Patent application number | Description | Published |
20080309227 | EXTENDED PI-CONJUGATED PLATINUM (II) COMPLEXES - The invention provides organometallic complexes comprising an extended π-conjugated tridentate ligand having a platinum center in which chemical and/or physical properties of the complexes may be modified by changing the structure of the ligands. The complex finds use in devices incorporated into electroluminescent devices, flat panel displays, organic light emitting devices, polymer light emitting devices, transistors, serrors, and lasers. | 12-18-2008 |
20100069345 | Lanthanide-porphyrin complexes as anti-tumor agents - The present invention relates to lanthanide porphyrin complexes and their uses as anti-tumor agents. The described complexes show promising cytotoxic properties toward cancer cells in both in vitro and in vivo studies. | 03-18-2010 |
20100314994 | Platinum (II) Isoqulinoline-Pyridine-Benzene Based Complexes, Methods for Making Same, and Organic Light-Emitting Diodes Including Such Complexes - This invention provides a class of organometallic complexes comprising a tridentate isoquinoline-pyridine-benzene based ligand, a mono-dentate ligand and a platinum (II) center which show high emission quantum efficiency and good thermal stability. This invention also discloses organometallic complexes in organic light-emitting diode (OLED) including them. | 12-16-2010 |
20110098263 | HYDROXY-SUBSTITUTED COLD(III) PORPHYRIN COMPLEXES AS HISTONE DEACETYLASE INHIBITORS - A method for treatment of cancer by inhibiting the activity of histone deacetylase, comprising administering to a human in need of such treatment a composition containing a therapeutically effective amount of a gold(III) complex having the structural formula of | 04-28-2011 |
20110282065 | SOLID SUPPORTED GOLD NANOPARTICLES, METHODS OF USE THEREOF, AND METHODS FOR MAKING SAME - Solid-supported gold nanoparticles for use as a catalyst for the synthesis of quinolines from anilines and aldehydes using oxygen as an oxidant are provided. Also provided are a method for the preparation of SiO | 11-17-2011 |
20120018711 | PLATINUM (II) TETRADENTATE ONCN COMPLEXES FOR ORGANIC LIGHT-EMITTING DIODE APPLICATIONS - Described are novel platinum (II) containing organometallic materials. These materials show green to orange emissions with high emission quantum efficiencies. Using the materials as emitting materials; pure green emitting organic light-emitting diodes can be fabricated. Since the novel platinum (II) containing organometallic materials are soluble in common solvents, solution process methods such as spin coating and printing can be used for device fabrication. | 01-26-2012 |
20150090337 | PHOTOVOLTAIC CONVERSION ELEMENT AND PHOTOVOLTAIC CELL - Described herein are organic photovoltaic (OPV) cells using gold complex(es) with as chemical structure of Structure I as active material: | 04-02-2015 |
20150287937 | PLATINUM (II) EMITTERS FOR OLED APPLICATIONS - Described herein are novel platinum(II) emitters. These material show high emission quantum efficiency, low self-quenching constant and stable in thermal deposition process. The OLED fabricated from these materials can have pure green emission, high efficiency and low efficiency roll-off. | 10-08-2015 |
Patent application number | Description | Published |
20080299039 | Aprotinin Polypeptides for Transporting a Compound Across the Blood-Brain Barrier - The invention relates to improvements in the field of drug delivery. More particularly, the invention relates to polypeptides derived from aprotinin and from aprotinin analogs as well as conjugates and pharmaceutical compositions comprising these polypeptides or conjugates. The present invention also relates to the use of these polypeptide for transporting a compound or drug across the blood-brain barrier of a mammal and in the treatment and diagnosis of neurological diseases. | 12-04-2008 |
20090016959 | Delivery of antibodies to the central nervous system - The invention relates to improvements in the field of drug delivery. More particularly, the invention relates to polypeptide derived from aprotinin and from aprotinin analogs as well as conjugates and pharmaceutical compositions comprising these polypeptides. The present invention also relates to the use of these polypeptide for transporting an antibody or antibody fragment across the blood-brain barrier of an individual and in the treatment and diagnosis of neurological diseases. | 01-15-2009 |
20090082277 | Potentiation of anticancer agents - The present invention relates to carriers, conjugate and pharmaceutical compositions and their use to increase the potency of drugs and to modify the pharmacokinetics of compounds. More particularly, the present invention relates to conjugates comprising the carrier described herein and their use in the treatment and diagnostic of cancer. | 03-26-2009 |
20100297120 | APROTININ-LIKE POLYPEPTIDES FOR DELIVERING AGENTS CONJUGATED THERETO TO TISSUES - Based on our identification of a polypeptide (Angiopep-7) that is efficiently transported to cells such as liver, lung, kidney, spleen, and muscle, the invention provides polypeptides, conjugates including the polypeptides, and methods for treating diseases associated with these cell types. Unlike other aprotinin related polypeptides identified herein (including Angiopep-3, Angiopep-4a Angiopep-4b Angiopep-5, and Angiopep-6) which efficiently cross the blood-brain barrier (BBB), Angiopep-7 is not efficiently transported across the BBB. | 11-25-2010 |
Patent application number | Description | Published |
20110039785 | POLYPEPTIDE-NUCLEIC ACID CONJUGATES AND USES THEREOF - The present invention is directed to polypeptide-nucleic acid conjugates. These conjugates can allow for targeted application of a therapeutic RNAi agent across the blood-brain barrier to treat, for example, a cancer, neurodegenerative disease, or lysosomal storage disorder. | 02-17-2011 |
20110112036 | PHARMACEUTICAL COMPOSITIONS OF PACLITAXEL, PACLITAXEL ANALOGS OR PACLITAXEL CONJUGATES AND RELATED METHODS OF PREPARATION AND USE - Pharmaceutical compositions useful for hydrophobic agents paclitaxel, paclitaxel analogs and conjugates thereof (e g ANG1005) which do not contain Cremophor™ The compositions further comprise an optional tonicity agent, a buffering agent a bulking agent and a solubilizmg agent which is not Cremophor™ Methods of preparing said compositions and of said compositions in the treatment of cancer are also included. | 05-12-2011 |
20110171128 | APROTININ POLYPEPTIDES FOR TRANSPORTING A COMPOUND ACROSS THE BLOOD-BRAIN BARRIER - The invention relates to improvements in the field of drug delivery. More particularly, the invention relates to polypeptides derived from aprotinin and from aprotinin analogs as well as conjugates and pharmaceutical compositions comprising these polypeptides or conjugates. The present invention also relates to the use of these polypeptides for transporting a compound or drug across the blood-brain barrier of a mammal and in the treatment and diagnosis of neurological diseases. | 07-14-2011 |
20110288009 | LEPTIN AND LEPTIN ANALOG CONJUGATES AND USES THEREOF - The present invention features a compound having the formula A-X-B, where A is peptide vector capable of enhancing transport of the compound across the blood-brain barrier or into particular cell types, X is a linker, and B is a leptin, a leptin analog, or OB receptor agonist. The compounds of the invention can be used to treat any disease in which increased amounts of leptin are desired, such as metabolic diseases including obesity and diabetes. | 11-24-2011 |
20120135914 | ETOPOSIDE AND DOXORUBICIN CONJUGATES FOR DRUG DELIVERY - The invention relates to improvements in the field of drug delivery. More particularly, the invention relates to polypeptides having a hydrolyzable covalent bond to a therapeutic agent that includes, etoposide, etoposide 4′-dimethylglycine or doxorubicin. These polypeptide conjugates can be used as vectors to transport the podophyllotoxin derivative across the blood brain barrier (BBB) or into particular cell types such as ovary, liver, lung, or kidney. The invention also relates to pharmaceutical compositions that include the compounds of the invention and to uses thereof in methods of treatment. | 05-31-2012 |
20120141416 | MULTIMERIC PEPTIDE CONJUGATES AND USES THEREOF - The present invention relates to multimeric (e.g., dimeric, trimeric) forms of peptide vectors that are capable of crossing the blood-brain barrier (BBB) or efficiently entering particular cell types. These multimeric peptide vectors, when conjugated to agents (e.g., therapeutic agents) are capable of transporting the agents across the BBB or into particular cell types. These compounds are therefore particularly useful in the treatment of neurological diseases. | 06-07-2012 |
20120277158 | COMPOSITIONS AND METHODS FOR THE TRANSPORT OF THERAPEUTIC AGENTS - The present invention is directed to conjugates that include a polypeptide capable of crossing the blood-brain barrier or entering one or more cell types attached to a transport vector, i.e., a composition capable of transporting an agent (e.g., a therapeutic agent). In certain cases, the polypeptides are directly conjugated to a lipid or polymeric vector to allow targeted application of a therapeutic agent to treat, for example, a cancer, a neurodegenerative disease, or a lysosomal storage disorder. | 11-01-2012 |
20130280281 | SHORT AND D-AMINO ACID-CONTAINING POLYPEPTIDES FOR THERAPEUTIC CONJUGATES AND USES THEREOF - The present invention relates to short polypeptides (e.g., fewer than 19 amino acids in length) and longer polypeptides (e.g., 19 or more amino acids in length) having one or more D-amino acids as targeting moieties. These polypeptides, when conjugated to agents (e.g., therapeutic agents or transport vectors) are capable of transporting the agents across the BBB or into particular cell types. In particular, the short polypeptides can include one or more D-amino acids. These compounds are therefore particularly useful in the treatment of neurological diseases or diseases associated with particular cell types, organs, or tissues. | 10-24-2013 |
20150038429 | ETOPOSIDE AND DOXORUBICIN CONJUGATES FOR DRUG DELIVERY - The invention relates to improvements in the field of drug delivery. More particularly, the invention relates to polypeptides having a hydrolyzable covalent bond to a therapeutic agent that includes, etoposide, etoposide 4′-dimethylglycine or doxorubicin. These polypeptide conjugates can be used as vectors to transport the podophyllotoxin derivative across the blood brain barrier (BBB) or into particular cell types such as ovary, liver, lung, or kidney. The invention also relates to pharmaceutical compositions that include the compounds of the invention and to uses thereof in methods of treatment. | 02-05-2015 |
20150174266 | APROTININ POLYPEPTIDES FOR TRANSPORTING A COMPOUND ACROSS THE BLOOD-BRAIN BARRIER - The invention relates to improvements in the field of drug delivery. More particularly, the invention relates to polypeptides derived from aprotinin and from aprotinin analogs as well as conjugates and pharmaceutical compositions comprising these polypeptides or conjugates. The present invention also relates to the use of these polypeptides for transporting a compound or drug across the blood-brain barrier of a mammal and in the treatment and diagnosis of neurological diseases. | 06-25-2015 |
20150314010 | POTENTIATION OF ANTICANCER AGENTS - The present invention relates to carriers, conjugate and pharmaceutical compositions and their use to increase the potency of drugs and to modify the pharmacokinetics of compounds. More particularly, the present invention relates to conjugates comprising the carrier described herein and their use in the treatment and diagnostic of cancer. | 11-05-2015 |
Patent application number | Description | Published |
20100167471 | REDUCING WARPAGE FOR FAN-OUT WAFER LEVEL PACKAGING - Fan-out wafer level packaging includes an integrated circuit having a top surface, a bottom surface, a plurality of side surfaces, and a bond pad defined on the top surface. A layer of encapsulant substantially surrounds the side surfaces of the integrated circuit, the layer of encapsulant having a height substantially equal to a height of the integrated circuit. A bump is spaced apart from the integrated circuit, and a redistribution layer electrically couples the bond pad of the integrated circuit to the bump. | 07-01-2010 |
20120244664 | REDUCING WARPAGE FOR FAN-OUT WAFER LEVEL PACKAGING - Fan-out wafer level packaging includes an integrated circuit having a top surface, a bottom surface, a plurality of side surfaces, and a bond pad defined on the top surface. A layer of encapsulant substantially surrounds the side surfaces of the integrated circuit, the layer of encapsulant having a height substantially equal to a height of the integrated circuit. A bump is spaced apart from the integrated circuit, and a redistribution layer electrically couples the bond pad of the integrated circuit to the bump. | 09-27-2012 |
20130001795 | Wafer Level Package and a Method of Forming the Same - A wafer level package is provided. The wafer level package includes at least one chip with at least one electronic component, and at least one connecting chip with at least one through-silicon via, wherein the at least one through-silicon via is electrically coupled to the at least one chip. Further embodiments relate to a method of forming the wafer level package. | 01-03-2013 |
Patent application number | Description | Published |
20160044871 | PLANT CULTIVATION METHOD - To provide a technique whereby, in cultivating a crop, factors relating to differentiation into flower buds and leaf buds, sprouting, flowering, and fruiting, growth of young shoots, etc., are regulated. For example, the invention addresses the problem of regulating the growth of a crop so that the leaf buds sprout in tandem and with the sprouting of flower buds and flowering and fruiting are repeated under fresh foliage. [Solution] A plant cultivation method which comprises environmentally stimulating a plant to regulate differentiation into flower buds and/or differentiation into leaf buds. In a typical embodiment, the plant is help in an environment at a temperature of 16-40° C. at a photoperiod of 8-12 hours immediately after harvesting fruits. As another environmental stimulus, the plant is held in, for example, an environment at a temperature of 3-7° C. As still another environmental stimulus, the plant is held in, for example, an environment at a temperature of 16-23° C. at a photoperiod of 8-11 hours. | 02-18-2016 |
Patent application number | Description | Published |
20120078189 | NEEDLE ARRAY TRANSDERMAL ABSORPTION SHEET AND METHOD FOR MANUFACTURING NEEDLE ARRAY TRANSDERMAL ABSORPTION SHEET - A needle array transdermal absorption sheet to be attached onto a skin for supplying a drug into the skin, includes: a plurality of needle portions each having a tapered shape, each of the needle portions including a needle having a conical or pyramidal shape and a body part which has a columnar shape and whose end surface is connected to a base of the needle; a sheet portion having a flat-plate shape; and a plurality of frustum portions each having a frustum shape, the frustum portions which are arranged on a surface of the sheet portion in a manner that perimeters of larger bases of adjacent frustum portions are in contact with each other on the surface of the sheet portion, and smaller bases of which are respectively connected to the body parts of the needle portions. | 03-29-2012 |
20150196746 | NEEDLE ARRAY TRANSDERMAL ABSORPTION SHEET AND METHOD FOR MANUFACTURING NEEDLE ARRAY TRANSDERMAL ABSORPTION SHEET - A needle array transdermal absorption sheet to be attached onto a skin for supplying a drug into the skin, includes: a plurality of needle portions each having a tapered shape, each of the needle portions including a needle having a conical or pyramidal shape and a body part which has a columnar shape and whose end surface is connected to a base of the needle; a sheet portion having a flat-plate shape; and a plurality of frustum portions each having a frustum shape, the frustum portions which are arranged on a surface of the sheet portion in a manner that perimeters of larger bases of adjacent frustum portions are in contact with each other on the surface of the sheet portion, and smaller bases of which are respectively connected to the body parts of the needle portions. | 07-16-2015 |
20150238413 | METHOD FOR MANUFACTURING TRANSDERMAL-ABSORPTION SHEET - A method is provided which enables a drug to be concentrated at needle-like protruding portions and which further allows transdermal-absorption sheets to be manufactured at high production efficiency. The method repeats a step of feeding a drug-containing solution from a liquid feeding apparatus to a mold and filling needle-like recessed portions with the drug-containing solution through a nozzle aligned over the needle-like recessed portions in a state where the nozzle and a front surface of the mold are brought into contact with each other, and a step of moving the liquid feeding apparatus relative to the mold in a state where the nozzle and the front surface of the mold are brought into contact with each other. Thus, the two-dimensionally arranged needle-like recessed portions are filled with the drug-containing solution. | 08-27-2015 |
20150238434 | TRANSDERMAL ABSORPTION SHEET, AND MANUFACTURING METHOD FOR THE SAME - A transdermal absorption sheet and a manufacturing method for the transdermal absorption sheet includes a laminating step of forming a multilayer film with a viscosity difference by forming, on a support, a lower layer containing a first transdermal absorption material and an upper layer containing a drug and a second transdermal absorption material and having a lower viscosity than the lower layer, a filling step of filling needle-like recessed portions corresponding to inverted needle-like protruding portions with a solution of the transdermal absorption material by pressing a mold in which the needle-like recessed portions are arranged in a two-dimensional array, against a surface of the multilayer film supported by the support to allow the multilayer film to flow, a solidifying step of solidifying the multilayer film with the mold pressed against the surface of the multilayer film, and a peeling-off step of peeling the solidified multilayer film from the mold. | 08-27-2015 |
20150238743 | MOLDING COMPACT, AND MANUFACTURING METHOD FOR TRANSDERMAL ABSORPTION SHEET - A molding compact for forming a transdermal absorption sheet on which a needle-shaped protruding part is arranged is a molding compact that is a laminate of: a first member having a needle-shaped recessed part formed on a front surface thereof, the needle-shaped recessed part being an inverse of the needle-shaped protruding part; a second member provided on a back surface of the first member, the second member being composed of a waterproof and moisture-permeable material; and a third member provided on a back surface of the second member, the third member being composed of a rigid body. Provided are a molding compact that makes it possible to prevent leakage of a drug-containing solution filled into the needle-shaped recessed part, and a manufacturing method for a transdermal absorption sheet using the molding compact. | 08-27-2015 |
Patent application number | Description | Published |
20080223723 | METHOD FOR MANUFACTURING MASTER INFORMATION CARRIER FOR MAGNETIC TRANSFER - There is provided a method for manufacturing a high quality master information carrier for magnetic transfer, the method preventing the metallic disk formed by electroforming from coming off from the conduction ring and decreasing the distortion of the master information carrier. A conduction ring connected to a cathode is arranged on a matrix and electroforming is performed with the conduction ring being smaller in bore diameter than a presser ring for fixing the conduction ring and the matrix. | 09-18-2008 |
20080237912 | METHOD OF PRODUCING STAMPER FOR OPTICAL RECORDING MEDIUM, METHOD OF PRODUCING SUBSTRATE, METHOD OF PRODUCING OPTICAL RECORDING MEDIUM, AND APPARATUS FOR PRODUCING STAMPER FOR OPTICAL RECORDING MEDIUM - In a method of producing a stamper for roughening a substrate of an optical recording medium, a masking treatment is carried out prior to a blasting treatment, whereby a second pit forming site of a metal plate is protected such that the second pit forming site is not broken in the following blasting treatment. A mask of an adhesive sheet is attached to the second pit forming site in the masking treatment, and then a part of one major surface of the metal plate, exposed between the mask, is roughened in the blasting treatment. An original stamper of the metal plate, having a partly roughened major surface, is obtained by the blasting treatment. | 10-02-2008 |
20090008257 | METHOD OF PRODUCING STAMPER FOR OPTICAL RECORDING MEDIUM, METHOD OF PRODUCING SUBSTRATE, AND METHOD OF PRODUCING OPTICAL RECORDING MEDIUM - A method of producing a stamper for roughening a substrate of an optical recording medium contains the steps of placing a conductive ring having a hole at the center thereof on a major surface of an original metal plate, electroforming a metal layer over a portion of the metal plate exposed in the hole of the conductive ring, an inner end-face of the conductive ring, and a portion of a major surface of the conductive ring, and entirely or partly roughening a major surface of the metal layer by a blasting treatment to obtain an original stamper. | 01-08-2009 |