Patent application number | Description | Published |
20130316001 | PARTICLES, COMPOSITIONS AND METHODS FOR OPHTHALMIC AND/OR OTHER APPLICATIONS - Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye. | 11-28-2013 |
20130316006 | PARTICLES, COMPOSITIONS AND METHODS FOR OPHTHALMIC AND/OR OTHER APPLICATIONS - Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye. | 11-28-2013 |
20130323179 | NANOCRYSTALS, COMPOSITIONS, AND METHODS THAT AID PARTICLE TRANSPORT IN MUCUS - Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier. | 12-05-2013 |
20150125539 | COMPOSITIONS AND METHODS FOR OPHTHALMIC AND/OR OTHER APPLICATIONS - Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye. | 05-07-2015 |
20150265542 | NANOCRYSTALS, COMPOSITIONS, AND METHODS THAT AID PARTICLE TRANSPORT IN MUCUS - Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier. | 09-24-2015 |
20150265543 | NANOCRYSTALS, COMPOSITIONS, AND METHODS THAT AID PARTICLE TRANSPORT IN MUCUS - Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier. | 09-24-2015 |
20160039823 | Meropenem Derivatives and Uses Thereof - The present invention provides novel derivative of β-lactam antibiotics, such as meropenem. The inventive compounds include compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. Also provided are particles (e.g., nanoparticles) and pharmaceutical compositions thereof that are mucus penetrating. The inventive particles and pharmaceutical compositions may be useful in delivering an inventive compound to the respiratory tract of a subject. The invention further provides methods of using and kits including the inventive compounds, particles thereof, and/or pharmaceutical compositions thereof for treating and/or preventing a pulmonary disease (e.g., a respiratory tract infection). | 02-11-2016 |
Patent application number | Description | Published |
20090010986 | Polymeric gel delivery system for pharmaceuticals - Implantable, injectable, insertable, or otherwise administrable compositions that form hydrogels when implanted, injected, inserted, or administered into or onto living tissues comprise a pharmaceutically effective compound wherein the pharmaceutically effective compound is a codrug, or pharmaceutically acceptable salt or prodrug thereof in admixture with a hydrogel-forming compound. The pharmaceutically effective compound may be any compound that is soluble in bodily fluids, or that forms bodily fluid-soluble adducts when exposed to bodily fluids. Exemplary compounds include analgesic, anti-inflammatory and antibiotic compounds. The hydrogel-forming compound is a biologically tolerated substance that forms a hydrogel upon exposure to bodily fluids, such as the interstitial fluid surrounding or within a joint. | 01-08-2009 |
20090123546 | Polymer-based, sustained release drug delivery system - Disclosed is a sustained release system that includes a polymer and a pharmaceutically active agent dispersed in the polymer. The agent is in granular or particulate form, and has a rate of release from the system that is limited primarily by the rate at which the agent dissolves from the granules into the polymer matrix. Advantageously, the polymer is permeable to the agent and is non-release-rate-limiting with respect to the rate of release of the agent from the polymer. | 05-14-2009 |
20090163457 | Compositions and methods for delivering a biologically active agent - The invention relates to codrugs having improved properties, methods for preparing and administering them, and methods of formulating and administering the codrugs as pharmaceutical preparations. In certain embodiments, the codrugs can be locally administered to deliver the constituent biologically active compound in a sustained-release fashion, reducing systemic concentrations of the biologically active compound. | 06-25-2009 |
20100080830 | SYSTEMIC DELIVERY OF ANTIVIRAL AGENTS - The systems and methods disclosed herein provide sustained delivery of a therapeutic agent for treating a patient, e.g., human, to obtain a desired local or systemic physiological or pharmacological effect. Method includes positioning the sustained released drug delivery system at an area wherein release of the agent is desired and allowing the agent to pass through the device to the desired area of treatment. In some embodiments, the method is for treating or reducing the risk of retroviral or lentiviral infection. In certain embodiments, the method is for preventing or reducing the risk of mother-to-child transmission of HIV, wherein the therapeutic agent is an antiviral agent. | 04-01-2010 |
Patent application number | Description | Published |
20090075901 | PEPTIDES FOR ACTIVATION AND INHIBITION OF DELTAPKC - Peptides able to inhibit or activate the translocation or function of δPKC are identified. Administration of the peptides for protection or enhancement of cell damage due to ischemia is described. Therapeutic methods to reduce damage to cells or to enhance damage to cells due to ischemia are also described, as well as methods for screening test compounds for δPKC-selective agonists and antagonists. | 03-19-2009 |
20090192089 | Peptides for activation and inhibition of deltaPKC - Peptides able to inhibit or activate the translocation or function of δPKC are identified. Administration of the peptides for protection or enhancement of cell damage due to ischemia is described. Therapeutic methods to reduce damage to cells or to enhance damage to cells due to ischemia are also described, as well as methods for screening test compounds for δPKC-selective agonists and antagonists. | 07-30-2009 |
20090318351 | METHOD OF TREATING ACUTE ST-ELEVATION MYOCARDIAL INFARCTION WITH A DELTA PKC ANTAGONIST - Compositions, kits and methods are provided for preventing or treating tissue injury caused by stresses or shocks related to oxygen deficiency, such as ischemia, anoxia, hypoxia, reperfusion and other environmental stresses. In particular, protein kinase C (PKC) isozyme-specific agonists and antagonists are provided for treating cardiac tissue damage due to ischemia-reperfusion, such as acute myocardial infarction. | 12-24-2009 |
20110098224 | PROTEIN KINASE C PEPTIDE MODULATORS OF ANGIOGENESIS - The present invention provides peptides for inhibiting various protein kinase C isozymes. The peptide can be directed to any region of the protein kinase C isozyme, and in one embodiment, is directed to the V5 domain. The peptide can be conjugated to a carrier, in a releasable or non-releasable manner. The peptides can be used to inhibit angiogenesis and/or vascular permeability. The peptides can be used to treat subjects having, for example, cancer, diabetic blindness, macular degeneration, rheumatoid arthritis, or psoriasis. | 04-28-2011 |
20110143991 | Peptides for Activation and Inhibition of Delta-PKC - Peptides able to inhibit or activate the translocation or function of δPKC are identified. Administration of the peptides for protection or enhancement of cell damage due to ischemia is described. Therapeutic methods to reduce damage to cells or to enhance damage to cells due to ischemia are also described, as well as methods for screening test compounds for δPKC-selective agonists and antagonists. | 06-16-2011 |
Patent application number | Description | Published |
20110106514 | FORMATION MODELING WHILE DRILLING FOR ENHANCED HIGH ANGLE FOR HORIZONTAL WELL PLACEMENT - Methods for three-dimensionally characterizing a reservoir while drilling a high angle or horizontal wellbore through the reservoir are disclosed. An initial reservoir model for the reservoir is selected and a section is extracted for a planned trajectory of the wellbore. A secondary model is generated by performing secondary modeling for at least part of the planned trajectory. An area of interest is identified within the secondary model where statistical uncertainty is high. Possible causes of the statistical uncertainty are identified for the area of interest within the secondary model that are not present or accounted for in the initial reservoir model. A set of parameters for the area of interest are defined at that are based on the possible causes of statistical uncertainty. The area of interest is logged with at least one logging while drilling LWD tool. Sensitivities of the LWD tool response to the subset of parameters are evaluated by performing at least one tertiary model for a range of the subset of parameters. The most sensitive parameters from the subset of parameters and corresponding measurements are identified. One or more real-time LWD measurements to be used for proactive well placement along the planned trajectory are identified and are based on the most sensitive parameters. The initial reservoir model is updated while drilling with information from the tertiary model. The model update is based on physics-based modeling or on inversion and on running multiple models and selection of a best candidate model based on correlations between the tool measurements and modeled results for each geologic model. | 05-05-2011 |
20120119744 | SYSTEM AND METHOD FOR IMAGING PROPERTIES OF SUBTERRANEAN FORMATIONS - A system and method for imaging properties of subterranean formations in a wellbore is provided. The system comprises a formation sensor for collecting currents injected into the subterranean formations, the formation sensor positionable on a downhole tool deployable into the wellbore. The system comprises a controller for controlling the formation sensor and a formation imaging unit. The formation imaging unit comprises a current management unit for collecting data from the currents injected into the subterranean formations, the currents having at least two different frequencies. The formation imaging unit comprises a drilling mud data unit for determining at least one drilling mud parameter, a formation data unit for determining at least one formation parameter from the collected data, and an inversion unit for determining at least one formation property by inverting the at least one formation parameter. | 05-17-2012 |
20140191762 | System and Method for Imaging Properties of Subterranean Formations - A system and method for imaging properties of subterranean formations in a wellbore is provided. The system comprises a formation sensor for collecting currents injected into the subterranean formations, the formation sensor positionable on a downhole tool deployable into the wellbore. The system comprises a controller for controlling the formation sensor and a formation imaging unit. The formation imaging unit comprises a current management unit for collecting data from the currents injected into the subterranean formations, the currents having at least two different frequencies. The formation imaging unit comprises a drilling mud data unit for determining at least one drilling mud parameter, a formation data unit for determining at least one formation parameter from the collected data, and an inversion unit for determining at least one formation property by inverting the at least one formation parameter. | 07-10-2014 |
20140239960 | System and Method for Imaging Properties of Subterranean Formations - A system and method for imaging properties of subterranean formations in a wellbore is provided. The system comprises a formation sensor for collecting currents injected into the subterranean formations, the formation sensor positionable on a downhole tool deployable into the wellbore. The system comprises a controller for controlling the formation sensor and a formation imaging unit. The formation imaging unit comprises a current management unit for collecting data from the currents injected into the subterranean formations, the currents having at least two different frequencies. The formation imaging unit comprises a drilling mud data unit for determining at least one drilling mud parameter, a formation data unit for determining at least one formation parameter from the collected data, and an inversion unit for determining at least one formation property by inverting the at least one formation parameter. | 08-28-2014 |
20150260874 | System and Method for Imaging Subterranean Formations - Systems and methods for imaging properties of subterranean formations in a wellbore include a formation sensor for collecting currents injected into the subterranean formations and a formation imaging unit. The formation imaging unit includes a current management unit for collecting data from the currents injected into the subterranean formations and a formation data unit for determining at least one formation parameter from the collected data. The formation imaging unit also includes an inversion unit for determining at least one formation property by inverting the at least one formation parameter. The inversion unit is suitable for generating an inverted standoff image and an inverted permittivity image for comparison with a composite image of the formation imaging unit. | 09-17-2015 |