| Patent application number | Description | Published |
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| 20110311516 | Chemically Programmed Vaccination - Provided herein is a method for chemically programmed vaccination. Methods include inducing a covalent-binding polyclonal antibody response in a subject and programming the polyclonal response with a targeting compound. | 12-22-2011 |
| 20120020966 | Multispecific antibody targeting and multivalency through modular recognition domains - Antibodies containing one or more modular recognition domains (MRDs) that can be used to target the antibodies to specific sites are described. The use of antibodies containing one or more modular recognition domains to treat disease, and methods of making antibodies containing one or more modular recognition domains are also described. | 01-26-2012 |
| 20120020967 | VEGF antibodies comprising modular recognition domains - Antibodies containing one or more modular recognition domains (MRDs) that can be used to target the antibodies to specific sites are described. The use of antibodies containing one or more modular recognition domains to treat disease, and methods of making antibodies containing one or more modular recognition domains are also described. | 01-26-2012 |
| 20120034211 | EGFR antibodies comprising modular recognition domains - Antibodies containing one or more modular recognition domains (MRDs) that can be used to target the antibodies to specific sites are described. The use of antibodies containing one or more modular recognition domains to treat disease, and methods of making antibodies containing one or more modular recognition domains are also described. | 02-09-2012 |
| 20120058114 | ERBB2 antibodies comprising modular recognition domains - Antibodies containing one or more modular recognition domains (MRDs) that can be used to target the antibodies to specific sites are described. The use of antibodies containing one or more modular recognition domains to treat disease, and methods of making antibodies containing one or more modular recognition domains are also described. | 03-08-2012 |
| 20120329067 | Methods of Generating Zinc Finger Nucleases Having Altered Activity - Provided herein are zinc linger nucleases having altered, arid in particular, improved catalytic activity and methods of generating such nucleases. Accordingly, there are provided methods for identifying improved catalytic activity of a ZFN by expressing a mutated zinc finger nuclease in a cell containing a reporter construct with a toxic gene, and a zinc finger nuclease cleavage site that is recognized by the ZFN. Survival of the cell is positively correlated with catalytic activity of the ZFN; thus, libraries of mutated ZFKs may be selected for altered catalytic activity based on relative survival rates, Methods of using identified ZFNs are also provided. | 12-27-2012 |
| 20130195860 | Antibody targeting through a modular recognition domain - The present invention provides antibodies containing one or more modular recognition domains (MRDs) for targeting the antibodies to specific sites. The use of the antibodies containing one or more modular recognition domains to treat disease, and methods of making antibodies containing one or more modular recognition domains are also provided in the invention. | 08-01-2013 |
| 20140093518 | Chemically Programmed Vaccination - Provided herein is a method for chemically programmed vaccination. Methods include inducing a covalent-binding polyclonal antibody response in a subject and programming the polyclonal response with a targeting compound. | 04-03-2014 |
| 20140127200 | Multispecific Antibody Targeting and Multivalency Through Modular Recognition Domains - Antibodies containing one or more modular recognition domains (MRDs) that can be used to target the antibodies to specific sites are described. The use of antibodies containing one or more modular recognition domains to treat disease, and methods of making antibodies containing one or more modular recognition domains are also described. | 05-08-2014 |
| 20140378668 | Tyrosine Bioconjugation through Aqueous Ene-Like Reactions - A new and versatile class of cyclic diazodicarboxamides that reacts efficiently and selectively with phenols and the phenolic side chain of tyrosine through an Ene-like reaction is reported. This mild aqueous tyrosine ligation reaction works over a broad pH range and expands the repertoire of aqueous chemistries available for small molecule, peptide, and protein modification. The tyrosine ligation reactions are shown to be compatible with the labeling of native enzymes and antibodies in buffered aqueous solution. This reaction provides a novel synthetic approach to bispecific antibodies. This reaction will find broad utility in peptide and protein chemistry and in the chemistry of phenol-containing compounds. | 12-25-2014 |
| 20150284728 | CHIMERIC POLYPEPTIDES HAVING TARGETED BINDING SPECIFICITY - Disclosed herein are chimeric polypeptides, including compositions thereof, expression vectors, and methods of use thereof, for the generation of transgenic cells, tissues, plants, and animals. The compositions, vectors, and methods of the present invention are also useful in gene therapy techniques. The invention provides a chimeric polypeptide. The polypeptide includes: a) a recombinase, nuclease or transcription factor, or fragment thereof; and b) a transcription activator-like effector (TALE) protein. | 10-08-2015 |
| Patent application number | Description | Published |
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| 20090007300 | SYNTHETIC ZINC FINGER PROTEIN ENCODING SEQUENCES AND METHODS OF PRODUCING THE SAME - The invention relates to the field of plant and agricultural technology. More specifically, the invention relates to the use of zinc finger proteins and fusions of said proteins to regulate gene expression and metabolic pathways in plants. | 01-01-2009 |
| 20090029468 | ZINC FINGER BINDING DOMAINS FOR CNN - Polypeptides that contain zinc finger-nucleotide binding regions that bind to nucleotide sequences of the formula CNN are provided. Compositions containing a plurality of polypeptides, polynucleotides that encode such polypeptides and methods of regulating gene expression with such polypeptides, compositions and polynucleotide's are also provided. | 01-29-2009 |
| 20100015595 | Phage Particle Diagnostic Reagents - The present invention relates to novel methods for detecting a member of a known binding pair in a sample, including a cell, where one member of the pair (termed the “receptor”) is expressed by a bacteriophage, which phage is then used to detect the presence of the other member of the pair (termed the “ligand” or “target”). Rather than detecting the binding of the phage using antibody-based technology, the present invention relates to detecting marker molecule associated with the phage. In one aspect, the invention relates to identifying an antigen-bearing moiety (e.g., a red blood cell antigen) of interest present on a cell, e.g., a red blood cell, using antibody-displaying bacteriophage, as well as detecting anti-red blood cell auto- or alloantibodies and/or complement in a sample, using antiglobulin reagent-displaying bacteriophage and detecting a marker molecule associated with the phage. In one aspect, the phenotype of the phage is not linked with the genotype of the phage. | 01-21-2010 |
| 20100056457 | Zinc Finger Binding Domains for CNN - Polypeptides that contain zinc finger-nucleotide binding regions that bind to nucleotide sequences of the formula CNN are provided. Compositions containing a plurality of polypeptides, polynucleotides that encode such polypeptides and methods of regulating gene expression with such polypeptides, compositions and polynucleotides are also provided. | 03-04-2010 |
| 20100086532 | CHIMERIC ZINC FINGER RECOMBINASES OPTIMIZED FOR CATALYSIS BY DIRECTED EVOLUTION - The present invention is directed to chimeric recombinases comprising a serine recombinase operatively linked to a zinc finger nucleotide binding domain such that the chimeric recombinase protein catalyzes site-specific recombination at a DNA site specifically bound by the zinc finger nucleotide binding domain. The serine recombinase can be one of several naturally occurring serine recombinases. The invention also includes nucleic acids encoding the chimeric recombinases, vectors including the nucleic acids, host cells transformed or transfected with the vectors, methods of using the chimeric recombinases to carry out recombination, methods of using substrate-linked protein evolution to generate additional chimeric recombinases, methods of using the chimeric recombinases for gene therapy, and pharmaceutical compositions. | 04-08-2010 |
| 20110189206 | Antibody Targeting Through a Modular Recognition Domain - Antibodies containing one or more modular recognition domains (MRDs) used to target the antibodies to specific sites are described. The use of the antibodies containing one or more modular recognition domains to treat disease, and methods of making antibodies containing one or more modular recognition domains are also described. | 08-04-2011 |
| 20120289682 | Tyrosine Bioconjugation through Aqueous Ene-Like Reactions - A new and versatile class of cyclic diazodicarboxamides that reacts efficiently and selectively with phenols and the phenolic side chain of tyrosine through an Ene-like reaction is reported. This mild aqueous tyrosine ligation reaction works over a broad pH range and expands the repertoire of aqueous chemistries available for small molecule, peptide, and protein modification. The tyrosine ligation reactions are shown to be compatible with the labeling of native enzymes and antibodies in buffered aqueous solution. This reaction provides a novel synthetic approach to bispecific antibodies. This reaction will find broad utility in peptide and protein chemistry and in the chemistry of phenol-containing compounds. | 11-15-2012 |
| Patent application number | Description | Published |
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| 20080222232 | Method and Apparatus for Widget and Widget-Container Platform Adaptation and Distribution - A method includes receiving a request for a widget-container defined in response to a reference to the widget-container being accessed from a content aggregation point. The widget-container is a procedural software framework configured to be executed within the content aggregation point. The widget-container has a portion configured for receiving a widget. The method includes modifying a portion of the widget-container. The portion of the widget-container is based on a first configuration before the modifying and based on a second configuration substantially compliant with a content rule associated with the content aggregation point after the modifying. | 09-11-2008 |
| 20080222613 | METHOD AND APPARATUS FOR DATA PROCESSING - A method and system can include multiple data handling stages for manipulating tracked information associated with content distributed to users and/or computers, such as static objects, media objects, and/or software objects, for example. The content can be distributed as widget instances and the associated tracked information can be received over a network. The information received can be associated with a session corresponding to each widget instance and/or with multiple identifiers, such as widget, user, content, session, content aggregation point, processor, and/or placement identifiers, for example. Data handling processes, including sorting, storing, filtering, combining, queuing, and/or authenticating, for example, can be performed during the data handling stages. The processed information can be used to determine modifications to a behavior associated with widgets and/or widget containers. | 09-11-2008 |
| 20080222658 | METHOD AND APPARATUS FOR WIDGET AND WIDGET-CONTAINER DISTRIBUTION CONTROL BASED ON CONTENT RULES - A method includes receiving an instruction used to define a widget-container containing a service module associated with a widget. The widget-container is a procedural software framework configured to be executed at a widget-container processing device in response to a reference to the widget-container being accessed from a content aggregation point. The widget-container has a portion configured for receiving the widget. The method also includes determining whether processing of the widget within the portion of the widget-container is restricted and/or allowed. | 09-11-2008 |
| 20090094339 | METHODS AND APPARATUS FOR WIDGET SHARING BETWEEN CONTENT AGGREGATION POINTS - In one embodiment, a method includes receiving a request from a processing device to send a widget to a handheld mobile device. The request can be defined after at least a portion of an instance of the widget has been processed at the processing device. The request can be associated with a widget identifier. The method can also include defining a widget precursor at a widget-sharing server in response to the request from the processing device. The widget precursor can be associated with the widget identifier and a placement identifier. | 04-09-2009 |
| 20120227060 | METHOD AND APPARATUS FOR WIDGET-CONTAINER HOSTING AND GENERATION - A method includes receiving at least one of a widget or a reference to a widget, where the widget can be at least one of a static data object, a media object, or a software object. At least a portion of a widget container, which is a procedural software framework containing a service module associated with the widget and the widget, is generated. The service module can be a pre-defined function associated with the widget container before the widget container is generated. The widget container can be configured to be executed at a widget-container processing device in response to a reference to the widget container being accessed from a processor-readable vehicle. | 09-06-2012 |
