Patent application number | Description | Published |
20080305011 | MICROFLUIDIC CHIP AND METHOD OF FABRICATING THE SAME - Provided are a microfluidic chip and a method of fabricating the same. The microfluidic chip includes: a lower substrate; an upper substrate formed of a silicone resin, wherein the lower substrate and the upper substrate, bonded together, provide a channel through which a fluid can flow and a chamber to receive the fluid; and an organic thin film formed on the upper surface of the lower substrate except for portions on which the lower substrate and the upper substrate are attached to each other. | 12-11-2008 |
20090057599 | ELASTIC VALVE AND MICROFLUIDIC DEVICE INCLUDING THE SAME - An elastic valve and a microfluidic device including the same are provided. The elastic valve includes a channel dented by external pressure so as to be elastically restituted; and a plurality of channel closing protrusions, which comprise elastomer as a material, which are protruded from at least one inner side surface of the channel toward an opposite inner side surface, and which are separated from each other so as not to interrupt a flow of fluids, wherein, when external pressure is applied in order to dent the channel, the plurality of channel closing protrusions are deformed so as to be elastically restituted, thereby closing the channel. | 03-05-2009 |
20090071542 | MICROVALVE HAVING MAGNETIC WAX PLUG AND FLUX CONTROL METHOD USING MAGNETIC WAX - Provided is a microvalve having a magnetic wax plug which includes a micro fluidic structure having an inlet portion and an outlet portion, a magnetic wax plug provided at a predetermined section where the inlet portion and the outlet portion meet, existing in a solid state, melted at a temperature higher than a predetermined temperature, and reversibly moving along a magnetic field, so as to control flux of a fluid through the micro fluidic structure, a heating portion provided corresponding to the section and heating the magnetic wax plug to be melted, and a magnetic field application portion selectively applying a magnetic field to a position where the melted magnetic wax plug arrives. | 03-19-2009 |
20090074623 | MICROFLUIDIC DEVICE - Provided is a microfluidic device including a substrate; a chamber formed by a groove in a bottom surface of the substrate, whereby a fluid can be accommodated in the chamber; and an adhesive tape adhered to the bottom surface of the substrate, wherein the adhesive tape includes a polymer film and a silicone adhesive agent coated on the polymer film. | 03-19-2009 |
20090098291 | METHOD OF PRODUCING SOLID SUPPORT FOR BIOLOGICAL ANALYSIS USING PLASTIC MATERIAL - The present invention provides a method of manufacturing a solid support for biological analysis using a plastic material, the method including: depositing a metal film on a plastic substrate on which a microstructure is formed; depositing an inorganic oxide on the metal film; and anchoring a compound with an amino functional group or a compound with a water contact angle of 70 to 95 degrees on the inorganic oxide. | 04-16-2009 |
20090098612 | METHOD OF AMPLIFYING A TARGET NUCLEIC ACID BY ROLLING CIRCLE AMPLIFICATION - Provided is kit for and a method of amplifying a nucleic acid using rolling cyclic amplification (RCA), including amplifying a nucleic acid together with formation of a single-strand circular DNA template using RCA by reacting a reaction solution including: (a) two hairpin oligos, (b) a target nucleic acid, (c) a DNA ligase,(d) an endonuclease, (e) a DNA polymerase, and (f) a primer. | 04-16-2009 |
20090142798 | METHOD OF SELECTIVELY LYSING NON-VIABLE CELLS IN CELL POPULATION IN SAMPLE - The present invention provides a method of selectively lysing non-viable cells from a cell population within a sample, the method including selectively lysing non-viable cells by mixing a cell-containing sample with a lysis buffer including a non-ionic surfactant and a divalent cation salt. | 06-04-2009 |
20090150085 | METHOD OF DETERMINING INITIAL CONCENTRATION OF NUCLEIC ACID IN SAMPLE USING REAL-TIME AMPLIFICATION DATA - Disclosed is a method of determining an initial concentration of a target nucleic acid within a sample using real-time nucleic acid amplification data. Amplification efficiencies of the target nucleic acid with respect to amplification time are obtained from signals of amplified products, and an amplification efficiency function with respect to amplification time is formulated employing the amplification efficiencies. | 06-11-2009 |
20090170189 | MICROFLUIDIC DEVICE AND METHOD OF FABRICATING THE SAME - Provided are a microfluidic device that performs a biochemical reaction using a small amount of a biochemical fluid and detects the result thereof, and a method of fabricating the same. The microfluidic device includes: a substrate which comprises a chamber that is formed as a concave groove and accommodates a fluid in the bottom surface of the substrate, and is formed of polymer; and a film welded on the bottom surface of the substrate to seal the chamber so that the chamber is not open at the bottom surface of the substrate, and formed of polymer. The method of fabricating a microfluidic device includes: preparing a substrate which comprises a chamber that is formed as a concave groove and accommodates a fluid in the bottom surface of the substrate, and is formed of polymer; and welding a film on a bottom surface of the substrate to seal the chamber so that the chamber is not opened at the bottom surface of the substrate, the film being formed of polymer. | 07-02-2009 |
20100111770 | Microfluidic Chip and Method of Fabricating The Same - Provided are a microfluidic structure including a polysiloxane layer and a method of fabricating the microfluidic structure. The polysiloxane layer is coupled to substrates via a SiO | 05-06-2010 |
20100229979 | FLUID CONTROL APPARATUS - A fluid control apparatus includes a fluid system, a pump and valve array, which selectively provides a pressure or a vacuum of various degrees, and an intermediate bin, which is connected between the pump and valve array and the fluid system, the intermediate bin including a reservoir unit, which stores a fluid discharged from the fluid system. | 09-16-2010 |
20100230334 | FILTER UNIT FOR SEPARATING TARGET MATERIAL AND MICROFLUIDIC DEVICE INCLUDING THE FILTER UNIT - A filter unit for separating target materials from microparticles using an eluent includes: an inlet; a separator unit which separates the target materials from the microparticles using the eluent; an outlet; and a filter which is interposed between the outlet and the separator unit and filters the microparticles. A volume of the separator unit is less than a volume of the eluent provided to the separator unit. | 09-16-2010 |
20100233038 | TUBE CONNECTION COMPONENT AND MICROFLUIDIC SYSTEM INCLUDING THE SAME - A tube connection component includes; a body defining a through hole in fluid communication with an end of a tube, wherein the body connects a tapered fluid communication hole of a microfluidic device to the end of the tube, and a tapered protrusion which protrudes from the body and is accommodated in the tapered fluid communication hole when the body is fixed to the microfluidic device. | 09-16-2010 |
20100311070 | POLYMERASE CHAIN REACTION (PCR) MODULE AND MULTIPLE PCR SYSTEM USING THE SAME - Provided are a PCR module and a multiple PCR system using the same. More particularly, provided are a PCR module with a combined PCR thermal cycler and PCR product detector, and a multiple PCR system using the same. | 12-09-2010 |
20110033919 | METHOD OF REDUCING TEMPERATURE DIFFERENCE BETWEEN A PAIR OF SUBSTRATES AND FLUID REACTION DEVICE USING THE SAME - A method of reducing a temperature difference between a high-temperature and a low-temperature substrate includes interposing a heat transfer facilitating layer which has a higher thermal conductivity than air and can hold particles between the substrates, and maintaining close contact between the high-temperature substrate, the heat transfer facilitating layer, and the low-temperature substrate, wherein formation of an air layer can be at least substantially prevented between the high-temperature substrate and the heat transfer facilitating layer, and between the low-temperature substrate and the heat transfer facilitating layer. A fluid reaction device includes a microfluidic reaction chip which accommodates a fluid, a heater, and a heat transfer facilitating layer which is interposed between the microfluidic reaction chip and the heater, the heat transfer facilitating layer has a higher thermal conductivity than air and can hold particles, wherein formation of an air layer can be prevented. | 02-10-2011 |
20110056565 | FLUID RECEIVING CHAMBER, MICROFLUIDIC DEVICE INCLUDING FLUID RECEIVING CHAMBER, AND FLUID MIXING METHOD - A fluid receiving chamber including a fluid inlet hole through which a fluid flows from outside, an inner space which contains the fluid, a fluid supply hole through which the fluid flows from the fluid inlet hole to the inner space, and a fluid outlet hole through which the fluid contained in the inner space is discharged to the outside, where the fluid supply hole is disposed above the fluid outlet hole, and the fluid is supplied to the inner space through the fluid supply hole by gravity. | 03-10-2011 |
20110079289 | MICROVALVE HAVING MAGNETIC WAX PLUG AND FLUX CONTROL METHOD USING MAGNETIC WAX - Provided is a microvalve having a magnetic wax plug which includes a micro fluidic structure having an inlet portion and an outlet portion, a magnetic wax plug provided at a predetermined section where the inlet portion and the outlet portion meet, existing in a solid state, melted at a temperature higher than a predetermined temperature, and reversibly moving along a magnetic field, so as to control flux of a fluid through the micro fluidic structure, a heating portion provided corresponding to the section and heating the magnetic wax plug to be melted, and a magnetic field application portion selectively applying a magnetic field to a position where the melted magnetic wax plug arrives. | 04-07-2011 |
20110081280 | MICROFLUIDIC CHIP AND METHOD OF FABRICATING THE SAME - Provided are a microfluidic chip and a method of fabricating the same. The microfluidic chip includes: a lower substrate; an upper substrate formed of a silicone resin, wherein the lower substrate and the upper substrate, bonded together, provide a channel through which a fluid can flow and a chamber to receive the fluid; and an organic thin film formed on the upper surface of the lower substrate except for portions on which the lower substrate and the upper substrate are attached to each other. | 04-07-2011 |
20110089034 | DIELECTROPHORESIS APPARATUS INCLUDING CONCENTRATION GRADIENT GENERATING UNIT, METHOD OF SEPARATING MATERIAL USING THE SAME, AND METHOD OF SCREENING CONDITION FOR SEPARATING MATERIAL - A dielectrophoresis (DEP) apparatus including a concentration gradient generating unit, a method of separating a target material in a sample solution using the DEP apparatus, and a method of screening the optimum condition for separating a target material are provided. | 04-21-2011 |
20110151543 | CELL SEPARATION METHOD USING HYDROPHOBIC SOLID SUPPORTS - Provided is a method of separating cells using a hydrophobic solid support. The method comprises contacting a solution containing cells with a hydrophobic solid support having a water contact angle between 70 and 90 degrees. By allowing cells to be adsorbed to the hydrophobic solid substrate, the cells can be separated. Thus, the cell separation efficiency can be rapidly and simply increased. | 06-23-2011 |
20110269193 | METHOD OF AMPLIFYING A TARGET NUCLEIC ACID BY ROLLING CIRCLE AMPLIFICATION - Provided is a method of amplifying a nucleic acid using rolling cyclic amplification (RCA), including amplifying a nucleic acid together with formation of a single-strand circular DNA template using RCA by reacting a reaction solution including: (a) two hairpin oligos, (b) a target nucleic acid, (c) a DNA ligase, (d) an endonuclease, (e) a DNA polymerase, and (f) a primer. | 11-03-2011 |
20110286885 | MICROFLUIDIC DEVICE HAVING NORMALLY OPEN TYPE MICROVALVE AND METHOD OF MANUFACTURING THE MICROFLUIDIC DEVICE - A microfluidic device includes a microvalve formed by disposing a thin elastic film and a valve seat in a microfluidic channel of the microfluidic device. The microvalve is a normally open type valve in which the elastic film does not contact the valve seat. According to the microvalve of the microfluidic device, an additional process for separating the elastic film from the valve seat is not required. Accordingly, the microfluidic device may have a relatively simple manufacturing process. Also, since an initialization operation to use the microfluidic device is not required, the flow of a fluid in the microfluidic device may be efficiently controlled without additional processing steps. | 11-24-2011 |
20110286895 | MICROVALVE DEVICE AND METHOD OF MANUFACTURING THE SAME - A microvalve device comprises: a first substrate having a first surface, wherein at least one fluidic channel are formed into the first surface of the first substrate; and at least one valve seat are formed in the fluidic channel; a second substrate having a second surface, the second substrate comprising at least one air channel and at least one air chamber formed on the second surface of the second substrate, wherein the air chamber is connected to the air channel; and an elastic film interposed between the first substrate and the second substrate, where an upper portion of the valve seat is lower than the first surface of the first substrate. | 11-24-2011 |
20110305607 | MICROFLUIDIC DEVICE HAVING MICROVALVE - A microfluidic device including a microvalve includes a first substrate, a second substrate facing the first substrate, an elastic film between the first and second substrates, a microfluidic channel on the second substrate, a valve seat of the second substrate protruding in the microfluidic channel, and a fine structure on a surface of the elastic film, facing the valve seat and which contacts the valve seat when the microvalve is operated. | 12-15-2011 |
20120039770 | MICROFLUIDIC DEVICE INCLUDING MICROVALVE - A microfluidic device including at least one microvalve which controls a flow of a fluid, where the at least one microvalve includes: a pneumatic layer, a fluidic layer disposed opposite to the pneumatic layer; an elastomer membrane disposed between the pneumatic layer and the fluidic layer; and an asymmetric valve seat protruding from a surface of the fluidic layer toward a surface of the elastomer membrane and asymmetrically dividing a space between the fluidic layer and the elastomer membrane. | 02-16-2012 |
20120103832 | MICROFLUIDIC DEVICE FOR ELECTROCHEMICALLY REGULATING pH OF FLUID THEREIN AND METHOD OF REGULATING pH OF FLUID USING THE MICROFLUIDIC DEVICE - A microfluidic device for electrochemically regulating the pH of a fluid includes: an ion-exchange material; an anode chamber having a surface defined by a surface of the ion-exchange material and an anode electrode disposed along an edge of the surface of the anode chamber; and a cathode chamber having a surface defined by an opposite surface of the ion-exchange material and a cathode electrode disposed along an edge of the surface of the cathode chamber. | 05-03-2012 |
20120107823 | MICRO-DEVICE AND METHODS FOR DISRUPTING CELLS - A micro-device for disrupting cells includes a first chamber in which the cells are disrupted, a second chamber which is pressurized and depressurized, a flexible membrane which separates the first chamber and the second chamber and is vibrated by pressuring and depressurizing the second chamber, and a micro-unit confined in the first chamber, where the micro-unit disrupts the cells in the first chamber | 05-03-2012 |
20120107912 | CELL LYSIS DEVICE AND METHODS OF LYSING CELLS OR VIRUSES - A method of lysing at least one of a cell and a virus, the method including: contacting a sample, which includes at least one of a cell and a virus, with a plurality of beads which are disposed in a first chamber to obtain a combination of the sample and the beads; and agitating the combination of the sample and the beads to lyse the at least one of the cell and the virus, wherein in the first chamber a liquid volume fraction is 0.6 or less, and wherein the liquid volume fraction is a value obtained by dividing a liquid volume of the first chamber by a pure void volume equivalent to a sum of the liquid volume of the first chamber and a void volume of the first chamber. | 05-03-2012 |
20120141999 | GENE ANALYSIS APPARATUS AND GENE ANALYSIS METHOD USING THE SAME - A gene analysis apparatus includes a sample preparation chip in which a polymerase chain reaction (“PCR”) sample is prepared, a PCR chip in which a PCR is performed on the PCR sample, and a package layer on which the sample preparation chip and the PCR chip are mounted. The package layer includes a channel through which a material flows from the sample preparation chip to the PCR chip. The sample preparation chip and the PCR chip are on a same side or on opposing sides of the package layer. | 06-07-2012 |
20120168016 | MICROVALVE HAVING MAGNETIC WAX PLUG AND FLUX CONTROL METHOD USING MAGNETIC WAX - Provided is a microvalve having a magnetic wax plug which includes a micro fluidic structure having an inlet portion and an outlet portion, a magnetic wax plug provided at a predetermined | 07-05-2012 |
20120309004 | MICRO-DEVICE AND METHODS FOR DISRUPTING CELLS - A micro-device for disrupting cells includes a first chamber in which the cells are disrupted, a second chamber which is pressurized and depressurized, a flexible membrane which separates the first chamber and the second chamber and is vibrated by pressuring and depressurizing the second chamber, and a micro-unit confined in the first chamber, where the micro-unit disrupts the cells in the first chamber. | 12-06-2012 |
20120309082 | MICRO-FLUID SUPPLYING DEVICE HAVING GAS BUBBLE TRAPPING FUNCTION - A micro-fluid supplying device having a gas bubble trapping function. The micro-fluid supplying device includes: a fluid supplier including a fluid having a biomaterial; a trap chamber in which a gas bubble is removed from the fluid supplied from the fluid supplier; and a fluid discharger which externally discharges a material supplied from the trap chamber. Material properties of a side wall and a bottom of an inside of the trap chamber are different from each other. The side wall has a better property of wetting with respect to the fluid supplied from the fluid supplier than the bottom. | 12-06-2012 |
20130137165 | GENE ANALYSIS DEVICE - A gene analysis device including an illumination optical system radiating exciting light onto a sample solution; a microfluidic device for forming a bio-reaction space of the sample solution and including at least one micro-chamber in which a reflection pattern is formed; and a detection optical system for detecting a fluorescence signal generated by a bio-reaction in the micro-chamber and comprising a photodetector. | 05-30-2013 |
20130156658 | MICROFLUIDIC DEVICE AND METHOD OF MANUFACTURING THE SAME - Embodiments of the disclosure describe a microfluidic device and a method of manufacturing the same. An embodiment of the microfluidic device includes a first substrate in which a micro-flow path and a valve seat protruding toward the micro-flow path are formed; a second substrate disposed to face the first substrate and in which a cavity corresponding to the valve seat is formed; and a polymer film disposed between the first substrate and the second substrate and comprising a bonding unit bonded to the first and second substrates and a variable unit having a variable shape according to pneumatic pressure of the cavity, wherein the variable unit has a curvature and is spaced apart from the valve seat when pneumatic pressure is not provided to the variable unit. | 06-20-2013 |
20130174964 | MICROFLUIDIC DEVICE AND METHOD OF FABRICATING THE SAME - Provided are a microfluidic device that performs a biochemical reaction using a small amount of a biochemical fluid and detects the result thereof, and a method of fabricating the same. The microfluidic device includes: a substrate which comprises a chamber that is formed as a concave groove and accommodates a fluid in the bottom surface of the substrate, and is formed of polymer; and a film welded on the bottom surface of the substrate to seal the chamber so that the chamber is not open at the bottom surface of the substrate, and formed of polymer. The method of fabricating a microfluidic device includes: preparing a substrate which comprises a chamber that is formed as a concave groove and accommodates a fluid in the bottom surface of the substrate, and is formed of polymer; and welding a film on a bottom surface of the substrate to seal the chamber so that the chamber is not opened at the bottom surface of the substrate, the film being formed of polymer. | 07-11-2013 |
20130337234 | METHOD OF BONDING TWO SURFACES AND STRUCTURE MANUFACTURED BY USING THE SAME - A method of efficiently bonding two surfaces using nitrogen plasma, and a structure manufactured by using the same. | 12-19-2013 |
20140154688 | REAGENT CONTAINER FOR AMPLIFYING NUCLEIC ACID, METHOD OF PREPARING THE REAGENT CONTAINER, METHOD OF STORING THE REAGENT, AND MICROFLUIDIC SYSTEM FOR NUCLEIC ACID ANALYSIS - Provided is a reagent container that can maintain stability of a reagent for a long period of time, a method of preparing the reagent container, a method of storing the reagent, and microfluidic systems for conducting cell binding, lysis, nucleic acid extraction, and amplification. | 06-05-2014 |
20140178982 | REAGENT SUPPLY DEVICE FOR ANALYSIS OF NUCLEIC ACID - A reagent supply device includes a plurality of chambers which are separated from each other such that different reagents may be injected, the plurality of chambers having bottom surfaces made of a membrane, the membrane comprising a destruction pattern which is formed at a position corresponding to each of the plurality of chambers and breachable by an external impact to discharge the injected reagent from the chamber. | 06-26-2014 |
20140206073 | MICROFLUIDIC SYSTEM FOR NUCLEIC ACID ANALYSIS - A microfluidic system for analyzing nucleic acid, the microfluidic system including a reagent supply device including a sample chamber into which a sample can be injected, one or more reagent chambers for containing one or more reagents for extracting nucleic acid from the sample, and a waste chamber in which the used reagent can be discarded; a binding-lysis chamber in which cells are captured from the sample and lysed to form a cell lysate containing nucleic acid; plurality of particles for cell binding disposed in the binding-lysis chamber; a plurality of rehydration chambers into which the cell lysate formed in the binding-lysis chamber can be distributed and mixed with a nucleic acid amplification reagent to form an amplification reaction mixture; a plurality of amplification chambers in which a nucleic acid amplification reaction is performed on the amplification reaction mixture introduced from the plurality of rehydration chambers; and a flow channel system including an outlet and a plurality of inlets connected to the reagent supply device and forming an integrated fluid flow between the binding-lysis chamber, the rehydration chambers, and the amplification chambers. | 07-24-2014 |
20140356853 | AUTOMATED NUCLEIC ACID ANALYSIS SYSTEM - A nucleic acid analysis system comprising a seating area configured to receive a microfluidic cartridge; a pneumatic module configured to supply a pneumatic pressure or a vacuum to the cartridge when mounted on the seating area; a thermal module configured to control temperature in a predetermined portion of the cartridge when mounted on the seating area; an optic module positioned to irradiate light onto the cartridge when mounted on the seating area, and detect light generated or reflected from a sample inside the cartridge when mounted on the seating area; a fluid sensing module that determines whether a fluid in a predetermined portion of a cartridge mounted on the seating area is in a gaseous state or a liquid state; a scanning module that moves the optic module and the fluid sensing module relative to the seating area; and a control module that controls operations of the pneumatic module, the thermal module, the optic module, the fluid sensing module, and the scanning module, and processes and analyzes data received therefrom. | 12-04-2014 |
20150031125 | MICRO-DEVICE AND METHODS FOR DISRUPTING CELLS - A micro-device for disrupting cells includes a first chamber in which the cells are disrupted, a second chamber which is pressurized and depressurized, a flexible membrane which separates the first chamber and the second chamber and is vibrated by pressuring and depressurizing the second chamber, and a micro-unit confined in the first chamber, where the micro-unit disrupts the cells in the first chamber | 01-29-2015 |
20150037876 | MULTI-CHANNEL FLUORESCENCE DETECTING MODULE AND NUCLEIC ACID ANALYSIS SYSTEM HAVING THE SAME - Provided are a multi-channel fluorescence detecting module and a nucleic acid analysis system including the multi-channel fluorescence detecting module. The nucleic acid analysis system includes: a plurality of loaders configured to accommodate a plurality of cartridges respectively, the cartridges comprising microfluidic devices; a transfer module including a linear actuator, the linear actuator including a movable unit configured to move linearly; and a fluorescence detecting module fixed to the movable unit, the fluorescence detecting module being configured to emit excitation light to the cartridges and detect fluorescence emitted from samples on the cartridges. The loaders are arranged in a row in a linearly moving direction of the movable unit. | 02-05-2015 |
20150053666 | SEMICONDUCTOR DEVICE INCLUDING ASYMMETRIC ELECTRODE ARRANGEMENT - Provided is a semiconductor device including an asymmetric electrode arrangement in which a plurality of electrodes are arranged asymmetrically in a vertical or horizontal direction. | 02-26-2015 |