Patent application number | Description | Published |
20100137449 | SUBSTITUTED 1,3-CYCLOPENTADIONE MULTI-TARGET PROTEIN KINASE MODULATORS OF CANCER, ANGIOGENESIS AND THE INFLAMMATORY PATHWAYS ASSOCIATED THEREWITH - Compounds and methods for multi-targeted protein kinase modulation for angiogenesis, cancer treatment or the inflammatory pathways associated with those conditions are disclosed. The compounds and methods disclosed are based on substituted 1,3-cyclopentadione compounds. | 06-03-2010 |
20110257074 | METHOD FOR THE PURIFICATION OF SUBSTITUTED CYCLOPENT-2-EN-1-ONE CONGENERS AND SUBSTITUTED 1,3-CYCLOPENTADIONE CONGENERS FROM A COMPLEX MIXTURE USING COUNTERCURRENT SEPARATION - Methods of purifying individual congeners of substituted cyclohexa-2,4-dienones, substituted cyclohexane-1,3,5-triones, substituted cyclopent-2-en-1-ones, and substituted 1,3-cyclopentadiones and compositions using the same are disclosed. The purification method includes the steps of: (a) selecting a congener to be isolated; (b) dissolving the mixture of congeners in a bi-phasic solvent system specific to the selected congener to be isolated, wherein said bi-phasic system has a partition coefficient from about 0.5 to 5.0; (c) subjecting the mixture dissolved in the bi-phasic solvent system to a counter current chromatography; and (d) isolating the selected congener in substantially pure form. | 10-20-2011 |
20110275721 | METHOD FOR THE PURIFICATION OF SUBSTITUTED CYCLOPENT-2-EN-1-ONE CONGENERS AND SUBSTITUTED 1,3-CYCLOPENTADIONE CONGENERS FROM A COMPLEX MIXTURE USING COUNTERCURRENT SEPARATION - Methods of purifying individual congeners of substituted cyclohexa-2,4-dienones, substituted cyclohexane-1,3,5-triones, substituted cyclopent-2-en-1-ones, and substituted 1,3-cyclopentadiones and compositions using the same are disclosed. The purification method includes the steps of: (a) selecting a congener to be isolated; (b) dissolving the mixture of congeners in a bi-phasic solvent system specific to the selected congener to be isolated, wherein said bi-phasic system has a partition coefficient from about 0.5 to 5.0; (c) subjecting the mixture dissolved in the bi-phasic solvent system to a counter current chromatography; and (d) isolating the selected congener in substantially pure form. | 11-10-2011 |
20120108671 | CIS 3,4-DIHYDROXY-2-(3-METHYLBUTANOYL)-5-(3-METHYLBUTYL)-4-(4-METHYLPENTAN- OYL)CYCLOPENT-2-EN-1-ONE DERIVATIVES, SUBSTANTIALLY ENANTIOMERICALLY PURE COMPOSITIONS AND METHODS - The present application provides cis 3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one derivatives and substantially enantiomerically pure compositions thereof. These derivatives include (+)-(4S,5R)-3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one, (−)-(4R,5S)-3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one, and salts and crystals thereof. The application further provides methods of using the disclosed compounds and compositions to activate PPARγ, activate GPR120, inhibit inflammation, and treat conditions responsive to PPARγ modulation, conditions responsive to GPR120 modulation, and metabolic disturbances such as diabetes. | 05-03-2012 |
20130018105 | CIS, 3,4-DIHYDROXY-2-(3-METHYLBUTANOYL)-5-(3-METHYLBUTYL)-4-(4-METHYLPENTA- NOYL)CYCLOPENT-2-EN-1-ONE DERIVATIVES, SUBSTANTIALLY ENANTIOMERICALLY PURE COMPOSITIONS AND METHODS - The present application provides cis 3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one derivatives and substantially enantiomerically pure compositions thereof. These derivatives include (+)-(4S,5R)—3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one, (−)-(4R,5S)-3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one, and salts and crystals thereof. The application further provides methods of using the disclosed compounds and compositions to activate PPARγ, activate GPR120, inhibit inflammation, and treat conditions responsive to PPARγ modulation, conditions responsive to GPR120 modulation, and metabolic disturbances such as diabetes. | 01-17-2013 |
20130217781 | CIS 3,4-DIHYDROXY-2-(3-METHYLBUTANOYL)-5-(3-METHYLBUTYL)-4-(4-METHYLPENTAN- OYL)CYCLOPENT-2-EN-1-ONE DERIVATIVES, SUBSTANTIALLY ENANTIOMERICALLY PURE COMPOSITIONS AND METHODS - The present application provides cis 3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one derivatives and substantially enantiomerically pure compositions thereof. These derivatives include (+)-(4S,5R)-3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one, (−)-(4R,5S)-3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one, and salts and crystals thereof. The application further provides methods of using the disclosed compounds and compositions to activate PPARγ, activate GPR120, inhibit inflammation, and treat conditions responsive to PPARγ modulation, conditions responsive to GPR120 modulation, and metabolic disturbances such as diabetes. | 08-22-2013 |
20150119461 | TETRAHYDRO-ISOHUMULONE DERIVATIVES, METHODS OF MAKING AND USING - The present application provides novel tetrahydro-isohumulone (THIAA) derivatives and substantially enantiomerically pure compositions and pharmaceutical formulations thereof. The application further provides methods of using the disclosed compounds and compositions to activate PPARγ, inhibit inflammation, and treat conditions associated with inflammation and conditions responsive to PPARγ modulation such as diabetes. | 04-30-2015 |
Patent application number | Description | Published |
20150039599 | METHODS AND SYSTEMS FOR RECOMMENDING TOP LEVEL AND SECOND LEVEL DOMAINS - A system and method are presented for recommending domain names. One or more computer servers receive a query including at least one keyword from a user. A business category associated with the user is determined and a data base storing a plurality of top level domain name rankings is accessed to identify a first ranking of top level domain names for the business category. A listing of candidate domain names relevant to the query is generated and the listing of candidate domain names relevant to the query is displayed for selection and registration by the user. The listing of candidate domain names is ordered according to the first ranking of top level domain names for the business category. | 02-05-2015 |
20150058330 | METHODS AND SYSTEMS FOR RECOMMENDING PACKAGES OF DOMAIN NAMES FOR REGISTRATION - A system and method are presented for recommending packages of domain names. One or more computer servers receive a query including at least one keyword from a user. A business category associated with the user is identified and a first ranking of top level domain names for the business category is identified. A package of candidate domain names is generated containing a candidate domain name for each top level domain in the first ranking of top level domain names. The package of candidate domain names relevant to the query is displayed for selection and registration by the user. | 02-26-2015 |
20150370914 | SOFTWARE APPLICATION CUSTOMIZED FOR TARGET MARKET - A system and method are presented for customizing a software application for a target market. A request to access an application is received, by one or more computer servers, from a user. At least one of a preferred language of the user and a location of the user are determined by the one or more computer servers, and a target market is determined using the at least one of the preferred language of the user and the location of the user. The target market defines a language and a region. The application is rendered by the one or more computer servers by modifying at least one of a user interface of the application and a content of the application using the target market. | 12-24-2015 |
20150371222 | WEBSITE CONTENT OPTIMIZATION FOR TARGET MARKET - A system and method are presented for website content optimization for a target market. A request for a web page is received by one or more computer servers from a user. The web page is configured to enable the user to perform a financial transaction. A location of the user and one or more preferred methods of payment for a geographical region including the location of the user are determined by the one or more computers servers. The one or more computer servers generate the web page in response to the request. The web page is configured to enable the user to use at least one of the one or more preferred methods of payment to perform the financial transaction. The web page is transmitted to the user. | 12-24-2015 |
Patent application number | Description | Published |
20090006455 | Automated time metadata deduction - An arrangement for deducing descriptive metadata from data contained in a column of a relational table and associated existing metadata (e.g., that which identifies column data type and/or column name) is provided by a metadata deduction engine in a set of OLAP tools which operates in conjunction with an analysis services server. The metadata deduction engine applies one or more criteria that are configured to evaluate column data in order to deduce metadata that provides additional contextual meaning to the column data beyond that given by the existing metadata. The metadata deduction engine maps the column data to a metadata tag that is passed to the analysis services server to enable it to create an OLAP cube using the deduced metadata. | 01-01-2009 |
20110295865 | Schema Contracts for Data Integration - A system and method for extracting data from an input source, transforming the data, and loading the transformed data to an output destination. A schema contract including constraints is used to validate a set of input data column types and translate them into a set of actual types. Mapping data in the schema contract enable mapping input data columns to data columns used by data integration components. The constraints and mapping data provide flexibility in transforming sets of data having different sets of input data column types, while providing a fixed set of types for use during dataflow executions. Flexibility may enable optional columns, sets of one or more columns, varying arrangements of columns, and variations in type definitions of each column. | 12-01-2011 |
20110307866 | MULTI-ENVIRONMENT CONFIGURATION OF DATA INTEGRATION PROJECTS - A system and method for facilitating execution of one or more data integration projects in multiple environments or an environment that undergoes changes. Each project has a set of project parameters, which are bound to environment variables. Each environment has a corresponding environment representation with environment variables and corresponding values. Each project is mapped to an environment representation. Values of environment variables are provided to projects with corresponding parameters. When one or more projects are changed to a different environment with a different corresponding environment representation, the environment variable values of the new environment representation are provided to the projects. When an environment change is reflected in the environment representation, the changed variable values are provided to mapped projects. | 12-15-2011 |
20120254259 | FLEXIBLE ORDER OF AUTHORING FOR DATA INTEGRATION SOLUTIONS - A method includes connecting an integration process to a first set of inputs. The first set of inputs may include one or more inputs. The integration process includes one or more data transformation operations using the inputs. The method further includes receiving metadata about one or more of the inputs in the first set of inputs. The metadata about one or more of the inputs in the first set of inputs is cached. The integration process is then connected to a second set of inputs based on the cached metadata about one or more of the inputs in the first set of inputs. | 10-04-2012 |
20150012907 | MULTI-ENVIRONMENT CONFIGURATION OF DATA INTEGRATION PROJECTS - A system and method for facilitating execution of one or more data integration projects in multiple environments or an environment that undergoes changes. Each project has a set of project parameters, which are bound to environment variables. Each environment has a corresponding environment representation with environment variables and corresponding values. Each project is mapped to an environment representation. Values of environment variables are provided to projects with corresponding parameters. When one or more projects are changed to a different environment with a different corresponding environment representation, the environment variable values of the new environment representation are provided to the projects. When an environment change is reflected in the environment representation, the changed variable values are provided to mapped projects. | 01-08-2015 |
Patent application number | Description | Published |
20100070611 | Dye Injected Request Generation - Web server processes can host multiple web applications that process multiple requests from multiple clients. Recorded diagnostic information may not provide a useful separation of server execution data (e.g., functionality executed to process a request) based on a client's use of the web server process. An effective method for separating server execution data by client information is provided herein. Dye is injected into a request from a client, the dye comprises information regarding the client application making the request and a transaction (e.g., client defined set of requests) that the request is comprised within. The dye injected request is sent to a web server process (e.g., on a web server) that extracts the dye and executes the request. During execution of the request, executed functionality is associated and stored with the extracted dye. The recorded server execution data may be organized based upon the request, client, application, and/or transaction. | 03-18-2010 |
20140040669 | Historical Software Diagnostics using Lightweight Process Snapshots - A debugging and diagnostics system allows users to take lightweight process snapshots of running debuggee processes so the users may analyze those snapshots at a later time. The snapshot mechanism allows diagnostic tools to compare an original process or one or more process snapshots or to compare any of a series of snapshots to each other. The snapshot mechanism further allows users to inspect a snapshot of process memory while allowing the original process to continue running with minimal impact. A user may do historical debugging using process snapshots of a debuggee process taken over time. This allows the user to view the state of the debuggee process as it existed when the snapshot was taken. The lightweight process snapshot is less invasive because it does not require a full copy of the memory and allows the original process to run un-interrupted while specific collections and inspections are completed. | 02-06-2014 |
20150127991 | Historical Software Diagnostics using Lightweight Process Snapshots - A debugging and diagnostics system allows users to take lightweight process snapshots of running debuggee processes so the users may analyze those snapshots at a later time. The snapshot mechanism allows debugging tools to compare an original process or one or more process snapshots or to compare any of a series of snapshots to each other. The snapshot mechanism further allows users to inspect a snapshot of process memory while allowing the original process to continue running with minimal impact. A user may do historical debugging using process snapshots of a debuggee process taken over time. This allows the user to view the state of the debuggee process as it existed when the snapshot was taken. The lightweight process snapshot is less invasive because it does not require a full copy of the memory and allows the original process to run un-interrupted while specific collections and inspections are completed. | 05-07-2015 |
Patent application number | Description | Published |
20100274327 | SYSTEM AND METHOD FOR STIMULATING SENSORY NERVES - An electrotherapy system for stimulating sensory nerves within skin tissue includes a electrode carrier, a pulse generator, an array of skin-penetrating electrodes and surface skin electrodes, a pulse conditioning circuit, and a power source. The system administers biphasic pulsed current at the surface skin electrodes and monophasic pulsed current at each skin-penetrating electrode. The skin-penetrating surfaces and skin contact surfaces of the electrotherapy system may be sterilized or may be replaceable for outpatient reusability. | 10-28-2010 |
20110295339 | APPARATUS AND METHOD FOR STABILIZING, IMPROVING MOBILITY, AND CONTROLLING CARTILAGE MATRIX DEGRADATION OF WEIGHT-BEARING ARTICULAR JOINTS - An apparatus and method for improving mobility and/or the quality of synovial fluid of an affected articular joint are disclosed, wherein the joint is associated with at least a first muscle group and at least a second muscle group each having an antagonistic relationship for effecting mobility of the joint through a range of motion when recruited by natural neural impulses. The apparatus and method include an electro-medical device configured to apply motor-level electrical stimulation in a multiphasic pattern via at least a first channel and at least a second channel, the multiphasic pattern being programmed into the electro-medical device and corresponding to the sequence of an electromyographic output for the joint; at least two first electrodes connected to the at least first channel of said electro-medical device, the at least two first electrodes being positioned proximate to the at least first muscle group; at least two second electrodes connected to the at least second channel of said electro-medical device, the at least two second electrodes being positioned proximate to the at least second muscle group; and an applicator configured to be worn on the articular segment such that the at least two first electrodes and the at least two second electrodes are disposed between the applicator and the articular segment, the applicator being further configured to reduce compressive forces on at least one compartment of the affected joint. | 12-01-2011 |
20130165829 | APPARATUS AND METHOD FOR STABILIZING, IMPROVING MOBILITY, AND CONTROLLING CARTILAGE MATRIX DEGRADATION OF WEIGHT-BEARING ARTICULAR JOINTS - An apparatus and method for improving mobility and/or the quality of synovial fluid of an affected articular joint are disclosed, wherein the joint is associated with at least a first muscle group and at least a second muscle group each having an antagonistic relationship for effecting mobility of the joint through a range of motion when recruited by natural neural impulses. An electro-medical device is configured to apply motor-level electrical stimulation in a multiphasic pattern via at least a first channel and at least a second channel. An applicator is worn on the articular segment such that the at least two first electrodes and the at least two second electrodes are disposed between the applicator and the articular segment and reduces compressive forces on at least one compartment of the affected joint. | 06-27-2013 |
20150142077 | Spinal Cord Stimulation with Interferential Current - A stimulator and a method for the treatment of intractable pain syndromes by electrical stimulation of the spinal cord is disclosed in which implantable electrodes positioned around a targeted area of the spinal cord transmit an interferential current that has a base medium frequency alternating current between 500 Hz-20 KHz. A digital signal processor generates a sine-wave-like waveform from a pulse generator which after further processing is used to generate at least two circuits for use in producing the beat frequency signal. An effective area of stimulation is controlled by the quantity of electrodes, positioning of the electrodes and electrode cross pattern orientation. Amplitude modulation of electrical circuits created at the electrode placements also augments the effective area of stimulation. The stimulator and method reduce accommodation of the body to the electrical stimulation and provide deeper penetration of the resultant signal. | 05-21-2015 |