Patent application number | Description | Published |
20090246885 | Media for affinity chromatography - The invention relates generally to solid supports for chromatography. In specific embodiments the invention provides for solid supports suitable for affinity chromatography along with methods, systems and kits which use the same. | 10-01-2009 |
20100174051 | Asymmertric porous adsorptive bead - The present invention relates to an asymmetric chromatography media suitable for separations applications, particularly as packed bed, fluidized bed or magnetized bed chromatography media. In certain embodiments, the asymmetric chromatography media comprises asymmetric particles, preferably beads, having at least two distinct, controlled pore size distributions. Preferably one of the distinct pore size distributions is in an internal region of the particle, and the other is in an external region or coating on the particle. These distinct pore size distributions can be modified with uniform or alternatively unique functional groups or mixtures of functional groups. The present invention allows for the control over pore size distribution within an asymmetric porous particle by providing a distinct internal region, preferably in the form of a bead, and a distinct external region, preferably in the form of a coating on the bead. | 07-08-2010 |
20110105730 | AFFINITY CHROMATOGRAPHY MATRICES AND METHODS OF MAKING AND USING THE SAME - The invention provides methods of coupling protein ligands to a solid support. The invention also provides affinity chromatography matrices and methods of using affinity chromatography matrices to purify a target molecule. | 05-05-2011 |
20140073769 | ASYMMETRIC POROUS ADSORPTIVE BEAD - The present invention relates to an asymmetric chromatography media suitable for separations applications, particularly as packed bed, fluidized bed or magnetized bed chromatography media. In certain embodiments, the asymmetric chromatography media comprises asymmetric particles, preferably beads, having at least two distinct, controlled pore size distributions. Preferably one of the distinct pore size distributions is in an internal region of the particle, and the other is in an external region or coating on the particle. These distinct pore size distributions can be modified with uniform or alternatively unique functional groups or mixtures of functional groups. The present invention allows for the control over pore size distribution within an asymmetric porous particle by providing a distinct internal region, preferably in the form of a bead, and a distinct external region, preferably in the form of a coating on the bead. | 03-13-2014 |
Patent application number | Description | Published |
20100297429 | COMPOSITE MEMBRANE AND METHOD OF MAKING - The present invention provides a composite membrane comprising a porous base membrane and a polyamide coating disposed on said porous base membrane, said polyamide coating comprising a C | 11-25-2010 |
20120292249 | COMPOSITE MEMBRANE AND METHOD OF MAKING - The present invention provides a composite membrane comprising a porous base membrane and a polyamide coating disposed on said porous base membrane, said polyamide coating comprising a C | 11-22-2012 |
20130022813 | METHOD FOR PREPARING GRAPHENE NANORIBBON ON INSULATING SUBSTRATE - A method for growing a graphene nanoribbon on an insulating substrate having a cleavage plane with atomic level flatness is provided, and belongs to the field of low-dimensional materials and new materials. The method includes the following steps. Step 1: Cleave an insulating substrate to obtain a cleavage plane with atomic level flatness, and prepare a single atomic layer step. Step 2: Directly grow a graphene nanoribbon on the insulating substrate having regular single atomic steps. In the method, a characteristic that nucleation energy of graphene on the atomic step is different from that on the flat cleavage plane is used, and conditions, such as the temperature, intensity of pressure and supersaturation degree of activated carbon atoms, are adjusted, so that the graphene grows only along a step edge into a graphene nanoribbon of an adjustable size. The method is mainly applied to the field of new-type graphene optoelectronic devices. | 01-24-2013 |
20130263892 | ECO-DISHWASHER SYSTEM AND METHODOLOGY - A dishwashing apparatus and a methodology are provided for washing dishware using electrolyzed water to provide alkaline and acidic water for wash and rinse cycles. The water used at the beginning of a pre-wash stage is repeatedly used in plural pre-wash cycles and filtered through sediment and oil filtration between pre-wash cycles. Water from a final rinse cycle is saved for use for future pre-wash cycles. The sediment and oil filtration filter are reversely flushed to regenerate the filtration systems. | 10-10-2013 |
20130292034 | METHOD AND APPARATUS FOR FABRICATING SEPARATOR ASSEMBLY - The present invention provides a method and apparatus for fabricating a separator assembly. The method comprises: providing a central core element comprising at least one concentrate exhaust conduit and at least one permeate exhaust conduit; disposing a first portion of a membrane stack assembly comprising a permeate carrier layer, a membrane layer, and a feed carrier layer within the central core element such that the concentrate exhaust conduit and permeate exhaust conduit are separated by the first portion of the membrane stack assembly; radially winding a second portion of the membrane stack assembly around the central core element; and sealing the wound assembly comprising two opposing end surfaces made of the membrane stack assembly by applying an adhesive on both end surfaces of the wound assembly; and applying a negative pressure inside the central core element so that the adhesive penetrates into the membrane stack assembly. | 11-07-2013 |
20140076790 | CENTRAL CORE ELEMENT FOR A SEPARATOR ASSEMBLY - The present invention provides a central core element a reverse osmosis separator assembly useful in the purification of fluids. The central core element comprises an outer exhaust conduit defining an inner volume and a gap starting at a first end thereof the outer exhaust conduit and extending towards a second end of the outer exhaust conduit, and an inner porous exhaust conduit comprising a first section disposed within the inner volume defined by outer exhaust conduit and a second section configured to abut and seal the first end of the outer exhaust conduit. The outer exhaust conduit is configured to accommodate a first portion of a membrane stack assembly within the inner volume and a second portion of the membrane stack assembly disposed as a multilayer membrane assembly on an outer surface of the outer exhaust conduit. The gap is configured to accommodate a transition section of the membrane stack assembly linking the first portion of the membrane stack assembly with the second portion of the membrane stack assembly. The first inner porous exhaust conduit section is configured to be disposed within the first portion of the membrane stack assembly. | 03-20-2014 |
20150060359 | SPIRAL WOUND MEMBRANE ELEMENT AND METHOD FOR CLEANING SPIRAL WOUND MEMBRANE SHEET - A spiral wound membrane element and a method for cleaning a spiral wound membrane sheet are provided. The spiral wound membrane element comprising a perforated central tube; one or more membrane sleeves, each sleeve comprising two membrane sheets enclosed at two edges around a feed spacer sheet and wrapped around the central tube; a permeate carrier sheet attached to the central tube at a first edge opposite a second edge; and a seal on third and fourth edges of the permeate carrier sheet. The method comprises introducing two solution with different solute concentration to two sides of the spiral wound membrane sheet; establishing a concentration gradient between the first and second sides; communicating a first solvent from the first side to the second side to remove a foulant located on the second side of the membrane sheet and collecting a waste stream that contains the foulant. | 03-05-2015 |
20150083657 | MEMBRANE AND METHOD FOR MAKING THE SAME - A membrane comprises: a porous base membrane; a polyol layer comprising polyols and a metalorganic compound; and a polyamide film layer sandwiched between the porous base membrane and the polyol layer. A method of making the membrane is also described. | 03-26-2015 |
20150144547 | SPIRAL FLOW WATER TREATMENT APPARATUS - A spiral flow water treatment apparatus including: a core collector comprising a first portion and a second portion; a spacer spirally wound around the core collector; a separator spirally wound around the core collector and alternately with the spacer; a first spiral flow conduit located outside the separator, connected with the first portion, and decreasing in volume thereof from far to close to the core collector; and a second spiral flow conduit located within the separator, in fluid communication with the first spiral flow conduit, and connected to the second portion. | 05-28-2015 |
20150157985 | SPIRAL WOUND MEMBRANE WITH BI-DIRECTIONAL PERMEATE FLOW - Disclosed is a spiral wound membrane element that provides two permeate streams through a permeate carrier sheet. The spiral wound membrane element is sealed such that the only communication with the permeate carrier is through a membrane sleeve. The first permeate stream flows spirally inward and the second permeate stream flows in the opposite direction, spirally outward. The permeate carrier sheet is sealed at two edges so that the permeate streams can only discharge from opposite, unsealed edges of the permeate carrier sheet. The first permeate stream may be collected in a central collection tube and the second permeate stream may be collected in a peripheral region of the membrane element. | 06-11-2015 |
20150336126 | VACUUM DIP COATING APPARATUS - A dip coating apparatus includes a sealed case assembly for containing at least one workpiece to be coated; an air pump communicated with the sealed case assembly, for pumping air from the sealed case assembly and injecting air into the sealed case assembly; and a coating solution container containing a coating solution and communicated with the sealed case assembly, for injecting the coating solution to the sealed case assembly and retrieving the coating solution from the sealed case assembly. | 11-26-2015 |
Patent application number | Description | Published |
20080274461 | Perinucleolar Compartment Markers for Cancer - The present invention relates to compositions and methods for cancer diagnostics, prognostics and predictions, including but not limited to, cancer markers. In particular, the present invention provides perinucleolar compartments and their resident molecules as cancer markers. | 11-06-2008 |
20100075365 | PERINUCLEOLAR COMPARTMENT AS A CANCER MARKER - The present invention relates to compositions and methods for cancer diagnostics, prognostics and predictions, including but not limited to, cancer markers. In particular, the present invention provides perinucleolar compartments and their resident molecules as cancer markers. | 03-25-2010 |
20120309017 | PERINUCLEOLAR COMPARTMENT AS A CANCER MARKER - The present invention relates to compositions and methods for cancer diagnostics, prognostics and predictions, including but not limited to, cancer markers. In particular, the present invention provides perinucleolar compartments and their resident molecules as cancer markers. | 12-06-2012 |
Patent application number | Description | Published |
20080216076 | METHODS FOR DISTRIBUTING PROGRAMS FOR GENERATING TEST DATA - Described herein are methods and systems for distributed execution of circuit testing algorithms, or portions thereof. Distributed processing can result in faster processing. Algorithms or portions of algorithms that are independent from each other can be executed in a non-sequential manner (e.g., parallel) over a network of plurality of processors. The network comprises a controlling processor that can allocate tasks to other processors and conduct the execution of some tasks on its own. Dependent algorithms, or portions thereof, can be performed on the controlling processor or one of the controlled processors in a sequential manner. To ensure consistency between the performance of algorithms, or portions thereof, in a distributed manner and a non-distributed manner, the order of processing results from execution is according to some pre-determined order, or according to the order in which the results would have been processed during a non-distributed (e.g., sequential) execution, for instance. For algorithms that are highly sequential in nature, portions of algorithms can be modified to delay the need for dependent results between algorithm portions by creating a rolling window of independent tasks that is iterated. | 09-04-2008 |
20080320352 | METHODS FOR DISTRIBUTION OF TEST GENERATION PROGRAMS - As described herein, circuit testing algorithms, or portions thereof, can be executed in a distributed manner so that their execution can be over a network of processors. In one aspect, the results that are obtained by such distributed execution are ensured to be consistent with the results that would be obtained by executing them in a non-distributed manner. Thus, in one aspect, the algorithms, or portions thereof, have to be made distributable. The algorithms, or portions thereof, are made distributable by isolating any random number generation therewith to be independent of each other. This isolation applies to any random number generation associated with different call instances of the same algorithm as well. In one aspect, the isolation is accomplished by ensuring that the calculation of random number sequences for the algorithms, or portions thereof, is not dependent on random number sequences calculated for the others or between call instances of the same algorithm. | 12-25-2008 |
20090249147 | FAULT DIAGNOSIS OF COMPRESSED TEST RESPONSES - Methods, apparatus, and systems for diagnosing failing scan cells from compressed test responses are disclosed herein. For example, in one nonlimiting exemplary embodiment, at least one error signature comprising multiple bits (including one or more error bits) is received. Plural potential-error-bit-explaining scan cell candidates are evaluated using a search tree. A determination is made as to whether one or more of the evaluated scan cell candidates explain the error bits in the error signature and thereby constitute one or more failing scan cells. An output is provided of any such one or more failing scan cells determined. Tangible computer-readable media comprising computer-executable instructions for causing a computer to perform any of the disclosed methods are also provided. Tangible computer-readable media comprising lists of failing scan cells identified by any of the disclosed methods are also provided. | 10-01-2009 |
20120174049 | TIMING-AWARE TEST GENERATION AND FAULT SIMULATION - Disclosed herein are exemplary methods, apparatus, and systems for performing timing-aware automatic test pattern generation (ATPG) that can be used, for example, to improve the quality of a test set generated for detecting delay defects or holding time defects. In certain embodiments, timing information derived from various sources (e.g. from Standard Delay Format (SDF) files) is integrated into an ATPG tool. The timing information can be used to guide the test generator to detect the faults through certain paths (e.g., paths having a selected length, or range of lengths, such as the longest or shortest paths). To avoid propagating the faults through similar paths repeatedly, a weighted random method can be used to improve the path coverage during test generation. Experimental results show that significant test quality improvement can be achieved when applying embodiments of timing-aware ATPG to industrial designs. | 07-05-2012 |
20140047404 | TIMING-AWARE TEST GENERATION AND FAULT SIMULATION - Disclosed herein are exemplary methods, apparatus, and systems for performing timing-aware automatic test pattern generation (ATPG) that can be used, for example, to improve the quality of a test set generated for detecting delay defects or holding time defects. In certain embodiments, timing information derived from various sources (e.g. from Standard Delay Format (SDF) files) is integrated into an ATPG tool. The timing information can be used to guide the test generator to detect the faults through certain paths (e.g., paths having a selected length, or range of lengths, such as the longest or shortest paths). To avoid propagating the faults through similar paths repeatedly, a weighted random method can be used to improve the path coverage during test generation. Experimental results show that significant test quality improvement can be achieved when applying embodiments of timing-aware ATPG to industrial designs. | 02-13-2014 |
20150323600 | TIMING-AWARE TEST GENERATION AND FAULT SIMULATION - Disclosed herein are exemplary methods, apparatus, and systems for performing timing-aware automatic test pattern generation (ATPG) that can be used, for example, to improve the quality of a test set generated for detecting delay defects or holding time defects. In certain embodiments, timing information derived from various sources (e.g. from Standard Delay Format (SDF) files) is integrated into an ATPG tool. The timing information can be used to guide the test generator to detect the faults through certain paths (e.g., paths having a selected length, or range of lengths, such as the longest or shortest paths). To avoid propagating the faults through similar paths repeatedly, a weighted random method can be used to improve the path coverage during test generation. Experimental results show that significant test quality improvement can be achieved when applying embodiments of timing-aware ATPG to industrial designs. | 11-12-2015 |
Patent application number | Description | Published |
20090048023 | METHOD AND APPARATUS FOR RECORDING AND REPLAYING NETWORK GAME - Embodiments of the present invention provide a method for recording and replaying a network game. The method includes copying all game messages sent by a game server to a game client during a game process; replaying the game process according to the copied game messages. Besides, embodiments of the present invention also provide an apparatus for recording and replaying a network game. In accordance with the method and apparatus in the embodiments of the present invention, unlike the prior art, the technical solution of recording and replaying a network game is independent of the network game itself and is dependent on the game messages sent by the game server. Therefore, the technical solution in the embodiments of the present invention can be used commonly for recording and replaying to all kinds of network games. | 02-19-2009 |
20110204973 | AMPLIFYING DEVICE AND SIGNAL PROCESSING METHOD BASED ON AMPLIFYING DEVICE - An amplifying device and a signal processing method based on an amplifying device are provided, capable of reducing performance requirements of modules and reducing design difficulty of the modules. The amplifying device includes at least one amplifying module, including two receiving paths, in which a first receiving path is configured to attenuate and amplify an input signal after the input signal is pre-amplified, and a second receiving path is configured to amplify the input signal when the input signal is not pre-amplified. The signal processing method based on the amplifying device is further provided. The amplifying device and the signal processing method may be applied in a communication network system. | 08-25-2011 |
20120134302 | Method and Service Device for Realizing a Private Call During A Conference in an IP Multimedia Subsystem - The present application discloses a method for realizing a private call during a conference in an IP multimedia subsystem, which includes the following steps: a service device receives a first request message that is sent by a first communication device to request a private call with a second communication device; if the first communication device is a communication device at the conference presider side, the service device modifies conference media of the communication device having participated in the conference within the first and the second communication devices; and after modifying the conference media, the service device establishes a private call between the first and the second communication devices. The present application also correspondingly discloses a service device for realizing a private call during a conference in an IP multimedia subsystem. In the present application, after a request for a private call is received, the conference media of the conference presider and/or conference members is modified, thus enabling the conference presider or conference members to make a private call with the conference members or the conference presider freely or as needed. | 05-31-2012 |
20120195414 | Method and system for service access of user in access gateway control function entity - The disclosure discloses a method for a service access of a user in an Access Gateway Control Function (AGCF) entity, wherein a corresponding relationship between a logic number and a physical number of the user in the AGCF entity is stored in a Home User Server (HSS), the method includes that: in a registration process initiated by the user, the AGCF entity acquires the corresponding relationship between the physical number of the user and the logic number of the user from the HSS and stores it. The disclosure further discloses a system for a service access of a user in an AGCF entity, the system includes: a first storage unit, located in the HSS and configured to store a corresponding relationship between the logic number of the user and the physical number of the user in the AGCF entity; a registration unit, configured to register the user; a first acquisition unit, configured to acquire the corresponding relationship between the physical number of the user and the logic number of the user from the HSS in a registration process initiated by the user; and a second storage unit, located in the AGCF entity and configured to store the corresponding relationship between the logic number of the user and the physical number of the user. The disclosure realizes very low maintenance cost during a diversion and other operation. | 08-02-2012 |
20120201369 | Method and System for Performing Communication Transfer Service for Access Gateway Control Function User - The disclosure provides a method for performing a communication transfer service for an access gateway control function user, comprising: after the AGCF user accesses to a public Switched Telephone Network/Integrated Services Digital Network Emulation Subsystem (PSTN/ISDN Emulation Subsystem (PES)), performing the communication transfer service for the AGCF user, by applying a tight/loose coupling mode between an AGCF and an application server (AS) and by applying an AS main control/end to end control mode between the AS and non-AGCF users. The disclosure also provides a system for performing a communication transfer service for an access gateway control function user, comprising: a communication transfer unit configured to perform the communication transfer service for the user belonging to the AGCF by applying a tight/loose coupling mode between the AGCF and an application server (AS) and by applying an AS main control/end to end control mode between the AS and non-AGCF users. The communication transfer service for a user belonging to the AGCF can be is performed by using the method and the system of the disclosure. | 08-09-2012 |
20140309030 | COMMUNICATION METHOD, SYSTEM, SERVER AND CLIENT DEVICE FOR USER-INTERACTIVE SYSTEM - Communication methods, systems, servers, and client devices in a user-interactive system are provided herein. In an exemplary method, a communication interface can be started via a first user-interactive client by a first user to communicate with one or more communication tools via a communication backend server. The first user-interactive client can obtain and display a plurality of second user IDs of second users. The first user-interactive client can receive one or more second user IDs selected by the first user to add to a communication group. The first user-interactive client can send to the communication backend server a message for joining the communication group containing the one or more second user IDs. After receiving an accepting message from the communication backend server, during a user-interactive operation, the first user-interactive client can communicate with a second client corresponding to a user ID contained in the accepting message. | 10-16-2014 |
20150163255 | Method for Switching Session of IMS Network and EATF - A method for switching a session of an IP Multimedia Subsystem (IMS) network and an Emergency Access Transfer Function (EATF) entity are disclosed. The method includes: the EATF entity anchoring a call sent by a network element in a call initiation domain, and routing the call to an Emergency-Call Session Control Function (E-CSCF); the EATF entity receiving call transfer invite message sent by a network element in a call termination domain; and if identifying that the call transfer invite message is an invite message inviting to perform transfer of the call, the EATF entity performing media negotiation, and sending a response message carrying media information to the network element in the call termination domain. | 06-11-2015 |
20150304024 | Method and Device for Allocating Code Offset - A method and device for distributing a code offset are provided. The method includes: an RNC equally dividing the access time of a UE into one or more sets of access time which are not overlapped with one another, wherein each set of access time comprises one or more timeslots; and the RNC distributing a corresponding code offset τ | 10-22-2015 |
Patent application number | Description | Published |
20090035940 | COPPER METALLIZATION OF THROUGH SILICON VIA - A method for metallizing a through silicon via feature in a semiconductor integrated circuit device substrate comprising immersing the semiconductor integrated circuit device substrate into an electrolytic copper deposition composition comprising a source of copper ions, an organic sulfonic acid or inorganic acid, or one or more organic compounds selected from among polarizers and/or depolarizers, and chloride ions. | 02-05-2009 |
20130199935 | COPPER FILLING OF THROUGH SILICON VIAS - A method for metallizing a through silicon via feature in a semiconductor integrated circuit device substrate. The method comprises immersing the semiconductor integrated circuit device substrate into an electrolytic copper deposition composition, wherein the through silicon via feature has an entry dimension between 1 micrometers and 100 micrometers, a depth dimension between 20 micrometers and 750 micrometers, and an aspect ratio greater than about 2:1; and supplying electrical current to the electrolytic deposition composition to deposit copper metal onto the bottom and sidewall for bottom-up filling to thereby yield a copper filled via feature. The deposition composition comprises (a) a source of copper ions; (b) an acid selected from among an inorganic acid, organic sulfonic acid, and mixtures thereof; (c) an organic disulfide compound; (d) a compound selected from the group consisting of a reaction product of benzyl chloride and hydroxyethyl polyethyleneimine, a quaternized dipyridyl compound, and a combination thereof; and (d) chloride ions. | 08-08-2013 |
20140120722 | PROCESS FOR FILLING VIAS IN THE MICROELECTRONICS - A process for metalizing a through silicon via feature in a semiconductor integrated circuit device, the process including, during the filling cycle, reversing the polarity of circuit for an interval to generate an anodic potential at said metalizing substrate and desorb leveler from the copper surface within the via, followed by resuming copper deposition by re-establishing the surface of the copper within the via as the cathode in the circuit, thereby yielding a copper filled via feature. | 05-01-2014 |
Patent application number | Description | Published |
20110301342 | APPARATUS AND PROCESS FOR PURIFICATION OF PROTEINS - The invention is directed to an apparatus and method for purifying a protein. The apparatus involves the use of a capture chromatography resin, a depth filter arranged after the capture chromatography resin, and a mixed-mode chromatography resin arranged after the depth filter. The method involves providing a sample containing the protein, processing the sample through a capture chromatography resin, a depth filter, and a mixed-mode chromatography resin. A membrane adsorber or monolith may be substituted for the mixed-mode chromatography column. | 12-08-2011 |
20120264920 | PROCESSES FOR PURIFICATION OF PROTEINS - The invention is directed to a method for purifying a protein. The method involves providing a sample containing the protein, processing the sample through a capture chromatography resin, inactivating viruses in the sample, and processing through at least one depth filter and ion-exchange membrane. | 10-18-2012 |
20130195888 | ULTRAFILTRATION AND DIAFILTRATION FORMULATION METHODS FOR PROTEIN PROCESSING - Disclosed herein are methods of purifying proteins using ultrafiltration and diafiltration processes. | 08-01-2013 |
20130336957 | NOVEL PURIFICATION OF HUMAN, HUMANIZED, OR CHIMERIC ANTIBODIES USING PROTEIN A AFFINITY CHROMATOGRAPHY - Disclosed herein are compositions and methods for the isolation and purification of antibodies from a sample matrix. In particular, the present invention relates to compositions and methods for isolating and purifying antibodies exhibiting low or high binding capacity for Protein A resin. In certain embodiments, the methods herein employ a kosmotropic salt solution, an affinity chromatographic step, and may include one or more additional chromatography and/or filtration steps to achieve the desired degree of purification. The present invention is also directed toward pharmaceutical compositions comprising one or more antibodies purified by a method described herein. | 12-19-2013 |
20140154270 | PURIFICATION OF NON-HUMAN ANTIBODIES USING KOSMOTROPIC SALT ENHANCED PROTEIN A AFFINITY CHROMATOGRAPHY - The present invention is directed to methods for purifying a non-human antibody, or antigen binding portion thereof, exhibiting weak binding strength and low binding capacity for Protein A chromatography media. In one aspect, a kosmotropic salt solution is employed to promote the hydrophobic interaction between the non-human antibody, or antigen binding portion thereof, and the Protein A ligand, thereby enhancing the binding of the non-human antibody, or antigen binding portion thereof, to the Protein A chromatography media. In another aspect, the concentration of the non-human antibody, or antigen binding portion thereof, in a sample comprising the antibody, or antigen binding portion thereof, exposed to a Protein A chromatography media is increased to enhance the binding of the non-human antibody, or antigen binding portion thereof, on the Protein A chromatography media. | 06-05-2014 |
20140275494 | PROTEIN PURIFICATION USING DISPLACEMENT CHROMATOGRAPHY - Disclosed herein are compositions and methods for the isolation and purification of proteins from a sample. In particular, the present invention relates to compositions and methods for isolating and purifying proteins incorporating a displacement chromatographic step. The present invention is also directed toward pharmaceutical compositions comprising one or more antibodies purified by a method described herein. | 09-18-2014 |
20140323697 | MEDIA FOR AFFINITY CHROMATOGRAPHY - The invention relates generally to solid supports for chromatography. In specific embodiments the invention provides for solid supports suitable for affinity chromatography along with methods, systems and kits which use the same. | 10-30-2014 |
20150065696 | APPARATUS AND PROCESS FOR PURIFICATION OF PROTEINS - The invention is directed to an apparatus and method for purifying a protein. The apparatus involves the use of a capture chromatography resin, a depth filter arranged after the capture chromatography resin, and a mixed-mode chromatography resin arranged after the depth filter. The method involves providing a sample containing the protein, processing the sample through a capture chromatography resin, a depth filter, and a mixed-mode chromatography resin. A membrane adsorber or monolith may be substituted for the mixed-mode chromatography column. | 03-05-2015 |
20150110803 | LOW ACIDIC SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME USING DISPLACEMENT CHROMATOGRAPHY - The present invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods for producing such low AR compositions using displacement chromatography. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided. | 04-23-2015 |
20150329588 | PROTEIN PURIFICATION USING DISPLACEMENT CHROMATOGRAPHY - Disclosed herein are compositions and methods for the isolation and purification of proteins from a sample. In particular, the present invention relates to compositions and methods for isolating and purifying proteins incorporating a displacement chromatographic step. The present invention is also directed toward pharmaceutical compositions comprising one or more antibodies purified by a method described herein. | 11-19-2015 |