Patent application number | Description | Published |
20100151560 | Compact disk based platform for separating and detecting immunomagnetic bead labeled cells - Disclosed is a disk based platform for separating and detecting cells that are labeled with immunomagnetic beads. A disk-like carrier board forms therein at least one flow channel structure, which includes an inner reservoir for receiving a sample fluid, an outer reservoir, and a plurality of micro flow channels arranged between and in fluid communication with the inner and outer reservoirs. When the disk-like carrier board spins, cells labeled with immunomagnetic beads are attracted by a magnetic attraction unit that is arranged above the disk-like carrier board and adjacent to the inner reservoir to thereby remain in the inner reservoir, and cells that are not so labeled are acted upon by a centrifugal force induced by the spinning of the disk-like carrier board to flow with the sample fluid from the inner reservoir through the micro flow channels into the outer reservoir. | 06-17-2010 |
20100227379 | Compact disk based system for separating immunomagnetic bead labeledparticulates and method thereof - Disclosed is a disk based system for separating at least two types of particulates contained in a sample fluid. The system includes a disk-like carrier board and a magnetic attraction unit. The disk-like carrier board forms at least one flow channel structure, which includes an inner reservoir, at least one separation chamber, and at least one outer reservoir arranged in sequence from a geometric center of the disk-like carrier board to an outer circumferential rim of the disk-like carrier board. A method of separation carried out with the system includes introducing the sample fluid into the inner reservoir and then rotating the disk-like carrier board to induce a centrifugal force. The sample fluid contains particulates that are labeled with immunomagnetic beads and the labeled particulates are attracted by the magnetic force generated by the magnetic attraction unit to retain in the inner reservoir or the separation chamber. Particulates not labeled with the immunomagnetic beads and contained in the sample fluid move with the sample fluid to the outer reservoir. | 09-09-2010 |
20110059500 | METHOD FOR SEPARATING IMMUNOMAGNETIC BEAD LABELED PARTICULATES - Disclosed is a method for separating immunomagnetic bead labeled particulates. A carrier board is formed with at least one flow channel structure, which includes an inner reservoir, an outer reservoir, and at least one micro flow channel in communication with the inner reservoir and the outer reservoir. The method includes labeling target particulates with immunomagnetic bead, introducing a sample fluid into the inner reservoir, and applying a magnetic force and a driving force, wherein the driving force drives the particulates not labeled with immunomagnetic bead to flow through the micro flow channel to the outer reservoir, while the magnetic force attracts the particulates labeled with the immunomagnetic bead to retain in the inner reservoir. The driving force may be centrifugal force, pressure, or surface tension. | 03-10-2011 |
20120024083 | DISK-BASED FLUID SAMPLE SEPARATION DEVICE - A disk-based fluid sample separation device including at least one air vent forming a part of a flow channel pattern on a microfluidic disk is disclosed. The fluid sample separation device is provided with an air vent sealing cover having at least through hole and is placed on the top surface of the disk. The air vent sealing cover is rotated with respect to the disk either at a first position or a second position. At the first position, the hole of the air vent sealing cover is in correspondence to the air vent of the flow channel pattern to control the sample liquid delivery. At the second position, the air vent of the flow channel pattern is closed. The flow channel pattern includes at least one sample storage reservoir, at least one sample processing reservoir, and at least one communication channel which is in fluid communication between the sample storage reservoir and the sample processing reservoir. In alternative, the status of the hole of the air vent sealing cover is controlled by a control unit. | 02-02-2012 |
20120039769 | DISK-BASED FLUID SAMPLE COLLECTION DEVICE - A fluid sample collection device for a disk-based fluid separation system is disclosed. The disk-based separation system includes a compact microfluidic disk with at least one flow channel pattern formed on a side surface of the disk. At least one orifice is formed on an outflow boundary of the disk and is designed in fluid communication with the flow channel pattern through a communication channel. The fluid sample collection device includes at least one collection tube having an open end serving as a fluid receiving end and corresponding to the orifice of the disk with a distance. When the disk is rotated, at least a portion of fluid sample in a sample processing reservoir formed on the disk is delivered by centripetal force through the communication channel and the orifice, and finally the expelling fluid sample is collected in the collection tube. | 02-16-2012 |
20130287648 | DISK-BASED FLUID SAMPLE COLLECTION DEVICE - A fluid sample collection device for a disk-based fluid separation system is disclosed. The disk-based separation system includes a compact microfluidic disk with at least one flow channel pattern formed on a side surface of the disk. At least one orifice is formed on an outflow boundary of the disk and is designed in fluid communication with the flow channel pattern through a communication channel. The fluid sample collection device includes at least one collection tube having an open end serving as a fluid receiving end and corresponding to the orifice of the disk with a distance. When the disk is rotated, at least a portion of fluid sample in a sample processing reservoir formed on the disk is delivered by centripetal force through the communication channel and the orifice, and finally the expelling fluid sample is collected in the collection tube. | 10-31-2013 |