Chan, MA
A. Ken Chan, Framingham, MA US
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20120083740 | Introducer Sheath for Catheters - An introducer sheath includes a tubular body portion having a proximal region and a distal region, and defines an internal lumen configured and dimensioned to slidably receive a catheter. A penetrating portion at a distal end of the tubular body has a first tapered configuration to enlarge an opening in a body tissue during distal advancement of the introducer sheath through the body tissue and a second expanded configuration to enable the passage of a distal end portion of a catheter through the penetrating portion. | 04-05-2012 |
20120323180 | INTRODUCER SHEATH FOR CATHETERS - An introducer sheath includes a tubular body portion having a proximal region and a distal region, and defines an internal lumen configured and dimensioned to slidably receive a catheter. A penetrating portion at a distal end of the tubular body has a first tapered configuration to enlarge an opening in a body tissue during distal advancement of the introducer sheath through the body tissue and a second expanded configuration to enable the passage of a distal end portion of a catheter through the penetrating portion. | 12-20-2012 |
Alex C. Chan, Auburn, MA US
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20100088733 | DISTRIBUTED AUDIO AND VIDEO PROCESSING - A method of distributing audio and video processing tasks among devices interconnected to a display device via a local network is disclosed. In one embodiment, the display device offloads some processing tasks to a computing device on the local network to achieve improved processing performance. The computing device receives audiovisual data, decodes, processes, encodes and transmits the encoded data to the display device in a suitable data format. The processing in the computing device is complementary to any processing to be performed in the display device. In another embodiment, the display device utilizes a plurality of devices on the local network to perform particular signal processing tasks. The other devices in network perform the processing tasks indicated by the display, and send processed data back to the display device for presentation, which helps improve the overall audiovisual data processing performance. | 04-08-2010 |
Andy Chan, Franklin, MA US
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20110180426 | Modulating Polarization Voltage of Amperometric Sensors - The service life of amperometric electrochemical oxygen sensors is increased by operating the electrodes of such sensors at a polarization voltage suitable for measuring the oxygen content of samples only during calibration or when measuring such samples and thereafter modulating the polarization voltage to a lower voltage such that substantially no electrical current is produced by the electrodes. | 07-28-2011 |
Andy D. C. Chan, Frenklin, MA US
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20090045056 | Stable three enzyme creatinine biosensor - The invention provides methods for preparing a stable, multiple-use three enzyme biosensor for the amperometric determination of creatinine in biological liquids that has a useful lifetime that extends significantly beyond that of presently available amperometric biosensors. The biosensor prepared by the methods of the invention encompasses a plurality of immobilized enzymes that are applied to the biosensor as an enzyme-polymer composition. The enzymes, which can include creatinine amidohydrolase, creatine amidinohydrolase and sarcosine oxidase, are immobilized into the enzyme-polymer composition simultaneously as well as applied to the biosensor simultaneously. Prior to being immobilized, the enzymes can be chemically modified by attaching one or more polyethylene glycol (PEG) chains per enzyme monomer. The polymer component can be provided by a polyurethane membrane. The invention also provides a method of preparing a biosensor that limits the diffusion of silver ions emanating the reference electrode, thereby preventing, contact between the silver ions and the enzymes. Related methods of preparing an enzyme-polymer composition for incorporation into a multiple use three enzyme biosensor for the amperometric determination of creatinine in biological liquids also are provided. The invention also provides multiple-use biosensors and enzyme-polymer compositions prepared by the methods disclosed. | 02-19-2009 |
Barbara Chan, Cambridge, MA US
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20130158342 | PHOTOCHEMICAL TISSUE BONDING - Photochemical tissue boding methods for bonding neural tissues include the application of a photosensitizer to a tissue and/or tissue graft, followed by irradiation with electromagnetic energy to produce a tissue seal. The methods are useful for tissue adhesion, such as in wound closure, tissue grafting, skin grafting, musculoskeletal tissue repair, ligament or tendon repair, neural repair, blood vessel repair and corneal repair. | 06-20-2013 |
Benjamin Chan, Raynham, MA US
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20130261664 | SURGICAL FILAMENT ASSEMBLIES - A suture anchor, and a surgical filament assembly using same, capable of being fixated in a hole formed in a bone of a patient. The suture anchor preferably includes an anchor body with a passage extending from a proximal end toward a distal end, and at least one bone engaging feature on the exterior of the anchor. A knot patency element disposed within the passage holds a removable sliding knot formed, using the surgical filament. A tightening limb of the sliding knot enables the user to tighten the sliding knot against an object extending through a capture loop to secure the object to the anchor. | 10-03-2013 |
Cathy Chan, Burlington, MA US
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20090304019 | METHOD AND DEVICE FOR REDUCING MULTICAST TRAFFICE IN A UPNP NETWORK - Methods and devices for facilitating communications over a Universal Plug and Play (UPnP) network are disclosed. These methods and devices reduce network traffic while maintaining maximum freshness of the UPnP controlled device status. These and other features of the present invention are accomplished by introducing an intermediary proxy device to moderate multicast messages that are transmitted over the network. The proxy device receives unicast messages from a UPnP controlled device and transmits multicast information on behalf of the UPnP controlled device at a lower rate. In addition, the proxy device can detect unexpected unavailability of the UPnP controlled device and promptly alert other control points on the UPnP network. | 12-10-2009 |
Chunkong Barden Chan, Allston, MA US
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20080199426 | Methods and compositions for the treatment and diagnosis of vascular inflammatory disorders or endothelial cell disorders - Disclosed herein are methods for treating a vascular inflammatory disorder or endothelial cell disorder using inhibitor compounds that inhibit the expression or biological activity of Tie-1, Tie-1 endodomain, thrombin, VEGFR2, VEGFR2 endodomain, EphA2, and any of the cytokines or kinases that are upregulated by activation of Tie-1 or thrombin, as provided herein. Also disclosed are the use of combinations of inhibitor compounds or the use of an eNOS activator compound in combination with any one or more of the inhibitor compounds. Also disclosed are methods for inhibiting the pro-coagulant activity of thrombin using a Tie-1 or Tie-1 endodomain inhibitor compound or an EphA2 inhibitor compound. Methods for diagnosing and monitoring vascular inflammatory disorders or endothelial cell disorders that include the measurement of any of the polypeptides or nucleic acid molecules of the invention are also disclosed. | 08-21-2008 |
20100136001 | Methods and compositions for the treatment and diagnosis of vascular inflammatory disorders or endothelial cell disorders - Disclosed herein are methods for treating a vascular inflammatory disorder or endothelial cell disorder using inhibitor compounds that inhibit the expression or biological activity of Tie-1, Tie-1 endodomain, thrombin, VEGFR2, VEGFR2 endodomain, EphA2, and any of the cytokines or kinases that are upregulated by activation of Tie-1 or thrombin, as provided herein. Also disclosed are the use of combinations of inhibitor compounds or the use of an eNOS activator compound in combination with any one or more of the inhibitor compounds. Also disclosed are methods for inhibiting the pro-coagulant activity of thrombin using a Tie-1 or Tie-1 endodomain inhibitor compound or an EphA2 inhibitor compound. Methods for diagnosing and monitoring vascular inflammatory disorders or endothelial cell disorders that include the measurement of any of the polypeptides or nucleic acid molecules of the invention are also disclosed. | 06-03-2010 |
20120003227 | METHODS AND COMPOSITIONS FOR THE TREATMENT AND DIAGNOSIS OF VASCULAR INFLAMMATORY DISORDERS OR ENDOTHELIAL CELL DISORDERS - Disclosed herein are methods for treating a vascular inflammatory disorder or endothelial cell disorder using inhibitor compounds that inhibit the expression or biological activity of Tie-1, Tie-1 endodomain, thrombin, VEGFR2, VEGFR2 endodomain, EphA2, and any of the cytokines or kinases that are upregulated by activation of Tie-1 or thrombin, as provided herein. Also disclosed are the use of combinations of inhibitor compounds or the use of an eNOS activator compound in combination with any one or more of the inhibitor compounds. Also disclosed are methods for inhibiting the pro-coagulant activity of thrombin using a Tie-1 or Tie-1 endodomain inhibitor compound or an EphA2 inhibitor compound. Methods for diagnosing and monitoring vascular inflammatory disorders or endothelial cell disorders that include the measurement of any of the polypeptides or nucleic acid molecules of the invention are also disclosed. | 01-05-2012 |
20130273057 | METHODS AND COMPOSITIONS FOR THE TREATMENT AND DIAGNOSIS OF VASCULAR INFLAMMATORY DISORDERS OR ENDOTHELIAL CELL DISORDERS - Disclosed herein are methods for treating a vascular inflammatory disorder or endothelial cell disorder using inhibitor compounds that inhibit the expression or biological activity of Tie-1, Tie-1 endodomain, thrombin, VEGFR | 10-17-2013 |
Clement Tsz Chan, Cambridge, MA US
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20110262949 | GENETIC INCORPORATION OF 3-AMINOTYROSINE INTO REDUCTASES - This invention provides reductase proteins that comprise NH | 10-27-2011 |
Edwin P. Chan, Cambridge, MA US
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20110062635 | Stimuli-responsive surfaces and related methods of fabrication and use - Biomimetic stimuli-responsive surfaces and articles of manufacture, together with methods of fabrication and related methods of use. | 03-17-2011 |
Elayne Chan, Auburndale, MA US
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20110256526 | DETECTION OF HUMAN SOMATIC CELL REPROGRAMMING - The methods and kits described herein are based, in part, to the discovery phenotype representing a fully-reprogrammed iPS cell and several reprogramming intermediates. The methods and kits described herein permit identification of fully-reprogrammed iPS cells and further permits one of skill in the art to monitor the emergence of iPS cells during the reprogramming process. The methods/kits can also be performed using real time using live cell imaging. Also described herein are methods for screening candidate reprogramming agents by monitoring the emergence of fully-reprogrammed iPS cells in the presence and absence of such an agent. | 10-20-2011 |
20140336065 | DETECTION OF HUMAN SOMATIC CELL REPROGRAMMING - The methods and kits described herein are based, in part, to the discovery of a phenotype representing a fully-reprogrammed iPS cell and several reprogramming intermediates. The methods and kits described herein permit identification of fully-reprogrammed iPS cells and further permits one of skill in the art to monitor the emergence of iPS cells during the reprogramming process. The methods/kits can also be performed using real time using live cell imaging. Also described herein are methods for screening candidate reprogramming agents by monitoring the emergence of fully-reprogrammed iPS cells in the presence and absence of such an agent. | 11-13-2014 |
Eugene Y. Chan, Boston, MA US
Patent application number | Description | Published |
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20120196382 | Multicoded Analytical Nanostrips - Analytical nanostrips for clinical analysis are improved by using multifunctional coding (“multicoding”) to allow simultaneous identification of the particular assay, the value of the assayed analyte, and a calibration of the analyte. The multicoding layout on the nanostrip minimizes the number of zones that are required for a given assay. Moreover, the nanostrip can be scanned in real time during flow of the nanostrip through a detection beam. This both simplifies the assay and allows for alternative means of coding. | 08-02-2012 |
20120214224 | Flow based clinical analysis - Values of clinical properties are normally measured by taking a sample from a patient, mixing an aliquot with a reagent, placing the mixture into a selected instrument, and measuring a property. If another property is required, another measurement sequence must be created. This can be efficient on a large scale, for example in a centralized laboratory, but is inefficient on a small scale. It is shown that by using measurement systems based on manipulation of flowing streams, clinical assays can be performed by a hand held device. This flow based system allows complex assays to be performed in remote locations with automated portable instruments that can be flexible enough to conduct a wide variety of assays. | 08-23-2012 |
20120217161 | Methods and Products for Analyzing Polymers - Methods and products for analyzing polymers are provided. The methods include methods for determining various other structural properties of the polymers. | 08-30-2012 |
20130260474 | Microfluidic passive mixing chip - An improved device and method for passive mixing of fluids is described, and the use of the device in clinical diagnostic procedures. The mixer provides thorough mixing of a sample of blood or other fluid with an assay material, such as a diluent or a component of an assay system, in a closed system with a low and limited pressure drop. Sample size is small, typically 5 to 300 microliters. Mixing is accomplished by a combination of rotational vortex mixing due to a fluid stream coming tangent to a drain, and either or both of a second vortex mixer of opposite handedness, and a Dean mixer. Combinations of these techniques reliably provide complete mixing at low pressure drop. In a preferred usage, the microfluidic system can run a diluent continuously and inject samples at intervals, to facilitate automatic data processing of optical or other signatures of the well-mixed stream. | 10-03-2013 |
20140199209 | METHODS AND PRODUCTS FOR ANALYZING POLYMERS - Methods and products for analyzing polymers are provided. The methods include methods for determining various other structural properties of the polymers. | 07-17-2014 |
20150260745 | Sample consumable and loader - A sample consumable that carries a microvolume of sample to a sample loader. The consumable is precisely aligned utilizing a double-alignment feature to the loader. The loader is based on a crank-slider geometry and allows for simple, one-handed operation for the user. Overall, the consumable and sample loader increase reproducibility of in-line sample loading and offers ease-of-use. | 09-17-2015 |
20150283544 | Fluidics module - An integrated fluidics module that reduces mass and volume so that it can readily fit inside a compact biomedical instrument. A fluidics module that integrates discrete components (e.g., pump, connectors, tubing, regulator, and valves) reduces mass and volume requirements. | 10-08-2015 |
20150284486 | PEG-based microparticles - Synthesis of monodisperse PEG-based microparticles with stable coupling chemistries. Biomolecules are conjugated to monodisperse PEG microparticles using non-amine chemistries, such as sulfhydryl groups, azide, or alkyne-based chemistries. | 10-08-2015 |
20150285729 | Microparticle multiplexing - Multiplexing microparticles by measurement of particle length and dye. Utilization of length-based measurements in combination with dye concentrations to attain multiplexing for bioassays. | 10-08-2015 |
Eugene Y. Chan, Cambridge, MA US
Patent application number | Description | Published |
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20140165711 | Capillary Manipulation of Clinical Samples - A system for collection and delivery of sub-milliliter liquid samples is described that provides a dramatic simplification for the measurement of clinical values. The system produces high dilutions of capillary size samples, such as bodily fluids or blood, by a factor of 1000 or more. Multiple assays can be conducted on a sample of 0.1 cc or less. A small lancet can create a drop of blood on a fingertip or other location, which can be collected into a self-priming capillary blood collector. The sample is then loaded into a consumable loader. Then a fluid, such as saline, is flowed into the consumable loader, and passes through the capillary collector, washing out the fluid. Downstream, the blood in the capillary is reliably diluted by mixing with appropriate reagents to allow analysis of selected blood properties. One or more individual bubbles can be inserted into the stream during loading. The capillary loading system can be used for one or several assays on a single blood sample. It can be very compact and lightweight and is suitable for use in remote environments, such as outer space, in which it is difficult to access diagnostic assays. | 06-19-2014 |
20150177120 | Optical block - An integrated optical block that is highly portable and compact, designed to measure cells and particles. | 06-25-2015 |
Eugene Y. Chan, Brookline, MA US
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20110210272 | Methods and Products for Analyzing Polymers - Methods and products for analyzing polymers are provided. The methods include methods for determining various other structural properties of the polymers. | 09-01-2011 |
George Joe-Kueng Chan, Salem, MA US
Patent application number | Description | Published |
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20120107107 | ANTI-ROTATION SHROUD FOR TURBINE ENGINES - A shroud for turbine engines. The shroud has an integrated anti-rotation device that prevents circumferential movement of the shroud during normal engine operation, and which allows for circumferential installation in split annular case designs. Since the anti-rotation device is an integral part of the shroud and/or annular split turbine case, no additional parts are necessary for assembly or disassembly. Moreover, existing annular split turbine cases can be reworked to accept the anti-rotation device and yet still be backwards compatible with original shroud designs. | 05-03-2012 |
20140250893 | DEVICE AND METHOD FOR PREVENTING LEAKAGE OF AIR BETWEEN MULTIPLE TURBINE COMPONENTS - A turbine comprising a first turbine component being of a first material having a first coefficient of thermal expansion. A second turbine component being of a second material having a second coefficient of thermal expansion, said second turbine component adjacent said first turbine component. A space between said first and second turbine components. A seal assembly sealing said space, wherein at least a portion of said seal assembly has a coefficient of thermal expansion substantially similar to at least one of said first or second turbine components to thereby maintain a seal in said space during thermal expansion or contraction of said first and second turbine components. | 09-11-2014 |
Henry Hl Chan, Boston, MA US
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20140303696 | METHOD AND APPARATUS FOR CRYOGENIC TREATMENT OF SKIN TISSUE - Cosmetic method and apparatus are provided that can provide cooling and/or freezing of skin tissue proximal to the skin surface to generate an appearance of lightening or reduced pigmentation in the skin. The skin can be cooled to a temperature of less than about −5 degrees Celsius for a duration of about one minute or less, using a cooled surface that is at least 3 cm in width. A cooling arrangement can be provided to provide controlled heat removal from the skin tissue being treated. A sensor can optionally be provided to detect freezing of tissue proximal to the cooled surface. | 10-09-2014 |
20140303697 | METHOD AND APPARATUS FOR CRYOGENIC TREATMENT OF SKIN TISSUE - Cosmetic method and apparatus are provided that can provide cooling and/or freezing of skin tissue proximal to the skin surface to generate an appearance of lightening or reduced pigmentation in the skin. The skin can be cooled to a temperature of less than about −5 degrees Celsius for a duration of about one minute or less, using a plurality of cooled contact surfaces, each having a width between about 2 mm and about 20 mm. A cooling arrangement can be provided to provide controlled heat removal from the skin tissue being treated. A sensor can optionally be provided to detect freezing of tissue proximal to the cooled surfaces. | 10-09-2014 |
Ho Man Chan, Arlington, MA US
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20150354006 | MARKERS FOR ACUTE LYMPHOBLASTIC LEUKEMIA - The invention provides methods of detecting a NSD2 mutation in a cancer cell, methods cancer diagnosis and methods of screening for NSD2 inhibitors. | 12-10-2015 |
Jacky Chi-Hung Chan, Framingham, MA US
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20100206661 | ACOUSTIC WAVEGUIDE VIBRATION DAMPING - An acoustic waveguide with at least two portions coupled by vibration damping structure. The vibration damping structure may be a conformable material such as closed cell foam. The vibration damping structure may further include structure for inhibiting motion in a direction transverse to the interface between the vibration damping structure and a portion of the waveguide. | 08-19-2010 |
20110037906 | LOW FREQUENCY ENCLOSURE FOR VIDEO DISPLAY DEVICES - A television includes a flat panel display device for presenting video images, a housing for supporting the flat panel display device, and a first acoustic volume located substantially (a) inside the housing, and (b) behind the display device. Two or more acoustic drivers are provided for acoustically energizing the acoustic volume. The drivers are positioned such that acoustic energy put into the acoustic volume from the drivers is substantially additive and vibrational energy from the drivers substantially cancels out. | 02-17-2011 |
20110150259 | PORTABLE AUDIO SYSTEM HAVING WAVEGUIDE STRUCTURE - An apparatus includes a housing. A waveguide is located within the housing. The waveguide includes a first subsection that bends around a first axis and has a first cross-sectional area with an aspect ratio that is substantially different from unity. A second subsection bends around a second axis that is non-parallel to the first axis and includes a second cross-sectional area with an aspect ratio that is substantially different from unity. A third subsection acoustically couples the first subsection to the second subsection. The third subsection includes a third cross-sectional area with an aspect ratio that varies between the first aspect ratio and the second aspect ratio. | 06-23-2011 |
20110253473 | Acoustic Waveguide Vibration Damping - An acoustic waveguide with at least two portions coupled by vibration damping structure. The vibration damping structure may be a conformable material such as closed cell foam. The vibration damping structure may further include structure for inhibiting motion in a direction transverse to the interface between the vibration damping structure and a portion of the waveguide. | 10-20-2011 |
20130315429 | PORTABLE AUDIO SYSTEM HAVING WAVEGUIDE STRUCTURE - An audio system includes a housing and an acoustic exit that exits the housing, and has a configuration that facilitates the grasping of the housing with a plurality of fingers from a single human hand. The acoustic exit is located adjacent an exterior surface of the housing such that the shape of the exit together with the exterior surface facilitates grasping of the housing with a plurality of fingers and the thumb from the single human hand and the acoustic exit exits a back surface of the housing such that the plurality of fingers can be inserted into the exit while the thumb of the same hand can rest on at least one of the top surface and the front surface of the housing. | 11-28-2013 |
20150296283 | PORTABLE AUDIO SYSTEM HAVING WAVEGUIDE STRUCTURE - An audio system includes a housing and an acoustic opening that exits the housing, and has a configuration that facilitates the grasping of the housing with a plurality of fingers from a single human hand. The acoustic opening is located adjacent an exterior surface of the housing such that the shape of the exit together with the exterior surface facilitates grasping of the housing with a plurality of fingers and the thumb from the single human hand and the acoustic opening exits a back surface of the housing such that the plurality of fingers can be inserted into the exit while the thumb of the same hand can rest on at least one of the top surface and the front surface of the housing. | 10-15-2015 |
Joanne Chan, Medford, MA US
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20090280130 | METHOD FOR THE TREATMENT OF ANTHRAX TOXICITY - is a spore-forming Gram positive bacterium that is the causative agent of anthrax infection. Vascular leakage and pleural effusions are hallmarks of the fulminant phase of human anthrax disease following infection. The present invention provides a method of halting, treating, and preventing the rapid toxic effects of human anthrax disease by blocking the VEGF pathway with chemical inhibitors of the VEGFR signaling pathway. The invention is also applicable as an anti-anthrax therapeutic in bio-warfare defense. | 11-12-2009 |
John K. Chan, Needham, MA US
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20120117789 | Methods of Making a Cell Stack for an Electrical Purification Apparatus - An electrical purification apparatus and methods of making same are disclosed. The electrical purification apparatus may provide for increases in operation efficiencies, for example, with respect to current efficiencies and membrane utilization. | 05-17-2012 |
20120118728 | ELECTRICAL PURIFICATION APPARATUS HAVING A BLOCKING SPACER - An electrical purification apparatus and methods of making same are disclosed. The electrical purification apparatus may provide for increases in operation efficiencies, for example, with respect to current efficiencies and membrane utilization. | 05-17-2012 |
20120118738 | METHOD OF PROVIDING A SOURCE OF POTABLE WATER - An electrical purification apparatus and methods of making same are disclosed. The electrical purification apparatus may provide for increases in operation efficiencies, for example, with respect to current efficiencies and membrane utilization. | 05-17-2012 |
20120118743 | ELECTRICAL PURIFICATION APPARATUS - An electrical purification apparatus and methods of making same are disclosed. The electrical purification apparatus may provide for increases in operation efficiencies, for example, with respect to current efficiencies and membrane utilization. | 05-17-2012 |
20140115877 | METHODS OF MAKING A CELL STACK FOR AN ELECTRICAL PURIFICATION APPARATUS - An electrical purification apparatus and methods of making same are disclosed. The electrical purification apparatus may provide for increases in operation efficiencies, for example, with respect to current efficiencies and membrane utilization. | 05-01-2014 |
20150122657 | ELECTRICAL PURIFICATION APPARATUS HAVING A BLOCKING SPACER - An electrical purification apparatus and methods of making same are disclosed. The electrical purification apparatus may provide for increases in operation efficiencies, for example, with respect to current efficiencies and membrane utilization. | 05-07-2015 |
Juliana Chan, Cambridge, MA US
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20090074828 | POLY(AMINO ACID) TARGETING MOIETIES - The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries. | 03-19-2009 |
Juliana M. Chan, Cambridge, MA US
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20110143993 | ENDOTHELIAL BASEMENT MEMBRANE TARGETING PEPTIDE LIGANDS - Peptides that selectively bind to antigens exposed in vascular disease or dysfunction have been identified by biopanning a phage library. The ligands are useful when attached to a substrate to be in contact with endothelial surfaces, especially those where drug delivery is utilized, such as following angioplasty, with release from a drug delivery reservoir in a medical device such as a stent, or by administration intravenously in the form of nano or microparticles, although the peptides may also be used with other medical devices or substrates, for targeting or to increase adhesion to endothelial surfaces. The nanoparticle technology can be used to treat injured vasculature, a clinical problem of primary importance. The targeted nanoparticles are also useful in the treatment of other diseases and disorders such as oncologic and regenerative diseases and indications where neoangiogenesis is commonly observed. | 06-16-2011 |
20120156135 | PARTICLES WITH MULTIPLE FUNCTIONALIZED SURFACE DOMAINS - This disclosure relates to particles (e.g., nanoparticles and microparticles) that display multiple functionalized surface domains in a controlled mosaic pattern. The disclosure also provides simple methods to create various particles that have multiple functionalized surface domains while allowing the use of a wide variety of diverse core structures. The multiple functionalized domains provide controllable particle binding and orientation, and controlled and sustained drug release profiles. | 06-21-2012 |
Julian M.w. Chan, Boston, MA US
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20100316676 | Bisphosphonate Compounds and Methods for Bone Resorption Diseases, Cancer, Bone Pain, Immune Disorders, and Infectious Diseases - Bisphosphonate compounds and related methods of making and using are disclosed, including pyridinium-1-yl, quinolinium-1-yl, and related compounds. The activity of compounds is disclosed in the context of functional assays such as | 12-16-2010 |
Julian M. W. Chan, Boston, MA US
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20080318906 | BISPHOSPHONATE COMPOUNDS AND METHODS FOR BONE RESORPTION DISEASES, CANCER, BONE PAIN, IMMUNE DISORDERS, AND INFECTIOUS DISEASES - Bisphosphonate compounds and related methods of making and using are disclosed, including pyridinium-1-yl, quinolinium-1-yl, and related compounds. The activity of compounds is disclosed in the context of functional assays such as | 12-25-2008 |
Kok Ping Chan, Cambridge, MA US
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20110105515 | TARGETING THE ONCOPROTEIN NUCLEOPHOSMIN - (+)-Avrainvillamide, a naturally occurring alkaloid with antiproliferative activity, is shown to bind to the oncoprotein nucleophosmin. Nucleophosmin is known to regulate the tumor suppressor protein p53 and is overexpressed in many different human tumors. The invention provides methods of modulating nucleophosmin and p53 using (+)-avrainvillamide and analogues thereof. These compounds may provide leads for the development of novel anti-cancer therapies that target nucleophosmin. | 05-05-2011 |
Kwok Ho Chan, Dunstable, MA US
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20140328174 | TECHNIQUE FOR END-TO-END ADMISSION CONTROL OF REAL-TIME PACKET FLOWS - A technique for end-to-end admission control of real-time packet flows is disclosed. In one embodiment, the technique may be realized as a method for end-to-end admission control of real-time packet flows in a network having a plurality of network elements. The method may include transmitting at least one probe packet from a first network element to a second network element via a network path, determining, at at least one intermediate network element on the network path, at least one flow rate associated with a plurality of packets, marking at least one predetermined bit in the at least one probe packet if the at least one flow rate is greater than a predetermined rate, and controlling an admission of additional packets into the network based at least in part on the marking of the at least one predetermined bit in the at least one probe packet. | 11-06-2014 |
Lana Chan, Northborough, MA US
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20120199887 | METHODS OF CONTROLLING TUNGSTEN FILM PROPERTIES - Methods, apparatus, and systems for depositing tungsten having tailored stress levels are provided. According to various embodiments, the methods involve depositing high stress or low stress tungsten films. In certain embodiments depositing high stress tungsten involves a multi-stage chemical vapor deposition (CVD) process including a low temperature deposition followed by a high temperature deposition. In certain embodiments depositing low stress tungsten involves a CVD process using a relatively low tungsten precursor flow. Also provided are new classes of high and low stress tungsten films, which may also have low resistivity and/or high reflectivity. Also provided are integration methods involving depositing high or low stress tungsten, for example as contacts and/or metal gates, and semiconductor devices incorporating the tungsten films. | 08-09-2012 |
Lana Hiului Chan, Northborough, MA US
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20100035427 | METHODS FOR GROWING LOW-RESISTIVITY TUNGSTEN FILM - Improved methods for depositing low resistivity tungsten films are provided. The methods involve depositing a tungsten nucleation layer on a substrate and then depositing a tungsten bulk layer over the tungsten nucleation layer to form the tungsten film. The methods provide precise control of the nucleation layer thickness and improved step coverage. According to various embodiments, the methods involve controlling thickness and/or improving step coverage by exposing the substrate to pulse nucleation layer (PNL) cycles at low temperature. Also in some embodiments, the methods may improve resistivity by using a high temperature PNL cycle of a boron-containing species and a tungsten-containing precursor to finish forming the tungsten nucleation layer. | 02-11-2010 |
20100159694 | METHOD FOR DEPOSITING THIN TUNGSTEN FILM WITH LOW RESISTIVITY AND ROBUST MICRO-ADHESION CHARACTERISTICS - Methods of forming low resistivity tungsten films with good uniformity and good adhesion to the underlying layer are provided. The methods involve forming a tungsten nucleation layer using a pulsed nucleation layer process at low temperature and then treating the deposited nucleation layer prior to depositing the bulk tungsten fill. The treatment operation lowers resistivity of the deposited tungsten film. In certain embodiments, the depositing the nucleation layer involves a boron-based chemistry in the absence of hydrogen. Also in certain embodiments, the treatment operations involve exposing the nucleation layer to alternating cycles of a reducing agent and a tungsten-containing precursor. The methods are useful for depositing films in high aspect ratio and/or narrow features. The films exhibit low resistivity at narrow line widths and excellent step coverage. | 06-24-2010 |
20100273327 | METHOD FOR IMPROVING UNIFORMITY AND ADHESION OF LOW RESISTIVITY TUNGSTEN FILM - Methods of improving the uniformity and adhesion of low resistivity tungsten films are provided. Low resistivity tungsten films are formed by exposing the tungsten nucleation layer to a reducing agent in a series of pulses before depositing the tungsten bulk layer. According to various embodiments, the methods involve reducing agent pulses with different flow rates, different pulse times and different interval times. | 10-28-2010 |
20110223763 | METHODS FOR GROWING LOW-RESISTIVITY TUNGSTEN FOR HIGH ASPECT RATIO AND SMALL FEATURES - The present invention addresses this need by providing methods for depositing low resistivity tungsten films in small features and features having high aspect ratios. The methods involve depositing very thin tungsten nucleation layers by pulsed nucleation layer (PNL) processes and then using chemical vapor deposition (CVD) to deposit a tungsten layer to fill the feature. Depositing the tungsten nucleation layer involves exposing the substrate to alternating pulses of a boron-containing reducing agent and a tungsten-containing precursor without using any hydrogen gas, e.g., as a carrier or background gas. Using this process, a conformal tungsten nucleation layer can be deposited to a thickness as small as about 10 Angstroms. The feature may then be wholly or partially filled with tungsten by a hydrogen reduction chemical vapor deposition process. Resistivities of about 14 μΩ-cm for a 500 Angstrom film may be obtained. | 09-15-2011 |
20120015518 | METHOD FOR DEPOSITING THIN TUNGSTEN FILM WITH LOW RESISTIVITY AND ROBUST MICRO-ADHESION CHARACTERISTICS - Methods of forming low resistivity tungsten films with good uniformity and good adhesion to the underlying layer are provided. The methods involve forming a tungsten nucleation layer using a pulsed nucleation layer process at low temperature and then treating the deposited nucleation layer prior to depositing the bulk tungsten fill. The treatment operation lowers resistivity of the deposited tungsten film. In certain embodiments, the depositing the nucleation layer involves a boron-based chemistry in the absence of hydrogen. Also in certain embodiments, the treatment operations involve exposing the nucleation layer to alternating cycles of a reducing agent and a tungsten-containing precursor. The methods are useful for depositing films in high aspect ratio and/or narrow features. The films exhibit low resistivity at narrow line widths and excellent step coverage. | 01-19-2012 |
Lawrence K. Chan, Brookline, MA US
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20110028478 | ISOXAZOLINES AS INHIBITORS OF FATTY ACID AMIDE HYDROLASE - The present invention provides isoxazoline FAAH inhibitors of the formula (I): | 02-03-2011 |
20110028482 | ISOXAZOLINES AS INHIBITORS OF FATTY ACID AMIDE HYDROLASE - The present invention provides isoxazoline FAAH inhibitors of the formula (I): | 02-03-2011 |
20110034437 | ISOXAZOLINES AS INHIBITORS OF FATTY ACID AMIDE HYDROLASE - The present invention provides isoxazoline FAAH inhibitors of the formula (I): | 02-10-2011 |
20110274654 | TRIAZOLES AS INHIBITORS OF FATTY ACID SYNTHASE - Provided herein are triazole FASN inhibitors of the formula (I): | 11-10-2011 |
20110274655 | TETRAZOLONES AS INHIBITORS OF FATTY ACID SYNTHASE - Provided herein are tetrazolone FASN inhibitors of the formula (I): | 11-10-2011 |
20130243727 | TRIAZOLES AS INHIBITORS OF FATTY ACID SYNTHASE - Provided herein are triazole FASN inhibitors of the formula (I): | 09-19-2013 |
20140079667 | TETRAZOLONES AS INHIBITORS OF FATTY ACID SYNTHASE - Provided herein are tetrazolone FASN inhibitors of the formula (I): | 03-20-2014 |
20150099738 | ISOXAZOLINES AS INHIBITORS OF FATTY ACID AMIDE HYDROLASE - The present invention provides isoxazoline FAAH inhibitors of the formula (I): | 04-09-2015 |
Leo L. Chan, North Andover, MA US
Patent application number | Description | Published |
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20130099120 | SYSTEMS AND METHODS FOR COUNTING CELLS AND BIOMOLECULES - The invention generally relates to analytical and monitoring systems useful for analyzing and measuring cells and biological samples. More particularly, the invention relates to systems and methods for imaging, measuring, counting, analyzing, and monitoring microscopic particles such as cells and biological molecules in solution samples. | 04-25-2013 |
20130120747 | CELL COUNTING AND SAMPLE CHAMBER AND METHODS OF FABRICATION - The invention generally relates to analytical and monitoring systems useful for analyzing and measuring cells and biological sample. More particularly, the invention relates to a unique cell counting chamber, e.g., a thin gap fluidic cell chamber for both bright field and fluorescent imaging of bacteria or parasites, and methods for making the same. | 05-16-2013 |
20150183153 | CELL COUNTING AND SAMPLE CHAMBER AND METHODS OF FABRICATION - The invention generally relates to analytical and monitoring systems useful for analyzing and measuring cells and biological sample. More particularly, the invention relates to a unique cell counting chamber, e.g., a thin gap fluidic cell chamber for both bright field and fluorescent imaging of bacteria or parasites, and methods for making the same. | 07-02-2015 |
20150232906 | AUTOMATED YEAST BUDDING MEASUREMENT - The invention generally relates to analyzing yeast viability and reproduction rate of yeasts. More particularly, the invention relates to efficient and effective methods and compositions for accessing and measuring budding percentages, viability and concentration of yeast cells. | 08-20-2015 |
Leo L. Chan, Andover, MA US
Patent application number | Description | Published |
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20130336567 | INTERNAL FOCUS REFERENCE BEADS FOR IMAGING CYTOMETRY - The invention generally relates to analytical and monitoring systems useful for analyzing and measuring cells and biological samples. More particularly, the invention provides systems and methods for internal calibration and focus reference for cytometry imaging. | 12-19-2013 |
20140024074 | YEAST CONCENTRATION AND VIABILITY MEASUREMENT - The invention generally relates to analyzing yeast viability. More particularly, the invention relates to efficient and effective methods and compositions for accessing and measuring viability and concentration of yeast cells. | 01-23-2014 |
Lung Chan, Somerville, MA US
Patent application number | Description | Published |
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20110194469 | SYSTEM AND METHOD FOR EXTENDING COMMUNICATION COVERAGE IN A WIRELESS NETWORK - A wireless communication system may include a first base station having a first communication coverage area and operating in an HFDD mode using a first frequency and a second frequency in an alternating pattern. The system may also include a second base station having a second communication coverage area different than the first communication coverage area and also operating in an HFDD mode. The second base station may communicate using the first frequency and the second frequency in an opposite alternating pattern from the first base station. | 08-11-2011 |
Maria R. Chan, Cambridge, MA US
Patent application number | Description | Published |
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20140343139 | COMPOSITIONS, METHODS, AND KITS COMPRISING PLATINUM COMPOUNDS ASSOCIATED WITH A LIGAND COMPRISING A TARGETING MOIETY - Compositions, kits, and methods for treatment of cancers are generally provided. In some embodiments, the compositions, kits, and methods comprise a platinum (e.g., Pt(II) or Pt(IV)) compound associated with a ligand (e.g., a beta-diketonate ligand) comprising a targeting moiety. Methods of synthesizing platinum (e.g., Pt(II) or Pt(IV)) compounds associated with a ligand comprising a targeting moiety are also provided. | 11-20-2014 |
Marya L. Chan, Boston, MA US
Patent application number | Description | Published |
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20090013559 | Mechanical cushioning system for footwear - An element forming at least part of a midsole for footwear includes a top portion, a bottom portion, and at least two strut members disposed between the top and bottom plates for supporting the top plate a distance away from the bottom plate. The top, bottom and struts may be formed of different materials. Adjacent strut members have a C shaped cross-section facing in the same direction when the midsole resting its top or bottom portion is viewed from the side. The midsole element may further comprise a heel cleft to increase the flexibility of the sole. In a preferred embodiment, the strut members on the medial side are arranged at an angle to the strut members on the lateral side of the sole. The directional design provides flexibility and stiffness anisotropically to the sole in the longitudinal and lateral directions of the sole respectively. | 01-15-2009 |
Marya Lourdes Chan, Boston, MA US
Patent application number | Description | Published |
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20140259769 | CAMBERED SOLE - The invention relates to shoes including sole elements having a cambered profile. An example sole element includes a midsole having a heel portion, a midfoot portion, and a forefoot portion, the midfoot portion including a longitudinal arch including a medial longitudinal arch portion and a lateral longitudinal arch portion, wherein the longitudinal arch is at least partially elevated above a ground surface in an unloaded condition and deforms towards a ground surface and elongates longitudinally in a loaded condition. | 09-18-2014 |
Michael S. Chan, Medford, MA US
Patent application number | Description | Published |
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20130057698 | SYSTEM AND METHOD FOR SITUATIONAL AWARENESS AND TARGET CUEING - A system and method for situational awareness and target cueing for use in military applications is disclosed. In extreme low light situations where the LLL sensor cannot provide SA information, the system allocates thermal information to the green SA channel to maintain the supply of contextual information to the user and thus situational awareness (SA) never drops below the native resolution of the thermal sensor. This improved SA capability, surpasses any existing LLL sensor technology in a single channel (stand-alone) application in overcast star light and below conditions. | 03-07-2013 |
Michael Tin-Lung Chan, Bedford, MA US
Patent application number | Description | Published |
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20120016827 | BIOMETRICS WITH MENTAL/ PHYSICAL STATE DETERMINATION METHODS AND SYSTEMS - Methods and systems for determining whether a particular individual is to be granted, among other things, access to information, access to a particular room or other space, or permission to perform a given act or transaction are disclosed. For example, disclosed is an exemplary method that includes performing multiple biometrics tests on the individual to retrieve multiple biometrics test results, performing at least a first data fusion operation on the multiple biometrics test results to determine an identity result, performing at least one biological state test to determine one or more biological state test results of the individual, and conditionally granting authority to the individual based on the identity result and the one or more biological state results. | 01-19-2012 |
Michelle Chan, Florence, MA US
Patent application number | Description | Published |
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20140212498 | OIL-IN-WATER EMULSIONS THAT CONTAIN NUCLEIC ACIDS - This invention generally relates to cationic oil-in-water emulsions that can be used to deliver nucleic acid molecules, such as an RNA molecule. The emulsion particles comprise an oil core and a cationic lipid. The emulsion particles have an average diameter of about 80 nm to about 180 nm, and the emulsion have an N/P ratio of at least 1.1:1. | 07-31-2014 |
20140220083 | CATIONIC OIL-IN-WATER EMULSIONS - This invention generally relates to cationic oil-in-water emulsions that contain high concentrations of cationic lipids and have a defined oil:lipid ratio. The cationic lipid can interact with the negatively charged molecule thereby anchoring the molecule to the emulsion particles. The cationic emulsions described herein are useful for delivering negatively charged molecules, such as nucleic acid molecules to cells, and for formulating nucleic acid-based vaccines. | 08-07-2014 |
Moon Z. Chan, Boston, MA US
Patent application number | Description | Published |
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20120196382 | Multicoded Analytical Nanostrips - Analytical nanostrips for clinical analysis are improved by using multifunctional coding (“multicoding”) to allow simultaneous identification of the particular assay, the value of the assayed analyte, and a calibration of the analyte. The multicoding layout on the nanostrip minimizes the number of zones that are required for a given assay. Moreover, the nanostrip can be scanned in real time during flow of the nanostrip through a detection beam. This both simplifies the assay and allows for alternative means of coding. | 08-02-2012 |
20130260474 | Microfluidic passive mixing chip - An improved device and method for passive mixing of fluids is described, and the use of the device in clinical diagnostic procedures. The mixer provides thorough mixing of a sample of blood or other fluid with an assay material, such as a diluent or a component of an assay system, in a closed system with a low and limited pressure drop. Sample size is small, typically 5 to 300 microliters. Mixing is accomplished by a combination of rotational vortex mixing due to a fluid stream coming tangent to a drain, and either or both of a second vortex mixer of opposite handedness, and a Dean mixer. Combinations of these techniques reliably provide complete mixing at low pressure drop. In a preferred usage, the microfluidic system can run a diluent continuously and inject samples at intervals, to facilitate automatic data processing of optical or other signatures of the well-mixed stream. | 10-03-2013 |
Nicholas Chan, Boston, MA US
Patent application number | Description | Published |
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20090265839 | Fluid Safety Liner - A fluid safety liner includes a liner of closed-cell foam that uses a series of channels and reservoirs to spread forces and distribute fluid contained within the liner throughout different areas of the liner. The liner is useable in protective gear such as a helmet and has a shape that conforms to the area of protection. The channel and reservoir system generally includes a mesh of coupled channels and reservoirs in the closed-cell foam. The channel and reservoir system also generally includes an incompressible fluid movable throughout the system for redistributing pressure and absorbing the force of any impact through viscous flow. The reduction in peak force and lengthening of the duration of the force reduces the biomechanical severity (e.g. HIC, Head Injury Criterion) of a blow to the protective gear. | 10-29-2009 |
Randolph W. Chan, Lexington, MA US
Patent application number | Description | Published |
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20090034057 | COMPONENTS AND METHODS FOR USE IN ELECTRO-OPTIC DISPLAYS - A front plane laminate useful in the manufacture of electro-optic displays comprises, in order, a light-transmissive electrically-conductive layer, a layer of an electro-optic medium in electrical contact with the electrically-conductive layer, an adhesive layer and a release sheet. This front plane laminate can be prepared as a continuous web, cut to size, the release sheet removed and the laminate laminated to a backplane to form a display. Methods for providing conductive vias through the electro-optic medium and for testing the front plane laminate are also described. | 02-05-2009 |
20090168067 | COMPONENTS AND METHODS FOR USE IN ELECTRO-OPTIC DISPLAYS - A front plane laminate useful in the manufacture of electro-optic displays comprises, in order, a light-transmissive electrically-conductive layer, a layer of an electro-optic medium in electrical contact with the electrically-conductive layer, an adhesive layer and a release sheet. This front plane laminate can be prepared as a continuous web, cut to size, the release sheet removed and the laminate laminated to a backplane to form a display. Methods for providing conductive vias through the electro-optic medium and for testing the front plane laminate are also described. | 07-02-2009 |
20100142030 | COMPONENTS AND METHODS FOR USE IN ELECTRO-OPTIC DISPLAYS - A front plane laminate useful in the manufacture of electro-optic displays comprises, in order, a light-transmissive electrically-conductive layer, a layer of an electro-optic medium in electrical contact with the electrically-conductive layer, an adhesive layer and a release sheet. This front plane laminate can be prepared as a continuous web, cut to size, the release sheet removed and the laminate laminated to a backplane to form a display. Methods for providing conductive vias through the electro-optic medium and for testing the front plane laminate are also described. | 06-10-2010 |
20100149630 | COMPONENTS AND METHODS FOR USE IN ELECTRO-OPTIC DISPLAYS - A front plane laminate useful in the manufacture of electro-optic displays comprises, in order, a light-transmissive electrically-conductive layer, a layer of an electro-optic medium in electrical contact with the electrically-conductive layer, an adhesive layer and a release sheet. This front plane laminate can be prepared as a continuous web, cut to size, the release sheet removed and the laminate laminated to a backplane to form a display. Methods for providing conductive vias through the electro-optic medium and for testing the front plane laminate are also described. | 06-17-2010 |
20110075248 | COMPONENTS AND METHODS FOR USE IN ELECTRO-OPTIC DISPLAYS - A front plane laminate useful in the manufacture of electro-optic displays comprises, in order, a light-transmissive electrically-conductive layer, a layer of an electro-optic medium in electrical contact with the electrically-conductive layer, an adhesive layer and a release sheet. This front plane laminate can be prepared as a continuous web, cut to size, the release sheet removed and the laminate laminated to a backplane to form a display. Methods for providing conductive vias through the electro-optic medium and for testing the front plane laminate are also described. | 03-31-2011 |
20140340738 | COMPONENTS AND METHODS FOR USE IN ELECTRO-OPTIC DISPLAYS - A front plane laminate useful in the manufacture of electro-optic displays comprises, in order, a light-transmissive electrically-conductive layer, a layer of an electro-optic medium in electrical contact with the electrically-conductive layer, an adhesive layer and a release sheet. This front plane laminate can be prepared as a continuous web, cut to size, the release sheet removed and the laminate laminated to a backplane to form a display. Methods for providing conductive vias through the electro-optic medium and for testing the front plane laminate are also described. | 11-20-2014 |
Raymond C. Chan, Brookline, MA US
Patent application number | Description | Published |
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20080279430 | System and Method for Enabling Selection of an Image Registration Transformation - System and method for enabling intra-operative selection of an image registration transformation for use in displaying a first image dataset and a second image dataset in correspondence with one another. Image dataset acquisition devices ( | 11-13-2008 |
20100266220 | FEATURES-BASED 2D-3D IMAGE REGISTRATION - An image registration apparatus comprises: a features detector ( | 10-21-2010 |
Shi-Hong Chan, Ipswich, MA US
Patent application number | Description | Published |
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20080268507 | Recombinant Dna Nicking Endonuclease and Uses Thereof - Recombinant nicking endonucleases and associated methylases have been obtained and sequenced and their specificity has been defined. A mutant form of the nicking endonuclease has been cloned where the mutation includes deletion of amino acid sequences at the C-terminal end of the protein. The nicking enzymes have been used for a number of purposes including: amplifying DNA from as few cells as can be found in a single bacterial colony in the presence of a strand displacing polymerase; and for removing genomic DNA in a biological preparation where it is deemed to be a contaminant. | 10-30-2008 |
Siu-Hong Chan, Ipswich, MA US
Patent application number | Description | Published |
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20090029376 | High Fidelity Restriction Endonucleases - Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions include restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor. | 01-29-2009 |
20110151450 | High Fidelity Restriction Endonucleases - Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (FI) in a specified buffer that is greater than the FI of the non-mutated enzyme in the same buffer. | 06-23-2011 |
20130115676 | High Fidelity Restriction Endonucleases - Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor. | 05-09-2013 |
20130115677 | High Fidelity Restriction Endonucleases - Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor. | 05-09-2013 |
20130115678 | High Fidelity Restriction Endonucleases - Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor. | 05-09-2013 |
20130115679 | High Fidelity Restriction Endonucleases - Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor. | 05-09-2013 |
20130115680 | High Fidelity Restriction Endonucleases - Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor. | 05-09-2013 |
20130115681 | High Fidelity Restriction Endonucleases - Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor. | 05-09-2013 |
20130122568 | High Fidelity Restriction Endonucleases - Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor. | 05-16-2013 |
20130130935 | High Fidelity Restriction Endonucleases - Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor. | 05-23-2013 |
20130190209 | High Fidelity Restriction Endonucleases - Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor. | 07-25-2013 |
20140154676 | High Fidelity Restriction Endonucleases - Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (FI) in a specified buffer that is greater than the FI of the non-mutated enzyme in the same buffer. | 06-05-2014 |
20140154778 | High Fidelity Restriction Endonucleases - Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (FI) in a specified buffer that is greater than the FI of the non-mutated enzyme in the same buffer. | 06-05-2014 |
20140154779 | High Fidelity Restriction Endonucleases - Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (FI) in a specified buffer that is greater than the FI of the non-mutated enzyme in the same buffer. | 06-05-2014 |
20140154780 | High Fidelity Restriction Endonucleases - Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (FI) in a specified buffer that is greater than the FI of the non-mutated enzyme in the same buffer. | 06-05-2014 |
Tak-Sang Chan, Sharon, MA US
Patent application number | Description | Published |
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20140129365 | SYSTEMS AND METHODS FOR NEGOTIATING A PURCHASE PRICE - Systems and methods to facilitate a purchase of a product by a user from a seller. | 05-08-2014 |
Thomas Chan, Hopkinton, MA US
Patent application number | Description | Published |
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20090214443 | METHOD FOR RETARDING SYSTEMIC DELIVERY RATE FOR EASILY ABSORBABLE ACTIVE AGENTS - Drugs such as hormones, which are easily absorbable through the stratum corneum into the vascular network, are administered to the skin of a patient in an absorption retarding matrix material, thereby retarding the rate at which the drug penetrates into and through the skin. | 08-27-2009 |
Thomas C.k. Chan, Winchester, MA US
Patent application number | Description | Published |
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20100297075 | COMBINATIONAL COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER - The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a pyrroloquinolinyl-pyrrole-2,5-dione compound or a pyrroloquinolinyl-pyrrolidine-2,5-dione compound in combination with a therapeutically effective amount of a second anti-proliferative agent. | 11-25-2010 |
20110301194 | Method for Determining Treatment Efficacy - The present invention provides a method for determining the efficacy of a c-Met inhibitor in treating a cell proliferative disorder, comprising: a) administering to a subject in need thereof a therapeutically effective amount of the c-Met inhibitor, or a pharmaceutically acceptable salt, prodrug or metabolite thereof, either alone or in combination with a therapeutically effective amount of a second anti-proliferative agent; and b) measuring the concentration of hepatocyte growth factor (HGF) in the serum from the subject, wherein if the concentration of serum HGF does not decrease, or if the concentration of serum HGF increases, the c-Met inhibitor is efficacious in treating the cell proliferative disorder. | 12-08-2011 |
20120004191 | Combinational Compositions And Methods For Treatment Of Cancer - The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a pyrroloquinolinyl-pyrrole-2,5-dione compound or a pyrroloquinolinyl-pyrrolidine-2,5-dione compound in combination with a therapeutically effective amount of a second anti-proliferative agent. | 01-05-2012 |
20120021432 | Phosphorylated NF45 Biomarkers, Antibodies And Methods Of Using Same - The present invention relates to isolated phosphorylated NF45 peptides and isolated phosphorylation site-specific antibody or antigen-binding portion thereof that specifically binds a phosphorylated NF45 protein. The present invention also relates to methods of utilizing these antibodies to determine the therapeutic efficacy of a candidate compound and methods for screening for candidate compounds that increase the phosphorylation of NF45 protein in a cell. | 01-26-2012 |
20150328208 | COMBINATIONAL COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER - The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a pyrroloquinolinyl-pyrrole-2,5-dione compound or a pyrroloquinolinyl-pyrrolidine-2,5-dione compound in combination with a therapeutically effective amount of a second anti-proliferative agent. | 11-19-2015 |
Tiffany Chan, Weston, MA US
Patent application number | Description | Published |
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20140188932 | PROVIDING CUSTOMIZED INFORMATION FOR MOBILE DEVICES AND EFFICIENTLY SEARCHING THE SAME - Account information associated with a mobile device is obtained through a mobile wireless communication network from a database of subscriber account records for mobile wireless communication service subscribers. The account information may identify the previous mobile device, the mobile device, and/or length of usage of the mobile device. Advice information is selected from a database of advice regarding operation of the mobile devices such that the selected advice information is adapted for the account, and the selected advice information is then provided via a user interface element of the mobile device. Additionally, multiple levels of search related phrases, in which the phrases at each level correspond to a user-selected phrase at the previous level, are presented via a user element of a mobile device. | 07-03-2014 |
Timothy Chan, Cambridge, MA US
Patent application number | Description | Published |
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20150274663 | S1P AND/OR ATX MODULATING AGENTS - Compounds of formula (I) wherein: X is —O—, —S(O) | 10-01-2015 |
20150299123 | S1P AND/OR ATX MODULATING AGENTS - Compounds of formula (I), and pharmaceutically acceptable salts thereof, can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX). | 10-22-2015 |
Timothy Chan, Newton, MA US
Patent application number | Description | Published |
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20110152260 | Indazole derivatives as modulators of interleukin-1 receptor-associated kinase - The present invention relates to modulators of IRAK kinases of formula (I) and provides compositions comprising such modulators, as well as methods therewith for treating IRAK-mediated or IRAK-associated conditions or diseases. | 06-23-2011 |
20120208819 | HETEROCYCLIC COMPOUNDS USEFUL AS PDK1 INHIBITORS - The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases. | 08-16-2012 |
Timothy R. Chan, Newton, MA US
Patent application number | Description | Published |
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20150126528 | INHIBITORS OF BRUTON'S TYROSINE KINASE - The present invention provides a compound, solid forms, and compositions thereof, which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same. The present invention also provides methods of making provided compound and solid forms. | 05-07-2015 |
20150158843 | PYRIMIDINYL TYROSINE KINASE INHIBITORS - The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same. | 06-11-2015 |
Tsz Yu Chan, Boston, MA US
Patent application number | Description | Published |
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20140122179 | METHOD AND SYSTEM FOR DETERMINING LONG RANGE DEMAND FORECASTS FOR PRODUCTS INCLUDING SEASONAL PATTERNS - An improved method and system for forecasting product demand using a causal methodology, based on multiple regression techniques. The improved causal method identifies year-over-year trending effects within historical product demand data, removes the trending effects from the calculation of seasonal factors used in determining product demand forecasts, calculates trend factors from the identified trending effects, and applies the trend factors and de-trended seasonal factors to initial product demand forecasts when determining final demand forecasts for the products. | 05-01-2014 |
20140122180 | METHOD AND SYSTEM FOR ADJUSTING PRODUCT ORDERS DURING REPLENISHMENT SOURCE CHANGES - A method and system for adjusting product store order quantities when a retail store is moving a replenishment source from a current distribution center to a new distribution center. The method determines a last delivery date for a last product order from the current distribution center to be placed prior to a product replenishment source change date, and a first delivery date for a first product order from the new distribution center to be placed following the product replenishment source change date; and compares the two delivery dates to determine which delivery will occur first. When the first delivery date for new distribution center predates the last delivery date for the current distribution center, the last product order from the current distribution center is suspended. When the last delivery date for the current distribution center predates the first delivery date for the new distribution center, the quantity of product associated with the last product order from the current distribution center is increased to avoid a product deficiency at the retail store. | 05-01-2014 |
20140278775 | METHOD AND SYSTEM FOR DATA CLEANSING TO IMPROVE PRODUCT DEMAND FORECASTING - A method for cleansing product demand data to improve product demand forecasting. The improved data cleansing methodology enhances product weekly demand forecast accuracy by adjusting stock-out week demand values, and employing separate outlier logic for regular and promotional demand periods. | 09-18-2014 |
Victor D. Chan, Newton, MA US
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20150189490 | ORCHESTRATING USER DEVICES TO FORM IMAGES AT VENUE EVENTS - A method, performed by one or more computer devices, may include generating a sequence script for a venue event, wherein the sequence script is configured to synchronize a plurality of user devices located at the venue during the venue event to form one or more images discernable when the devices are viewed collectively. The method may further include obtaining user registration information associated with the venue event, wherein the user registration information identifies user devices registered to participate in the generation of the one or more images; detecting a trigger event associated with the sequence script; and orchestrating the plurality of user devices to form the one or more images, in response to detecting the trigger event. | 07-02-2015 |
Walker Chan, Cambridge, MA US
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20110284059 | THERMOPHOTOVOLTAIC ENERGY GENERATION - Inventive systems and methods for the generation of energy using thermophotovoltaic cells are described. Also described are systems and methods for selectively emitting electromagnetic radiation from an emitter for use in thermophotovoltaic energy generation systems. In at least some of the inventive energy generation systems and methods, a voltage applied to the thermophotovoltaic cell (e.g., to enhance the power produced by the cell) can be adjusted to enhance system performance. Certain embodiments of the systems and methods described herein can be used to generate energy relatively efficiently. | 11-24-2011 |
Walker R. Chan, Cambridge, MA US
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20140042890 | High Efficiency Incandescent Lighting - Incandescent lighting structure. The structure includes a thermal emitter that can, but does not have to, include a first photonic crystal on its surface to tailor thermal emission coupled to, in a high-view-factor geometry, a second photonic filter selected to reflect infrared radiation back to the emitter while passing visible light. This structure is highly efficient as compared to standard incandescent light bulbs. | 02-13-2014 |
Yinthai Chan, Cambridge, MA US
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20090068820 | Microspheres including nanoparticles - A microparticle can include a central region and a peripheral region. The peripheral region can include a nanoparticle, such as a metal nanoparticle, a metal oxide nanoparticle, or a semiconductor nanocrystal. The microparticle can be a member of a monodisperse population of particles. | 03-12-2009 |
20100303119 | Microfluidic Lasers - The present invention generally relates to lasers comprising fluidic channels, such as microfluidic channels. In some instances, the channel contains two or more fluids. The fluids may remain non-mixed within the channel, for example, due to immiscibility and/or laminar flow within the channel. The fluids may be arranged in the channel such that light propagating in a first fluid is prevented by the second fluid from exiting the first fluid, for example, due to differences in the indexes of refraction (e.g., causing internal reflection of the fluid to occur). Thus, in one embodiment, a first fluid may be at least partially surrounded by a second fluid having a second index of refraction lower than the index of refraction of the first fluid. In some embodiments, the fluidic channel is used as a laser, for instance, a dye laser, i.e., a laser created by directing light at a dye to produce coherent light. The dye may be present in one or more fluids within the fluidic channel. The incident light (for example, created by another laser) may be directed at the channel from any angle. In some cases, laser light may be produced in a direction substantially aligned with the longitudinal axis of the channel. In some embodiments, the laser is free of mirrors, prisms, or gratings, or the laser may produce coherent light using a non-resonant photonic pathway. However, in other cases, mirrors, prisms, or gratings may be used to reflect light along the channel to enhance stimulated emission of coherent light. Another aspect of the invention includes optical diffractors, such as prisms or gratings, which can contain a fluid. The optical diffractors, in certain embodiments, are positioned to diffract light, such as coherent light, emanating from the fluidic channel. Still other aspects of the invention provide devices, kits, and methods of making and using such lasers. | 12-02-2010 |
Yin Thai Chan, Cambridge, MA US
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20110089375 | MICROSPHERES INCLUDING NANOPARTICLES - A microparticle can include a central region and a peripheral region. The peripheral region can include a nanoparticle, such as a metal nanoparticle, a metal oxide nanoparticle, or a semiconductor nanocrystal. The microparticle can be a member of a monodisperse population of particles. | 04-21-2011 |