Butlin, US
Albert H. Butlin, Beverly Hills, MI US
Patent application number | Description | Published |
---|---|---|
20100052360 | Door Assembly and Method for a Vehicle - A door assembly for a vehicle includes an outer panel. A support panel is operatively connected to the outer panel and configured such that the support panel provides bending resistance to the outer panel when the outer panel is deflected toward the support panel during a first deflection distance of the outer panel. A cable is operatively connected in the door assembly between a first end and a second end of the outer panel such that the cable provides additional bending resistance to the outer panel when the outer panel is deflected toward the support panel during a second deflection distance of the outer panel, greater than the first deflection distance. | 03-04-2010 |
Jane Butlin, Canton, MA US
Patent application number | Description | Published |
---|---|---|
20080216233 | CRIB BUMPER SECURED WITH A TOY - A crib bumper including a bumper pad and a set of attachment members. The attachment members pass from in the interior of the crib through bores in the bumper pad and secure behind bars of the crib. Securing and releasing the bumper pad to the crib is simplified through the use of the bores and attachment members. | 09-11-2008 |
Jared D.g. Butlin, Durham, NC US
Patent application number | Description | Published |
---|---|---|
20100280312 | Self-Contained Medical Applicators for Surgical Sealants, and Methods of Use Thereof - Aspects of the invention relate to an applicator, and methods of use thereof, which can house multiple component formulations in separate material receptacles, which components can then be easily combined at the time of use without assembly by the user. In certain embodiments, a device of the invention can be used for, but is not limited to, applying hydrogel formulations to dura mater, abdominal tissue in hernia repair, tissues near the spine, lung tissue, intestinal tissue, or any of the internal tissues. In certain embodiments, a device of the invention can be configured to apply a spray or a stream of a liquid formulation to a surface. In certain embodiments, a device of the invention can be configured to deliver the formulation through an endoscope or laparoscope. | 11-04-2010 |
20110044932 | Crosslinked Polyalkyleneimine Hydrogels with Tunable Degradation Rates - One aspect of the present invention relates to methods of sealing a wound or tissue plane or filling a void space, or securing meshes, films or other devices within the body. In certain embodiments, the wound is an ophthalmic, pleural or dural wound, or a hernia repair mesh. Remarkably, disclosed herein is the discovery that the use of certain crosslinkers in combination with polyalkyleneimines at specific concentrations can result in hydrogels with tunable degradation properties. | 02-24-2011 |
Jared D. G. Butlin, Durham, NC US
Patent application number | Description | Published |
---|---|---|
20090215923 | Crosslinked Polyalkyleneimine Hydrogels with Tunable Degradation Rates - One aspect of the present invention relates to methods of sealing a wound or tissue plane or filling a void space, or securing meshes, films or other devices within the body. In certain embodiments, the wound is an ophthalmic, pleural or dural wound, or a hernia repair mesh. Remarkably, disclosed herein is the discovery that the use of certain crosslinkers in combination with polyalkyleneimines at specific concentrations can result in hydrogels with tunable degradation properties. | 08-27-2009 |
20100280547 | Applicator System for the Delivery of Surgical Sealants - One aspect of the invention relates to a simple, inexpensive applicator system which can be used for the delivery of a hydrogel formulation. In certain embodiments, the applicator system is suitable for use in sealing of dura mater, especially dura matter within the spinal column. In other embodiments, the applicator system may be used to repair cardiovascular defects, defects of the gall or urinary bladder, or repair of any of the other ducts within the body. | 11-04-2010 |
20130338631 | Disposable Syringe Applicators for Multi-Component Formulations, and Methods of Use Thereof - Aspects of the invention relate to an applicator which can house multiple components of a formulation in separate receptacles. In certain embodiments, an applicator of the invention can be used for, but is not limited to, applying hydrogel formulations to dura mater, abdominal tissue in hernia repair, tissues near the spine, lung tissue, intestinal tissue, or any of the internal tissues. | 12-19-2013 |
Nathaniel G. Butlin, Pacifica, CA US
Patent application number | Description | Published |
---|---|---|
20100167289 | MULTI-COLOR TIME RESOLVED FLUOROPHORES BASED ON MACROCYCLIC LANTHANIDE COMPLEXES - The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands. | 07-01-2010 |
20120190012 | COMPOSITIONS AND METHODS FOR DNA SEQUENCING - The invention provides compositions and methods useful in DNA sequencing. In exemplary embodiments, a detectable label such as a luminescent macrocycle is used. | 07-26-2012 |
20120214253 | MACROCYCLIC HOPO CHELATORS - The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds comprise hydroxypyridinonyl moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. | 08-23-2012 |
Nathaniel G. Butlin, San Francisco, CA US
Patent application number | Description | Published |
---|---|---|
20100151591 | RAPID HOMOGENEOUS DIAGNOSTIC TESTING PLATFORM BASED ON LANTHANIDE FLUORESCENT RESONANCE ENERGY TRANSFER - The present invention provides compositions and methods for detecting the presence of an analyte in a sample. Exemplary compositions comprise macrocyclic lanthanide complexes that are useful for transferring energy to an energy transfer acceptor to indicate the presence of the analyte. The compositions and methods are particularly suited for detecting antibodies in a sample. | 06-17-2010 |
20110189088 | RADIOPHARMACEUTICAL COMPLEXES - The invention provides compounds such as chelating agents useful in chelating metal ions, particularly radionuclides, to provide metal ion complexes. The invention also provides methods of using the compounds and complexes of the invention, such as in therapeutic and diagnostic applications. | 08-04-2011 |
Nathaniel G. Butlin, Davis, CA US
Patent application number | Description | Published |
---|---|---|
20080213780 | MULTI-COLOR TIME RESOLVED FLUOROPHORES BASED ON MACROCYCLIC LANTHANIDE COMPLEXES - The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands. | 09-04-2008 |
20090093618 | STREPTAVIDIN-BIOTIN-LINK ANTIBODY-HAPTEN SYSTEM - The present invention provides antibodies comprising an antigen recognition domain that specifically binds to a metal chelate: mutant antibodies comprising a reactive site not present in the wild-type of the antibody, wherein the reactive site is in a position proximate to or within the antigen recognition domain; and methods of using such antibodies to diagnose and treat disease. | 04-09-2009 |
Nathaniel G. Butlin US
Patent application number | Description | Published |
---|---|---|
20110015543 | FLUID SAMPLE COLLECTION SYSTEM - A sample collection container adapted to be connected to, and disconnected from, a sample collection adapter and a sample collection container cap. The sample collection adapter has a downward sloping interior surface that provides a free-flowing path for samples provided by a subject to the sample collection container. The sample collection adapter may have a three-dimensional rim surface that is curved in two different non-parallel planes. | 01-20-2011 |
20110028863 | FLUID SAMPLE COLLECTION SYSTEM - A sample collection container adapted to be connected to, and disconnected from, a sample collection adapter and a sample collection container cap. The sample collection adapter has a downward sloping interior surface that provides a free-flowing path for samples provided by a subject to the sample collection container. The sample collection adapter may have a three-dimensional rim that is curved in two different non-parallel planes. | 02-03-2011 |