Patent application number | Description | Published |
20130054588 | SYSTEMS AND METHODS FOR PROVIDING SEARCH RELEVANCY IN COMMUNICATION INITIATION SEARCHES - Systems and methods for generating relevant search results for a user are disclosed. In one example, the method comprises receiving a search query from the user performing a communication initiation search, receiving, by the computer system, search results from a search engine based on the search query, linking, by the computer system, the search results to a communications dataset generated based on communication metadata received from a communication system, and ordering, by the computer system, the search results based on the communication dataset in order from most relevant to least relevant to the user performing the communication initiation search. | 02-28-2013 |
20130054716 | SYSTEM AND METHOD FOR ABSTRACT COMMUNICATION - Systems and methods for providing communication between a user and at least one entity are disclosed. In one example, the method comprises receiving an entity selection input of the at least one entity, and a message from the user to the at least one entity, analyzing the selection input and the message to determine entity information and inquiry information associated with the message and the selection input, determining least one communication channel based on the entity information and the inquiry information, obtaining a response to the message via the at least one communication channel from the at least one entity, and transmitting the response to the user. | 02-28-2013 |
20130066987 | MULTI-USER COMMUNICATION SYSTEM AND METHOD - Systems and methods for enabling communication between a user and at least one entity by a communication service are disclosed. In one example, the method comprises acts of receiving a search for the at least one entity, analyzing the search, by a processor, to determine search results based on the search including the at least one entity, receiving a message from the user to the at least one entity, the message including inquiry information directed to the at least one entity, determining, by the processor, presence status associated with the at least one entity, establishing, by the processor, a communication channel between the user and the at least one entity based on the presence status, and transmitting a response to the message based on the inquiry information via the communication channel. | 03-14-2013 |
20130066988 | SYSTEM AND METHOD FOR ESTABLISHING PRESENCE IN A BROKERED CHAT SYSTEM - Systems and methods for determining status of a user in a brokered chat service are disclosed. In one example, the method comprises acts of receiving, via the brokered chat service, a check-in message from the user, establishing the status of the user as available in the brokered chat service, transmitting at least one message to the user via the brokered chat service in response to establishing the status of the user as available, and updating the status of the user in the brokered chat service in response to communication from the user. | 03-14-2013 |
20130268446 | SYSTEM AND METHOD FOR ENTRY OF STRUCTURED DATA - Systems and methods for enabling communication between a user and at least one entity by a communication service are disclosed. In one example, the method comprises providing at least one predefined text string for display to the user on a device, the at least one predefined text string comprising an inquiry to the at least one entity, receiving a structured text input associated with the at least one predefined text string, and transmitting a message to another device having the at least one predefined text string and the structured text input to the at least one entity. | 10-10-2013 |
Patent application number | Description | Published |
20090202430 | COMPOSITION FOR CYTOCOMPATIBLE, INJECTABLE, SELF-GELLING POLYSACCHARIDE SOLUTIONS FOR ENCAPSULATING AND DELIVERING LIVE CELLS OR BIOLOGICALLY ACTIVE FACTORS - The present invention provides compositions and methods for tissue repair using a cytocompatible self-gelling cross-linked hydrogel. The composition comprises a biocompatible mixture of chitosan, bifunctional dialdehyde, and hydroxylated polymer, which can be used to immobilize or encapsulate viable cells, or bioactive substances. The method includes the process of mixing bioactive substances, live cells, and/or extracellular matrix components with a cross-linking solution comprising a bifunctional aldehyde-treated hydroxylated polymer such as hydroxyethyl cellulose. The cross-linking solution is then mixed homogenously with a neutral isotonic chitosan solution. The chitosan becomes cross-linked by the bifunctional aldehyde, while the cells are protected from potentially nocive effects of the aldehyde cross-linker by the hydroxylated polymer. The injectable solution retains cell viability and bioactivity, and immobilizes cells at the site of injection or delivery. Depending on the particular application, mixtures of chitosan and bifunctional dialdehyde may be employed. The injectable solution also liberates bioactive substances with controlled release kinetics from the site of injection. | 08-13-2009 |
20110034797 | NON-INVASIVE MEASURING OF LOAD-INDUCED ELECTRIC POTENTIALS IN DIARTHROIDIAL JOINTS - There is described a method for non-invasively measuring electrical activity in a joint of a subject, the method comprising: removably attaching in a non-invasive manner at least two electrodes to a skin surface around an articulation comprising the joint; generating electroarthrographic potentials within the joint by loading the articulation; capturing the electroarthrographic potentials using the at least two electrodes; discriminating between electroarthrographic potentials originating from joint tissue activity and those from other sources; and generating measurement signals representing the electrical activity of joint tissue. | 02-10-2011 |
20120321721 | NOVEL FORMULATION OF PHYSIOLOGICAL CHITOSAN-INORGANIC SALT SOLUTION/BLOOD MIXTURES FOR TISSUE REPAIR - The present description relates to a polymer composition for use in repairing tissue of a patient comprising at least one blood component, a polymer, such as chitosan, and at least one inorganic salt, such as NaCl, method of using the composition and method of preparing the composition. | 12-20-2012 |
20130004474 | SOLUBLE PHYSIOLOGICAL CHITOSAN FORMULATIONS COMBINED WITH PLATELET-RICH PLASMA (PRP) FOR TISSUE REPAIR - The present disclosure relates to an activated polymer composition for use in repairing tissue of a patient comprising platelet-rich plasma (PRP), a chitosan solution, a salt such as NaCl or glycerol phosphate, and an activator such as at least one of CaCI | 01-03-2013 |
Patent application number | Description | Published |
20090075383 | COMPOSITION AND METHOD FOR EFFICIENT DELIVERY OF NUCLEIC ACIDS TO CELLS USING CHITOSAN - There is disclosed a composition and a method for the efficient non-viral delivery of nucleic acids to cells using chitosan. In order to achieve high efficiency of transfection, the composition contains a nucleic acid and a chitosan that has the following physico-chemical properties: a combination of a number-average molecular weight between 8 kDa and 185 kDa and a degree of deacetylation between 72% and 92%. The chitosan molecule can also present additional physiochemical properties such as a block distribution of acetyl groups obtained by a heterogeneous treatment of chitin, and/or a polydispersity index between 1.4 and 7.0. By correctly controlling these parameters, efficient delivery systems may be produced that are effective when optimized for different conditions such as the pH of transfection media and amine-to-phosphate ratio. | 03-19-2009 |
20090149421 | GEL FORMATION OF POLYELECTROLYTE AQUEOUS SOLUTIONS BY THERMALLY INDUCED CHANGES IN IONIZATION STATE - There is disclosed aqueous solutions of polyelectrolytes that can be neutralized by increasing temperature, under suitable polyelectrolyte charge state conditions, in order to obtain a homogeneous gel. This can be achieved by adding an appropriate weak electrolyte to the polyelectrolyte so that an increase of temperature will lead to a spatially homogeneous neutralization of the polyelectrolyte via proton transfer between the polyelectrolyte and the weak electrolyte. The ability of such a system to be thermally sensitive and to gel upon heating relies on the temperature dependence of the ionization equilibrium for the two components. This thermally induced neutralization reduces electrostatic repulsion between polyelectrolyte molecules allowing the manifestation of attractive polyelectrolyte-polyelectrolyte hydrophobic interactions and hydrogen bonding that result in gel formation. These new kinds of thermo sensitive gels can be used for biomedical applications. | 06-11-2009 |
20110034930 | DRILL BURR AND METHOD FOR PERFORMING HOLES IN SUBCHONDRAL BONE TO PROMOTE CARTILAGE REPAIR - A method for performing holes in subchondral bone to promote cartilage repair comprises selecting a drill burr having a drilling head and an axial stop, as a function of the distance between the tip of the drilling head and the axial stop and of a desired depth to reach a desired subchondral bone marrow compartment of a patient; drilling a hole through a base of a cartilage lesion with the drill burr to reach the desired subchondral bone marrow compartment of the patient; abutting the base of the cartilage lesion defining a periphery of the hole with the axial stop while drilling; and withdrawing the drill burr from the hole; whereby the hole has the desired depth and reaches the desired subchondral bone marrow compartment to promote cartilage repair. | 02-10-2011 |
20110086008 | COMPOSITION AND METHOD FOR THE REPAIR AND REGENERATION OF CARTILAGE AND OTHER TISSUES - The present invention relates to a new method for repairing human or animal tissues such as cartilage, meniscus, ligament, tendon, bone, skin, cornea, periodontal tissues, abscesses, resected tumors, and ulcers. The method comprises the step of introducing into the tissue a temperature-dependent polymer gel composition such that the composition adhere to the tissue and promote support for cell proliferation for repairing the tissue. Other than a polymer, the composition preferably comprises a blood component such as whole blood, processed blood, venous blood, arterial blood, blood from bone, blood from bone-marrow, bone marrow, umbilical cord blood, placenta blood, erythrocytes, leukocytes, monocytes, platelets, fibrinogen, thrombin and platelet rich plasma. The present invention also relates to a new composition to be used with the method of the present invention. | 04-14-2011 |
20110313056 | GEL FORMATION OF POLYELECTROLYTE AQUEOUS SOLUTIONS BY THERMALLY INDUCED CHANGES IN IONIZATION STATE - There is disclosed aqueous solutions of polyelectrolytes that can be neutralized by increasing temperature, under suitable polyelectrolyte charge state conditions, in order to obtain a homogeneous gel. This can be achieved by adding an appropriate weak electrolyte to the polyelectrolyte so that an increase of temperature will lead to a spatially homogeneous neutralization of the polyelectrolyte via proton transfer between the polyelectrolyte and the weak electrolyte. The ability of such a system to be thermally sensitive and to gel upon heating relies on the temperature dependence of the ionization equilibrium for the two components. This thermally induced neutralization reduces electrostatic repulsion between polyelectrolyte molecules allowing the manifestation of attractive polyelectrolyte-polyelectrolyte hydrophobic interactions and hydrogen bonding that result in gel formation. These new kinds of thermo sensitive gels can be used for biomedical applications. | 12-22-2011 |
20130210717 | GENE THERAPY FOR DIABETES WITH CHITOSAN-DELIVERED PLASMID ENCODING GLUCAGON-LIKE PEPTIDE 1 - Chitosan delivers a plasmid encoding Glucagon-Like Peptide 1 (GLP-1) to cells in a patient for gene therapy of diabetes. Chitosan is optimized for plasmid transfection by modulating three of its physico-chemical properties: degree of deacetylation (DDA), molecular weight (MW), and ratio of amines on chitosan to phosphates on DNA (N:P ratio), Chitosan 92-10-5 (DDA-MW-N:P) is more efficient than chitosans 80-10-10 and 80-80-5 in delivering a plasmid encoding luciferase or GLP-1(7-37) to cells. In the Zucker Diabetic Fatty (ZDF) rat model of diabetes, chitosan-delivered pVax plasmid encoding GLP-1 lowers glucose levels, increases insulin production and reduces weight gain. | 08-15-2013 |
20150087689 | COMPOSITIONS AND METHODS FOR EFFICACIOUS AND SAFE DELIVERY OF siRNA USING SPECIFIC CHITOSAN-BASED NANOCOMPLEXES - There is disclosed a composition and a method for the efficient delivery of a therapeutic RNAi-inducing nucleic acid to cells both in vitro and in vivo through specific formulations of a non viral delivery system using chitosans. Particularly, the composition contains a nucleic acid and a specific chitosan that has the following physico-chemical properties: a number-average molecular weight between 5 kDa and 200 kDa, a degree of deacetylation between 80% and 95% and a chitosan amine to nucleic acid phosphate ratio below 20. | 03-26-2015 |