Patent application number | Description | Published |
20090042294 | Hydroxyphenyl cross-linked macromolecular network and applications thereof - A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties. | 02-12-2009 |
20090142309 | Hydroxyphenyl cross-linked macromolecular network and applications thereof - A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties. | 06-04-2009 |
20090143766 | Hydroxyphenyl cross-linked macromolecular network and applications thereof - A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties. | 06-04-2009 |
20090204227 | Molecular enhancement of extracellular matrix and methods of use - A composition comprising a human- or animal-derived extracellular matrix and a macromolecular network which is prepared ex vivo is provided that is useful in the repair of a tissue injury, particularly in repair of tears or gaps between a tendon and a bone, such as in a rotator cuff tear. In an embodiment, the composition comprises a human- or animal-derived extracellular matrix having impregnated therein a macromolecular network of hyaluronan macromolecules that have been cross-linked via dihydroxyphenyl linkages, so that the cross-linked network is interlocked within the extracellular matrix. The resulting HA-incorporated extracellular matrix can be supplied in the form of a patch to reinforce a tissue repair or cover a tissue defect. | 08-13-2009 |
20090252700 | Hydroxyphenyl cross-linked macromolecular network and applications thereof - A synthetic nucleus pulposus is provided that is useful in treatment of degenerative disc disease, augmentation of a degenerate disc, and alleviation of back pain. In an embodiment the synthetic nucleus pulposus comprises hyaluronan macromolecules that have been cross-linked via dihydroxyphenyl linkages. The synthetic nucleus pulposus restores or improves the water-retention capability of the disc. A method of treating an intervertebral disc with the cross-linked hyaluronan macromolecules is also provided. A method of regenerative therapy to address loss of cells of nucleus pulposus of an intervertebral disc based on treatment with the cross-linked hyaluronan macromolecules and mesenchymal stem cells is also provided. | 10-08-2009 |
20120309672 | TREATMENT OF EXTRACELLULAR MATRIX TO REDUCE INFLAMMATION - Pharmaceutical compositions are provided. The compositions comprise a compound comprising the hyaluronan-containing structure A-(low molecular weight hyaluronan domain)-B. The compositions also comprise a pharmaceutically acceptable excipient. A is hydrogen, a substituent that does not comprise a binding site for tumor necrosis factor stimulated gene-6 (“TSG-6”) protein, a substituent that interferes with binding of TSG-6 protein immediately adjacent thereto, or chondroitin. B is hydroxyl, a substituent that does not comprise a binding site for TSG-6 protein, a substituent that interferes with binding of TSG-6 protein immediately adjacent thereto, or chondroitin. The composition is suitable for administration by injection, inhalation, topical rub, or ingestion. Also disclosed are methods and kits for treating a site of inflammation in an individual in need thereof and for decreasing heavy chain modification of pathological hyaluronan at a site of inflammation in an individual in need thereof based on administering the compounds or the compositions. | 12-06-2012 |
20140135256 | TREATMENT OF EXTRACELLULAR MATRIX TO REDUCE INFLAMMATION - Pharmaceutical compositions are provided. The compositions comprise a compound comprising the hyaluronan-containing structure A-(low molecular weight hyaluronan domain)-B. The compositions also comprise a pharmaceutically acceptable excipient. A is hydrogen, a substituent that does not comprise a binding site for tumor necrosis factor stimulated gene-6 (“TSG-6”) protein, a substituent that interferes with binding of TSG-6 protein immediately adjacent thereto, or chondroitin. B is hydroxyl, a substituent that does not comprise a binding site for TSG-6 protein, a substituent that interferes with binding of TSG-6 protein immediately adjacent thereto, or chondroitin. The composition is suitable for administration by injection, inhalation, topical rub, or ingestion. Also disclosed are methods and kits for treating a site of inflammation in an individual in need thereof and for decreasing heavy chain modification of pathological hyaluronan at a site of inflammation in an individual in need thereof based on administering the compounds or the compositions. | 05-15-2014 |
20160058534 | BIOCOMPATIBLE TISSUE GRAFT - Biocompatible tissue grafts are provided. The biocompatible tissue grafts comprise a bulk graft comprising a biocompatible material and having at least a first surface. The biocompatible tissue grafts also comprise a coating comprising a hydrogel and being immobilized on the bulk graft at the first surface. The biocompatible material comprises at least one of a biologic material or a biologic-synthetic composite material. The hydrogel comprises cross-linked hydroxyphenyl-substituted hyaluronan (HPS-HA), cross-linked hydroxyphenyl-substituted collagen (HPS-C), or both. The cross-linked HPS-HA, cross-linked HPS-C, or both have been formed by cross-linking of hydroxyphenyl groups of HPS-HA, HPS-C, or both to form dihydroxyphenyl bridges. Also disclosed are methods for repair of tissue damage in a subject in need thereof. The methods comprise surgically implanting the biocompatible tissue graft into a site of the tissue damage in the subject. | 03-03-2016 |
Patent application number | Description | Published |
20110150730 | CARBON DIOXIDE SORBENTS - Improved CO | 06-23-2011 |
20120060686 | Mixed Amine and Non-Nucleophilic Base CO2 Scrubbing Process for Improved Adsorption at Increased Temperatures | 03-15-2012 |
20120061614 | NON-AQUEOUS AMINE SCRUBBING FOR REMOVAL OF CARBON DIOXIDE - A method is described for separating CO | 03-15-2012 |
20120063978 | IONIC LIQUIDS AS AMINE PROMOTER SOLVENTS FOR REMOVAL OF CARBON DIOXIDE - Ionic liquids are capable of acting as solvents for amine CO | 03-15-2012 |
20120063979 | High CO2 to Amine Adsorption Capacity CO2 Scrubbing Processes | 03-15-2012 |
20120063980 | Alkanolamine CO2 Scrubbing Process | 03-15-2012 |
20120160097 | Epoxy-Amine Acid Gas Adsorption-Desorption Polymers and Oligomers, Processes for Preparing Same, and Uses Thereof - This disclosure involves an adsorption-desorption material, e.g., crosslinked epoxy-amine material having an M | 06-28-2012 |
20120164043 | Organo-Amine Acid Gas Adsorption-Desorption Polymers, Processes for Preparing Same, and Uses Thereof - An adsorption-desorption material, in particular, crosslinked organo-amine polymeric materials having an M | 06-28-2012 |
20120164044 | Vinylepoxide-Amine Acid Gas Adsorption-Desorption Polymers and Oligomers, Processes for Preparing Same, and Uses Thereof - An adsorption-desorption material, in particular, crosslinked vinylepoxide-amine polymeric materials having an M | 06-28-2012 |
20120164045 | Polyvinyl-Amine Acid Gas Adsorption-Desorption Polymers, Processes for Preparing Same, and Uses Thereof - This disclosure involves an adsorption-desorption material, e.g., crosslinked polyvinyl-amine material having an M | 06-28-2012 |
20120298558 | FUNCTIONALIZED FILTERS FOR HEAVY OIL UPGRADING - This invention relates to a process for separating a hydrocarbon stream via a filtration process to produce an upgraded permeate stream with decreased Conradson Carbon Residue (“CCR”) content. The invention involves the modification of a porous ceramic filter by functionalizing the surface of the ceramic filter with an multi-ring aromatic-diimide polymer. Preferably, the multi-ring aromatic-diimide polymer is comprised of a multi-ring aromatic monomer component. The functionalized filters of the present invention can be used in a process to selectively separate components of a hydrocarbon stream to produce an improved permeate (or “filtrate”) product stream with a lower CCR content and improved processing capabilities. The functionalized filters of the present invention are particularly beneficial in filtration processes for upgrading heavy hydrocarbon feedstreams, such as whole crudes, topped crudes, synthetic crude blends, shale oils, oils derived from bitumens, oils derived from tar sands, atmospheric resids, vacuum resids, or other heavy hydrocarbon streams. | 11-29-2012 |
20130313473 | CARBON DIOXIDE SORBENTS - Improved CO | 11-28-2013 |
20130317180 | CARBON DIOXIDE SORBENTS - Improved CO | 11-28-2013 |
20140178278 | CO2 CAPTURE VIA AMINE-CO2 PRODUCT PHASE SEPARATION - Systems and methods are provided for performing CO | 06-26-2014 |
20140186246 | REVERSIBLE CO2 FIXATION VIA SELF-ASSEMBLED SILOXANES - Methods are provided for synthesizing novel types of self-assembled siloxanes, such as polysiloxanes, with a sufficiently high density of amine functional groups to be useful for CO | 07-03-2014 |
20150306535 | ORGANO-AMINE ACID GAS ADSORPTION-DESORPTION POLYMERS, PROCESES FOR PREPARING SAME, AND USES THEREOF - An adsorption-desorption material, in particular, crosslinked organo-amine polymeric materials having a weight average molecular weight of from about 500 to about 1×10 | 10-29-2015 |
20150306542 | ORGANO-AMINE ACID GAS ADSORPTION-DESORPTION POLYMERS, PROCESSES FOR PREPARING SAME, AND USES THEREOF - An adsorption-desorption material, in particular, crosslinked organo-amine polymeric materials having a weight average molecular weight of from about 500 to about 1×10 | 10-29-2015 |
20150307661 | ORGANO-AMINE ACID GAS ADSORPTION-DESORPTION POLYMERS, PROCESSES FOR PREPARING SAME, AND USES THEREOF - An adsorption-desorption material, in particular, crosslinked organo-amine polymeric materials having a weight average molecular weight of from about 500 to about 1×10 | 10-29-2015 |
20150307680 | ORGANO-AMINE ACID GAS ADSORPTION-DESORPTION POLYMERS, PROCESES FOR PREPARING SAME, AND USES THEREOF - An adsorption-desorption material, in particular, crosslinked organo-amine polymeric materials having a weight average molecular weight of from about 500 to about 1×10 | 10-29-2015 |