Patent application number | Description | Published |
20130147919 | Multi-View Difraction Grating Imaging With Two-Dimensional Displacement Measurement For Three-Dimensional Deformation Or Profile Output - Hardware and software methodology is described for three-dimensional imaging in connection with optical transmission grating used to achieve a plurality of views of an area or entirety of an object imaged with a single digital camera for recording and subsequent processing. Such processing produces three-dimensional data (in terms of element displacement and/or object profile) using a two-dimensional displacement measurement technique only. | 06-13-2013 |
20130207639 | WIRELESS VOLTAGE SENSING DEVICE - A voltage sensing apparatus on a semiconductor substrate, including one or more inputs comprising metal contacts, an output comprising a laser transmitter, circuitry electrically connecting and interfacing the inputs to the output; and a power module. A method of fabricating the apparatus is also described. | 08-15-2013 |
20130209448 | Carrier Nanoparticles and Related Compositions, Methods and Systems - Carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle and related compositions, methods and systems. | 08-15-2013 |
20130209454 | ANTI-HIV ANTIBODIES HAVING INCREASED POTENCY AND BREADTH - Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) antibodies having improved potency and breadth. | 08-15-2013 |
20130210073 | METHODS OF INCORPORATING AMINO ACID ANALOGS INTO PROTEINS - The invention provides a method of incorporating nonstandard amino acids into a protein by utilizing a modified aminoacyl-tRNA synthetase to charge the nonstandard amino acid to a modified tRNA, which forms strict Watson-Crick base-pairing with a codon that normally forms wobble base-pairing with natural tRNAs. | 08-15-2013 |
20130210080 | PC BOARD-BASED POLYMERASE CHAIN REACTION SYSTEMS, METHODS AND MATERIALS - An apparatus for performing a Polymerase Chain Reaction (PCR) is disclosed. The apparatus comprises a PCR chamber for performing a Polymerase Chain Reaction and a printed circuit board (PCB) fluidic device. The PCR chamber is a fluidic chamber and is located in, or is part of, the printed circuit board (PCB) fluidic device. A method for manufacturing an apparatus for performing the Polymerase Chain Reaction and a method for performing the Polymerase Chain Reaction are further disclosed. | 08-15-2013 |
20130210646 | HEMOMOSAIC: HIGH-THROUGHPUT TECHNIQUE FOR RARE CELL DETECTION IN LIQUID SAMPLES BY MASSIVELY MULTIPLEXED PCR IN A PHOTOLITHOGRAPHIC MATRIX - Described microfluidic technology focused on: 1) direct integration of microfluidic devices with solidified liquid tissue samples, 2) subordination of architectural and operational principles of microfluidic devices specific tissue structure and needs and/or 3) on-chip sample acquisition integrated with the detection measurement within the same device. In contrast to conventional methods of off-chip sample prep and subsequent insertion into a detection device, new applications are possible on solidified liquid or solid tissue samples, such as in situ PCR. | 08-15-2013 |
20130211012 | Carrier Nanoparticles and Related Compositions, Methods and Systems - Carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle and related compositions, methods and systems. | 08-15-2013 |
20130213462 | AXIALLY-INTEGRATED EPITAXIALLY-GROWN TANDEM WIRE ARRAYS - A photoelectrode, methods of making and using, including systems for water-splitting are provided. The photoelectrode can be a semiconducting material having a photocatalyst such as nickel or nickel-molybdenum coated on the material. The photoelectrode includes an elongated axially integrated wire having at least two different wire compositions. | 08-22-2013 |
20130213860 | OPPOSED MIGRATION AEROSOL CLASSIFIER GAS AND HEAT EXCHANGER - A method is provided for changing a property of a sample. A sample, comprising particles suspended within a sample fluid, is introduced into a channel which comprises two walls that are permeable to a flow of fluid. A cross-flow is introduced at a predetermined temperature and of a predetermined chemical composition into the channel through a wall. This cross-flow flows at a first velocity and exits in a first direction through the other wall. An imposed field is applied on the particles in a second direction counter to the first direction of the cross-flow. The imposed field causes the particles to migrate at a second velocity opposite and/or equal to the first velocity of the cross-flow. Particles that are approximately balanced by the first and second velocities travel through the channel and are discharged in a fluid of predetermined chemical composition and at the predetermined temperature of the cross-flow. | 08-22-2013 |
20130213861 | RADIAL OPPOSED MIGRATION AEROSOL CLASSIFIER WITH GROUNDED AEROSOL ENTRANCE AND EXIT - A radial opposed migration classifier is provided for separating particles in a sample, introducing and removing the particles into and out of the classifier at the same potential. A sample passes through a classification channel having two circular walls. The sample is introduced and exits the classifier through the same plane as the first wall, which is at a different potential from the second wall. A cross-flow fluid enters the classification channel through one of the walls. The cross-flow fluid flows at a first velocity and exits in a first direction through the other wall. An imposed field is applied on the particles in a second direction counter to the first direction of the cross-flow. This causes the particles of a desired size and/or charge to migrate at a second velocity opposite and/or equal to a first velocity of the cross-flow. The particles that travel through the channel are discharged. | 08-22-2013 |
20130213881 | FILTRATION MEMBRANES AND RELATED COMPOSITIONS, METHODS AND SYSTEMS - Described herein are filtration membranes and related, compositions, methods and systems and in particular filtration membranes with embedded polymeric micro/nanoparticles and related compositions, methods, and systems. | 08-22-2013 |
20130220729 | METHOD AND APPARATUS FOR WAVE GENERATION AND DETECTION USING TENSEGRITY STRUCTURES - A tensegrity apparatus having multiple tensegrity units for the transmission of solitary waves with adjustable profiles into a material or structure, and the detection of such waves from a material or structure. | 08-29-2013 |
20130222115 | AUTONOMOUS AND CONTROLLABLE SYSTEMS OF SENSORS AND METHODS OF USING SUCH SYSTEMS - An autonomous and controllable system of sensors and methods for using such a system of sensors are described. | 08-29-2013 |
20130224550 | Lithium-Based High Energy Density Flow Batteries - Systems and methods in accordance with embodiments of the invention implement a lithium-based high energy density flow battery. In one embodiment, a lithium-based high energy density flow battery includes a first anodic conductive solution that includes a lithium polyaromatic hydrocarbon complex dissolved in a solvent, a second cathodic conductive solution that includes a cathodic complex dissolved in a solvent, a solid lithium ion conductor disposed so as to separate the first solution from the second solution, such that the first conductive solution, the second conductive solution, and the solid lithium ionic conductor define a circuit, where when the circuit is closed, lithium from the lithium polyaromatic hydrocarbon complex in the first conductive solution dissociates from the lithium polyaromatic hydrocarbon complex, migrates through the solid lithium ionic conductor, and associates with the cathodic complex of the second conductive solution, and a current is generated. | 08-29-2013 |
20130249598 | MICROSCALE DIGITAL VACUUM ELECTRONIC GATES - Systems and methods in accordance with embodiments of the invention implement microscale digital vacuum electronic gates. In one embodiment, a microscale digital vacuum electronic gate includes: a microscale field emitter that can emit electrons and that is a microscale cathode; and a microscale anode; where the microscale field emitter and the microscale anode are disposed within at least a partial vacuum; where the microscale field emitter and the microscale anode are separated by a gap; and where the potential difference between the microscale field emitter and the microscale anode is controllable such that the flow of electrons between the microscale field emitter and the microscale anode is thereby controllable; where when the microscale anode receives a flow of electrons, a first logic state is defined; and where when the microscale anode does not receive a flow of electrons, a second logic state is defined. | 09-26-2013 |
20130309679 | FLUIDIC DEVICES AND SYSTEMS FOR SAMPLE PREPARATION OR AUTONOMOUS ANALYSIS - The present invention relates to fluidic devices for preparing, processing, storing, preserving, and/or analyzing samples. In particular, the devices and related systems and methods allow for preparing and/or analyzing samples (e.g., biospecimen samples) by using one or more of capture regions and/or automated analysis. | 11-21-2013 |
20130322807 | Integrated Light Source Independent Linewidth Reduction - An integrated optical linewidth reduction system detects/estimates the phase noise of an incoming optical signal and subtracts the detected phase noise from the phase noise of the incoming signal. A first coupler/splitter of the linewidth reduction system may split the incoming signal into first and second optical signals travelling through first and second optical paths. A second coupler/splitter may split the second optical signal into third and fourth optical signals travelling through third and fourth optical paths. The third optical path has a longer propagation delay than the fourth optical path. Two different coupling ratios of the third and fourth optical signals are used to generate an electrical signal representative of the phase noise of the incoming signal. A phase detector/estimator estimates the phase noise from the electrical signal. A phase modulator subtracts the detected/estimated phase noise from the phase noise of the incoming signal. | 12-05-2013 |
20130341190 | Method and Apparatus for Analysis and Sorting of Polynucleotides Based on Size - The invention relates to a microfabricated device and methods of using the device for analyzing and sorting polynucleotide molecules by size. | 12-26-2013 |
20140031243 | MULTIPLEX DETECTION OF MOLECULAR SPECIES IN CELLS BY SUPER-RESOLUTION IMAGING AND COMBINATORIAL LABELING - Methods and systems are provided for creating molecular barcodes or indicia for cellular constituents within single cells and for resolving such barcodes or indicia with super-resolution technologies such as super-resolution microscopy. By this approach, numerous molecular species that can be measured simultaneously in single cells. It has been demonstrated that multiple mRNA transcripts can be labeled with a spatially ordered sequence of fluorophores, and that barcodes can be resolved. In addition, alternative splicing events can be characterized by identifying and quantifying mRNA isoforms in an individual cell. | 01-30-2014 |
20140055832 | Integrated Two-Dimensional Planar Optical Phased Array - An optical phased array includes, in part, a multitude of optical signal emitters and a multitude of optical signal phase/delay elements each associated with and disposed between a different pair of the optical signal emitters. Each optical signal phase/delay element is adapted to cause a phase/delay shift between the optical signals emitted from its associated pair of optical signal emitters. Each optical signal phase/delay element is optically a ring resonator that includes a p-i-n junction. By varying the bias applied to the p-i-n junction, the phase/delay generated by the ring resonator is varied. Furthermore, each optical signal emitter is optionally an optical grating having a multitude of grooves. The groove lengths of the optical gratings are optionally selected so as to increase along the direction of travel of the input optical signal through the optical phase array. | 02-27-2014 |
20140065653 | MICROFLUIDIC LARGE SCALE INTEGRATION - High-density microfluidic chips contain plumbing networks with thousands of micromechanical valves and hundreds of individually addressable chambers. These fluidic devices are analogous to electronic integrated circuits fabricated using large scale integration (LSI). A component of these networks is the fluidic multiplexor, which is a combinatorial array of binary valve patterns that exponentially increases the processing power of a network by allowing complex fluid manipulations with a minimal number of inputs. These integrated microfluidic networks can be used to construct a variety of highly complex microfluidic devices, for example the microfluidic analog of a comparator array, and a microfluidic memory storage device resembling electronic random access memories. | 03-06-2014 |
20140070286 | NANO-PILLAR TRANSISTOR FABRICATION AND USE - A field effect nano-pillar transistor has a pillar shaped gate element incorporating a biomimitec portion that provides various advantages over prior art devices. The small size of the nano-pillar transistor allows for advantageous insertion into cellular membranes, and the biomimitec character of the gate element operates as an advantageous interface for sensing small amplitude voltages such as transmembrane cell potentials. The nano-pillar transistor can be used in various embodiments to stimulate cells, to measure cell response, or to perform a combination of both actions. | 03-13-2014 |
20140072993 | SENSOR PROBE FOR BIO-SENSING AND CHEMICAL-SENSING APPLICATIONS - The basic structure and functionality of a probe as disclosed herein allows for flexibly incorporating into the probe, various sensing elements for various sensing applications. Two example applications among these various sensing applications include bio-sensing and chemical-sensing applications. For bio-sensing applications the probe, which is fabricated upon a silicon substrate, includes a bio-sensing element such as a nano-pillar transistor, and for chemical-sensing applications the probe includes a sensing element that has a functionalized contact area whereby the sensing element generates a voltage when exposed to one or more chemicals of interest. | 03-13-2014 |
20140096831 | MULTI-VALVE MICROFLUIDIC DEVICES AND METHODS - Multi-valve autoregulatory microfluidic devices and methods are described. The described devices and methods offer improved performance and new means of tuning autoregulatory effects in microfluidic devices. | 04-10-2014 |
20140100651 | Medical Device Fastener Mechanisms - Connecting mechanisms between medical device or other physical components are described. One or more plug pin connector(s) is received in a matching socket connector(s) to either permanently or temporarily join at least two components together along with associated components. Each plug connector is associated with a releasable pull line to facilitate such assembly. | 04-10-2014 |
20140105232 | ON-CHIP OPTICAL REFERENCE CAVITY EXHIBITING REDUCED RESONANCE CENTER FREQUENCY FLUCTUATIONS - An optical apparatus comprises a waveguide substrate and an optical reference cavity. The optical reference cavity comprises an optical waveguide formed on the waveguide substrate and arranged to form a closed loop greater than or about equal to 10 cm in length. The RMS resonance frequency fluctuation is less than or about equal to 100 Hz. The Q-factor can be greater than or about equal to 10 | 04-17-2014 |
20140140652 | Integrated Light Source Independent Linewidth Reduction of Lasers Using Electro-Optical Feedback Techniques - An integrated optical linewidth reduction system includes a phase modulator adapted to modulate the phase of an incoming optical signal in response to a feedback control signal defined by a first electrical signal. The phase modulator is further adapted to generate a first optical signal travelling through a first optical path. The first electrical signal is representative of a phase noise of the first optical signal. An optical linewidth of the first optical signal is less than an optical linewidth of the incoming optical signal. | 05-22-2014 |
20140190255 | ULTRA HIGH RESOLUTION GRAVITY GRADIOMETERY TECHNIQUE - A method and system provide the ability to measure relative displacement and rotation. A first light is continuously shined from a first light source that is fixed on a first entity to a first two-dimensional (2D) plate fixed on a second entity. The first direction of propagation of the first light does not change relative to the first entity. A second light is shined from a second light source that is fixed on the first entity to a second 2D plate fixed on the second entity. A second direction of propagation of the second light does not change relative to the first entity and is different from the first direction of propagation. The displacement of the lights on plates is directly monitored to determine a 3D displacement vector that represents a relative displacement between the first entity and the second entity. Thus, a three dimensional gravity gradient tensor is constructed. | 07-10-2014 |
20140205829 | METHOD FOR CONTROLLING MICROSTRUCTURAL ARRANGEMENT OF NOMINALLY-ALIGNED ARRAYS OF CARBON NANOTUBES - A method for controlling the microstructural arrangement of nominally-aligned arrays of carbon nanotubes (CNTs) and a foam structure of CNTs are disclosed. The method includes a functionalization of CNT surfaces, for example, a non-covalent functionalization. The non-covalent functionalization of CNT surfaces can be obtained by way of a wetting process, for example by the use of a solution of surfactant or silica (SiO | 07-24-2014 |
20150044084 | METHODS FOR FABRICATING GRADIENT ALLOY ARTICLES WITH MULTI-FUNCTIONAL PROPERTIES - Systems and methods for fabricating multi-functional articles comprised of additively formed gradient materials are provided. The fabrication of multi-functional articles using the additive deposition of gradient alloys represents a paradigm shift from the traditional way that metal alloys and metal/metal alloy parts are fabricated. Since a gradient alloy that transitions from one metal to a different metal cannot be fabricated through any conventional metallurgy techniques, the technique presents many applications. Moreover, the embodiments described identify a broad range of properties and applications. | 02-12-2015 |
20150047683 | In2Te3 Precipitates in Bulk Bi2Te3 for Thermoelectric Applications - The present invention teaches a successful synthesis regime to grow highly oriented plate-like In | 02-19-2015 |
20150056109 | SOLAR FUEL GENERATOR - The disclosure provides conductive membranes for water splitting and solar fuel generation. The membranes comprise an embedded semiconductive/photoactive material and an oxygen or hydrogen evolution catalyst. Also provided are chassis and cassettes containing the membranes for use in fuel generation. | 02-26-2015 |