Caulfield, US
Adrian Caulfield, Oceanside, CA US
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20130254477 | METHOD FOR REDUCING LATENCY OF ACCESSING DATA STORED IN A FILE SYSTEM ON A COMPUTER STORAGE DEVICE BY CACHING FILE SYSTEM PERMISSION INFORMATION IN THE COMPUTER STORAGE DEVICE - Systems and methods of storage device access are provided, where the operating system copies permission and mapping information to the storage array and/or to the application program's memory. The application program can then access the storage device without the operating system's intervention and the storage device will check whether the application has permission to access the data. As a result, in most cases, neither the operating system nor the file system needs to be invoked, and since both of them increase the amount of time required to access the data in the file system, considerable performance improvements are possible. | 09-26-2013 |
Carey Caulfield, Santa Barbara, CA US
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20160094716 | One-Tap Conference Calling On Devices - Methods and systems for creating mobile conference rooms for conference calls between client devices and one or more contacts are described herein. A server receives, from the client device, a request to create a mobile conference room. The server creates the mobile conference room by assigning a phone number to the mobile conference room. After notifying the client device, the server receives data regarding one or more contacts to add to the mobile conference room. The server receives, from the client device, a request to initiate a conference call with a subset of contacts. A call is received, from the server, concurrently by each of the subset of contacts. The server bridges the client device and the contacts that have answered the call on the conference call. | 03-31-2016 |
20160105472 | Seamless Switching Between Computing Devices During an Online Meeting - Methods and systems for switching between computing devices during an online meeting are described herein. A collaboration server may receive a token from a first computing device connected to an online meeting hosted by the collaboration server. The collaboration server may receive another token from a second computing device and determine whether the received tokens match. If so, the collaboration server may establish an association between the second computing device and the meeting participant attending the online meeting via the first computing device. The collaboration server may accept a request from the second computing device to join the online meeting thus allowing the meeting participant to continue the online meeting from the second computing device. | 04-14-2016 |
Dorinda Angela Caulfield, Chico, CA US
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20090293178 | Trouser anti tuck device - Trouser anti tuck device that will prevent a wearers trousers from tucking between their shoe and their heel. Comprising of, two identical sheets that when inserted into the inside, rear, bottom of trousers, and adhesively applied, will be slippery enough on the inside for the wearers heel and shoe to move freely, yet will have enough vertical rigidity to prevent tucking of the trousers. | 12-03-2009 |
Frances Caulfield, Basking Ridge, NJ US
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20140101814 | GARMENT WITH TETHERING SYSTEM - A garment includes an outer garment having a skirt portion with an inner side and a pair of elastic tethers having first fastening elements, and an undergarment having a front panel and a pair of second fastening elements. Each of the first fastening elements of the tethers of the outer garment is adapted to engage releasably a corresponding one of the second fastening elements of the undergarment. The first and second fastening elements may include snap elements, buttons, pins, zippers, or hook and loop fasteners. | 04-17-2014 |
20140101815 | GARMENT WITH TETHERING SYSTEM - A garment includes an outer garment having a shorts portion with an inner side and a pair of elastic tethers having first fastening elements, and an undergarment having a front panel and a pair of second fastening elements. Each of the first fastening elements of the tethers of the shorts portion is adapted to engage releasably a corresponding one of the second fastening elements of the undergarment. The first and second fastening elements may include snap elements, buttons, pins, zippers, or hook and loop fasteners. | 04-17-2014 |
20140215690 | GARMENTS - A garment including a pants portion, an upper portion, and a plurality of tethers attached to a waistline portion of the pants portion. Each tether includes a first fastening element adapted to engage releasably a second fastening element of an outer garment. A garment including a pants portion, an upper portion having a plurality of loops located on an inner side thereof, and a pair of straps having hooks at ends thereof. The hooks of the straps are adapted to engage releasably the loops of the upper portion. A pants portion having an inner crotch portion and a pad attached to the inner crotch portion. | 08-07-2014 |
Francis D. Caulfield, Research Triangle Park, NC US
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20130118270 | GYRATORY COMPACTOR APPARATUSES AND ASSOCIATED METHODS - A gyratory compactor apparatus adapted to interact with a mold that defines a mold axis is provided. The gyratory compactor apparatus includes a frame defining a frame axis, a pivoted support carried by the frame, and a mold-engaging device carried by the pivoted support and having a carriage plate spaced-apart from the pivoted support for receiving the mold. The carriage plate is movable relative to the frame axis by rotation of the pivoted support. At least one actuator is in engagement with the carriage plate for imparting translation to the carriage plate relative to the frame axis. | 05-16-2013 |
Francis D. Caulfield, Raleigh, NC US
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20100281945 | CALIBRATION OF GYRATORY COMPACTOR APPARATUSES AND ASSOCIATED METHODS - A method for calibrating a gyratory compactor apparatus is provided. The gyratory compactor apparatus is of the type being configured to compact and impart an orbital motion to a sample in a mold that defines a mold axis and includes at least one actuator for imparting lateral displacement of the mold relative to a longitudinal axis of the gyratory compactor apparatus. The method includes the steps of imparting lateral orbital displacement of the mold relative to the gyratory compactor apparatus by actuation of the at least one actuator to thereby define a gyratory angle between the gyratory compactor apparatus and the mold axis, measuring the gyratory angle, and determining adjustments to actuation of the at least one actuator based on the measured gyratory angle and a target angle. An associated apparatus and method for calibrating the apparatus are also included. | 11-11-2010 |
20100281995 | GYRATORY COMPACTOR APPARATUSES AND ASSOCIATED METHODS - A gyratory compactor apparatus is provided that is adapted to interact with a mold that defines a mold axis. The gyratory compactor apparatus includes a frame that defines a frame axis and has a first mounting plate and a spaced-apart second mounting plate. A pivoted support is carried by the frame and capable of rotation in at least a first and a second rotational degree of freedom. A mold-engaging device is carried by the pivoted support and has a first carriage plate proximal the pivoted support and a second carriage plate axially spaced-apart from the pivoted support for receiving the mold therebetween. At least one actuator having a first end is carried by the frame and a second end is carried by the second carriage plate for imparting lateral translation to the second carriage plate relative to the frame axis. An associated method is also provided. | 11-11-2010 |
20100288053 | GYRATORY COMPACTOR APPARATUSES AND ASSOCIATED METHODS - A gyratory compactor apparatus adapted to interact with a mold that defines a mold axis is provided. The gyratory compactor apparatus includes a frame defining a frame axis and having a first mounting plate and a pivoted support carried by the frame and capable of rotation in at least a first and a second rotational degree of freedom. A mold-engaging device is carried by the pivoted support and includes a first carriage plate proximal the pivoted support and a spaced-apart second carriage plate that defines a space therebetween for receiving the mold. The second carriage plate has at least one clamping rod in communication with an actuator for translating the second carriage plate about the mold axis to thereby secure the mold in the space between the first and second carriage plates. An associated method is also provided. | 11-18-2010 |
Iain Caulfield, Houston, TX US
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20080236827 | Fluid Communication Nipple - A fluid communication nipple including a tubular mandrel having an interior surface defining an internal bore and a passageway extending substantially lengthwise along a portion of the mandrel. The passageway is defined by an exterior wall section and an interior wall section, wherein the interior wall section extends outward from the interior surface into the bore. When it is desired to establish fluid communication through the passageway between the exterior and interior of the nipple an opening is formed through the internal wall section. | 10-02-2008 |
Jesse Caulfield, Mclean, VA US
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20110069690 | METHOD, SYSTEM, AND COMPUTER-READABLE MEDIUM FOR THE PROTECTION OF AD-HOC WIRELESS DEVICE OPERATION - In an embodiment of the invention, a system may include one or more wireless transmitters and a transportable transmitter having at least one processor and at least one storage device. The transportable transmitter may be configured to communicate with the one or more wireless transmitters, store operational data in the storage device, encapsulate the operational data into a message, and transmit the message to establish a geographic protected contour for the wireless transmitter. The wireless transportable transmitter may, after transmitting the message, transmit information from within the geographic protected contour to a receiver outside the geographic protected contour while receiving interference protection on the transmitting frequency within the geographic contour. | 03-24-2011 |
20110070838 | OPERATION OF A COGNITIVE RADIO RESOURCE COORDINATOR - In an embodiment of the invention, a method may include receiving spectrum occupancy data regarding spectrum occupancy in a radio frequency environment, generating, with a processor, spectrum information regarding a plurality of transmission options for a transmitter based on the spectrum occupancy data, and providing the spectrum information to the transmitter. | 03-24-2011 |
20110070841 | METHOD, SYSTEM, AND COMPUTER-READABLE MEDIUM FOR IMPROVED PREDICTION OF SPECTRUM OCCUPANCY AND ESTIMATION OF RADIO SIGNAL FIELD STRENGTH - In an embodiment of the invention, a system may include a specially configured computer having at least one processor and at least one storage device. The computer may be configured to calculate an estimate of radio propagation and signal strength using a first radio propagation model. The computer may recalculate the estimate of radio propagation and signal strength using one or more additional radio propagation models. The computer may store the recalculated estimate of radio propagation and signal strength in storage. | 03-24-2011 |
John Caulfield, Santa Barbara, CA US
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20130126703 | Imaging Detecting with Automated Sensing of an Object or Characteristic of that Object - Detection of a target object or a characteristic of that object, e.g. temperature or movement in an image of a scene at a focal plane of the image and with processing of signals representative of the image occurring at that focal plane with a sensor and an integrated circuit processor on an imaging circuit chip used to record the scene. Moreover, processing of the signals representative of the image and the object or characteristic of the object can all be processed in parallel. This arrangement allows for filtering of objects with the ability to distinguish the object generating signals from background clutter. The incorporation of the entire circuit in this integrated circuit chip increases the compactness and efficiency. Moreover, all signal processing will occur at the focal plane eliminates the need for external processing electronics thereby increasing compactness and efficiency while reducing spatial noise. | 05-23-2013 |
John Keith Caulfield, Houston, TX US
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20120227974 | METHOD AND APPARATUS FOR PULLING A CROWN PLUS - Provided is a method and apparatus for pulling a crown plug comprising: (a) providing a subsea lubricator having a longitudinal through bore and a jack attached to the subsea lubricator, the jack having a landing area; (b) providing a jacking string which includes a landing sub and a crown plug connector, the sub having a landing surface; (c) without the jacking string in step “b”, lowering the subsea lubricator of step “a”, to the horizontal christmas tree and attaching the lubricator to the christmas tree; (d) lowering the jacking string to the lubricator; (e) jacking up the jack such that the landing area of the jack contacts the landing surface of the landing sub; and; (f) while the lubricator remains attached to the christmas tree, raising the jacking string and crown plug through and out of the lubricator. | 09-13-2012 |
20150107846 | METHOD AND APPARATUS FOR PULLING A CROWN PLUG - Provided is a method and apparatus for pulling a crown plug from a subsea horizontal christmas tree, the method comprising: (a) providing a subsea lubricator having a longitudinal through bore and a jack attached to the subsea lubricator, the jack having a landing area, and the landing area having an opening which is fluidly connected to the lubricator's through bore; (b) providing a jacking string which includes a landing sub and a crown plug connector, the sub having a landing surface; (c) without the jacking string in step “b”, lowering the subsea lubricator of step “a”, to the horizontal christmas tree and attaching the lubricator to the christmas tree; (d) lowering the jacking string to the lubricator, and, while the landing surface of the landing sub is spaced above and not supported by the landing area of the jack, connecting the plug connector to the crown plug while the landing sub is above and not touching the landing area of the jack; (e) jacking up the jack such that the landing area of the jack contacts the landing surface of the landing sub, and pushes up on the jacking sub and jacking string causing tensile forces to be placed on the crown plug and releasing the crown plug from the profile of the christmas tree; (f) while the lubricator remains attached to the christmas tree, raising the jacking string and crown plug through and out of the lubricator and to the surface of the water to remove the tree; and (g) detaching the crown plug from the crown plug connector. | 04-23-2015 |
John T. Caulfield, Santa Barbara, CA US
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20160142657 | SYSTEM AND METHOD FOR USING FILTERING AND PIXEL CORRELATION TO INCREASE SENSITIVITY IN IMAGE SENSORS - An over sampled image sensor in which the pixel size is small enough to provide spatial oversampling of the minimum blur size of the sensor optics is disclosed. Image processing to detect targets below the typical limit of 6× the temporal noise floor is also disclosed. The apparatus is useful in detecting dimmer targets and targets at a longer range from the sensors. The inventions exploits signal processing, which allows spatial temporal filtering of the superpixel image in such manner that the Noise Equivalent Power is reduced by a means of Superpixel Filtering and Pooling, which increases the sensitivity far beyond a non-oversampled imager. Overall visual acuity is improved due to the ability to detect dimmer targets, provide better resolution of low intensity targets, and improvements in false alarm rejection. | 05-19-2016 |
Joseph N. Caulfield, Aston, PA US
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20100228000 | NYLON EXTRACTION FROM COMMINGLED MATERIALS - The present invention provides energetically and economically efficient methods for separating polyamide polymer(s) from commingled materials. The methods generally involve precipitating a polyamide polymer dissolved in a solvent (e.g., formic acid) using dimethyl ether (DME) as an antisolvent. The methods comprise dissolving the polyamide polymer in a solvent that (i) selectively dissolves the polyamide polymer relative to the other materials and (ii) has a higher solubility for DME relative to the polyamide polymer; and then contacting the mixture of the solvent with the dissolved polyamide polymer with DME, thereby precipitating the polyamide polymer. | 09-09-2010 |
20140321942 | FLOATING CAPTIVE SCREW - A captive screw for securing together two panels has a screw and a spring extending between the screw head and a ferrule. A collar is formed on the screw shank under the ferrule to limit penetration of the screw threads in a bottom panel so that the upper panel floats on the spring. | 10-30-2014 |
Justin Paul Caulfield, Northport, NY US
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20140046832 | METHODS TO ACCESS, SHARE AND ANALYZE INFORMATION RELATED TO FRAUD, MONEY LAUNDERING, TERRORIST FINANCING AND OTHER SPECIFIED UNLAWFUL ACTIVITIES - The present invention is directed to a system for storage, evaluation, and transmission of information related to suspicious underlying activity that in turn is related to financial transactions comprising: (1) a secure data processing center, wherein the secure data processing center receives, stores, and transmits reports related to suspicious underlying activity that in turn is related to financial transactions, the secure data processing center including therein a storage mechanism for the reports including a memory; (2) at least one terminal in communication with the secure data processing center, wherein the terminal transmits and receives the reports related to suspicious underlying activity that in turn is related to financial transactions; and (3) means for authenticating and controlling communication between the at least one terminal and the secure data processing center; wherein the storage of the reports in the secure data processing center modifies the state of the secure data processing center in terms of the physical state of as the memory as the result of the storage of the reports. The invention further encompasses the use of the system to post, communicate, and analyze information related to such financial transactions. | 02-13-2014 |
Laura Caulfield, Woodinville, WA US
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20160092140 | STORAGE DEVICE MANAGEMENT IN COMPUTING SYSTEMS - Various techniques of managing storage devices in a computing system are described in this application. In one embodiment, a method includes receiving an input containing consumption data representing consumption of a storage device in one of the processing units and determining if the storage device in one of the processing units is consumed excessively. In response to determining that the storage device is consumed excessively, an indicator may be generated to indicate a potential program migration from the one of the processing units to another one of the processing units in the computing system. | 03-31-2016 |
Laura Marie Caulfield, Woodinville, WA US
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20160125958 | TESTING STORAGE DEVICE POWER CIRCUITRY - The present invention extends to methods, systems, and computer program products for testing storage device power circuitry. A storage device controller includes an embedded test program. The storage device controller executes the test program in response to receiving a test command. In one aspect, the test program issues a plurality of different command patterns to test shared power circuitry of storage device components (e.g., shared by an array of NAND flash memory devices). The test program identifies a command pattern that causes a greatest total current draw. In another aspect, the test program issues a specified command pattern (possibly repeatedly) to shared power circuitry to determine if the shared power circuitry fails. | 05-05-2016 |
Matt Caulfield, Clinton, MA US
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20150288730 | Efficient On-Demand Generation of ABR Manifests - In one embodiment of the present invention, an HLS transcoder inserts a plurality of encoder boundary points (EBPs) into an HLS formatted content item, a processor places hints about locations of the inserted EBPs, and an inputter inputs the HLS formatted content item into an on-demand encapsulation process. Related systems, apparatus and methods are also described. | 10-08-2015 |
20150288736 | Method for Enabling Use of HLS as a Common Intermediate Format - In one embodiment a method, system, and apparatus is described for providing multimedia content from a server to a plurality of media devices, the method including providing a computing device an HTTP Live Streaming (HLS) playlist for playing in an adaptive bitrate client, the playlist including a list of at least two segments, each of the segments having an associated duration field, for each segment in the playlist, assigning a timestamp which is equal to the sum the durations of each previous segment in the playlist, calculating a calculated duration of the playlist by subtracting a time stamp of the first segment in the playlist from the time stamp of the last segment in the playlist, determining a real duration of the playlist by subtracting a first presentation time stamp (PTS) of the first segment in the playlist from the last presentation time stamp (PTS) of the last segment in the playlist, computing a playlist drift by subtracting the calculated duration of the playlist from the real duration of the playlist, determining a correction factor by dividing the playlist drift by the number of segments in the playlist, and calculating a new timestamp for each segment in the playlist by adding the correction factor to the time stamp of the segment. Related methods, systems, and apparatus are also described. | 10-08-2015 |
Matthew Caulfield, Wyckoff, NJ US
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20090138123 | Robotic CBRNE Automated Deployment, Detection, and Reporting System - A system having a plurality of networked detectors for detecting chemical, biological, or radiological, nuclear, or explosive agents is disclosed. The system includes a plurality of remote units, wherein each remote unit includes a robotic base, a lift, a sensor module, transceiver, navigation system, and power source. The remote units communicate with a base station, which receives data from the remotes and determines, based on the data, if an alarm condition exists. | 05-28-2009 |
Matthew F. Caulfield, Clinton, MA US
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20150261600 | RECONCILING REDUNDANT COPIES OF MEDIA CONTENT - A system can include a reconciliation engine configured to evaluate metadata in a given manifest file of a plurality of manifest files generated for redundant copies of a given media asset. The metadata describes a condition of a given chunk of media content in one of the redundant copies of the given media asset. The system can also include a manifest modification function configured to modify the given manifest file for the given chunk of media content in response to the reconciliation engine detecting that the given chunk of media content is damaged based on the evaluation of the metadata associated with the given chunk of media content in the given manifest file. | 09-17-2015 |
Matthew Francis Caulfield, Clinton, MA US
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20140325023 | SIZE PREDICTION IN STREAMING ENVIROMENTS - A method is provided in one example embodiment and includes receiving a request for video content from a client device and accessing a common format representation for a requested chunk within the video content. The common format representation is provided in one or more files that include metadata indicative of one or more counters. The method can also include using the common format representation in conjunction with a deterministic equation to identify a predicted size of an output to be sent to the client device; and using the predicted size of the output to initiate transmitting at least a portion of a response to the client. | 10-30-2014 |
20140351318 | ON-DEMAND ENCAPSULATING OF TIMED METADATA IN A NETWORK ENVIRONMENT - A method is provided in one example and includes receiving media content including timed metadata, generating a common format asset including the timed metadata and a timed metadata index including at least one reference point corresponding to the common format asset. Each reference point includes state context information of the timed metadata at a particular instance of time. The method may further include receiving a request for the timed metadata from a particular client device, and retrieving a determined amount of the timed metadata from the common format asset using the timed metadata index. In a particular example, the determined amount of the timed metadata is an amount sufficient to display a current timed metadata context corresponding to the request. | 11-27-2014 |
20140351455 | PRODUCING EQUIVALENT CONTENT ACROSS ENCAPSULATORS IN A NETWORK ENVIRONMENT - A method is provided in one example and includes receiving first synchronization information associated with a first encapsulated output, receiving second synchronization information associated with a second encapsulated output, and determining whether the first encapsulated output and the second encapsulated output are in synchronization based upon the first synchronization information and the second synchronization information. The method may further include, when the first encapsulated output and the second encapsulated output are determined to out of synchronization, generating corrected synchronization information, and sending the corrected synchronization information to an encapsulator generating at least one of the first encapsulated output and the second encapsulated output. | 11-27-2014 |
20150052236 | LOAD BASED TARGET ALTERATION IN STREAMING ENVIRONMENTS - A method is provided in one example embodiment and includes receiving, at a virtual server, a request for video content from a client device; identifying a policy for a set of transform sessions; accessing a resource monitor in order to evaluate current load conditions associated with the virtual server; and determining an action to take based on the current load conditions. | 02-19-2015 |
20150074129 | AUGMENTING MEDIA PRESENTATION DESCRIPTION AND INDEX FOR METADATA IN A NETWORK ENVIRONMENT - A method is provided in one example and includes receiving common format media including timed metadata associated with a timed metadata event. The method further includes extracting timed metadata information from the timed metadata, and generating a manifest corresponding to the common format media including the timed metadata information. The timed metadata information includes an indicator of a start time and an indicator of a duration of the timed metadata event. The method further includes generating a common format asset including the manifest. | 03-12-2015 |
20150106472 | VIRTUAL ASSETS FOR ON-DEMAND CONTENT GENERATION - A method is provided in one example embodiment and includes generating a key associated with a virtual asset associated with content to be provided to a client device, where the key indicates at least one parameter for accessing the content; generating the virtual asset; receiving a request for the content; identifying a format being requested for the content; using the virtual asset to identify common format content to be retrieved and to identify the key; using the key to retrieve the common format content; and transforming the common format content such that it can be delivered to the client device in the format that was requested. | 04-16-2015 |
20150113173 | SYSTEM AND METHOD FOR LOCATING A BOUNDARY POINT WITHIN ADAPTIVE BITRATE CONDITIONED CONTENT - A method is provided in one example and includes determining an occurrence of an exception to a predetermined cadence associated with an input stream of a profile; determining a shifted cadence based, at least in part, on the exception; receiving an indication of a key frame in the profile; determining that the key frame aligns with the shifted cadence; designating the key frame as a boundary point based, at least in part, on the shifted cadence; and communicating the boundary point. | 04-23-2015 |
Michael Caulfield, Fort Washington, PA US
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20140212458 | NOVEL HIV-1 ENVELOPE GLYCOPROTEIN - The present application relates to novel HIV-1 envelope glycoproteins, which may be utilized as HIV-1 vaccine immunogens, and antigens for crystallization, electron micrsocopy and other biophysical, biochemical and immunological studies for the identification of broad neutralizing antibodies. The present invention encompasses the preparation and purification of immunogenic compositions, which are formulated into the vaccines of the present invention. | 07-31-2014 |
Michael J. Caulfield, West Point, PA US
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20110014226 | HIGH THROUGHPUT PROTEIN INTERACTION ASSAY - A method to identify small molecules useful as therapeutics and/or vaccines to prevent, alleviate or ameliorate a pathogenic infection or an autoimmune disorder. The method can be used to screen small molecule test compounds for the ability to disrupt particular antigen-antibody interactions of interest. In one embodiment, the antigen is a pathogen-derived antigen and the antibody decreases or inhibits virulence of the pathogen when bound to the antigen (e.g., a neutralizing antibody, antibody with serum bactericidal activity, etc.). In another embodiment, the antigen is a self-antigen (autoantigen) and the antibody is an autoantibody that is known to be associated with a pathological condition (e.g., autoimmune disorder). Compounds that bind to the antigen or antibody disrupt binding can be used as therapeutics to decrease or inhibit the autoimmune disorder. | 01-20-2011 |
Michael J. Caulfield, Ft. Washington, PA US
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20110195086 | 15-VALENT PNEUMOCOCCAL POLYSACCHARIDE-PROTEIN CONJUGATE VACCINE COMPOSITION - The present invention provides a multivalent immunogenic composition having 15 distinct polysaccharide-protein conjugates. Each conjugate consists of a capsular polysaccharide prepared from a different serotype of | 08-11-2011 |
20120301502 | 15-VALENT PNEUMOCOCCAL POLYSACCHARIDE-PROTEIN CONJUGATE VACCINE COMPOSITION - The present invention provides a multivalent immunogenic composition having 15 distinct polysaccharide-protein conjugates. Each conjugate consists of a capsular polysaccharide prepared from a different serotype of | 11-29-2012 |
Michael P. Caulfield, Oceanside, CA US
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20080305549 | LIPOPROTEIN ANALYSIS BY DIFFERENTIAL CHARGED-PARTICLE MOBILITY - The invention provides methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention. | 12-11-2008 |
Michael P. Caulfield, San Clemente, CA US
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20100047849 | DETERMINATION OF TESTOSTERONE BY MASS SPECTROMETRY - Provided are methods for determining the presence or amount of testosterone in a test sample, comprising ionizing all or a portion of the testosterone present in the sample to produce one or more testosterone ions that are detectable in a mass spectrometer. All or a portion of the testosterone present in the sample is ionized to produce one or more testosterone ions, which may be isolated and fragmented to produce precursor ions. A separately detectable internal testosterone standard can be provided in the sample. In a preferred embodiment, the reference is 2,2,4,6,6-d | 02-25-2010 |
20100148055 | METHODS FOR DETECTING CATECHOLAMINES BY MASS SPECTROMETRY - Provided are methods for determining the amount of one or more of one or more of epinephrine (E), norepinephrine (NE), and dopamine (D) in a sample using mass spectrometry. The methods generally involve ionizing one or more of E, NE, and D in a sample and detecting and quantifying the amount of the ion to determine the amount of one or more of E, NE, and D in the sample. | 06-17-2010 |
20110059534 | DETERMINATION OF TESTOSTERONE BY MASS SPECTROMETRY - Provided are methods for determining the presence or amount of testosterone in a test sample, comprising ionizing all or a portion of the testosterone present in the sample to produce one or more testosterone ions that are detectable in a mass spectrometer. All or a portion of the testosterone present in the sample is ionized to produce one or more testosterone ions, which may be isolated and fragmented to produce precursor ions. A separately detectable internal testosterone standard can be provided in the sample. In a preferred embodiment, the reference is 2,2,4,6,6-d | 03-10-2011 |
20110223685 | OXIDIZED APOA1 DETERMINATION BY MASS SPECTROMETRY - Methods are provided for the detection and quantitation of proteins generally and apolipoprotein A-I and oxidized derivatives thereof in particular. Further provided are methods for the assessment of the risk cardiovascular disease in a subject, wherein the assessment is based on the amount of oxidized and unoxidized apolipoprotein A-I in a biological sample obtained from a subject. | 09-15-2011 |
20110226946 | DETERMINATION OF TESTOSTERONE BY MASS SPECTROMETRY - Provided are methods for determining the presence or amount of testosterone in a test sample, comprising ionizing all or a portion of the testosterone present in the sample to produce one or more testosterone ions that are detectable in a mass spectrometer. All or a portion of the testosterone present in the sample is ionized to produce one or more testosterone ions, which may be isolated and fragmented to produce precursor ions. A separately detectable internal testosterone standard can be provided in the sample. In a preferred embodiment, the reference is 2,2,4,6,6-d | 09-22-2011 |
20110240843 | METHODS FOR DETECTING CATECHOLAMINES BY MASS SPECTROMETRY - Provided are methods for determining the amount of one or more of one or more of epinephrine (E), norepinephrine (NE), and dopamine (D) in a sample using mass spectrometry. The methods generally involve ionizing one or more of E, NE, and D in a sample and detecting and quantifying the amount of the ion to determine the amount of one or more of E, NE, and D in the sample. | 10-06-2011 |
20110306080 | DETERMINATION OF LAMOTRIGINE BY MASS SPECTROMETRY - The present invention relates to compositions and methods for analyzing analytes of interest in liquid samples by mass spectrometry, and preferably in patient samples. Preferred analytes of interest include sirolimus (rapamycin), corticosteroids, bile acids and lamotrigine (lamictal). In one embodiment, by careful selection of target ions, a number of corticosteroids can be analyzed simultaneously and without interference from closely related molecules. In another embodiment, the present methods combine high turbulence liquid chromatography with mass spectrometry performed in positive and negative mode in a single assay to enable the detection and quantification of the composition of bile acid pools. By combining mass spectrometry and high-throughput chromatography, the methods and compositions described herein can provide a rapid, sensitive, and accurate assay for use in large clinical laboratories. | 12-15-2011 |
20120103072 | PROGNOSTIC ASSAYS FOR MAINTENANCE HEMODIALYSIS PATIENTS - Described herein are methods for determining the overall survival of maintenance hemodialysis patients. The methods include measuring low density lipoprotein (LDL) particle size and subfraction concentrations as prognostic tools for early mortality risk detection. For example, the presence of increased very small LDL concentration or decreased LDL particle size in blood-serum serves as a useful means for prognostic risk assessment and monitoring. | 05-03-2012 |
20120285831 | MAGNETIC SEPARATION OF LIPOPROTEINS USING DEXTRAN SULFATE - The invention provides apparatus and methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged-particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged-particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention. | 11-15-2012 |
20120315706 | LIPOPROTEIN ANALYSIS BY DIFFERENTIAL CHARGED-PARTICLE MOBILITY - The invention provides methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention. | 12-13-2012 |
20130122602 | METHODS FOR DETECTING CATECHOLAMINES BY MASS SPECTROMETRY - Provided are methods for determining the amount of one or more of one or more of epinephrine (E), norepinephrine (NE), and dopamine (D) in a sample using mass spectrometry. The methods generally involve ionizing one or more of E, NE, and D in a sample and detecting and quantifying the amount of the ion to determine the amount of one or more of E, NE, and D in the sample | 05-16-2013 |
20130292560 | METHODS FOR DETECTING CATECHOLAMINES BY MASS SPECTROMETRY - Provided are methods for determining the amount of one or more of one or more of epinephrine (E), norepinephrine (NE), and dopamine (D) in a sample using mass spectrometry. The methods generally involve ionizing one or more of E, NE, and D in a sample and detecting and quantifying the amount of the ion to determine the amount of one or more of E, NE, and D in the sample | 11-07-2013 |
20140287530 | LIPOPROTEIN ANALYSIS BY DIFFERENTIAL CHARGED-PARTICLE MOBILITY - The invention provides methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention. | 09-25-2014 |
20150260739 | LIPOPROTEIN ANALYSIS BY DIFFERENTIAL CHARGED-PARTICLE MOBILITY - The invention provides methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention. | 09-17-2015 |
Micheal J. Caulfield, Fort Washington, PA US
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20130129778 | VIRAL PARTICLES DERIVED FROM AN ENVELOPED VIRUS - The invention relates to generating a vaccine based on immunogens from viral particles that initially have replication competency but are then inactivated by chemical, biophysical or other methods. The components of this vaccine may be a non-HIV enveloped virus that contains and expresses a gene related to the HIV Envelope gene such that the Envelope protein is expressed on the surface of viral particles. These viral particles may be further treated to reduce their replication competency. The vaccine further may contain components to improve its immunogenicity, tolerability, stability and ease of manufacture. | 05-23-2013 |
Thomas Caulfield, Lebanon, NJ US
Thomas Caulfield, Pleasanton, CA US
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20120274069 | DUAL FLUID CIRCUIT SYSTEM FOR GENERATING A VAPOROUS WORKING FLUID USING SOLAR ENERGY - Systems for producing vaporous working fluid are provided, including: a first fluid passage configured to convey a working fluid to a first solar heating system, wherein the first solar heating system heats the working fluid to produce a heated working fluid having a temperature t | 11-01-2012 |
Thomas J. Caulfield, Lebanon, NJ US
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20100113462 | SUBSTITUTED BENZOYLAMINO-INDAN-2-CARBOXYLIC ACIDS AND RELATED COMPOUNDS - The present invention relates to novel compounds of the formula I: | 05-06-2010 |
Thomas R. Caulfield, Jacksonville, FL US
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20150274742 | Treating Brain Cancer using Agelastatin A (AA) and Analogues Thereof - This document relates to compounds and compositions useful for treating cancers, such as brain and nervous system cancers. | 10-01-2015 |