Chen, CT
Alexander Chen, Ellington, CT US
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20090094984 | Staging for rich catalytic combustion - A catalytic reactor for a gas turbine engine comprising an air inlet, a premixing zone, a reacting zone comprising a reactive portion and a nonreactive portion, a post reaction mixing zone, a first fuel injection system for introducing fuel into the reactive portion, and a second fuel injection system for introducing fuel into the nonreactive portion. | 04-16-2009 |
20100206535 | HEAT EXCHANGERS HAVING BAFFLED MANIFOLDS - A heat exchanger for a fluid having a vapor-phase and a liquid-phase is provided. The heat exchanger includes a first manifold, a second manifold, a plurality of parallel channels, a mixing device, and one or more baffles. The parallel channels are in fluid communication with the first and second manifolds. The mixing device mixes the fluid flowing into the first manifold so that the fluid is a substantially homogeneous two-phase mixture of the vapor and liquid phases. The baffles are within the first manifold and ensure that the fluid enters the parallel channels as the substantially homogeneous two-phase mixture. | 08-19-2010 |
20100293962 | METHOD FOR CONFIGURING COMBINED HEAT AND POWER SYSTEM - A CHP system can include one or more heat sources generating heat output and producing emissions. The CHP system can further include one or more power converters configured to convert the heat into a useful power output. The power converters can deliver the balance of heat to one or more thermally-activated devices (TADs) configured to convert the heat into a useful thermal (heating and cooling) output. The method for configuring the CHP system can comprise the steps of: representing the useful power output by the power converters as a function of the heat output by the heat sources; representing the useful thermal output by the TADs as a function of the heat output by the heat sources; representing the specific emission output as a function of the heat output by the heat sources; and determining the values of the individual heat source heat output which are sufficient to attain the pre-defined levels for useful power output and useful thermal output, while meeting the regulated specific emission levels. | 11-25-2010 |
20110132585 | HEAT EXCHANGER TUBE CONFIGURATION FOR IMPROVED FLOW DISTRIBUTION - A microchannel heat exchanger includes for each channel, a serpentine shaped tube for providing a plurality of parallel flow passes for successively conducting fluid flow therethrough, and being fluidly interconnected between an inlet and an outlet manifold. Multiple circuits are obtained by the individual serpentine shaped tubes. Various methods are provided for forming the serpentine shaped tubes. | 06-09-2011 |
Alexander G. Chen, Ellington, CT US
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20100064894 | FUEL SYSTEM AND METHOD OF REDUCING EMISSION - A fuel system includes a fuel deoxygenator for removing oxygen from a liquid fuel. A vaporizer is in fluid communication with the fuel deoxygenator. The vaporizer vaporizes at least a portion of the liquid fuel to produce vaporized fuel. At least a portion of the vaporized fuel pre-mixes with oxidizer to reduce formation of undesirable emissions. | 03-18-2010 |
Augustin T. Chen, Cheshire, CT US
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20080249239 | Process for improving water-whitening resistance of pressure sensitive adhesives - Pressure sensitive adhesive compositions having enhanced resistance to water-whitening comprising an aqueous emulsion polymer are disclosed. The polymer comprises the polymerization reaction product of a polymerizable aqueous emulsion comprising: (i) at least one hydrophobic alkyl acrylate or alkyl methacrylate ester of an alcohol, (ii) at least about 1 wt. % of at least one hydrophilic monomer, (iii) at least about 5 wt. % of at least one partially hydrophilic alkyl acrylate or alkyl methacrylate ester of an alcohol, and (iv) a water-soluble or water-dispersible polymerizable surfactant selected from compounds having a terminal allyl amine moiety, substituted phenyl compounds having at least one alkenyl substituent, polyoxyalkylene-1-(allyloxymethyl) alkyl ether sulfate salts, or mixtures thereof, and the average particle size of the polymer is less than or equal to 200 nm. Also disclosed are processes for preparing same. | 10-09-2008 |
Augustin Chen, Cheshire, CT US
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20100081764 | AQUEOUS POLYMER DISPERSION AND PROCESS - There is described a multi step process for preparing an aqueous dispersion of heterogeneous polymer particles by mini-emulsion polymerisation, the process comprising the steps of (I) (a) forming a mixture comprising: (i) water; (ii) at least one stabiliser (such as a surfactant and a hydrophobic co-stabiliser); (iii) at least one tackifier (such as polyterpenes, rosin resins and/or hydrocarbon resins); (iv) at least one α,β-ethylenically unsaturated monomer; (b) applying high shear to the mixture from step (a) to form an essentially stable mini-emulsion comprising an aqueous continuous phase and dispersed therein stabilised droplets of average diameter from about 10 to about 1000 nm, (c) polymerising the monomer(s) within the droplets in the presence of a free radical initiator; (d) adding further monomer to the dispersed phase to form a dispersion; then: (II) using the dispersion from step (I) as a seed to form a dispersion of heterogeneous polymer particles in a subsequent emulsion polymerisation. The resultant tackified PSAs may have a core shell structure and are stable under high shear. | 04-01-2010 |
20100093930 | Polymer Composition and Process - There is described a multi step mini-emulsion process for preparing a hybrid acrylic/polyurethane pressure sensitive adhesive (PSA) of very high shear strength, good peel strength and/or also high moisture vapor transmission rate, the process comprising the steps of: a) forming a first aqueous mixture comprising a hydrophilic stabilizer; b) forming separately a second oil mixture comprising: i) at least one vinyl functional polyurethane (optionally prepared from an isocyanate functional monomer; at least one monol and/or at least one α,β-ethylenically unsaturated monomer ii) optionally at least one hydrocarbon polymer (such as polystyrene); and iii) at least one α,β-ethylenically unsaturated monomer (such as (meth)acrylate or acids thereof; and/or iv) option-=ally at least one hydrophobic stabilizer; where components (ii), (iii) and/or (iv) may optionally be the same; c) mixing the aqueous and oil mixtures together to form a pre-(macro) emulsion; d) generating a stable mini-emulsion there-from optionally by applying high shear to form an aqueous continuous phase and stabilized oil droplets of average diameter from about 10 to about 1000 nm, and e) polymerizing the polymer precursor(s) within the droplets, optionally in the presence of a free radical initiator; to obtain a polymer latex. | 04-15-2010 |
Bing-Guan Chen, Madison, CT US
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20080293659 | FC gamma RIIA-specific nucleic acid interference - The present invention provides methods and compositions for attenuating expression of FcγRIIA. In general, the described methodology involves the use of RNAi constructs that are targeted to a FcγRIIA mRNA sequence. | 11-27-2008 |
Chung-Pin H. Chen, Madison, CT US
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20100210599 | PRODRUGS OF PIPERAZINE AND SUBSTITUTED PIPERIDINE ANTIVIRAL AGENTS - This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection. | 08-19-2010 |
20120238755 | SALTS OF PRODRUGS OF PIPERAZINE AND SUBSTITUTED PIPERIDINE ANTIVIRAL AGENTS - This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection. | 09-20-2012 |
20130030178 | METHODS OF MAKING HIV ATTACHMENT INHIBITOR PRODRUG COMPOUND AND INTERMEDIATES - A method for making the compound of Formula I: | 01-31-2013 |
20130253196 | SALTS OF PRODRUGS OF PIPERAZINE AND SUBSTITUTED PIPERIDINE ANTIVIRAL AGENTS - This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection. | 09-26-2013 |
20150025240 | SALTS OF PRODRUGS OF PIPERAZINE AND SUBSTITUTED PIPERIDINE ANTIVIRAL AGENTS - This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection. | 01-22-2015 |
Dawei Chen, Middletown, CT US
Patent application number | Description | Published |
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20090023730 | SUBSTITUTED ARYL ACYLTHIOUREAS AND RELATED COMPOUNDS; INHIBITORS OF VIRAL REPLICATION - The invention provides compounds and pharmaceutically acceptable salts of Formula I | 01-22-2009 |
20090041720 | HETEROARYL SUBSTITUTED THIAZOLES - The invention provides heteroaryl substituted thiazolo compounds of Formula I and II | 02-12-2009 |
20090082261 | UREA-CONTAINING PEPTIDES AS INHIBITORS OF VIRAL REPLICATION - The invention provides compounds urea-containing peptide compounds of Formula I | 03-26-2009 |
20100152103 | 4-AMINO-4-OXOBUTANOYL PEPTIDE CYCLIC ANALOGUES, INHIBITORS OF VIRAL REPLICATION - The invention provides 4-amino-4-oxobutanoyl peptides and cyclic analogues thereof of Formula I | 06-17-2010 |
20100216725 | 4-AMINO-4-OXOBUTANOYL PEPTIDES AS INHIBITORS OF VIRAL REPLICATION - The invention provides 4-amino-4-oxobutanoyl peptides of Formula I | 08-26-2010 |
20100292219 | TERTIARY AMINE SUBSTITUTED PEPTIDES USEFUL AS INHIBITORS OF HCV REPLICATION - The present invention provides tertiary amine substituted peptides of Formula (I) useful as inhibitors of HCV replication. The variables R and R | 11-18-2010 |
20120108576 | THIAZOLE COMPOUNDS AND METHODS OF USE - The present invention provides compounds, salts and hydrates of Formula I, | 05-03-2012 |
20120302538 | SUBSITUTED ALIPHANES, CYCLOPHANES, HETERAPHANES, HETEROPHANES, HETERO-HETERAPHANES AND METALLOCENES USEFUL FOR TREATING HCV INFECTIONS - The present disclosure provides substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes, of Formula I | 11-29-2012 |
20140113890 | NEW 4-AMINO-4-OXOBUTANOYL PEPTIDES AS INHIBITORS OF VIRAL REPLICATION - The invention provides 4-amino-4-oxobutanoyl peptides of Formula I | 04-24-2014 |
20140206604 | 4-AMINO-4-OXOBUTANOYL PEPTIDE CYCLIC ANALOGUES, INHIBITORS OF VIRAL REPLICATION - The invention provides 4-amino-4-oxobutanoyl peptides and cyclic analogues thereof of Formula I | 07-24-2014 |
20140323458 | SUBSTITUTED ALIPHANES, CYCLOPHANES, HETERAPHANES, HETEROPHANES, HETERO-HETERAPHANES AND METALLOCENES USEFUL FOR TREATING HCV INFECTIONS - The present disclosure provides substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes, of Formula I | 10-30-2014 |
Dean Chen, Easy Haven, CT US
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20140297470 | SYSTEMS AND METHODS TO DELIVER GOODS TO A BUYER THAT IS DYNAMICALLY LOCATED - Systems and methods to deliver goods to a buyer that is dynamically located are described. The system communicates a user interface to a device that is identified as being located at a first location and associated with a customer. The user interface includes items that are identified as being located within a predetermined distance from the device. The system receives an order from the device that authorizes the purchase of an item and delivery of the item to the customer. The system automatically selects a courier from a plurality of couriers that are identified as being located at different locations. The system communicates a user interface to a courier mobile device that includes instructions to enable the courier to retrieve the item from a second location and deliver the item to the first location. | 10-02-2014 |
Felix Chen, Newtown, CT US
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20090153011 | INJECTOR FOR BETATRON - An electron acceleration portion of a Betatron having a vacuum chamber with an interior wall spaced from an exterior wall with a main electron orbit located approximate to the exterior wall and the interior wall. An electron injector has an anode structured and arranged adjacent a wall selected from the group consisting of the interior wall and the exterior wall that is shaped so as to not impede the main electron orbit. There is at least one electron deflection plate disposed approximate an anode end of the anode and the main electron orbit. There can be two electron deflection plates spaced apart that form a gap of a width effective to receive emitted electrons from the electron injector. Such that, there is a voltage potential between the two electron deflection plates that is effective to deflect emitted electrons towards the main electron orbit. | 06-18-2009 |
20090153279 | SINGLE DRIVE BETATRON - A betatron includes a betatron magnet with a first guide magnet having a first pole face and a second guide magnet having a second pole face. Both the first and the second guide magnet have a centrally disposed aperture and the first pole face is separated from the second pole face by a guide magnet gap. A core is disposed within the centrally disposed apertures in an abutting relationship with both guide magnets. The core has at least one core gap. A drive coil is wound around both guide magnet pole faces. An orbit control coil has a contraction coil portion wound around the core gap and a bias control portion wound around the guide magnet pole faces. The contraction coil portion and the bias control portion are connected but in opposite polarity. Magnet fluxes in the core and guide magnets return through peripheral portions of the betatron magnet. | 06-18-2009 |
20100057378 | DOWNHOLE SANDING ANALYSIS TOOL - Methods and devices for detecting particles in a fluid within a medium, such the analyzing device includes: a source adapted to transmit signals into the medium; at least one detector adapted to detect signals transmitted from the source such that the at least one detector and the source are structured and arranged on opposite sides of the medium; at least one processing unit in communication with the at least one detector and adapted to produce a plurality of output signals representative of one of at least one particle characteristic or one or more particle property. | 03-04-2010 |
20110307179 | METHOD OF EXTRACTING FORMATION DENSITY AND PE USING A PULSED ACCELERATOR BASED LITHO-DENSITY TOOL - A method for a pulsed gamma-gamma density tool to simultaneously compensate for interactions due to the photoelectric effect and density variations caused by standoff enables a more precise determination of bulk formation density. This method includes the steps of providing a source of energetic particles and directing those energetic particles at a formation having a known photoelectric factor and electron density and capturing one or more photons either emitted or deflected from the formation either a first detector or a second detector. The first detector is spaced a first distance from the source, the second detector is spaced a second distance from the detector and a third distance separates the first detector from the second detector. Measuring a first total energy of the photons striking the first detector during a time interval and measuring a second total energy of the photons striking the second detector as a function of the time interval and disposing a first filter between the first detector and the formation effective to cause Pe response to match standoff influence thereby compensating for both effects simultaneously. In addition to the first filter, the required compensation may include a second filter between the second detector and the formation as well as adjustments to the respective first distance, second distance and third distance. | 12-15-2011 |
Felix K. Chen, Newtown, CT US
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20100148705 | METHOD OF DRIVING AN INJECTOR IN AN INTERNAL INJECTION BETATRON - A betatron magnet, the betatron magnet comprising at least one electron injector positioned approximate an inside of a radius of an betatron orbit, such that electrons are injected into the betatron orbit with the at least one electron injector positioned within an electron acceleration passageway, whereby the electron acceleration passageway is located within a vacuum chamber; and wherein the at least one electron injector is driven with an inductive means. | 06-17-2010 |
20100150312 | INTERNAL INJECTION BETATRON - A betatron magnet having at least one electron injector positioned approximate an inside of a radius of a betatron orbit, the betatron magnet further includes a first guide magnet having a first pole face and a second guide magnet having a second pole face. Both the first and the second guide magnet have a centrally disposed aperture and the first pole face is separated from the second pole face by a guide magnet gap. A core is disposed within the centrally disposed apertures in an abutting relationship with both guide magnets. The core has at least one core gap. A drive coil is wound around both guide magnet pole faces. An orbit control coil has a core portion wound around the core gap and a field portion wound around the guide magnet pole faces. The core portion and the field portion are connected but in opposite polarity. | 06-17-2010 |
Feng-Jing Chen, Danbury, CT US
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20100278918 | EXTENDED RELEASE FORMULATION OF NEVIRAPINE - The invention relates to an extended release pharmaceutical composition comprising nevirapine. | 11-04-2010 |
20110160149 | Pharmaceutical Composition for a Hepatitis C Viral Protease Inhibitor - Disclosed is a pharmaceutical composition of a hepatitis C viral protease inhibitor which is suitable for oral administration via a liquid- or semi-solid-filled capsule and methods of using this composition for inhibiting the replication of the hepatitis C virus (HCV) and for the treatment of an HCV infection. The liquid- or semi-solid pharmaceutical composition of the present invention comprises a compound of formula I, or a pharmaceutically acceptable salt thereof, together with one or more pharmaceutically acceptable lipids and hydrophilic surfactants. | 06-30-2011 |
20150064243 | PHARMACEUTICAL COMPOSITIONS AND DOSAGE FORMS FOR ADMININISTRATION OF HYDROPHOBIC DRUGS - Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs are provided. The pharmaceutical compositions include a therapeutically effective amount of a hydrophobic drug, preferably a steroid; a solubilizer, and a surfactant. The synergistic effect between the hydrophobic drug and the solubilizer results in a pharmaceutical formulation with improved dispersion of both the active agent and the solubilizer. As a result of the improved dispersion, the pharmaceutical composition has improved bioavailability upon administration. Methods of improving the bioavailability of hydrophobic drugs administered to a patient are also provided. | 03-05-2015 |
Gengxin Chen, Branford, CT US
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20090305899 | Compositions and methods for determining immune status - The present invention provides compositions and methods for identifying molecules in samples that bind to molecules associated with pathogenic agents (e.g., infectious agents). In certain aspects, the invention may be used to identify individuals that have been exposed to one or more pathogenic agent or have generated antibodies in response to one or more pathogenic agent. In other aspects, the invention is directed to the identification of molecules of one or more pathogenic agent that may be used to generate immune responses in other individuals. | 12-10-2009 |
20120094861 | Compositions and Methods for Determining Immune Status - The present invention provides compositions and methods for identifying molecules in samples that bind to molecules associated with pathogenic agents (e.g., infectious agents). In certain aspects, the invention may be used to identify individuals that have been exposed to one or more pathogenic agent or have generated antibodies in response to one or more pathogenic agent. In other aspects, the invention is directed to the identification of molecules of one or more pathogenic agent that may be used to generate immune responses in other individuals. | 04-19-2012 |
Haujie Chen, Danbury, CT US
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20090294923 | Structure and Method for Reducing Threshold Voltage Variation - A structure comprises at least one transistor on a substrate, an insulator layer over the transistor, and an ion stopping layer over the insulator layer. The ion stopping layer comprises a portion of the insulator layer that is damaged and has either argon ion damage or nitrogen ion damage. | 12-03-2009 |
Haunn-Lin Tony Chen, Darien, CT US
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20090169447 | METHODS AND COMPOSITIONS FOR THE REMOVAL OF IMPURITIES AND WATER FROM THE BAYER PROCESS - A liquid phase that comprises an oxalate-extracting amount of an organic salt is useful as an extractant in a liquid/liquid extraction process for purifying Bayer process streams. | 07-02-2009 |
20100021370 | Flotation Reagents and Flotation Processes Utilizing Same - Methods of enhancing recovery of value sulfide or precious minerals from an ore containing Mg-silicate, slime forming minerals, and/or clay by crushing the ore, grinding the ore, and subjecting the ground ore to a flotation process, in conjunction with the addition of at least one monovalent ion modifier enhancing agent and/or froth phase modifier agent to the ore, are provided herein. | 01-28-2010 |
20100098607 | USE OF SILICON-CONTAINING POLYMERS FOR IMPROVED FLOCCULATION OF SOLIDS IN PROCESSES FOR THE PRODUCTION OF ALUMINA FROM BAUXITE - The suspended solids content of a process stream in a process for digesting bauxite ore to produce alumina is reduced by contacting the stream with silicon-containing polymers. | 04-22-2010 |
20120103916 | USE OF SILICON-CONTAINING POLYMERS FOR IMPROVED FLOCCULATION OF SOLIDS IN PROCESSES FOR THE PRODUCTION OF ALUMINA FROM BAUXITE - The suspended solids content of a process stream in a process for digesting bauxite ore to produce alumina is reduced by contacting the stream with silicon-containing polymers. | 05-03-2012 |
20120152852 | PROCESSES FOR REMOVING HYDRAZINE FROM HYDROXYLAMINE SOLUTIONS - The present invention relates to processes for reducing or eliminating the amount of hydrazine from a hydroxylamine-free base containing hydrazine by treating said hydroxylamine-free base with a scavenger agent, and to the hydroxylamine-free base thereby obtained, as well as to its use for producing microdispersions containing a hydroxamated polymer for use as a flocculant in the Bayer process. | 06-21-2012 |
20120153209 | MICRODISPERSIONS OF HYDROXAMATED POLYMERS AND METHODS OF MAKING AND USING THEM - Methods of producing microdispersions containing hydroxamated polymers by reacting water-in-oil microdispersions having vinyl polymers containing one or more pendant functional groups that react with hydroxylamine, with a hydroxylamine-free base substantially free of inorganic salt and containing less than 500 ppm hydrazine are disclosed herein, along with the microdispersions thereby obtained. | 06-21-2012 |
20130315812 | PROCESS FOR REMOVING HYDRAZINE FROM HYDROXLYAMINE SOLUTIONS - The present invention relates to processes for reducing or eliminating the amount of hydrazine from a hydroxylamine-free base containing hydrazine by treating said hydroxylamine-free base with a scavenger agent, and to the hydroxylamine-free base thereby obtained, as well as to its use for producing microdispersions containing a hydroxamated polymer for use as a flocculant in the Bayer process. | 11-28-2013 |
20140314641 | FLOTATION REAGENTS AND FLOTATION PROCESSES UTILIZING SAME - Methods of enhancing recovery of value sulfide and/or precious-metal minerals from an ore containing said minerals and a Mg-silicate, slime forming mineral, and/or clay, and which is subjected to a froth flotation process, by adding to one or more stage of the froth flotation process a froth phase modifier having a polymer containing one or more functional groups, and optionally a monovalent ion modifier enhancing agent, thereby enhancing recovery of a value sulfide mineral and/or a precious metal-bearing mineral. | 10-23-2014 |
H-L Tony Chen, Darien, CT US
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20080257827 | USE OF SILICON-CONTAINING POLYMERS TO IMPROVE RED MUD FLOCCULATION IN THE BAYER PROCESS - The suspended solids content of a Bayer process stream is reduced by contacting the stream with silicon-containing polymers. | 10-23-2008 |
20120125862 | USE OF SILICON-CONTAINING POLYMERS TO IMPROVE RED MUD FLOCCULATION IN THE BAYER PROCESS - The suspended solids content of a Bayer process stream is reduced by contacting the stream with silicon-containing polymers. | 05-24-2012 |
Hui Chuan Chen, Norwich, CT US
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20110272886 | Craps blackjack - A playing method of modified blackjack card game using 6 or 8 decks of standard playing cards without jokers named Craps Blackjack is using two steps wagering, win or lose at two initial cards and continue to play or fold the hand method to play the blackjack card game and provide five optional side bets. It begins with an initial wager on two different wagering circle named Bet and Any Craps, or either one in order initially dealing two cards to players face-up and to a house dealer one card face-up and one card face-down one at a time, then, resolve the wager on first bet named any craps and continue to play with or without additional wager. | 11-10-2011 |
20120181749 | Kan pia baccarat - Kan Pia is a traditional baccarat card game playing with a two steps wagering method with the side bets such as, engage bet, tie and blackjack, by using at least one deck or multi decks standard playing card. It provides players a choice to raise the bet or fold the hand. | 07-19-2012 |
Huimin Chen, Willington, CT US
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20120024799 | Nanostructured Compositions Having Reduced Dissolution of manganese and methods of making and using the same - Nanostructured manganese-containing compositions having reduced manganese dissolution and methods of making and using the same are provided. In one embodiment, a composition of matter comprises a nanostructured oxide or hydroxide doped with Mn | 02-02-2012 |
Ing-Shin Chen, Danbury, CT US
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20080251104 | Systems and Methods for Determination of Endpoint of Chamber Cleaning Processes - Apparatus and method for determination of the endpoint of a cleaning process in which cleaning fluid is contacted with a structure to effect cleaning thereof. The cleaning process includes contacting a cleaning fluid with a structure to be cleaned and producing a cleaning effluent having a sensible heat thermal energy characteristic corresponding to extent of cleaning of the structure, disposing an object in the cleaning effluent that interacts with the cleaning effluent to produce a response indicative of the sensible heat thermal energy characteristic of the cleaning effluent, and monitoring such response to determine when the cleaning is completed. An endpointing algorithm and endpoint monitoring are also described, as well as endpoint monitor sensor elements that are useful to determine endpoint conditions in an efficient and reproduceable manner. | 10-16-2008 |
20090305427 | APPARATUS AND PROCESS FOR SENSING FLUORO SPECIES IN SEMICONDUCTOR PROCESSING SYSTEMS - A gas detector and process for detecting a fluorine-containing species in a gas containing same, e.g., an effluent of a semiconductor processing tool undergoing etch cleaning with HF, NF | 12-10-2009 |
20100139369 | FEEDBACK CONTROL SYSTEM AND METHOD FOR MAINTAINING CONSTANT RESISTANCE OPERATION OF ELECTRICALLY HEATED ELEMENTS - A system and method for controlling electrical heating of an element to maintain a constant electrical resistance, by adjusting electrical power supplied to such element according to an adaptive feedback control algorithm, in which all the parameters are (1) arbitrarily selected; (2) pre-determined by the physical properties of the controlled element; or (3) measured in real time. Unlike the conventional proportion-integral-derivative (PID) control mechanism, the system and method of the present invention do not require re-tuning of proportionality constants when used in connection with a different controlled element or under different operating conditions, and are therefore adaptive to changes in the controlled element and the operating conditions. | 06-10-2010 |
Ing-Shin Barry Chen, Danbury, CT US
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20120131990 | FLUID MONITORING APPARATUS - A fluid monitoring apparatus, including a circuitry housing containing circuitry for processing fluid sensing signals and responsively transmitting an output, with a sensor assembly adapted for mechanical and electrical coupling to the circuitry housing. The sensor assembly includes at least one sensing member arranged to respond to a fluid species of interest in the monitored fluid, for generation of an output. The apparatus includes at least one of (A) a printed circuit board adapted to engage the circuitry housing and to mechanically couple to the sensor assembly, (B) the sensor assembly including a base and sensing element removably connected to the base by press-fit coupling elements, and (C) the sensor assembly including a base and a sensing filament connected thereto, and a filament guard to protectively circumscribe the sensing filament. | 05-31-2012 |
20140134823 | HIGH-K PEROVSKITE MATERIALS AND METHODS OF MAKING AND USING THE SAME - High-k materials and devices, e.g., DRAM capacitors, and methods of making and using the same. Various methods of forming perovskite films are described, including methods in which perovskite material is deposited on the substrate by a pulsed vapor deposition process involving contacting of the substrate with perovskite material-forming metal precursors. In one such method, the process is carried out with doping or alloying of the perovskite material with a higher mobility and/or higher volatility metal species than the metal species in the perovskite material-forming metal precursors. In another method, the perovskite material is exposed to elevated temperature for sufficient time to crystallize or to enhance crystallization of the perovskite material, followed by growth of the perovskite material under pulsed vapor deposition conditions. Various perovskite compositions are described, including: (Sr, Pb)TiO | 05-15-2014 |
Jianging Chen, New Haven, CT US
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20100075967 | PYRIMIDINE DERIVATIVES FOR TREATMENT OF HYPERPROLIFERATIVE DISORDERS - Pyrimidine derivatives of formula (I) | 03-25-2010 |
Jianqing Chen, New Haven, CT US
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20100075971 | SUBSTITUTED PYRIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISORDERS - This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies. | 03-25-2010 |
20110098301 | Pyrimidine Derivatives for Treatment of Hyperproliferative Disorders - Pyrimidine derivatives of formula | 04-28-2011 |
Jianquan Chen, New Haven, CT US
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20140312673 | Easy-to-operate travel sleep bracket - An easy to operate sleep support frame for travelling is disclosed. The support frame includes a movable and curved chest rod which can move from a passenger's chest to the bottom of the seat; a chest cushion connected with the chest rod; and a headrest connected with the chest rod. The headrest can be placed in the back of the front seat or above the chest rod. The chest rod includes a circular arc segment with meshing gear teeth on the inner circular arc side of the chest rod. One end of the chest rod goes through the driving gear box under the seat to be driven by a driving gear box. The passenger can press a button to drive motors to raise chest cushion, and press the button to lower the chest cushion to be close to the seat bottom if the chest cushion is not used. | 10-23-2014 |
Jill Q. Chen, Norwalk, CT US
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20120078796 | SYSTEM AND METHOD FOR PAYMENT FOR BUSINESS REPLY MAIL - A business reply mail payment system and method is provided. A business reply mail payment system establishes a master account with the postal system for the payment of business reply mail. A plurality of mailers each establish a separate account with the payment system and transfer control of payment for business reply mail accepted under their respective permit imprints to the payment system. When the mailer will be receiving business reply mail, a request for payment of postage is made to the payment system, which processes the information related to the business reply mail. The post office acceptance site communicates with the payment system as the business reply mail is received and compares the received business reply mail with the information processed by the payment system to determine if it should be accepted or rejected. If the business reply mail is accepted, the master account is debited for payment. | 03-29-2012 |
Jim Jianquiang Chen, Danbury, CT US
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20140214461 | INDEXING TRAVEL ACCOMMODATIONS IN A NETWORK ENVIRONMENT - A method for evaluating travel accommodations is provided that includes identifying a plurality of hotel properties and assigning a hotel marketability index score to one or more of the properties such that one or more of the properties may be ranked. The hotel marketability index score may be based on a selected one or more characteristics associated with one or more of the hotel properties, the characteristics including rate competitiveness, hotel availability, hotel location within a cluster location, and hotel quality within the cluster location. | 07-31-2014 |
Jinshan Chen, Hamden, CT US
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20100160371 | INHIBITION OF P38 KINASE ACTIVITY BY ARYL UREAS - This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases other than cancer and proteolytic enzyme mediated diseases other than cancer, and pharmaceutical compositions for use in such therapy. | 06-24-2010 |
Jinshan Michael Chen, Madison, CT US
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20120316105 | Polymyxin Derivates Useful As Antibacterial Agents - The present invention provides a new class of polymyxin derivates useful for treating bacterial infections, especially Gram-negative infections, that have reduced renal cytotoxicity. | 12-13-2012 |
20140024690 | Isoxazole Derivatives Useful As Antibacterial Agents - The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections. | 01-23-2014 |
20140038975 | Imidazole, Pyrazole, and Triazole Derivatives Useful As Antibacterial Agents - The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections. | 02-06-2014 |
Jinshan Michael Chen, Clinton, CT US
Patent application number | Description | Published |
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20080280879 | SUBSTITUTED HETEROCYCLIC DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS - Compounds of the general Formula I, wherein X | 11-13-2008 |
20110092480 | Substituted Heterocyclic Derivatives and Their Pharmaceutical Use and Compositions - Compounds of the general Formula I, wherein X | 04-21-2011 |
20120065188 | SUBSTITUTED HETEROCYCLIC DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS - Compounds of the general Formula I, wherein X | 03-15-2012 |
Libing Chen, Milford, CT US
Patent application number | Description | Published |
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20090209451 | HETEROARYLAMINOPYRAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF DIABETES - The present invention relates to heteroarylaminopyrazole compounds, pharmaceutical compositions, and methods for treating diabetes and related disorders. | 08-20-2009 |
20100204472 | Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation - This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation. | 08-12-2010 |
Lienjing Chen, Tolland, CT US
Patent application number | Description | Published |
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20090028714 | METHOD OF DESIGNING TOOL AND TOOL PATH FOR FORMING A ROTOR BLADE INCLUDING AN AIRFOIL PORTION - A method of designing a tool for forming a rotor blade including an airfoil portion includes generating a computer model of a rotor blade having an airfoil portion, and determining a curvature and radius of curvature at sections of the rotor blade. An inner and outer diameter of a circumferential forming portion of a tool operable to form the rotor blade may then be calculated. A method of designing a tool path for forming a rotor blade including an airfoil portion includes generating a computer model of a cylindrical tool operable to form a rotor blade including an airfoil portion and of a rotor having a plurality of the rotor blades. The computer models of the rotor and tool are used to generate a first and second tool motion corresponding to airfoil suction and pressure portions. A method of forming a rotor with integral blades is also disclosed. | 01-29-2009 |
20100042244 | METHOD OF DESIGNING TOOL AND TOOL PATH FOR FORMING A ROTOR BLADE INCLUDING AN AIRFOIL PORTION - A method of designing a tool for forming a rotor blade including an airfoil portion includes generating a computer model of a rotor blade having an airfoil portion, and determining a curvature and radius of curvature at sections of the rotor blade. An inner and outer diameter of a circumferential forming portion of a tool operable to form the rotor blade may then be calculated. A method of designing a tool path for forming a rotor blade including an airfoil portion includes generating a computer model of a cylindrical tool operable to form a rotor blade including an airfoil portion and of a rotor having a plurality of the rotor blades. The computer models of the rotor and tool are used to generate a first and second tool motion corresponding to airfoil suction and pressure portions. A method of forming a rotor with integral blades is also disclosed. | 02-18-2010 |
Lieping Chen, Hamden, CT US
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20110245468 | B7-H5, A COSTIMULATORY POLYPEPTIDE - B7-HS costimulatory polypeptides, nucleic acids encoding such polypeptides, and methods for using the polypeptides and nucleic acids to enhance a T cell response are provided herein. | 10-06-2011 |
20120003220 | B7-DC Variants - Variant costimulatory polypeptides, nucleic acids encoding such polypeptides, and methods for using the polypeptides and nucleic acids to enhance a T cell response are provided herein. | 01-05-2012 |
20120064626 | B7-H7 ANTIBODIES AND METHOD OF USE - The invention provides novel polypeptides useful for co-stimulating T cells, isolated nucleic acid molecules encoding them, vectors containing the nucleic acid molecules, and cells containing the vectors. Also included are methods of making and using these co-stimulatory polypeptides. | 03-15-2012 |
20120141504 | METHODS FOR TREATING INFLAMMATION USING B7-H4 POLYPEPTIDES AND FRAGMENTS THEREOF - The invention provides novel B7-H3 and B7-H4 polypeptides useful for co-stimulating T cells, isolated nucleic acid molecules encoding them, vectors containing the nucleic acid molecules, and cells containing the vectors. Also included are methods of making and using these co-stimulatory polypeptides. | 06-07-2012 |
20120225043 | Enhancement of Immune Responses By 4-1BB-Binding Agents - This invention features methods of enhancing immune responses in mammalian subjects and in vitro methods of enhancing the response of a T cell. Also embodied by the invention are methods of receiving and preventing the induction of energy in T cells. | 09-06-2012 |
20130267685 | B7-H3 and B7-H4, Novel Immunoregulatory Molecules - The invention provides novel B7-H3 and B7-H4 polypeptides useful for co-stimulating T cells, isolated nucleic acid molecules encoding them, vectors containing the nucleic acid molecules, and cells containing the vectors. Also included are methods of making and using these co-stimulatory polypeptides. | 10-10-2013 |
20130315905 | B7-H5, A Costimulatory Polypeptide - B7-H5 costimulatory polypeptides, nucleic acids encoding such polypeptides, and methods for using the polypeptides and nucleic acids to enhance a T cell response are provided herein. | 11-28-2013 |
20130330329 | B7-H7 ANTIBODIES AND METHOD OF USE - The invention provides novel polypeptides useful for co-stimulating T cells, isolated nucleic acid molecules encoding them, vectors containing the nucleic acid molecules, and cells containing the vectors. Also included are methods of making and using these co-stimulatory polypeptides. | 12-12-2013 |
20140234352 | B7-H3 AND B7-H4, NOVEL IMMUNOREGULATORY MOLECULES - The invention provides novel B7-H3 and B7-H4 polypeptides useful for co-stimulating T cells, isolated nucleic acid molecules encoding them, vectors containing the nucleic acid molecules, and cells containing the vectors. Also included are methods of making and using these co-stimulatory polypeptides. | 08-21-2014 |
20140335541 | B7-H1 AND B7-H4 IN CANCER - Methods of determining prognosis of a subject with cancer or determining risk of cancer progression by assessing expression of B7-H4, or B7-H1 and B7-H4 in combination. | 11-13-2014 |
20150044165 | COSTIMULATORY B7-H1 IN RENAL CELL CARCINOMA PATIENTS: INDICATOR OF TUMOR AGGRESSIVENESS AND POTENTIAL THERAPEUTIC TARGET - The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with B7-H1-receptor interaction, methods of selecting candidate subjects likely to benefit from cancer immunotherapy, and methods of inhibiting expression of B7-H1. | 02-12-2015 |
Lieping Chen, New Haven, CT US
Patent application number | Description | Published |
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20120164168 | B7-DC VARIANTS IMMUNOGENIC COMPOSITIONS AND METHODS OF USE THEREOF - Compositions and methods for costimulating T cells (i.e., increasing antigen-specific proliferation of T cells, enhancing cytokine production by T cells, stimulating differentiation ad effector functions of T cells and/or promoting T cell survival) are provided. Suitable compositions include variant B7-DC polypeptides, fragments and fusion proteins thereof. Variant B7-DC polypeptides have reduced binding affinity for the inhibitory PD-1 ligand and substantially retain the ability to costimulate T cells. Methods for using variant B7-DC polypeptides to stimulate immune responses in subjects in need thereof are provided. | 06-28-2012 |
Ling Chen, Woodbury, CT US
Patent application number | Description | Published |
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20140038081 | GASKET FOR FUEL CELL SYSTEM MANIFOLD SEAL - A gasket for a manifold seal for a fuel cell system includes a first layer of fibrous ceramic material having a first compressibility, a second layer of fibrous ceramic material having a second compressibility and a third layer of fibrous ceramic material having third compressibility. The third layer of fibrous ceramic material is positioned between and engaged with the first layer of fibrous ceramic material and the second layer of fibrous ceramic material. The third compressibility is less than the first compressibility and less than the second compressibility. | 02-06-2014 |
Li Ye Chen, Shelton, CT US
Patent application number | Description | Published |
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20110106589 | DATA VISUALIZATION PLATFORM FOR SOCIAL AND TRADITIONAL MEDIA METRICS ANALYSIS - According to some embodiments, data may be received from a plurality of remote data sources. The received data may be, for example, associated with a plurality of social and traditional media sources. The received data may be aggregated based on an association with an entity and stored. At least two superimposed graphs may then be automatically provided on a user display, including (i) a first graph having an x-axis representing time and a y-axis representing an amount of social networking activity in the aggregated data and (ii) a second graph having an x-axis shared with the first graph and a y-axis representing a financial value associated with the entity. | 05-05-2011 |
Maria J.m. Chen, Storrs, CT US
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20090221072 | COMPOSITIONS AND METHODS FOR MODULATING CELL DIFFERENTIATION - Compositions and methods are described for using the Ea4-peptide of pro-IGF-I or human Eb-peptide of pro-IGF-I to inhibit hematopoiesis and to induce differentiation of neuroblastoma cells and neuronal stem cells. | 09-03-2009 |
20090318355 | COMPOSITIONS AND METHODS FOR PROMOTING TISSUE REPAIR AND WOUND HEALING - A method is described for using the Ea4-peptide of pro-IGF-I or human Eb-peptide of pro-IGF-I for enhancing the proliferation of fibroblasts and closure of wound. The peptide species can be homologous of trout Ea4-peptide, human Eb-peptide of pro-IGF-I or a fusion protein comprising the Ea4- or Eb-peptide of pro-IGF-I. It can be administered any wound in a pharmaceutically acceptable composition alone or in combination with other compounds. | 12-24-2009 |
20110015126 | Compositions and Methods For Inducing Apoptosis In Tumor Cells - A method is described for using an E-domain peptide for the induction of apoptosis in a cancer cells. In particular, the invention relates to methods for using a-type E-domain peptide from trout IGF and/or a b-type E-domain peptide from human IGF for the induction of apoptosis in a broad spectrum of cancer cells. The peptide species can be a homologue of the E-domain of IGF-1 or a fusion protein comprising the E-domain of IGF-1. It can be administered to one or more cancer cells alone or in a pharmaceutically acceptable composition. | 01-20-2011 |
Michael M. Chen, Trumbull, CT US
Patent application number | Description | Published |
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20090141061 | METHOD FOR CONTROLLING A DC MOTOR - A method of controlling a motor to cause it to execute a move toward a target position including calculating a deceleration position, wherein when the deceleration position is reached, the motor will be caused to execute a deceleration in a manner that will result in the motor stopping short of the target position, and determining whether the requested move is a first move type after the motor has reached the deceleration position and the deceleration is complete. If the requested move is a first move type, the method includes causing the motor to move toward the target position at a first velocity, and if the requested move is a second move type, the method includes causing the DC motor to move toward the requested target position at a second velocity, wherein the second velocity is greater than the first velocity. Settling time is also varied depending on move type. | 06-04-2009 |
Mike Yi Ren Chen, Unionville, CT US
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20140011914 | METHODS AND DEVICES FOR CONTINUOUS PRODUCTION OF POLYMERIC DISPERSIONS - The present invention is directed to the use of continuous extrusion devices to form high quality polymer dispersions. Screw extruder devices of the present invention inject water into a zone of high pressure, temperature, and shear to cause the rapid inversion of a weld in less than, for example, one minute, which compares very favorably with conventional batch methods, which can take, for example, two or more hours to complete an inversion. This rapid inversion—a surprising result given the extended time inversion requires in batch processes—allows for the continuous production of polymer dispersions. | 01-09-2014 |
20140163162 | METHODS AND DEVICES FOR CONTINUOUS PRODUCTION OF POLYMERIC DISPERSIONS - The present invention is directed to the use of continuous extrusion devices to form high quality polymer dispersions. Screw extruder devices of the present invention inject water into a zone of high pressure, temperature, and shear to cause the rapid inversion of a weld in less than, for example, one minute, which compares very favorably with conventional batch methods, which can take, for example, two or more hours to complete an inversion. This rapid inversion—a surprising result given the extended time inversion requires in batch processes—allows for the continuous production of polymer dispersions. | 06-12-2014 |
Niancao Chen, Storrs, CT US
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20130196915 | AFFINITY HYDROGELS FOR CONTROLLED PROTEIN RELEASE - The present invention relates to novel porous matrix composites and formulations for controlled protein delivery and the uses therefor. The present invention also provides methods of synthesizing such protein delivery systems. The composites comprise affinity sites embedded in the matrix where the affinity sites are functionalized with nucleic acid aptamers having high affinity for proteins to be released. The aptamers function as binding affinity sites for the proteins to be released. In certain embodiments, release rates are controlled by tuning the binding affinity of the nucleic acid aptamers to the proteins at a desired level. In yet other embodiments, complementary oligonucleotides that hybridize with the aptamers are employed to trigger accelerated release of the proteins when desired. Various in situ injectable hydro gels functionalized with aptamers are provided for treating a condition and disease in a subject in need of a therapeutic protein. | 08-01-2013 |
Pei-Yu Chen, East Haven, CT US
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20140348889 | Compositions and Methods for Treating and Preventing Neointimal Stenosis - Methods for treating or preventing neointima stenosis are disclosed. The methods generally involve the use of a TGFβ inhibitor, a SMAD2 inhibitor, an FGF Receptor agonist, a Let-7 agonist, or a combination thereof, to inhibit endothelial-to-mesenchymal transition (Endo-MT) of vascular endothelial cells into smooth muscle cells (SMC) at sites of endothelial damage. The disclosed methods can therefore be used to prevent or inhibit neointimal stenosis or restenosis, e.g., after angioplasty, vascular graft, or stent. Also disclosed are methods for increasing the patency of biodegradable, synthetic vascular grafts using a composition that inhibits Endo-MT. A cell-free tissue engineered vascular graft (TEVG) produced by this method is also disclosed. | 11-27-2014 |
Philip S.h. Chen, Bethel, CT US
Patent application number | Description | Published |
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20080251104 | Systems and Methods for Determination of Endpoint of Chamber Cleaning Processes - Apparatus and method for determination of the endpoint of a cleaning process in which cleaning fluid is contacted with a structure to effect cleaning thereof. The cleaning process includes contacting a cleaning fluid with a structure to be cleaned and producing a cleaning effluent having a sensible heat thermal energy characteristic corresponding to extent of cleaning of the structure, disposing an object in the cleaning effluent that interacts with the cleaning effluent to produce a response indicative of the sensible heat thermal energy characteristic of the cleaning effluent, and monitoring such response to determine when the cleaning is completed. An endpointing algorithm and endpoint monitoring are also described, as well as endpoint monitor sensor elements that are useful to determine endpoint conditions in an efficient and reproduceable manner. | 10-16-2008 |
20090112009 | AMORPHOUS GE/TE DEPOSITION PROCESS - Germanium, tellurium, and/or antimony precursors are usefully employed to form germanium-, tellurium- and/or antimony-containing films, such as films of GeTe, GST, and thermoelectric germanium-containing films. Processes for using these precursors to form amorphous films are also described. Further described is the use of [{nBuC(iPrN) | 04-30-2009 |
20090215225 | TELLURIUM COMPOUNDS USEFUL FOR DEPOSITION OF TELLURIUM CONTAINING MATERIALS - Precursors for use in depositing tellurium-containing films on substrates such as wafers or other microelectronic device substrates, as well as associated processes of making and using such precursors, and source packages of such precursors. The precursors are useful for deposition of chalcogenide thin films in the manufacture of nonvolatile Phase Change Memory (PCM), by deposition techniques such as chemical vapor deposition (CVD) and atomic layer deposition (ALD). | 08-27-2009 |
20090305427 | APPARATUS AND PROCESS FOR SENSING FLUORO SPECIES IN SEMICONDUCTOR PROCESSING SYSTEMS - A gas detector and process for detecting a fluorine-containing species in a gas containing same, e.g., an effluent of a semiconductor processing tool undergoing etch cleaning with HF, NF | 12-10-2009 |
20090305458 | ANTIMONY AND GERMANIUM COMPLEXES USEFUL FOR CVD/ALD OF METAL THIN FILMS - Antimony, germanium and tellurium precursors useful for CVD/ALD of corresponding metal-containing thin films are described, along with compositions including such precursors, methods of making such precursors, and films and microelectronic device products manufactured using such precursors, as well as corresponding manufacturing methods. The precursors of the invention are useful for forming germanium-antimony-tellurium (GST) films and microelectronic device products, such as phase change memory devices, including such films. | 12-10-2009 |
20100317150 | ANTIMONY AND GERMANIUM COMPLEXES USEFUL FOR CVD/ALD OF METAL THIN FILMS - Antimony, germanium and tellurium precursors useful for CVD/ALD of corresponding metal-containing thin films are described, along with compositions including such precursors, methods of making such precursors, and films and microelectronic device products manufactured using such precursors, as well as corresponding manufacturing methods. The precursors of the invention are useful for forming germanium-antimony-tellurium (GST) films and microelectronic device products, such as phase change memory devices, including such films. | 12-16-2010 |
20110111556 | ANTIMONY COMPOUNDS USEFUL FOR DEPOSITION OF ANTIMONY-CONTAINING MATERIALS - Precursors for use in depositing antimony-containing films on substrates such as wafers or other microelectronic device substrates, as well as associated processes of making and using such precursors, and source packages of such precursors. The precursors are useful for deposition of A Ge | 05-12-2011 |
20110180905 | GeSbTe MATERIAL INCLUDING SUPERFLOW LAYER(S), AND USE OF Ge TO PREVENT INTERACTION OF Te FROM SbXTeY AND GeXTeY RESULTING IN HIGH Te CONTENT AND FILM CRYSTALLINITY - A multilayer film stack containing germanium, antimony and tellurium that can be annealed to form a GST product material of homogeneous and smooth character, wherein at least one antimony-containing layer is isolated from a tellurium-containing layer by an intervening germanium layer, and the multilayer film stack comprises at least two intervening germanium layers. The multilayer film stack can be formed by vapor deposition techniques such as chemical vapor deposition or atomic layer deposition. The annealable multilayer film stack can be formed in high aspect ratio vias to form phase change memory devices of superior character with respect to the stoichiometric and morphological characteristics of the GST product material. | 07-28-2011 |
20110263100 | ANTIMONY AND GERMANIUM COMPLEXES USEFUL FOR CVD/ALD OF METAL THIN FILMS - Antimony, germanium and tellurium precursors useful for CVD/ALD of corresponding metal-containing thin films are described, along with compositions including such precursors, methods of making such precursors, and films and microelectronic device products manufactured using such precursors, as well as corresponding manufacturing methods. The precursors of the invention are useful for forming germanium-antimony-tellurium (GST) films and microelectronic device products, such as phase change memory devices, including such films. | 10-27-2011 |
20120108038 | AMORPHOUS GE/TE DEPOSITION PROCESS - Germanium, tellurium, and/or antimony precursors are usefully employed to form germanium-, tellurium- and/or antimony-containing films, such as films of GeTe, GST, and thermoelectric germanium-containing films. Processes for using these precursors to form amorphous films are also described. Further described is the use of [{nBuC(iPrN) | 05-03-2012 |
20130029456 | ANTIMONY AND GERMANIUM COMPLEXES USEFUL FOR CVD/ALD OF METAL THIN FILMS - Antimony, germanium and tellurium precursors useful for CVD/ALD of corresponding metal-containing thin films are described, along with compositions including such precursors, methods of making such precursors, and films and microelectronic device products manufactured using such precursors, as well as corresponding manufacturing methods. The precursors of the invention are useful for forming germanium-antimony-tellurium (GST) films and microelectronic device products, such as phase change memory devices, including such films. | 01-31-2013 |
20130288462 | TELLURIUM COMPOUNDS USEFUL FOR DEPOSITION OF TELLURIUM CONTAINING MATERIALS - Precursors for use in depositing tellurium-containing films on substrates such as wafers or other microelectronic device substrates, as well as associated processes of making and using such precursors, and source packages of such precursors. The precursors are useful for deposition of Ge | 10-31-2013 |
20140206136 | ANTIMONY COMPOUNDS USEFUL FOR DEPOSITION OF ANTIMONY-CONTAINING MATERIALS - Precursors for use in depositing antimony-containing films on substrates such as wafers or other microelectronic device substrates, as well as associated processes of making and using such precursors, and source packages of such precursors. The precursors are useful for deposition of Ge | 07-24-2014 |
20140220733 | ANTIMONY AND GERMANIUM COMPLEXES USEFUL FOR CVD/ALD OF METAL THIN FILMS - Antimony, germanium and tellurium precursors useful for CVD/ALD of corresponding metal-containing thin films are described, along with compositions including such precursors, methods of making such precursors, and films and microelectronic device products manufactured using such precursors, as well as corresponding manufacturing methods. The precursors of the invention are useful for forming germanium-antimony-tellurium (GST) films and microelectronic device products, such as phase change memory devices, including such films. | 08-07-2014 |
20140329357 | TELLURIUM COMPOUNDS USEFUL FOR DEPOSITION OF TELLURIUM CONTAINING MATERIALS - Precursors for use in depositing tellurium-containing films on substrates such as wafers or other microelectronic device substrates, as well as associated processes of making and using such precursors, and source packages of such precursors. The precursors are useful for deposition of Ge | 11-06-2014 |
Philip S. H. Chen, Bethel, CT US
Patent application number | Description | Published |
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20110260132 | HIGH CONCENTRATION NITROGEN-CONTAINING GERMANIUM TELLURIDE BASED MEMORY DEVICES AND PROCESSES OF MAKING - A PCM device has the composition GexTeyNzAm deposited onto a substrate, where x is about 40% to about 60%, y is about 30% to about 49%, and z is about 5% to about 20% and more preferably about 5% to about 40%. The component represented as A is optional and representative of an element of Sb, Sn, In, Ga, or Zn, and m is up to about 15%. The composition is in the form of a film, and the nitrogen allows for the substantially conformal deposition of the film onto the substrate. A CVD process for depositing the PCM comprises delivering a Ge-based precursor and a Te-based precursor in vapor form to a CVD chamber, heating and pressurizing the chamber, and depositing the film onto a substrate. In making a phase change device using this process, the film is annealed and polished. | 10-27-2011 |
Qingyun Chen, Branford, CT US
Patent application number | Description | Published |
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20080254205 | SELF-INITIATED ALKALINE METAL ION FREE ELECTROLESS DEPOSITION COMPOSITION FOR THIN CO-BASED AND NI-BASED ALLOYS - A method and composition for electrolessly depositing a layer of a metal alloy onto a surface of a metal substrate in manufacture of microelectronic devices. The composition comprises a source of metal deposition ions, a borane-based reducing agent, and a two-component stabilizer, wherein the first stabilizer component is a source of hypophosphite and the second stabilizer component is a molybdenum (VI) compound. | 10-16-2008 |
20090155468 | METROLOGY IN ELECTROLESS COBALT PLATING - Electrolessly depositing a cobalt-based alloy on a metal surface of a substrate in a process which involves monitoring for Co | 06-18-2009 |
20100075496 | SURFACE PREPARATION PROCESS FOR DAMASCENE COPPER DEPOSITION - A method is disclosed for metallizing a substrate comprising an interconnect feature in the manufacture of a microelectronic device, wherein the interconnect feature comprises a bottom, a sidewall, and a top opening having a diameter, D. The method comprises the following steps: depositing a barrier layer on the bottom and the sidewall of the interconnect feature, the barrier layer comprising a metal selected from the group consisting of ruthenium, tungsten, tantalum, titanium, iridium, rhodium, and combinations thereof; contacting the substrate comprising the interconnect feature comprising the bottom and sidewall having the barrier layer thereon with an aqueous composition comprising a reducing agent and a surfactant; and depositing copper metal onto the bottom and the sidewall of the interconnect feature having the barrier layer thereon. | 03-25-2010 |
20100126872 | ELECTRODEPOSITION OF COPPER IN MICROELECTRONICS WITH DIPYRIDYL-BASED LEVELERS - A method for metallizing a via feature in a semiconductor integrated circuit device substrate, wherein the semiconductor integrated circuit device substrate comprises a front surface, a back surface, and the via feature and wherein the via feature comprises an opening in the front surface of the substrate, a sidewall extending from the front surface of the substrate inward, and a bottom. The method comprises contacting the semiconductor integrated circuit device substrate with an electrolytic copper deposition chemistry comprising (a) a source of copper ions and (b) a leveler compound, wherein the leveler compound is a reaction product of a dipyridyl compound and an alkylating agent; and supplying electrical current to the electrolytic deposition chemistry to deposit copper metal onto the bottom and sidewall of the via feature, thereby yielding a copper filled via feature. | 05-27-2010 |
20100285660 | COPPER DEPOSITION FOR FILLING FEATURES IN MANUFACTURE OF MICROELECTRONIC DEVICES - A method for plating copper onto a semiconductor integrated circuit device substrate by forming an initial metal deposit in the feature which has a profile comprising metal on the bottom of the feature and a segment of the sidewalls having essentially no metal thereon, electrolessly depositing copper onto the initial metal deposit to fill the feature with copper. A method for plating copper onto a semiconductor integrated circuit device substrate by forming a deposit comprising a copper wettable metal in the feature, forming a copper-based deposit on the top-field surface, and depositing copper onto the deposit comprising the copper wettable metal to fill the feature with copper. | 11-11-2010 |
20130241060 | METHOD AND COMPOSITION FOR ELECTRODEPOSITION OF COPPER IN MICROELECTRONICS WITH DIPYRIDYL-BASED LEVELERS - A method and composition for metallizing a via feature in a semiconductor integrated circuit device substrate, using a leveler compound which is a dipyridyl compound. | 09-19-2013 |
20140322912 | METHOD AND COMPOSITION FOR ELECTRODEPOSITION OF COPPER IN MICROELECTRONICS WITH DIPYRIDYL-BASED LEVELERS - A method and composition for metallizing a via feature in a semiconductor integrated circuit device substrate, using a leveler compound which is a dipyridyl compound. | 10-30-2014 |
Qingyun Chen, Brandford, CT US
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20080236619 | COBALT CAPPING SURFACE PREPARATION IN MICROELECTRONICS MANUFACTURE - Cleaning compositions and methods in connection with cobalt-based capping of interconnects in integrated circuit semiconductor devices. | 10-02-2008 |
Shawfu Chen, New Milford, CT US
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20100169275 | ACCESSING A HIERARCHICAL DATABASE USING SERVICE DATA OBJECTS (SDO) VIA A DATA ACCESS SERVICE (DAS) - Techniques for replicating modified data to a hierarchical database. A first list comprises records included in a set of records before at least one modification thereto. A second list comprises records included in the set of records after the at least one modification thereto. For each pre-modification record included in the first list and each post-modification record included in the second list having equal identifying values, a target record at the database and having a matching identifying value is modified. Specifically, if both records include corresponding indexes, information about a structure pointed to by the pre-modification record is removed from an index included in the target record, and information about a structure pointed to by the post-modification record is added to the index. If neither record includes an index, the target record is modified to contain at least one changed value included in the post-modification record. | 07-01-2010 |
Shawfu Chen, New Mildford, CT US
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20100169307 | PERFORMING AN EFFICIENT IMPLICIT JOIN OF MULTIPLE MIXED-TYPE RECORDS - A method, system, method and computer program product for retrieving data. Records are retrieved from a hierarchical database. The records are categorized into a plurality of record types. Each record comprises a unique identifier field. A record map contains zero or more entries. Each entry comprises an identifying value, data from at least one record and a set of Boolean flags. Each flag corresponds to a record type. A computer iterates over the retrieved records. Data from each record is stored at an entry in the record map having an identifying value equal to the value included in the unique identifier field of the record. Moreover, the flag in this entry which corresponds to the record type of the record is set. Inner joins and outer joins are then performed using the contents of the record map. | 07-01-2010 |
Shili Chen, Cheshire, CT US
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20090118502 | BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME - The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents. | 05-07-2009 |
20100234591 | BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME - The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents. | 09-16-2010 |
20100234615 | Process for the synthesis of triazoles - The present invention relates to processes for the preparation of triazoles. These compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. | 09-16-2010 |
20120010200 | Biaryl Heterocyclic Compounds And Methods Of Making And Using The Same - The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents. | 01-12-2012 |
20120202792 | Antimicrobial Compounds and Methods of Making and Using the Same - The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and/or reducing the risk of microbial infections in humans and animals. | 08-09-2012 |
20130066076 | Process for the Synthesis of Biaryl Oxazolidinones - The present invention relates to processes for the preparation of biaryl oxazolidinones. These compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. | 03-14-2013 |
20140031402 | Process for the Syntheses of Triazoles - The present invention relates to processes for the preparation of triazoles. These compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. | 01-30-2014 |
20140073624 | Biaryl Heterocyclic Compounds and Methods of Making and Using the Same - The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents. | 03-13-2014 |
20140163049 | Antimicrobial Compounds and Methods of Making and Using the Same - The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and reducing the risk of microbial infections in humans and animals. | 06-12-2014 |
20150072970 | BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME - The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents. | 03-12-2015 |
Sixing Chen, Stamford, CT US
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20100262450 | METHOD AND SYSTEM FOR MOBILE ASSET MANAGEMENT - A method and system related to managing mobile assets, the method including receiving asset event data associated with a plurality of mobile assets including information indicative of location status, motion status, and cargo status of the plurality of mobile assets; determining asset segment data defined by the asset event data of the plurality of mobile assets during a time interval based on the asset event data; determining turn time data for each of the plurality of mobile assets; calculating a set of metrics for the plurality of mobile assets based on the asset segment data and the turn time data; determining an optimal asset pool size for a location to be serviced by the plurality of mobile assets; and providing an output of the determined optimal asset pool size for the location. | 10-14-2010 |
Szuchain F. Chen, Hamden, CT US
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20090017327 | FRETTING AND WHISKER RESISTANT COATING SYSTEM AND METHOD - A coated electrically conductive substrate has particular utility where there are multiple closely spaced leads and tin whiskers constitute a potential short circuit. Such substrates include leadframes, terminal pins and circuit traces such as on printed circuit boards and flexible circuits. This electrically conductive substrate has a plurality of leads separated by a distance capable of bridging by a tin whisker, a silver or silver-base alloy layer coating at least one surface of at least one of the plurality of leads, and a fine grain tin or tin-base alloy layer directly coating said silver layer. | 01-15-2009 |
20110008616 | Support Layer for Thin Copper Foil - A composite material useful for the manufacture of a circuit has a support layer, a metal foil layer having opposing first and second sides and a thickness of 15 microns or less and a release layer effective to facilitate separation of the metal foil layer from the support layer, the release layer disposed between and contacting both the support layer and the metal foil layer. A reactive element containing layer, which may be the support layer, effective to react with gaseous elements or compounds to form thermally stable compounds contacts the release layer. The composite material is preferably subjected to a low temperature heat treatment. The combination of the low temperature heat treatment and the reactive element containing layer results in reduced defects including blisters in the copper foil during subsequent processing. | 01-13-2011 |
20140308538 | SURFACE TREATED ALUMINUM FOIL FOR ELECTRONIC CIRCUITS - The surface of an aluminum substrate is modified to enhance the adhesion of the metal to polymeric materials. Intermediate layers, such as Zn/Sn, Co/Ni, and a Cu strike are applied before depositing a nodular Cu layer for bond enhancement. The surface treated aluminum substrate can be used in printed circuit boards, leadframes, or any electrical/electronic devices where Cu is typically used to reduce the cost and weight of the devices. | 10-16-2014 |
Thomas T. Chen, Storrs, CT US
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20090221072 | COMPOSITIONS AND METHODS FOR MODULATING CELL DIFFERENTIATION - Compositions and methods are described for using the Ea4-peptide of pro-IGF-I or human Eb-peptide of pro-IGF-I to inhibit hematopoiesis and to induce differentiation of neuroblastoma cells and neuronal stem cells. | 09-03-2009 |
20090318355 | COMPOSITIONS AND METHODS FOR PROMOTING TISSUE REPAIR AND WOUND HEALING - A method is described for using the Ea4-peptide of pro-IGF-I or human Eb-peptide of pro-IGF-I for enhancing the proliferation of fibroblasts and closure of wound. The peptide species can be homologous of trout Ea4-peptide, human Eb-peptide of pro-IGF-I or a fusion protein comprising the Ea4- or Eb-peptide of pro-IGF-I. It can be administered any wound in a pharmaceutically acceptable composition alone or in combination with other compounds. | 12-24-2009 |
20110015126 | Compositions and Methods For Inducing Apoptosis In Tumor Cells - A method is described for using an E-domain peptide for the induction of apoptosis in a cancer cells. In particular, the invention relates to methods for using a-type E-domain peptide from trout IGF and/or a b-type E-domain peptide from human IGF for the induction of apoptosis in a broad spectrum of cancer cells. The peptide species can be a homologue of the E-domain of IGF-1 or a fusion protein comprising the E-domain of IGF-1. It can be administered to one or more cancer cells alone or in a pharmaceutically acceptable composition. | 01-20-2011 |
Xingrui Chen, Glastonbury, CT US
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20140012238 | SWITCH BLOCK CONTROL ASSEMBLY OF A MEDICAL DEVICE - The present disclosure provides a surgical device, comprising: a jaw assembly defining a first longitudinal axis and including a first jaw and a second jaw moveable relative to the first jaw; an elongated body defining a second longitudinal axis and coupled to a proximal end of the jaw assembly, wherein the jaw assembly is configured to articulate about an articulation axis transverse to the second longitudinal axis relative to the elongated body; a handle assembly coupled to a proximal end of the elongated body and comprising at least one motor mechanically coupled to the jaw assembly; and a control assembly coupled to the handle assembly, the control assembly including a first control button, a second control button, a first rocker device disposed about the first control button and configured to rotate thereabout, and a second rocker device disposed about the second control button and configured to rotate thereabout. | 01-09-2014 |
20150060516 | Hand Held Electromechanical Surgical Handle Assembly for Use with Surgical End Effectors, And Methods of Use - The present disclosure relates to hand held electromechanical powered surgical handle assemblies for use with surgical end effectors capable of clamping, cutting and/or stapling tissue and methods of use thereof. The surgical device includes a handle assembly and a drive unit assembly removably and selectively connectable to a selected first connecting feature and second connecting feature of the handle assembly. The drive unit assembly includes a motor and a drive shaft driven by the motor. | 03-05-2015 |
Xingrui Chen, Hamden, CT US
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20110125138 | SURGICAL CONSOLE AND HAND-HELD SURGICAL DEVICE - A surgical system and method includes a surgical instrument configured to wirelessly transmit identifying data specific to the surgical instrument and a console configured to receive the identifying data. The console is configured to register the surgical instrument based on the identifying data, establish a wireless two-way communication link between the surgical instrument and the console, receive at least one of operational data and commands from the surgical instrument, and provide operational feedback data to a user of the surgical instrument during an operation of the surgical instrument based on the at least one of operational data and commands. | 05-26-2011 |
20120303002 | Method Of Internally Potting Or Sealing A Handheld Medical Device - The present disclosure provides a powered surgical instrument including a housing defining an inner cavity therein; at least one internal component disposed within the housing; and potting material injected into the inner cavity encapsulating at least a portion of the at least one internal component. | 11-29-2012 |
20120323226 | QUICK CONNECT ASSEMBLY FOR USE BETWEEN SURGICAL HANDLE ASSEMBLY AND SURGICAL ACCESSORIES - A hand-held electromechanical surgical device is provided and configured to selectively connect with a surgical accessory. The surgical device includes a device housing defining a connecting portion for selectively receiving a coupling assembly of the surgical accessory. The connecting portion includes an annular wall defining a cylindrical recess dimensioned to receive the coupling assembly of the surgical accessory; a collar slidably supported about the annular wall, wherein the collar is slidable between a first position and a second position; and at least one socket member interposed between the annular wall and the collar, wherein each socket member is slidably supported in the annular wall. Each socket member includes a first fixed state wherein each socket member projects into the cylindrical recess of the annular wall; and a second movable state wherein each socket member is free to not project into the cylindrical recess of the annular wall. | 12-20-2012 |
20140166720 | Surgical Instrument with Pressure Distribution Device - The present disclosure is directed to a surgical apparatus, comprising an anvil jaw configured to form at least one surgical staple, a cartridge jaw configured to deploy one or more surgical staples against the anvil jaw, and a pressure distribution device attached to at least one of the anvil jaw and the cartridge jaw, wherein the pressure distribution device is configured to distribute a clamping pressure to a target tissue during a clamping and a stapling of the target tissue. | 06-19-2014 |
Yangbin Chen, Wethersfield, CT US
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20140248485 | SYNTHESIS OF METHYLENE MALONATES SUBSTANTIALLY FREE OF IMPURITIES - The present invention provides improved methods for the chemical synthesis of methylene malonates using the Knovenagel synthesis reaction. The method of the invention provides for improved methylene malonates by significantly reducing or eliminating the formation of alternative and/or deleterious side products, significantly reducing or eliminating unwanted consumption of methylene malonates, and significantly reducing or eliminating the degradation of methylene malonates. These advantages result in methylene malonates, which upon recovery, are of higher quality, greater purity, improved yield and possess overall improved performance characteristics (e.g., improved cure speed, retention of cure speed, improved shelf-life and/or stability). | 09-04-2014 |
20140275400 | METHYLENE BETA-DIKETONE MONOMERS, METHODS FOR MAKING METHYLENE BETA-DIKETONE MONOMERS, POLYMERIZABLE COMPOSITIONS AND PRODUCTS FORMED THEREFROM - The present invention provides methylene beta-diketone monomers, methods for producing the same, and compositions and products formed therefrom. In the method for producing the methylene beta-diketones of the invention, a beta-diketone is reacted with a source of formaldehyde in a modified Knoevenagel reaction optionally in the presence of an acidic or basic catalyst, and optionally in the presence of an acidic or non-acidic solvent, to form reaction complex. The reaction complex may be an oligomeric complex. The reaction complex is subjected to further processing, which may be vaporization by contact with an energy transfer means in order to isolate the beta-diketone monomer. The present invention further compositions and products formed from methylene beta-diketone monomers of the invention, including monomer-based products (e.g., inks, adhesives, coatings, sealants or reactive molding) and polymer-based products (e.g., fibers, films, sheets, medical polymers, composite polymers and surfactants). | 09-18-2014 |
Yen-Ming Chen, Broad Brook, CT US
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20140208994 | FLUID DISTRIBUTION AND MIXING GRID FOR MIXING GASES - A grid for distributing and mixing fluids in a duct includes a plurality of lances arranged in a first plane and configured to be positioned transverse to a direction of a first fluid flowing outside of the lances and within a predetermined flow area. Each of the plurality of lances has at least one first inlet and a plurality of outlet nozzles. One or more of the outlet nozzles is directed generally in the flow direction of the first fluid outside of the lances, and is configured to discharge a second fluid therefrom. | 07-31-2014 |
20140212825 | OXY-COMBUSTION COUPLED FIRING AND RECIRCULATION SYSTEM - A combustion system is provided for an oxy-combustion furnace. The combustion system includes at least one windbox mountable on the oxy-combustion furnace and having at least one main firing location. At least one primary inlet is positioned in the at least one main firing location for conveying fuel and the first oxidant into the oxy-combustion furnace. At least one secondary inlet is positioned in the at least one main firing location for conveying the second oxidant into the oxy-combustion furnace. The at least one secondary inlet is angularly offset from the at least one primary inlet. | 07-31-2014 |
Yi-Ju Chen, New Haven, CT US
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20090203086 | System and method for improved signal detection in nucleic acid sequencing - An embodiment of a system for reducing crosstalk in a parallel sequencing platform is described that comprises a substrate with a plurality of individual reaction environments that include a species of nucleic acid template, and a plurality of spatially localized reactants, wherein the localized reactants minimize the transmission of reaction products to a neighboring reaction environment due to a relative position of the localized reactants in the reaction environment. | 08-13-2009 |
20100192032 | System and Method for Correcting Primer Extension Errors in Nucleic Acid Sequence Data - An embodiment of method for correcting an error associated with phasic synchrony of sequence data generated from a population of substantially identical copy of a template molecule is described that comprises (a) detecting a signal generated in response to an incorporation of one or more nucleotides in a sequencing reaction; (b) generating a value for the signal; and (c) correcting the value for the phasic synchrony error using a first parameter and a second carry forward parameter. | 07-29-2010 |
20110201526 | BEAD EMULSION NUCLEIC ACID AMPLIFICATION - Disclosed are methods for nucleic acid amplification wherein nucleic acid templates, beads, and amplification reaction solution are emulsified and the nucleic acid templates are amplified to provide clonal copies of the nucleic acid templates attached to the beads. Also disclosed are kits and apparatuses for performing the methods of the invention. | 08-18-2011 |
20110213563 | SYSTEM AND METHOD TO CORRECT OUT OF PHASE ERRORS IN DNA SEQUENCING DATA BY USE OF A RECURSIVE ALGORITHM - An embodiment of a method for correcting an error associated with phasic synchrony of sequence data generated from a population of template molecules is described that comprises the steps of detecting signals generated in response to nucleotide species introduced during a sequencing reaction; generating an observed value for the signal detected from each of the nucleotide species; defining positive incorporation values and negative incorporation values from the observed values using a carry forward value and an incomplete extension value; revising the carry forward value and the incomplete extension value using a noise value that is derived from observed values associated with the negative incorporation values; re-defining the positive incorporation values and the negative incorporation values using the revised carry forward value and the revised incomplete extension value; and repeating the steps of revising and re-defining until convergence of the positive incorporation values and the negative incorporation values | 09-01-2011 |
20110287432 | SYSTEM AND METHOD FOR TAILORING NUCLEOTIDE CONCENTRATION TO ENZYMATIC EFFICIENCIES IN DNA SEQUENCING TECHNOLOGIES - An embodiment of a method for optimizing sequencing performance is described that comprises the steps of calculating a nucleotide species specific degradation rate of an apyrase enzyme for a plurality of nucleotide species; determining a concentration for each of the nucleotide species using the nucleotide species specific degradation rate; iteratively providing the concentration of each of the nucleotide species in a reaction environment comprising a polymerase enzyme and a species of template nucleic acid molecule, wherein one or more molecules of the nucleotide species are incorporated into a nascent molecule in a sequencing reaction and the apyrase enzyme is introduced to the reaction environment to degrade unincorporated nucleotide species molecules; and detecting a signal in response to the incorporation of the nucleotide species. | 11-24-2011 |
20130054171 | System and Method for Correcting Primer Extension Errors in Nucleic Acid Sequence Data - An embodiment of method for correcting an error associated with phasic synchrony of sequence data generated from a population of substantially identical copies of a template molecule is described that comprises (a) detecting a signal generated in response to an incorporation of one or more nucleotides in a sequencing reaction; (b) generating a value for the signal; and (c) correcting the value for the phasic synchrony error using a first parameter and a second carry forward parameter. | 02-28-2013 |
20130078638 | Bead Emulsion Nucleic Acid Amplification - Disclosed are methods for nucleic acid amplification wherein nucleic acid templates, beads, and amplification reaction solution are emulsified and the nucleic acid templates are amplified to provide clonal copies of the nucleic acid templates attached to the heads. Also disclosed are kits and apparatuses for performing the methods of the invention. | 03-28-2013 |
20130131995 | System And Method to Correct Out of Phase Errors In DNA Sequencing Data by Use of a Recursive Algorithm - An embodiment of a method for correcting an error associated with phasic synchrony of sequence data generated from a population of template molecules is described that comprises the steps of detecting signals generated in response to nucleotide species introduced during a sequencing reaction; generating an observed value for the signal detected from each of the nucleotide species; defining positive incorporation values and negative incorporation values from the observed values using a carry forward value and an incomplete extension value; revising the carry forward value and the incomplete extension value using a noise value that is derived from observed values associated with the negative incorporation values; re-defining the positive incorporation values and the negative incorporation values using the revised carry forward value and the revised incomplete extension value; and repeating the steps of revising and re-defining until convergence of the positive incorporation values and the negative incorporation values | 05-23-2013 |
20130311105 | System And Method For Generation And Use Of Optimal Nucleotide Flow Orders - An embodiment of a method for generating a flow order that minimizes the accumulation of phasic synchrony error in sequence data is described that comprises the steps of: (a) generating a plurality of sequential orderings of nucleotides species comprising a k-base length, wherein the sequential orderings define a sequence of introduction of nucleotide species into a sequencing by synthesis reaction environment; (b) simulating acquisition of sequence data from one or more reference genomes using the sequential orderings, wherein the sequence data comprises an accumulation of phasic synchrony error; and (c) selecting one or more of the sequential orderings using a read length parameter and an extension rate parameter. | 11-21-2013 |
20140162885 | Bead Emulsion Nucleic Acid Amplification - Disclosed are methods for nucleic acid amplification wherein nucleic acid templates, beads, and amplification reaction solution are emulsified and the nucleic acid templates are amplified to provide clonal copies of the nucleic acid templates attached to the beads. Also disclosed are kits and apparatuses for performing the methods of the invention. | 06-12-2014 |
Yuan Chen, New Haven, CT US
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20090325790 | SIZE-CONTROLLABLE TRANSITION METAL CLUSTERS IN MCM-41 FOR IMPROVING CHEMICAL CATALYSIS - A metal-substituted mesoporous oxide framework, such as Co-MCM-41, are disclosed which includes more than one ion species with different reduction kinetics. The reducibility correlates strongly with the pore radius of curvature, with the metal ions incorporated in smaller pores more resistant to complete reduction. The metal-ion substituted oxide framework improves catalytic processes by controlling the size of the catalytic particles forming in the pores. The metal-substituted mesoporous oxide framework can be employed in selective hydrogenation of organic chemicals, in ammonia synthesis, and in automotive catalytic exhaust systems. | 12-31-2009 |
Yuhpyng L. Chen, Waterford, CT US
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20080207712 | THIAZOLE-AMINE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS - The present invention relates to compounds of the Formula I | 08-28-2008 |
20080249094 | COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS - The present invention relates to compounds of the Formula | 10-09-2008 |
20100184737 | IMIDAZOLE COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS - The present invention relates to compounds of Formula I | 07-22-2010 |
Zhidong Chen, New Milford, CT US
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20080312185 | SUBSTITUTED 3-AMINO-THIENO[2,3-b]PYRIDINE-2-CARBOXYLIC ACID AMIDE COMPOUNDS AND PROCESSES FOR PREPARING AND THEIR USES - Disclosed are methods of treating cancer by administration of compounds according to formula (I): | 12-18-2008 |
20110224188 | DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-alpha]IMIDAZOLE-3-CARBOXYLIC ACID AMIDES - Derivatives of 6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-carboxylic acid amide exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease. | 09-15-2011 |
20110301161 | BENZIMIDAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION - The present invention relates to compounds of formula (I): | 12-08-2011 |
20120214787 | OXADIAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION - The present invention relates to compounds of formula (I): | 08-23-2012 |
20120220561 | OXADIAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION - The present invention relates to compound of formula (I): | 08-30-2012 |
20120245162 | OXADIAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION - The present invention relates to compounds of formula (I): | 09-27-2012 |
20120277226 | BENZIMIDAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION - The present invention relates to compounds of formula (IA) and (IB): | 11-01-2012 |
20120295896 | OXADIAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION - The present invention relates to compounds of formula (I) and (IA): | 11-22-2012 |
20120322795 | BIARYLAMIDE INHIBITORS OF LEUKOTRIENE PRODUCTION - The present invention relates to compounds of formula (I): | 12-20-2012 |
20130196967 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF LEUKOTRIENE PRODUCTION - The present invention relates to compound of formula (I): | 08-01-2013 |
20140323468 | ALDOSTERONE SYNTHASE INHIBITORS - The present invention relates to compounds of formula (I): | 10-30-2014 |
Zhoutao Chen, Milford, CT US
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20090053724 | System and method for adaptive reagent control in nucleic acid sequencing - An embodiment of a method for adaptive reagent control is described that comprising a) introducing a first concentration of an enzyme reagent into a reaction environment with a reaction substrate, where the enzyme reagent and reaction substrate are constituent parts of a sequencing process; b) measuring a level of activity of the first concentration of the enzyme reagent in the reaction environment, where the level of activity comprises a measurable product of a reaction between the enzyme reagent and the reaction substrate; c) identifying an optimal concentration using the measured level of activity of the first concentration; and d) performing the sequencing process in the reaction environment using the optimal concentration of the enzyme reagent, where the sequencing process comprises an iterative series of sequencing reactions. | 02-26-2009 |