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| 20100333240 | Fully Digitally Controller for Cantilever-Based Instruments - A controller for cantilever-based instruments, including atomic force microscopes, molecular force probe instruments, high-resolution profilometers and chemical or biological sensing probes. The controller samples the output of the photo-detector commonly used to detect cantilever deflection in these instruments with a very fast analog/digital converter (ADC). The resulting digitized representation of the output signal is then processed with field programmable gate arrays and digital signal processors without making use of analog electronics. Analog signal processing is inherently noisy while digital calculations are inherently “perfect” in that they do not add any random noise to the measured signal. Processing by field programmable gate arrays and digital signal processors maximizes the flexibility of the controller because it can be varied through programming means, without modification of the controller hardware. | 12-30-2010 |
| 20120266336 | Fully Digitally Controller for Cantilever-Based Instruments - A controller for cantilever-based instruments, including atomic force microscopes, molecular force probe instruments, high-resolution profilometers and chemical or biological sensing probes. The controller samples the output of the photo-detector commonly used to detect cantilever deflection in these instruments with a very fast analog/digital converter (ADC). The resulting digitized representation of the output signal is then processed with field programmable gate arrays and digital signal processors without making use of analog electronics. Analog signal processing is inherently noisy while digital calculations are inherently “perfect” in that they do not add any random noise to the measured signal. Processing by field programmable gate arrays and digital signal processors maximizes the flexibility of the controller because it can be varied through programming means, without modification of the controller hardware. | 10-18-2012 |
| 20150113687 | Fully Digitally Controller for Cantilever-Based Instruments - A controller for cantilever-based instruments, including atomic force microscopes, molecular force probe instruments, high-resolution profilometers and chemical or biological sensing probes. The controller samples the output of the photo-detector commonly used to detect cantilever deflection in these instruments with a very fast analog/digital converter (ADC). The resulting digitized representation of the output signal is then processed with field programmable gate arrays and digital signal processors without making use of analog electronics. Analog signal processing is inherently noisy while digital calculations are inherently “perfect” in that they do not add any random noise to the measured signal. Processing by field programmable gate arrays and digital signal processors maximizes the flexibility of the controller because it can be varied through programming means, without modification of the controller hardware. | 04-23-2015 |
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| 20090285469 | VISUAL-SERVOING OPTICAL MICROSCOPY - The present invention provides methods and devices for the knowledge-based discovery and optimization of differences between cell types. In particular, the present invention provides visual servoing optical microscopy, as well as analysis methods. The present invention provides means for the close monitoring of hundreds of individual, living cells over time; quantification of dynamic physiological responses in multiple channels; real-time digital image segmentation and analysis; intelligent, repetitive computer-applied cell stress and cell stimulation; and the ability to return to the same field of cells for long-term studies and observation. The present invention further provides means to optimize culture conditions for specific subpopulations of cells. | 11-19-2009 |
| 20110216953 | VISUAL-SERVOING OPTICAL MICROSCOPY - The present invention provides methods and devices for the knowledge-based discovery and optimization of differences between cell types. In particular, the present invention provides visual servoing optical microscopy, as well as analysis methods. The present invention provides means for the close monitoring of hundreds of individual, living cells over time; quantification of dynamic physiological responses in multiple channels; real-time digital image segmentation and analysis; intelligent, repetitive computer-applied cell stress and cell stimulation; and the ability to return to the same field of cells for long-term studies and observation. The present invention further provides means to optimize culture conditions for specific subpopulations of cells. | 09-08-2011 |
| 20140072955 | VISUAL-SERVOING OPTICAL MICROSCOPY - The present invention provides methods and devices for the knowledge-based discovery and optimization of differences between cell types. In particular, the present invention provides visual servoing optical microscopy, as well as analysis methods. The present invention provides means for the close monitoring of hundreds of individual, living cells over time; quantification of dynamic physiological responses in multiple channels; real-time digital image segmentation and analysis; intelligent, repetitive computer-applied cell stress and cell stimulation; and the ability to return to the same field of cells for long-term studies and observation. The present invention further provides means to optimize culture conditions for specific subpopulations of cells. | 03-13-2014 |
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| 20080235353 | System and method for confirming an association in a web-based social network - A method for confirming a request for an association with an organization by a user of a web-based social network is disclosed. In one embodiment, the request includes an e-mail address not controlled by the organization. The request may also be part of an application for membership with the web-based social network. A determination is made whether the request is accepted based at least partially on a specified number of prior requests for association with the organization or being identified as a member of the organization by another user already a member of the organization. The organization may be a high school, a college, a university, a business, a non-profit company, or any other group of people who may desire to associate with each other. | 09-25-2008 |
| 20110035789 | Determining a Trust Level of a User in a Social Network Environment - A system and method for determining a trust level for a non-approved user in a social network is described. The method includes monitoring requests for social network interactions between an approved user and the non-approved user and determining if each interaction requested is of a first type or a second type. The method further includes increasing a first trust value when the interaction requested is of the first type and increasing a second trust value when the interaction requested is of the second type. The method further includes determining the trust level based on the first trust value and the second trust value. The method further includes changing the status of the non-approved user to an approved user based on the trust level, the first trust value and/or the second trust value. | 02-10-2011 |
| 20140137201 | DETERMINING A TRUST LEVEL OF A USER IN A SOCIAL NETWORK ENVIRONMENT - A system and method for determining a trust level for a non-approved user in a social network is described. The method includes monitoring requests for social network interactions between an approved user and the non-approved user and determining if each interaction requested is of a first type or a second type. The method further includes increasing a first trust value when the interaction requested is of the first type and increasing a second trust value when the interaction requested is of the second type. The method further includes determining the trust level based on the first trust value and the second trust value. The method further includes changing the status of the non-approved user to an approved user based on the trust level, the first trust value and/or the second trust value. | 05-15-2014 |
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| 20080238026 | AERODYNAMIC BICYCLE FRAME - A bicycle that includes a main frame, a front wheel mounted for rotation relative to the main frame, a rear dropout, and a rear wheel mounted for rotation relative to the rear dropout. The rear wheel defines a center plane of the bicycle. The bicycle further includes a rear stay that couples the rear dropout to the main frame. The rear stay has an inner surface facing the rear wheel and an outer surface facing away from the rear wheel. The rear stay includes a steep portion having an outer surface at a steep angle of between about 25 degrees and about 75 degrees relative to the center plane. | 10-02-2008 |
| 20090140508 | BICYCLE FORK ASSEMBLY - A fork assembly for a bicycle including a frame having a head tube. The fork assembly includes a fork having a fork crown, a steerer tube, and a transition that couples the fork crown to the steerer tube. The transition is adapted to be positioned within the head tube, and defines a transition point between the transition and the steerer tube. The transition has an outer dimension that increases from the steerer tube toward the fork crown. The fork assembly also includes a bearing located adjacent the transition point and configured to rotatably support the fork within the head tube. | 06-04-2009 |
| 20120200060 | BICYCLE FRAME - A bicycle frame that supports a front wheel and a rear wheel defining a central plane. The bicycle frame includes a head tube, a bottom bracket configured to support a crank assembly, and a bicycle frame portion. The bicycle frame portion includes a leading edge and a trailing edge oriented such that a chord line between the leading edge and the trailing edge defines an angle of incidence greater than zero degrees relative to the central plane. | 08-09-2012 |
| 20120261896 | MODULAR TRAILING EDGE FOR BICYCLE STEM - A bicycle including a front wheel, a rear wheel, and a frame supported on the front and rear wheels, the frame having a frame member. The bicycle further includes a first fairing member protruding outward from the frame member and having a side surface defining an aerodynamic trailing edge and a second fairing member detachably mounted on the first fairing member such that the side surface is exposed. | 10-18-2012 |
| 20120261897 | BICYCLE WITH INTERNAL STORAGE SYSTEM - A bicycle including a front wheel, a rear wheel, and a frame supported on the front and rear wheels. The frame includes a hollow frame member having a wall with an opening, and a flexible bladder positioned in the hollow frame member. A stiffening member is positioned along at least a portion of the bladder to facilitate insertion of the bladder through the opening and into the frame member. The bicycle further includes a collar coupled to the open end of the bladder with at least a portion of the collar being positioned on an outer surface of the frame member. The bladder includes a first portion adjacent the open end and generally aligned with a first axis and a second portion distal to the open end and generally aligned with a second axis that is non-parallel to the first axis. | 10-18-2012 |
| 20130147152 | BICYCLE ASSEMBLY WITH BOTTOM BRACKET SHELL - A bicycle assembly can include a main frame having a bottom bracket shell to receive a bottom bracket. The bottom bracket shell can be made of carbon fiber with one or more metal rings to serve as bearing surfaces within the bottom bracket shell. The metal rings may also be split metal rings with a gap between two spaced apart ends. | 06-13-2013 |
| 20130313804 | AERODYNAMIC BICYCLE FRAME - A bicycle including a main frame, a front wheel mounted for rotation relative to the main frame. a rear dropout, and a rear wheel mounted for rotation relative to the rear dropout about an axis. The rear wheel defines a center plane of the bicycle and is driven by a chain. The bicycle also includes a seat stay coupling the rear dropout to the main frame. The seat stay has an inner surface facing the rear wheel and an outer surface facing away from the rear wheel. The seat stay includes a steep portion having an outer surface disposed at a steep angle of between about 25 degrees and about 75 degrees relative to the center plane, and at least a portion of the steep portion is disposed outboard of the chain. | 11-28-2013 |
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| 20090027080 | Low leakage and data retention circuitry - An integrated circuit includes first circuitry and sleep transistor circuitry. The first circuitry receives input signals and processes the input signals. The first circuitry also retains data in a sleep state that has low leakage. The sleep transistor circuitry is coupled to the first circuitry and receives a sleep signal that has a negative voltage. The sleep circuitry reduces power consumption of the first circuitry in the sleep state to have low leakage based on the sleep signal while retaining the data in the first circuitry. | 01-29-2009 |
| 20100060319 | LOW LEAKAGE AND DATA RETENTION CIRCUITRY - An integrated circuit includes first circuitry and sleep transistor circuitry. The first circuitry receives input signals and processes the input signals. The first circuitry also retains data in a sleep state that has low leakage. The sleep transistor circuitry is coupled to the first circuitry and receives a sleep signal that has a negative voltage. The sleep circuitry reduces power consumption of the first circuitry in the sleep state to have low leakage based on the sleep signal while retaining the data in the first circuitry. | 03-11-2010 |
| 20110260785 | Low Leakage and Data Retention Circuitry - An integrated circuit includes first circuitry and sleep transistor circuitry. The first circuitry receives input signals and processes the input signals. The first circuitry also retains data in a sleep state that has low leakage. The sleep transistor circuitry is coupled to the first circuitry and receives a sleep signal that has a negative voltage. The sleep circuitry reduces power consumption of the first circuitry in the sleep state to have low leakage based on the sleep signal while retaining the data in the first circuitry. | 10-27-2011 |
| 20130027125 | LOW LEAKAGE AND DATA RETENTION CIRCUITRY - An integrated circuit includes first circuitry and sleep transistor circuitry. The first circuitry receives input signals and processes the input signals. The first circuitry also retains data in a sleep state that has low leakage. The sleep transistor circuitry is coupled to the first circuitry and receives a sleep signal that has a negative voltage. The sleep circuitry reduces power consumption of the first circuitry in the sleep state to have low leakage based on the sleep signal while retaining the data in the first circuitry. | 01-31-2013 |
| 20140375354 | Low Leakage and Data Retention Circuitry - An integrated circuit includes first circuitry and sleep transistor circuitry. The first circuitry receives input signals and processes the input signals. The first circuitry also retains data in a sleep state that has low leakage. The sleep transistor circuitry is coupled to the first circuitry and receives a sleep signal that has a negative voltage. The sleep circuitry reduces power consumption of the first circuitry in the sleep state to have low leakage based on the sleep signal while retaining the data in the first circuitry. | 12-25-2014 |
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| 20090042296 | TRANSFECTION READY EUKARYOTIC CELLS - Described herein are frozen populations of transfection ready competent eukaryotic cells, transfection kits comprising the frozen populations of transfection ready competent cells, and methods of using the same. | 02-12-2009 |
| 20110045524 | TRANSFECTION READY EUKARYOTIC CELLS - Described herein are frozen populations of transfection ready competent eukaryotic cells, transfection kits comprising the frozen populations of transfection ready competent cells, and methods of using the same. | 02-24-2011 |
| 20140243232 | NUCLEIC ACID COMPLEXITY REDUCTION - In some embodiments, the present teachings provide compositions, systems, methods and kits for reducing the complexity of nucleotide sequences in a nucleic acid sample comprising the steps: hybridizing a plurality of polynucleotide constructs to at least one blocker oligonucleotide and to at least one capture oligonucleotide, wherein the plurality of polynucleotide constructs include a plurality of polynucleotides each joined to at least one nucleic acid adaptor, wherein the at least one nucleic acid adaptor can hybridize to the at least one blocker oligonucleotide, and wherein the at least one capture oligonucleotide can hybridize to at least a portion of target polynucleotides that are a sub-population of the plurality of polynucleotides, so as to produce a capture duplex. | 08-28-2014 |
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| 20120290294 | NEURAL TRANSLATOR - A method and apparatus are provided for processing a set of communicated signals associated with a set of muscles, such as the muscles near the larynx of the person, or any other muscles the person use to achieve a desired response. The method includes the steps of attaching a single integrated sensor, for example, near the throat of the person proximate to the larynx and detecting an electrical signal through the sensor. The method further includes the steps of extracting features from the detected electrical signal and continuously transforming them into speech sounds without the need for further modulation. The method also includes comparing the extracted features to a set of prototype features and selecting a prototype feature of the set of prototype features providing a smallest relative difference. | 11-15-2012 |
| 20130332173 | NEURAL TRANSLATOR - A method and apparatus are provided for processing a set of communicated signals associated with a set of muscles, such as the muscles near the larynx of the person, or any other muscles the person use to achieve a desired response. The method includes the steps of attaching a single integrated sensor, for example, near the throat of the person proximate to the larynx and detecting an electrical signal through the sensor. The method further includes the steps of extracting features from the detected electrical signal and continuously transforming them into speech sounds without the need for further modulation. The method also includes comparing the extracted features to a set of prototype features and selecting a prototype feature of the set of prototype features providing a smallest relative difference. | 12-12-2013 |
| 20140171120 | LOCATION-SPECIFIC DATA ACQUISITION - Devices, methods, and systems are provided that allow for acquiring and/or communicating data associated with a location. Embodiments of the present invention allow a mobile communication device to detect a sensor associated with a particular location, and information about that location is provided to the mobile communication device. Other embodiments allow data to be detected and processed in order to characterize a location and objects contained therein. | 06-19-2014 |
| 20150213003 | NEURAL TRANSLATOR - A method and apparatus for processing a set of communicated signals associated with a set of muscles, such as the muscles near the larynx of the person, or any other muscles the person use to achieve a desired response. The method may include attaching a sensor near an area of a user's body associated with speech production, detecting an electrical signal from the user's nervous system through the sensor, and processing the detected electrical signal to provide communication capability for the user. The processing may include extracting a set of features of the detected electrical signal. The extracted set of features may be compared with a set of prototype features. The set of prototype features may correspond to at least one of multiple response classes. The multiple response classes may include an affirmative response class and a negative response class. | 07-30-2015 |
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| 20090013770 | Material property measurements using multiple frequency atomic force microscopy - Apparatus and techniques for extracting information carried in higher eigenmodes or harmonics of an oscillating cantilever or other oscillating sensors in atomic force microscopy and related MEMs work are described. Similar apparatus and techniques for extracting information using contact resonance with multiple excitation signals are also described. | 01-15-2009 |
| 20110219479 | Variable Density Scanning - Systems and techniques for varying a scan rate in a measurement instrument. The techniques may be used in scanning probe instruments, including atomic force microscopes (AFMs) and other scanning probe microscopes, as well as profilometers and confocal optical microscopes. This allows the selective imaging of particular regions of a sample surface for accurate measurement of critical dimensions within a relatively small data acquisition time. | 09-08-2011 |
| 20120079631 | Material Property Measurements Using Multiple Frequency Atomic Fore Microscopy - Apparatus and techniques for extracting information carried in higher eigenmodes or harmonics of an oscillating cantilever or other oscillating sensors in atomic force microscopy and related MEMs work are described. Similar apparatus and techniques for extracting information using contact resonance with multiple excitation signals are also described. | 03-29-2012 |
| 20140041084 | Material Property Measurements Using Multiple Frequency Atomic Fore Microscopy - Apparatus and techniques for extracting information carried in higher eigenmodes or harmonics of an oscillating cantilever or other oscillating sensors in atomic force microscopy and related MEMs work are described. Similar apparatus and techniques for extracting information using contact resonance with multiple excitation signals are also described. | 02-06-2014 |
| 20150026846 | Variable Density Scanning - Systems and techniques for varying a scan rate in a measurement instrument. The techniques may be used in scanning probe instruments, including atomic force microscopes (AFMs) and other scanning probe microscopes, as well as profilometers and confocal optical microscopes. This allows the selective imaging of particular regions of a sample surface for accurate measurement of critical dimensions within a relatively small data acquisition time. | 01-22-2015 |
| 20150301080 | Automated Atomic Force Microscope and the Operation Thereof - Improvements for rapidly calibrating and automatically operating a scanning probe microscope are disclosed. A central component of the SPM is the force transducer, typically a consumable cantilever element. By automatically calibrating transducer characteristics along with other instrumental parameters, scanning parameters can be rapidly and easily optimized, resulting in high-throughput, repeatable and accurate measurements. In contrast to dynamic optimization schemes, this can be accomplished before the surface is contacted, avoiding tip or sample damage from the beginning of the measurement process. | 10-22-2015 |
