Patent application number | Description | Published |
20080207607 | Heterotricyclic metalloprotease inhibitors - The present invention relates generally to azatriocyclic containing pharmaceutical agents, and in particular, to azatricyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of azatricyclic MMP-3, MMP-8 and/or MMP-13 inhibiting compounds, that exhibit an increased potency and selectivity in relation to currently known MMP-13, MMP-8 and MMP-3 inhibitors. | 08-28-2008 |
20080261968 | Heterobicyclic metalloprotease inhibitors - The present invention relates generally to azabicyclic containing pharmaceutical agents, and in particular, to azabicyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of azabicyclic MMP-3, MMP-8 and/or MMP-13 inhibiting compounds, which exhibit an increased potency and selectivity in relation to currently known MMP-13, MMP-8 and MMP-3 inhibitors. | 10-23-2008 |
Patent application number | Description | Published |
20080221093 | Metalloprotease inhibitors containing a heterocyclic moiety - The present invention relates generally to pharmaceutical agents containing a heterocyclic moiety, and in particular, to heterocyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of heterocyclic MMP-13 inhibiting compounds with a benzoxazinone moiety, that exhibit an increased potency and selectivity in relation to currently known MMP-13 inhibitors. | 09-11-2008 |
20080221095 | Metalloprotease inhibitors containing a heterocyclic moiety - The present invention relates generally to pharmaceutical agents containing a heterocyclic moiety, and in particular, to heterocyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of heterocyclic MMP-3, MMP-8 and/or MMP-13 inhibiting compounds with a squaramide or benzoxazinone moiety, that exhibit an increased potency and selectivity in relation to currently known MMP-13, MMP-8 and MMP-3 inhibitors. | 09-11-2008 |
20080221128 | Metalloprotease inhibitors containing a squaramide moiety - The present invention relates generally to pharmaceutical agents containing a heterocyclic moiety, and in particular, to heterocyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of heterocyclic MMP-3, MMP-8 and/or MMP-13 inhibiting compounds with a squaramide or benzoxazinone moiety, that exhibit an increased potency and selectivity in relation to currently known MMP-13, MMP-8 and MMP-3 inhibitors. | 09-11-2008 |
20120196861 | IL17 AND IFN-GAMMA INHIBITION FOR THE TREATMENT OF AUTOIMMUNE INFLAMMATION - The present invention relates to compounds of the general formula (I), and the pharmaceutically acceptable salt or solvate thereof, as anti-inflammatory and immunomodulatory agents. | 08-02-2012 |
20120196862 | IL17 AND IFN-GAMMA INHIBITION FOR THE TREATMENT OF AUTOIMMUNE INFLAMMATION - The present invention relates to compounds of the general formula (I), and the pharmaceutically acceptable salt or solvate thereof, as anti-inflammatory and immunomodulatory agents. | 08-02-2012 |
Patent application number | Description | Published |
20100087420 | Heterotricyclic Metalloprotease Inhibitors - The present invention relates generally to azatriocyclic containing pharmaceutical agents, and in particular, to azatricyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of azatricyclic MMP-3, MMP-8 and/or MMP-13 inhibiting compounds, that exhibit an increased potency and selectivity in relation to currently known MMP-13, MMP-8 and MMP-3 inhibitors. | 04-08-2010 |
20100249102 | Heterotricyclic Metalloprotease Inhibitors - The present invention relates generally to azatriocyclic containing pharmaceutical agents, and in particular, to azatricyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of azatricyclic MMP-3, MMP-8 and/or MMP-13 inhibiting compounds, that exhibit an increased potency and selectivity in relation to currently known MMP-13, MMP-8 and MMP-3 inhibitors. | 09-30-2010 |
Patent application number | Description | Published |
20090148462 | METHODS AND COMPOSITIONS FOR USE IN TREATMENT OF PATIENTS WITH AUTOANTIBODY POSITIVE DISEASE - The present invention relates to methods and compositions for use in treatment of patients with autoantibody positive disease. In a specific embodiment, the present invention relates to a method of treating a patient that has an ANA titer of 1:80 or greater and/or greater than or equal to 30 IU/ml of anti-dsDNA antibodies in his/her blood plasma or serum comprising administering a therapeutically effective amount of an immunomodulatory agent, such as an antagonist of Neutrokine-alpha. Additionally provided is a method of reducing the frequency and/or quantity of corticosteroid administration to patients. In preferred embodiments, the patient has systemic lupus erythematosus. Methods for determining if a lupus patient is responding to medical treatment are also provided. | 06-11-2009 |
20090221008 | NEUTROKINE-ALPHA AND NEUTROKINE-ALPHA SPLICE VARIANT - The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention. | 09-03-2009 |
20100261207 | NEUTROKINE-ALPHA AND NEUTROKINE-ALPHA SPLICE VARIANT - The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention. | 10-14-2010 |
Patent application number | Description | Published |
20130231672 | METHOD AND SYSTEM FOR TRACKING OBJECTS IN COMPUTER-ASSISTED SURGERY - A computer-assisted surgery system comprises instruments adapted to be used to perform tasks related to surgery. A reference device is in a fixed relation to a bone. A rotating magnet creates a magnetic field plane, the rotating magnet being connected to one of the instrument and the reference device. A magnetometer on the other of the instrument and the reference device produces signals as a function of at least its orientation relative to the magnetic field plane. A processing unit tracks said orientation of the instrument relative to the bone using said signals from the magnetometer subjected to the magnetic field plane. | 09-05-2013 |
20140031829 | METHOD AND SYSTEM FOR CREATING FRAME OF REFERENCE FOR CAS WITH INERTIAL SENSORS - A digitizer device comprises an elongated body and legs connected to the elongated body. At least one joint is between the legs and the elongated body such that free ends of the legs are displaceable relative to one another. An inertial sensor unit is connected to the elongated body, the inertial sensor unit having a preset orientation aligned with the elongated body. A table reference device comprises a body adapted to be fixed to an operating table. An inertial sensor unit is with a preset orientation related to the operating table. A patient coordinate system comprising orientation data obtained from the inertial sensor units of the digitizer device and the table reference device | 01-30-2014 |
20140171967 | PROXIMITY-TRIGGERED COMPUTER-ASSISTED SURGERY SYSTEM AND METHOD - A computer-assisted surgery system comprises a first surgical device with a tracking unit tracked during a surgical procedure and adapted to perform a first function associated to the surgical procedure. A second surgical device is adapted to perform a second function associated to the surgical procedure. A triggered unit is triggered when the first surgical device and the second surgical device reach a predetermined proximity relation. A surgical procedure processing unit tracks the first surgical device. A trigger detector detects a triggering of the triggered unit. A CAS application operates steps of a surgical procedure. A controller commands the CAS application to activate a selected step associated with the second function in the surgical procedure when the trigger detector signals a detection. An interface displays information about the selected step in the surgical procedure. | 06-19-2014 |
20140364858 | ACETABULAR CUP PROSTHESIS POSITIONING INSTRUMENT AND METHOD - A method for assisting in positioning the acetabular cup comprises orienting a cup positioning instrument with a cup thereon in an initial reference orientation relative to an acetabulum of a pelvis with the cup forming a joint with the acetabulum, the cup positioning instrument comprising an inertial sensor unit with pre-planned orientation data for a desired cup orientation based on at least one landmark of the pelvis, The cup positioning instrument is rotated to a desired abduction angle as guided by an interface of the cup positioning instrument, based on movements relative to at least one landmark. The cup positioning instrument is rotated to a desired anteversion angle as guided by the interface of the cup positioning instrument, based on movements relative to the at least one landmark. Upon reaching the desired cup orientation as indicated by the interface, the cup is impacted into the acetabulum. | 12-11-2014 |
Patent application number | Description | Published |
20120212206 | ELECTRONIC DEVICE FOR OPTIMIZING THE OUTPUT POWER OF A SOLAR CELL AND METHOD FOR OPERATING THE ELECTRONIC DEVICE - An electronic device for optimizing the output power of a solar cell, the electronic device having: a variable resistor coupled in series between the solar cell and a load, a control unit that is configured to control the variable resistor, a sensor for measuring an output voltage and a sensor for measuring the output current of the solar cell, wherein the control unit is configured to vary the resistance of the series resistor over time such that the first order derivative of the output voltage over time has a constant value, to monitor the second order derivative of the output current over time simultaneously, to detect whether the second order derivative of the output current over time exceeds a predetermined threshold value and to identify the corresponding values of the output voltage and current as a maximum power point (MPP) of the solar cell. | 08-23-2012 |
20150020608 | Single-transceiver Ultrasonic Flow Meter Apparatus and Methods - Elements of a single beam-forming array of ultrasonic transducer elements are selectively activated to direct two or more ultrasonic beams to a series of acoustic mirrors mounted to or fabricated at known locations at an inside surface of the pipe. The ultrasonic beams traverse measurement path segments at known angles through a fluid flowing through the pipe before being received back at the single transducer array. Fluid flow velocity along the fluid flow path is calculated as a function of a difference in time-of-flight (TOF) along first and second ultrasonic beam paths after subtracting TOF components contributed by known-length non-measurement path segments. The difference in TOF results from an additive downstream fluid flow velocity vector component along a first measurement path segment and a subtractive upstream fluid flow velocity vector component along a second measurement path segment. | 01-22-2015 |
20150022923 | DRIVER CURRENT CONTROL APPARATUS AND METHODS - Apparatus and methods disclosed herein implement steady-state and fast transient electronic current limiting through power transistors, including power transistors used as pass elements associated with general purpose drivers. Embodiments herein prevent excessive steady-state current flow through one or more driver pass elements and/or through load elements in series with the pass element(s) via a current sensing and driver preamplifier feedback loop. A transient over-current protection circuit includes a fast transient switch and a transient over-current control circuit. The transient over-current control circuit rectifies one or more transient voltage spikes to create a momentary direct current (DC) voltage power supply (MVS) to power a fast transient driver circuit and to trip the fast transient switch. The fast transient switch discharges a transient pass element input voltage (e.g., a gate voltage on a MOSFET power transistor in some embodiments) and terminates current flow through the pass element current channel. | 01-22-2015 |