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| 20090038020 | HUMAN ALBUMIN ANIMAL MODELS FOR DRUG EVALUATION, TOXICOLOGY AND IMMUNOGENICITY STUDIES - An animal model is provided which is genetically engineered to express human serum albumin, and such animals may be advantageously used in assessing drugs, vaccines or other therapeutic compounds that may be used in humans. In addition, an animal model is provided which does not manufacture its own albumin and which has been injected with human serum albumin. Through the use of these animal models, drugs and other chemicals can be more accurately assessed in physiological environments that reflect the conditions to be expected in humans, and such models will be useful in assessing new drugs and evaluating toxic substances for potential dangers as carcinogens, mutagens, etc. Other applications include evaluating immunological properties of various albumin-engineered proteins which might be administered to humans as therapeutics or vaccines, and research of disease states, such as genetic diseases, to provide further insight in treating these diseases. | 02-05-2009 |
| 20100122357 | HUMAN ALBUMIN ANIMAL MODELS FOR DRUG EVALUATION, TOXICOLOGY AND IMMUNOGENICITY STUDIES - An animal model is provided which is genetically engineered to express human serum albumin, and such animals may be advantageously used in assessing drugs, vaccines or other therapeutic compounds that may be used in humans. In addition, an animal model is provided which does not manufacture its own albumin and which has been injected with human serum albumin. Through the use of these animal models, drugs and other chemicals can be more accurately assessed in physiological environments that reflect the conditions to be expected in humans, and such models will be useful in assessing new drugs and evaluating toxic substances for potential dangers as carcinogens, mutagens, etc. Other applications include evaluating immunological properties of various albumin-engineered proteins which might be administered to humans as therapeutics or vaccines, and research of disease states, such as genetic diseases, to provide further insight in treating these diseases. | 05-13-2010 |
| 20100240602 | METHODS AND COMPOSITIONS FOR OPTIMIZING BLOOD AND TISSUE STABILITY OF CAMPTOTHECIN AND OTHER ALBUMIN-BINDING THERAPEUTIC COMPOUNDS - The present invention provides methods and formulations for optimizing the anti-cancer and anti-HIV activities of a camptothecin drug, including camptothecin and its related analogs including 9-aminocamptothecin and 9-nitrocamptothecin. The invention involves methodologies and formulations that limit human serum albumin-mediated reduction of the anti-cancer and anti-HIV effects of the camptothecins, and the methods and formulations provide combination therapies in which binding of the camptothecin agent to human serum albumin can be modulated by the administration of a competing agent such as ibuprofen, clofibrate or clofibric acid that also binds human serum albumin. Reduced camptothecin drug binding to human serum albumin can result in elevated camptothecin free drug levels and thus improve the effectiveness of treatment regimens involving these drugs. Further agents such as methotrexate and AZT can also be used in cancer and HIV-positive patients employing camptothecin drugs. | 09-23-2010 |
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| 20130080592 | RECOMMENDER SYSTEM FOR A CONTENT SERVER BASED ON SECURITY GROUP MEMBERSHIP - Methods, systems, and techniques for recommending content using a measure of security group based similarity are provided. Embodiments described herein provide enhanced computer- and network-based methods, techniques, and systems for a recommender system, e.g., for content servers, that uses security group membership as the basis for determining user similarity. In particular, upon request for a recommendation, an enhanced content provider, through the use of the Security Based Recommender (SBR), provides indications of similar content based upon the security group membership of the requestor. The SBR determines similar content by determining what content was accessed by others within the security group membership of the requester. The recommendations may be ranked or filtered or combined with other types of recommendations, such as social network filtering, statistical based filtering, or the like. | 03-28-2013 |
| 20130091157 | FILE SERVER SEARCH AND RECOMMENDATION SYSTEM - Enhanced computer- and network-based methods, techniques, and systems for an enhanced file server that provides search and recommendations “in-band” as part of a request to the file server are provided. Example embodiments provide a Enhanced File Server (“EFS”), which enables file servers and the like, to search for and/or to recommend information (e.g., content, data, or the like) based upon a file request to the file server. This enables a user of the EFS to avoid the use of a separate search or recommendation system, such as a search engine, to find information. An Enhanced File Server implements its own search and recommendation capabilities and allows users to search for and obtain recommendations for information through its standard file-access mechanisms. Searches and requests for recommendations are performed using especially constructed file names The EFS may present results to the user using synthesized content. | 04-11-2013 |
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| 20080312010 | STEREOSCOPIC IMAGE CAPTURE WITH PERFORMANCE OUTCOME PREDICTION IN SPORTING ENVIRONMENTS - Methods and apparatus relating to predicting outcome in a sporting environment are described. The methods and apparatus are used to relate trajectory performance of an object to body motions and body orientation associated with a generating the trajectory of the object. When equipment is utilized to generate the trajectory of an object, than the effects of equipment motions and equipment orientation can be also related to trajectory performance. The method and apparatus can be used to predict body motions and body orientations that increase the likelihood of achieving a desired outcome including specifying optimum motions and orientations for a particular individual. The method and apparatus may be used in training, coaching and broadcasting environments. | 12-18-2008 |
| 20110143868 | TRAINING DEVICES FOR TRAJECTORY-BASED SPORTS - Methods and apparatus related to improving player performance for trajectory-based sports are described. In particular, sporting devices are described that can be utilized to improve player performance in basketball. The sporting devices can include a camera-based system configured to capture and analyze the trajectory of a shot taken by a player. The camera-based system can be configured to provide feedback that allows a player to optimize the trajectory mechanics associated with shooting a basketball. In one embodiment, the camera-based system can be used in conjunction with a training aid that is attached to a basketball rim. The training aid can be configured to improve the trajectory mechanics of individuals utilizing the modified basketball rim to practice their shooting. | 06-16-2011 |
| 20120289296 | METHOD AND APPARATUS FOR VIDEO GAME SIMULATIONS USING MOTION CAPTURE - A method in a video gaming system including a processor, a memory and a sensor system for capturing body motion is described. In one embodiment, the body motion can be associated with a person pretending to hit or launch an object, such as an object used in a sporting activity. In general, body motion can be associated with any activity involving similar body motions that are repeated during the activity. In a video game generated by the video gaming system, a consistency with which the repeated body motions are made over time can be used to determine an outcome for a single instance of the body motion. In a particular embodiment, a probability of a more desirable outcome resulting from the single instance of the body motion can increase as the consistency with which the repeated body motions are made increases. | 11-15-2012 |
| 20130095960 | TRAINING DEVICES FOR TRAJECTORY-BASED SPORTS - Methods and apparatus related to improving player performance for trajectory-based sports are described. In particular, sporting devices are described that can be utilized to improve player performance in basketball. The sporting devices can include a camera-based system configured to capture and analyze the trajectory of a shot taken by a player. The camera-based system can be configured to provide feedback that allows a player to optimize the trajectory mechanics associated with shooting a basketball. In one embodiment, the camera-based system can be used in conjunction with a training aid that is attached to a basketball rim. The training aid can be configured to improve the trajectory mechanics of individuals utilizing the modified basketball rim to practice their shooting. | 04-18-2013 |
| 20130172058 | METHOD AND APPARATUS FOR VIDEO GAME SIMULATIONS USING MOTION CAPTURE - A method in a video gaming system including a processor, a memory and a sensor system for capturing body motion is described. In one embodiment, the body motion can be associated with a person pretending to hit or launch an object, such as an object used in a sporting activity. In general, body motion can be associated with any activity involving similar body motions that are repeated during the activity. In a video game generated by the video gaming system, a consistency with which the repeated body motions are made over time can be used to determine an outcome for a single instance of the body motion. In a particular embodiment, a probability of a more desirable outcome resulting from the single instance of the body motion can increase as the consistency with which the repeated body motions are made increases. | 07-04-2013 |
| 20140092253 | TRAINING DEVICES FOR TRAJECTORY-BASED SPORTS - Methods and apparatus related to improving player performance for trajectory-based sports are described. In particular, sporting devices are described that can be utilized to improve player performance in basketball. The sporting devices can include a camera-based system configured to capture and analyze the trajectory of a shot taken by a player. The camera-based system can be configured to provide feedback that allows a player to optimize the trajectory mechanics associated with shooting a basketball. In one embodiment, the camera-based system can be used in conjunction with a training aid that is attached to a basketball rim. The training aid can be configured to improve the trajectory mechanics of individuals utilizing the modified basketball rim to practice their shooting. | 04-03-2014 |
| 20140301598 | TRUE SPACE TRACKING OF AXISYMMETRIC OBJECT FLIGHT USING DIAMETER MEASUREMENT - Methods and apparatus for determining a trajectory of a axisymmetric object in 3-D physical space using a digital camera which records 2-D image data are described. In particular, based upon i) a characteristic length of the axisymmetric object, ii) a physical position of the camera determined from sensors associated with the camera (e.g., accelerometers) and iii) captured 2-D digital images from the camera including a time at which each image is generated relative to one another, a position, a velocity vector and an acceleration vector can be determined in three dimensional physical space for axisymmetric object objects as a function of time. In one embodiment, the method and apparatus can be applied to determine the trajectories of objects in games which utilize axisymmetric object objects, such as basketball, baseball, bowling, golf, soccer, rugby or football. | 10-09-2014 |
| 20140301600 | TRUE SPACE TRACKING OF AXISYMMETRIC OBJECT FLIGHT USING DIAMETER MEASUREMENT - Methods and apparatus for determining a trajectory of a axisymmetric object in 3-D physical space using a digital camera which records 2-D image data are described. In particular, based upon i) a characteristic length of the axisymmetric object, ii) a physical position of the camera determined from sensors associated with the camera (e.g., accelerometers) and iii) captured 2-D digital images from the camera including a time at which each image is generated relative to one another, a position, a velocity vector and an acceleration vector can be determined in three dimensional physical space for axisymmetric object objects as a function of time. In one embodiment, the method and apparatus can be applied to determine the trajectories of objects in games which utilize axisymmetric object objects, such as basketball, baseball, bowling, golf, soccer, rugby or football. | 10-09-2014 |
| 20140301601 | TRUE SPACE TRACKING OF AXISYMMETRIC OBJECT FLIGHT USING DIAMETER MEASUREMENT - Methods and apparatus for determining a trajectory of a axisymmetric object in 3-D physical space using a digital camera which records 2-D image data are described. In particular, based upon i) a characteristic length of the axisymmetric object, ii) a physical position of the camera determined from sensors associated with the camera (e.g., accelerometers) and iii) captured 2-D digital images from the camera including a time at which each image is generated relative to one another, a position, a velocity vector and an acceleration vector can be determined in three dimensional physical space for axisymmetric object objects as a function of time. In one embodiment, the method and apparatus can be applied to determine the trajectories of objects in games which utilize axisymmetric object objects, such as basketball, baseball, bowling, golf, soccer, rugby or football. | 10-09-2014 |
