at the first level, wherein the notification message comprises an identification of database fragments accessible to the child server; transmitting, from child servers at the first level, respective notification messages to the root server, wherein the root server synchronizes an availability of database fragments from the respective notification messages transmitted to the root server. Subtrees may be cut from or joined to the tree topology. | 04-04-2013 |
20130159419 | SYSTEM AND METHOD OF ENHANCED COLLABORATION THROUGH TELEPORTATION - Embodiments of the present invention generally relate to a system and method enhanced collaboration through teleportation. In one or more embodiments, there is provided a system for moderating an enhanced collaboration environment for at least a set of participants, comprising a server for facilitating a 2-D federated collaboration environment for the at least one set of participants; a server for facilitating a 3-D virtual collaboration environment for the at least one set of participants; and a gateway server for facilitating teleportation of at least two participants of the at least one set of participants from the 2-D federated collaboration environment to form a teleported collaboration group in the 3-D virtual collaboration environment. | 06-20-2013 |
20130198298 | SYSTEM AND METHOD TO SYNCHRONIZE VIDEO PLAYBACK ON MOBILE DEVICES - System and method to synchronize video playback on mobile devices, the method including: receiving, from a first mobile device, a message directed to a second mobile device, the message including an instruction to display a video on the second mobile device; an indication of the time at which the first mobile device sent the message; and a video position of the first mobile device when the message was sent; calculating a delay between the first mobile device and the second mobile device; estimating a video seek time for the second mobile device to seek a video position on the second mobile device; seeking a video position p | 08-01-2013 |
20140112190 | System and Apparatus of Generalized Network Controller for a Software Defined Network (SDN) - A generalized network controller in a software defined network (SDN), controlling a network with mixed switches based on different and even incompatible OpenFlow (OF) standard versions, comprising a first transceiver connected to a first OF switch comprising a first OF standard version configured to receive messages from the first OF switch and to transmit messages to the first OF switch; a second transceiver connected to a second OF switch comprising a second OF standard version configured to receive messages from the second OF switch and to transmit messages to the second OF switch, wherein the first OF standard version is different from the second OF standard version, and wherein the first OF standard version is incompatible with the second OF standard version; and a processor coupled to the first and second transceivers and configured to control the first and the second OF switches. | 04-24-2014 |
20140112192 | System and Apparatus of a Software-Service-Defined-Network (SSDN) - A network apparatus for coupling control plane controllers and data plane switches in a global software service defined network (SSDN), wherein the global SSDN comprises a plurality of local SSDNs, comprising a network software service layer (NSSL) service bus comprising a processor, wherein the NSSL service bus is coupled to a plurality of network controllers and to a plurality of network switches, wherein the NSSL service bus is configured to coordinate the actions of the plurality of network controllers, wherein the NSSL service bus is configured to expose the plurality of controllers as services addressable by service names, wherein the NSSL service bus is configured to extend a local SSDN into a global SSDN network; and wherein the NSSL service bus is configured to provide the network controllers with global network information, such that the network controllers provide end-to-end service routing in the global SSDN network. | 04-24-2014 |
20140201820 | Adapting Federated Web Identity Protocols - A method of performing a Real-Time Communication in Web-browsers (RTCWEB) identity authentication based on an authentication of a non-RTCWEB compliant Identity Provider (IdP) server comprising receiving, by an RTCWEB IdP client, an RTCWEB identity authentication request from a user agent, creating a session resource with a Relying Party (RP) client, wherein the RP client guards the session resource, instructing the user agent to authenticate with the RP client by employing a non-RTCWEB identity protocol to access the session resource, receiving authentication results from the non-RTCWEB compliant IdP server via the RP client, and sending an RTCWEB authentication to the user agent via the session resource. | 07-17-2014 |
20140215083 | Mechanism to Dereference Layered URI in Web Browsers Using JavaScript - An apparatus comprising a processor configured to compose a plurality of protocol stacks, and dereference a layered URI using at least one of the plurality of protocol stacks. Also, a computer program product comprising computer executable instructions stored on a non-transitory medium that when executed by a processor cause the processor to perform the following receive a layered URI, and call a URI dereference extension, wherein the dereference extension is configured to construct a protocol stack, wherein the protocol stack comprises a first connector, a second connector, and a binder, and wherein the first and second connectors are selected from a plurality of connectors based on the URI. | 07-31-2014 |
20140223453 | Mechanism to Initiate Calls Between Browsers Without Predefined Call Signaling Protocol - An apparatus comprising a processor configured to receive an instruction to place a call to a remote user, load a communications application, wherein the communications application comprises an isolated security context, request a list of one or more supported communications protocols from a server, receive the list of one or more supported communications protocols from the server, select a protocol from the list of one or more supported communications protocols, load the selected communications protocol in the isolated security context, and initiate the call through the communications application with the remote server using the selected communications protocol. | 08-07-2014 |
20140258822 | Mechanisms to Compose, Execute, Save, and Retrieve Hyperlink Pipelines in Web Browsers - A method for composing and executing a plurality of hyperlink pipelines within a web browser, wherein the method comprises moving a first source hyperlink that corresponds to a first resource to a destination hyperlink that corresponds to a second resource, merging the first source hyperlink with the destination hyperlink to create a first hyperlink pipeline, moving a second source hyperlink that corresponds to a third resource to the first hyperlink pipeline, merging the second source hyperlink with the first hyperlink pipeline to create a second hyperlink pipeline, and executing the second hyperlink pipeline such that the second resource is invoked before the first resource and the third resource, and the first resource is invoked before the third resource. | 09-11-2014 |
20140282881 | Mechanism and Protocol to Authorize Bilateral Sessions Between Websites Based on Open Authorization - An apparatus for authorizing a bilateral session between two websites, comprising a processor configured to grant authorization for a first website to access a first resource located on a second website, grant authorization for the second website to access a second resource located on the first website, and establish the bilateral session between the first website and the second website when authorization is granted for the first website to access the first resource and authorization is granted for the second website to access the second resource, wherein the bilateral session supports the transfer of the first resource to the first website and the transfer of the second resource to the second website. | 09-18-2014 |
20150046544 | Mirror Presence Between Websites - A mirror presence system comprising a mirror site configured to couple to a visitor site via a communication network, establish a mirror presence relationship between the mirror site and the visitor site, perform a mirror presence at the mirror site by mirroring a direct presence of the user at the visitor site to a mirror presence of a user at the mirror site according to the established mirror presence relationship when the user is connect to the visitor site through a user device, wherein the direct presence of the user at the visitor site occurs when the user connects to the visitor site directly, and provide a caller accessing the mirror site through a calling site with an online presence state of the user at the mirror site according to the mirror presence even though the user is not directly connected to the mirror site. | 02-12-2015 |
20150058469 | Monitoring NAT Behaviors Through URI Dereferences in Web Browsers - A method comprising dereferencing, in a web browser, a Uniform Resource Identifier (URI) comprising a web resource and a reflex tag, creating a request message comprising a request for the web resource and a reflex request corresponding to the reflex tag, wherein the reflex request is a request for address and port information from a web server comprising the web resource, encapsulating the request message in a transport message comprising an Internet Protocol (IP) address and a port of the web browser, transmitting the transport message to the web server, receiving a response message from the web server, wherein the response message comprises a second IP address and a second port number of the browser as seen by the web server, and determining a characteristic of at least one Network Address Translation (NAT) device coupled between the web browser and the web server based on the second IP address and second port number. | 02-26-2015 |