Patent application number | Description | Published |
20100129824 | DISTINGUISHING PCA3 MESSENGER RNA SPECIES IN BENIGN AND MALIGNANT PROSTATE TISSUES - This invention concerns the discovery of two distinct PCA3 mRNA sequences. One of these sequences corresponds to a short PCA3 mRNA molecule whereas the other PCA3 RNA molecule is longer as it comprises an additional sequence between exon 3 and exon 4a. The short RNA is associated with prostate cancer whereas the long RNA sequence is associated with a non-malignant state of the prostate. Based on the differential expression levels of these two PCA3 RNA sequences, protocols for the diagnosis of prostate disease are provided. The invention also relates to therapeutic approaches to prostate cancer. | 05-27-2010 |
20110212449 | DISTINGUISHING PCA3 MESSENGER RNA SPECIES IN BENIGN AND MALIGNANT PROSTATE TISSUES - This invention concerns the discovery of two distinct PCA3 mRNA sequences. One of these sequences corresponds to a short PCA3 mRNA molecule whereas the other PCA3 RNA molecule is longer as it comprises an additional sequence between exon 3 and exon 4a. The short RNA is associated with prostate cancer whereas the long RNA sequence is associated with a non-malignant state of the prostate. Based on the differential expression levels of these two PCA3 RNA sequences, protocols for the diagnosis of prostate disease are provided. The invention also relates to therapeutic approaches to prostate cancer. | 09-01-2011 |
20120309001 | METHOD TO DETECT PROSTATE CANCER IN A SAMPLE - The present invention provides methods to detect prostate cancer by detecting the RNA encoded by PCA3. The disclosure provides a method for determining a predisposition, or presence of prostate cancer comprising: (a) contacting a sample with at least one oligonucleotide that hybridizes to a PCA3 polynucleotide; (b) detecting an amount of PCA3 and second prostate-specific polynucleotides; and (c) comparing the amount of PCA3 polynucleotide that hybridizes to the oligonucleotide to a predetermined cut off value, and determining the presence or absence of prostate cancer. Diagnostic kits are provided for detecting prostate cancer or the risk of developing same comprising: (a) at least one container means containing at least one oligonucleotide probe or primer that hybridizes to PCA3 (b) at least one oligonucleotide probe or primer that hybridizes with a second prostate specific nucleic acid; and (c) reagents for detecting PCA3 and the second prostate specific nucleic acid. | 12-06-2012 |
20120315634 | DISTINGUISHING PCA3 MESSENGER RNA SPECIES IN BENIGN AND MALIGNANT PROSTATE TISSUES - This invention concerns the discovery of two distinct PCA3 mRNA sequences. One of these sequences corresponds to a short PCA3 mRNA molecule whereas the other PCA3 RNA molecule is longer as it comprises an additional sequence between exon 3 and exon 4a. The short RNA is associated with prostate cancer whereas the long RNA sequence is associated with a non-malignant state of the prostate. Based on the differential expression levels of these two PCA3 RNA sequences, protocols for the diagnosis of prostate disease are provided. The invention also relates to therapeutic approaches to prostate cancer. | 12-13-2012 |
20130344487 | METHOD TO DETECT PROSTATE CANCER IN A SAMPLE - The present invention provides methods to detect prostate cancer by detecting the RNA encoded by PCA3. The disclosure provides a method for determining a predisposition, or presence of prostate cancer comprising: (a) contacting a sample with at least one oligonucleotide that hybridizes to a PCA3 polynucleotide; (b) detecting an amount of PCA3 and second prostate-specific polynucleotides; and (c) comparing the amount of PCA3 polynucleotide that hybridizes to the oligonucleotide to a predetermined cut off value, and determining the presence or absence of prostate cancer. Diagnostic kits are provided for detecting prostate cancer or the risk of developing same comprising: (a) at least one container means containing at least one oligonucleotide probe or primer that hybridizes to PCA3 (b) at least one oligonucleotide probe or primer that hybridizes with a second prostate specific nucleic acid; and (c) reagents for detecting PCA3 and the second prostate specific nucleic acid. | 12-26-2013 |
20140087384 | DISTINGUISHING PCA3 MESSENGER RNA SPECIES IN BENIGN AND MALIGNANT PROSTATE TISSUES - This invention concerns the discovery of two distinct PCA3 mRNA sequences. One of these sequences corresponds to a short PCA3 mRNA molecule whereas the other PCA3 RNA molecule is longer as it comprises an additional sequence between exon 3 and exon 4a. The short RNA is associated with prostate cancer whereas the long RNA sequence is associated with a non-malignant state of the prostate. Based on the differential expression levels of these two PCA3 RNA sequences, protocols for the diagnosis of prostate disease are provided. The invention also relates to therapeutic approaches to prostate cancer. | 03-27-2014 |
Patent application number | Description | Published |
20080250685 | Illuminated Sign with Single-Point LED Light Source - An illuminated sign includes a light source with a light emitting diode, and a sign panel. The sign panel is at least partially transparent, and the light source is at least partially embedded in the sign panel, thereby illuminating the sign panel. The sign may be mounted to a wall, ceiling, or any other mounting surface, and used as an emergency exit sign. The sign may be single- or double-sided with two panels separated by reflective material. The sign may include a positionable joint coupled to the sign panel, which selectively orients the sign panel with respect to a mounting surface, and a high-intensity light emitting diode adapted to provide floodlighting. A method of illuminating a sign includes providing a light source including a light emitting diode, and embedding the light source at least partially in a sign panel. The sign panel is at least partially transparent, thereby illuminating the sign panel. | 10-16-2008 |
20160141915 | EMERGENCY LIGHTING BATTERY CHARGER - An emergency lighting power supply includes a rechargeable battery; ballast circuitry configured to supply power to an external light, battery charging circuitry configured to charge the battery, and a controller. The controller determines an amount of time the rechargeable battery has discharged to supply power, via the ballast circuitry, to the external light. If the amount of time is less than a threshold, the controller causes the battery charging circuitry to supply a first current to charge the battery for a first charging period that is proportional to the amount of time, and causes the battery charging circuitry to supply a second current to charge the battery subsequent to the end of the first charging period. | 05-19-2016 |
Patent application number | Description | Published |
20110245428 | Polystyrene Blends - A method of preparing a polystyrene blend that includes combining a first polystyrene composition having a first melt flow index with a second polystyrene composition having a second melt flow index and forming a polystyrene blend, the second melt flow index being at least 2 dg/min higher that the first melt flow index. The polystyrene blend has an observed tensile strength value greater than 3% above the expected tensile strength value. The second polystyrene composition can include a recycled polystyrene material, which can include expanded polystyrene. An alternate method of preparing the polystyrene blend includes combining a polystyrene composition with a styrene monomer to form a reaction mixture, polymerizing the reaction mixture and obtaining a polystyrene blend, where the polystyrene containing composition has a melt flow index at least 2 dg/min higher than the melt flow index of the styrene monomer after it has been polymerized. | 10-06-2011 |
20120259071 | Polystyrene Blends - A method of preparing a polystyrene blend that includes combining a first polystyrene composition having a first melt flow index with a second polystyrene composition having a second melt flow index and forming a polystyrene blend, the second melt flow index being at least 2 dg/min higher that the first melt flow index. The polystyrene blend has an observed tensile strength value greater than 3% above the expected tensile strength value. The second polystyrene composition can include a recycled polystyrene material, which can include expanded polystyrene. An alternate method of preparing the polystyrene blend includes combining a polystyrene composition with a styrene monomer to form a reaction mixture, polymerizing the reaction mixture and obtaining a polystyrene blend, where the polystyrene containing composition has a melt flow index at least 2 dg/min higher than the melt flow index of the styrene monomer after it has been polymerized. | 10-11-2012 |
20130210948 | Polystyrene Blends - A method of preparing a polystyrene blend that includes combining a first polystyrene composition having a first melt flow index with a second polystyrene composition having a second melt flow index and forming a polystyrene blend, the second melt flow index being at least 2 dg/min higher that the first melt flow index. The polystyrene blend has an observed tensile strength value greater than 3% above the expected tensile strength value. The second polystyrene composition can include a recycled polystyrene material, which can include expanded polystyrene. An alternate method of preparing the polystyrene blend includes combining a polystyrene composition with a styrene monomer to form a reaction mixture, polymerizing the reaction mixture and obtaining a polystyrene blend, where the polystyrene containing composition has a melt flow index at least 2 dg/min higher than the melt flow index of the styrene monomer after it has been polymerized. | 08-15-2013 |
Patent application number | Description | Published |
20090313369 | Network-Assisted Remote Media Listening - Improved approaches for media listening amongst different users are disclosed. For example, methods, systems or computer program code can enable users to have a remote listening experience in real time. Advantageously, a remote user at a remote client device can in effect listen to a particular digital media asset that is being played at a local client device of a local user. Media information and/or user profiles can also be provided about themselves and shared with other users. | 12-17-2009 |
20100107090 | REMOTE LINKING TO MEDIA ASSET GROUPS - Improved approaches to access information concerning media asset groups are disclosed. In one embodiment, a first web page can include a user-selectable control that, upon selection, can request information on a particular media asset group from a remote media asset web server. In response to the request, the remote media asset web server can return a second web page containing the information on the particular media asset group. | 04-29-2010 |
20110093532 | NETWORK-ASSISTED REMOTE MEDIA LISTENING - Improved approaches for media listening amongst different users are disclosed. For example, methods, systems or computer program code can enable users to have a remote listening experience in real time. Advantageously, a remote user at a remote client device can in effect listen to a particular digital media asset that is being played at a local client device of a local user. Media information and/or user profiles can also be provided about themselves and shared with other users. | 04-21-2011 |
20140297729 | NETWORK-ASSISTED REMOTE MEDIA LISTENING - Improved approaches for media listening amongst different users are disclosed. For example, methods, systems or computer program code can enable users to have a remote listening experience in real time. Advantageously, a remote user at a remote client device can in effect listen to a particular digital media asset that is being played at a local client device of a local user. Media information and/or user profiles can also be provided about themselves and shared with other users. | 10-02-2014 |
Patent application number | Description | Published |
20130306321 | LIQUEFIED INDUSTRIAL GAS BASED SOLUTION IN HYDRAULIC FRACTURING - The present invention is a cryogenic subterranean fracturing fluid, comprising a liquefied industrial gas and a first additive. The liquefied industrial gas may be liquefied carbon dioxide, liquefied nitrogen, or a blend of the two. The liquefied industrial gas mixture should be substantially free of water. In this context, substantially free of water means less than 10% water by volume, or preferably less than 5% water by volume. In addition to the first additive, a proppant may be added to the fracturing fluid. In addition to the biocide and/or proppant additional additives may be added to the liquefied industrial gas as required. Non-limiting examples of such additives include ozone, a friction reducer, an acid, a gelling agent, a breaker, a scale inhibitor, a clay stabilizer, a corrosion inhibitor, an iron controller, an oxygen scavenger, a surfactant, a cross-linker, a non-emulsifier, a Ph Adjusting agent, or any combination thereof. | 11-21-2013 |
20140057813 | HYDRAULIC FRACTURING WITH IMPROVED VISCOSITY LIQUEFIED INDUSTRIAL GAS BASED SOLUTION - The present invention is a cryogenic subterranean fracturing fluid, comprising a liquefied industrial gas and a viscosity increasing additive. The liquefied industrial gas may be liquefied carbon dioxide, liquefied nitrogen, or a blend of the two. The liquefied industrial gas mixture should be substantially free of water. In this context, substantially free of water means less than 10% water by volume, or preferably less than 5% water by volume. In addition to the viscosity increasing additive, a proppant may be added to the fracturing fluid. In addition to the viscosity increasing additive and/or proppant additional additives may be added to the liquefied industrial gas as required. | 02-27-2014 |
Patent application number | Description | Published |
20150348379 | Synchronization of Independent Output Streams - A system determines to use at least two independent renderers to render at least two output streams that are to be synchronized. The independent renderers are provided with a shared synchronization object when instructed to render the respective output stream. A time when all of the independent renderers can render a respective first buffer of the respective output stream is determined from the shared synchronization object. Rendering of the output streams utilizing the independent renderers is begun at the determined time. In this way, rendering of the output streams may be synchronized. | 12-03-2015 |
20160063826 | Haptic Notifications - Embodiments of the present disclosure are directed to a haptic actuator or a device having a haptic actuator that is capable of producing short, sharp and crisp pulses in a short amount of time. | 03-03-2016 |
20160063848 | Providing Priming Cues to a User of an Electronic Device - An electronic device can output a priming cue prior to outputting an alert on the electronic device. A priming cue can be a haptic priming cue, a visual priming cue, an audio priming cue, or various combinations of these priming cues. The priming cue can be perceived by a user either consciously or subconsciously and can increase a user's perceptual state for the alert. | 03-03-2016 |
20160063850 | Context-Based Alerts for an Electronic Device - Embodiments of the present disclosure provide a system and method for providing an output for an electronic device. In certain embodiments, an alert is output in accordance with a current alert mode, which are selected based on one or more environmental conditions. The environmental conditions may be detected using one or more environmental sensors. The alert can optionally include one or more of: an audio component, a haptic component and a visual component. One or more of alert components correspond to an aspect of the environmental condition detected by the one or more environmental sensors. | 03-03-2016 |
20160098016 | ROTARY INPUT MECHANISM FOR AN ELECTRONIC DEVICE - One embodiment of the present disclosure is directed to a wearable electronic device. The wearable electronic device includes an enclosure having a sidewall with a button aperture defined therethrough, a display connected to the enclosure, a processing element in communication with the display. The device also includes a sensing element in communication with the processing element and an input button at least partially received within the button aperture and in communication with the sensing element, the input button configured to receive two types of user inputs. During operation, the sensing element tracks movement of the input button to determine the two types of user inputs. | 04-07-2016 |
Patent application number | Description | Published |
20160062464 | Semantic Framework for Variable Haptic Output - Methods and apparatus organize a plurality of haptic output variations into a cohesive semantic framework that uses various information about the alert condition and trigger, application context, and other conditions to provide a system of haptic outputs that share characteristics between related events. In some embodiments, an event class or application class provides the basis for a corresponding haptic output. In some embodiments, whether an alert-salience setting is on provides the basis for adding an increased salience haptic output to the standard haptic output for the alert. In some embodiments, consistent haptics provide for branding of the associated application class, application, and/or context. | 03-03-2016 |
20160062465 | Semantic Framework for Variable Haptic Output - Methods and apparatus organize a plurality of haptic output variations into a cohesive semantic framework that uses various information about the alert condition and trigger, application context, and other conditions to provide a system of haptic outputs that share characteristics between related events. In some embodiments, an event class or application class provides the basis for a corresponding haptic output. In some embodiments, whether an alert-salience setting is on provides the basis for adding an increased salience haptic output to the standard haptic output for the alert. In some embodiments, consistent haptics provide for branding of the associated application class, application, and/or context. | 03-03-2016 |
20160062466 | Semantic Framework for Variable Haptic Output - Methods and apparatus organize a plurality of haptic output variations into a cohesive semantic framework that uses various information about the alert condition and trigger, application context, and other conditions to provide a system of haptic outputs that share characteristics between related events. In some embodiments, an event class or application class provides the basis for a corresponding haptic output. In some embodiments, whether an alert-salience setting is on provides the basis for adding an increased salience haptic output to the standard haptic output for the alert. In some embodiments, consistent haptics provide for branding of the associated application class, application, and/or context. | 03-03-2016 |
20160063825 | Semantic Framework for Variable Haptic Output - Methods and apparatus organize a plurality of haptic output variations into a cohesive semantic framework that uses various information about the alert condition and trigger, application context, and other conditions to provide a system of haptic outputs that share characteristics between related events. In some embodiments, an event class or application class provides the basis for a corresponding haptic output. In some embodiments, whether an alert-salience setting is on provides the basis for adding an increased salience haptic output to the standard haptic output for the alert. In some embodiments, consistent haptics provide for branding of the associated application class, application, and/or context. | 03-03-2016 |
20160063827 | Semantic Framework for Variable Haptic Output - Methods and apparatus organize a plurality of haptic output variations into a cohesive semantic framework that uses various information about the alert condition and trigger, application context, and other conditions to provide a system of haptic outputs that share characteristics between related events. In some embodiments, an event class or application class provides the basis for a corresponding haptic output. In some embodiments, whether an alert-salience setting is on provides the basis for adding an increased salience haptic output to the standard haptic output for the alert. In some embodiments, consistent haptics provide for branding of the associated application class, application, and/or context. | 03-03-2016 |
20160063828 | Semantic Framework for Variable Haptic Output - Methods and apparatus organize a plurality of haptic output variations into a cohesive semantic framework that uses various information about the alert condition and trigger, application context, and other conditions to provide a system of haptic outputs that share characteristics between related events. In some embodiments, an event class or application class provides the basis for a corresponding haptic output. In some embodiments, whether an alert-salience setting is on provides the basis for adding an increased salience haptic output to the standard haptic output for the alert. In some embodiments, consistent haptics provide for branding of the associated application class, application, and/or context. | 03-03-2016 |