Changhui
Changhui Chen, Linhai CN
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20120142927 | METHOD FOR PREPARING PRASUGREL - The present invention relates to a method for synthesizing prasugrel, comprising, the following steps: converting o-fluorobenzyl cyclopropyl ketone into α-cyclopropylcarbonyl-2-fluorobenzyl halide (compound 2) using dibromohydantoinhydantoin as halogenation reagent and acetic acid as solvent, then 2-oxo-4,5,6,7-tetrahydrothieno[3,2-c]pyridine p-toluenesulfonate (compound 4) is obtained with high yield by a concerted catalysis using a phase transfer catalyst and an inorganic salt, then is condensed and acylated to obtain prasugrel as a gum. The present invention also provides a method for purifying prasugrel comprising crystallizing using alcohols as a crystallization solvent to obtain prasugrel crystals with a high purity. | 06-07-2012 |
20140142311 | METHOD FOR PREPARING PRASUGREL - The present invention relates to a method for synthesizing prasugrel, comprising the following steps: converting o-fluorobenzyl cyclopropyl ketone into α-cyclopropylcarbonyl-2-fluorobenzyl halide (compound 2) using dibromohydantoinhydantoin as halogenation reagent and acetic acid as solvent, then 2-oxo-4,5,6,7-tetrahydrothieno[3,2-c]pyridine p-toluenesulfonate (compound 4) is obtained with high yield by a concerted catalysis using a phase transfer catalyst and an inorganic salt, then is condensed and acylated to obtain prasugrel as a gum. The present invention also provides a method for purifying prasugrel comprising crystallizing using alcohols as a crystallization solvent to obtain prasugrel crystals with a high purity. | 05-22-2014 |
Changhui Liu, Walnut, CA US
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20150030540 | Imaging agents for detecting neurological dysfunction - Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherein the compound is selected from the group consisting of radiolabeled carbazoles and derivatives thereof and triazoles derivatives, allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimer's Disease. | 01-29-2015 |
Changhui Xia, Xiamen CN
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20150380180 | Clasping Connection Structure of Contactor - A clasping connection structure of a contactor is disclosed, including a base, a housing and a bobbin; accommodating chambers is formed on the housing and configured to accommodate contact head therein, the accommodating chambers are separated via a side plate, the bobbin and the housing are connected via a first clasp, the first clasp is protruded and extended at a central side plate of the housing, the central side plate is located at an axial center line of the housing, correspondingly, a limiting slot for matching with the central side plate is formed on the bobbin, the bobbin is inserted in the housing, the central side plate passes through the limiting slot, the clasp of the central side plate is hooked on the bobbin at a side of the limiting slot, to connect the bobbin and the housing, the housing and the base are connected via a second clasp. The contactor of the invention is adapted to the automatic assembling, and has reduced manufacturing cost. | 12-31-2015 |
Changhui Zhang, Coralville, IA US
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20150161899 | METHODS FOR IMPROVING TEST EFFICIENCY AND ACCURACY IN A COMPUTER ADAPTIVE TEST (CAT) - A method for use of pretest items in a test to calculate interim scores is provided. The method includes, for example, a computer implemented test having a plurality of test items that include, for example, a plurality of operational items and one or more pretest items having one or more pretest item parameters. An interim latent construct estimate is calculated using both operational and pretest items. The error for the latent construct estimation is controlled by weighting the contribution of the one or more pretest items. | 06-11-2015 |
20150161900 | METHODS FOR IMPROVING TEST EFFICIENCY AND ACCURACY IN A COMPUTER ADAPTIVE TEST (CAT) - A method for use of pretest items in a test to calculate interim scores is provided. The method includes, for example, a computer implemented test having a plurality of test items that include, for example, a plurality of operational items and one or more pretest items having one or more pretest item parameters. An interim latent construct estimate is calculated using both operational and pretest items. The error for the latent construct estimation is controlled by weighting the contribution of the one or more pretest items. | 06-11-2015 |
20150161901 | METHODS FOR IMPROVING TEST EFFICIENCY AND ACCURACY IN A COMPUTER ADAPTIVE TEST (CAT) - A method for test item selection is provided that includes a computer implemented test battery having at least two or more sections with a plurality of test items. An ability estimate is calculated from an earlier section(s) of the at least two or more sections and an initial item and subsequent items for a subsequent section are selected from the plurality of test items based upon the ability estimate(s) from the earlier section(s). Use of a more informative initial ability estimate in the item selection process can improve interim ability estimation accuracy and item selection efficiency while keeping item exposure and item usage rates at acceptable levels. | 06-11-2015 |
20150161902 | METHODS FOR IMPROVING TEST EFFICIENCY AND ACCURACY IN A COMPUTER ADAPTIVE TEST (CAT) - A method for test item selection is provided that includes a computer implemented test battery having at least two or more sections with a plurality of test items. An ability estimate is calculated from an earlier section(s) of the at least two or more sections and an initial item and subsequent items for a subsequent section are selected from the plurality of test items based upon the ability estimate(s) from the earlier section(s). Use of a more informative initial ability estimate in the item selection process can improve interim ability estimation accuracy and item selection efficiency while keeping item exposure and item usage rates at acceptable levels. | 06-11-2015 |