Burlingame, US
Al Burlingame, Sausalito, CA US
Patent application number | Description | Published |
---|---|---|
20140287957 | ISOTOPIC LABELING FOR THE MEASUREMENT OF GLOBAL PROTEIN LEVELS AND TURNOVER IN VIVO - An entire complement or plurality of isotopically labeled amino acids are introduced into the diet of a test subject. Sufficient amounts of the isotopically labeled amino acids are provided to the subject in order to ensure that the subject incorporates a large percentage of isotopically labeled amino acids into newly synthesized proteins. Tissue samples are removed from the subject at different points in time and proteins are extracted and separated so that different proteins of different tissues can be individually analyzed and their amount and pattern of isotopic labeling can be determined. In a preferred embodiment, the methodology can be combined with proteolytic digestion to peptides and analysis by mass spectrometry in order to measure rates of protein turnover in vivo relating to thousands of different proteins. | 09-25-2014 |
Alma L. Burlingame, Sausalito, CA US
Patent application number | Description | Published |
---|---|---|
20120065154 | Pyrazolo Pyrimidine Derivatives and Methods of Use Thereof - This invention generally relates to pyrazolo pyrimidine derivatives useful as, inter alia, inhibitors of short chain dehydrogenase/reductase (SDR) family of NAD(P)(H) dependent oxido-reductases. More specifically, the invention relates to pyrazolo pyrimidine derivatives, including derivatives and analogs of SDR inhibitors, pharmaceutical compositions containing derivatives and analogs of SDR inhibitors, methods of making derivatives and analogs of SDR inhibitors and methods of use thereof. | 03-15-2012 |
20150031881 | PYRAZOLO PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF - This invention generally relates to pyrazolo pyrimidine derivatives useful as, inter alia, inhibitors of short chain dehydrogenase/reductase (SDR) family of NAD(P)(H) dependent oxido-reductases. More specifically, the invention relates to pyrazolo pyrimidine derivatives, including derivatives and analogs of SDR inhibitors, pharmaceutical compositions containing derivatives and analogs of SDR inhibitors, methods of making derivatives and analogs of SDR inhibitors and methods of use thereof. | 01-29-2015 |
Efram Burlingame, San Diego, CA US
Patent application number | Description | Published |
---|---|---|
20140091773 | SYSTEM AND METHOD FOR GENERATING A REGULATED BOOSTED VOLTAGE USING A CONTROLLED VARIABLE NUMBER OF CHARGE PUMP CIRCUITS - A system, method, and computer program product for generating a regulated boosted load voltage. A comparator may use reduced versions of a reference voltage, a supply voltage, and a fed-back output load voltage to determine whether the output load voltage requires adjustment. If so, a controller may responsively vary the number of voltage boosting charge pumps connected in parallel to the load to best match a target voltage. The target voltage may be the reference voltage plus the supply voltage. A counter may track the number of active charge pumps, and may increment or decrement the number more slowly than the charge pumps operate. Loop gain may be limited by an integrating filter to prevent oscillation. The embodiments are of particular utility for signal conversion circuitry as they eliminate difficulties arising from gate-source voltage inadequacies and differences in switch transistors. A wider range of reference voltages may be accommodated. | 04-03-2014 |
Gregory Burlingame, Woburn, MA US
Patent application number | Description | Published |
---|---|---|
20130163783 | SYSTEMS, METHODS, AND APPARATUS TO FILTER AUDIO - Systems, methods, and apparatus to filter audio are disclosed. An example device includes first and second audio speakers having first audio characteristics, a third audio speaker having second audio characteristics, wherein the third speaker is positioned between the first and second audio speakers, a first audio filter to process an audio input signal to have a first frequency response including a first cutoff frequency, the first audio filter to output a first audio output signal to the first audio speaker, and a second audio filter to process the audio input signal to have a second frequency response to compensate for interference between the first and second frequency responses caused by a position of the first audio speaker relative to the second audio speaker. | 06-27-2013 |
20140321669 | SYSTEMS, METHODS, AND APPARATUS TO FILTER AUDIO - Systems, methods, and apparatus to filter audio are disclosed. An example method includes determining that an orientation of a playback device is one of (a) a first orientation and (b) a second orientation, the playback device including a first speaker and a second speaker and configuring the first speaker and the second speaker. In the example, configuring the first and second speakers includes, when the determined orientation is the first orientation, configuring a first audio filter to be applied to a first audio signal for the first speaker and configuring a second audio filter to be applied to a second audio signal for the second speaker. However, when the determined orientation is the second orientation, configuring the first and second speakers includes configuring a third audio filter to be applied to the first audio signal and the second audio signal. | 10-30-2014 |
Gregory B. Burlingame, Woburn, MA US
Patent application number | Description | Published |
---|---|---|
20110044476 | SYSTEM TO GENERATE ELECTRICAL SIGNALS FOR A LOUDSPEAKER - The present disclosure describes an apparatus and a system for generating electrical signals for a loudspeaker. The loudspeaker may include one or more piezoelectric actuators configured to deflect a diaphragm of the loudspeaker in response to an input signal. The apparatus may be configured to receive the input signal and to drive the piezoelectric actuators to deflect the diaphragm based on the received input signal. | 02-24-2011 |
John J. Burlingame, Camas, WA US
Patent application number | Description | Published |
---|---|---|
20120297227 | Method and system for managing plug network based on appliance identification - A method and system for managing a plug network based on appliance identification. In a basic implementation, when a new appliance is activated on the plug network, a power usage profile for the new appliance is computed based on current and voltage measurements. The new appliance is classified into an appliance class based on the power usage profile. A power management action message respecting the new appliance is generated based on the class and is outputted. By judiciously configuring the power management actions applicable to different appliance classes, a business can monitor which types of appliances are attached by employees to power outlets and/or set the terms and conditions under which such appliances operate. | 11-22-2012 |
Lee John Burlingame, Toledo, OH US
Patent application number | Description | Published |
---|---|---|
20120247042 | BOARD WITH PRE-APPLIED SEALING MATERIAL - A board with preformed seals. In an exemplary embodiment, a sealing material is applied to at least one edge of a board to form a preformed seal on that edge. The board is configured such that when the board is attached to a frame adjacent to a another board, at least a portion of the sealing material applied to the edge of the board seals against at least a portion of an edge another board. In one exemplary embodiment, the boards are configured to seal against edges of substantially identical boards. A plurality of the sheathing boards may be installed on a building frame to form a sheathing system that provides a moisture and/or gas barrier between and interior and exterior of a building. | 10-04-2012 |
Michael J. Burlingame, East Liverpool, OH US
Patent application number | Description | Published |
---|---|---|
20090096231 | COLLAPSIBLE WORKBASKET ASSEMBLY - A workbasket assembly for surrounding and protecting a workman when cleaning or maintaining a tall structure such as a building, tank or silo. The workbasket assembly comprises a frame made up from a plurality of vertical uprights and horizontal rails connected together by a plurality of pivot tabs. The workbasket assembly may be collapsed for storage or transport purposes or so that it may be passed through a relatively small aperture in a structure such as a tank. When expanded, the workbasket assembly is engageable with a hoist-operable base that permits the workman to be safely raised or lowered relative to the structure being maintained. The frame is only movable to the fully collapsed condition when detached from the base. The workbasket assembly can be expanded and collapsed without the use of any tools. | 04-16-2009 |
Nicholas H. Burlingame, Belmont, NY US
Patent application number | Description | Published |
---|---|---|
20100076566 | Metal/alloy coated ceramic - Ceramic surface can be coated with a metal or metal alloy and have extraordinary holding power between the surface and coating. For example, MgTTZ can be coated with CPT and may have a static shear strength for the coated surface of at least about 2,000 or 3,000 or 5,000 or 7,000 pounds or greater. The coated ceramic may be a prosthetic surgical load bearing implant. | 03-25-2010 |
20120271427 | Ceramic manufactures - Prosthetic knee implant or implant component is made with a magnesium oxide stabilized transformationally toughened zirconia. | 10-25-2012 |
20120271429 | Ceramic manufactures - Fired magnesium oxide stabilized transformation toughened zirconia ceramic can be for or of an implant or implant component of a one-piece unicompartmental knee spacer device; a multi-piece unicompartmental joint aligning device; a temporal mandibular joint cap implant; a vertebra cap; an ankle joint ensemble or component; a bridge, a tooth or teeth; a patellofemoral joint implant; a tibial tray for a knee joint replacement implant; an intermediary articulation plate for a tibial tray and liner for a knee joint replacement implant; or the intermediary articulation plate assembled in combination with the tibial tray. | 10-25-2012 |
20120292832 | Ceramic manufactures - Prosthetic implant or component therefor of a magnesium oxide stabilized transformation toughened zirconia (Mg-TTZ) ceramic can be made by providing a bisqued initial green body by compressing powder through a cold isostatic press and heating to a bisque stage. Then, without embedding it in an embedding mass, the bisque is machined to have a shape of the same proportions as the shape of, but larger than, the ceramic portion of a fired prosthetic implant or component product. Firing can provide the fired Mg-TTZ ceramic body product. | 11-22-2012 |
20130171047 | METHOD FOR RECYCLING OF RARE EARTH AND ZIRCONIUM OXIDE MATERIALS - A method is presented for recovery, in reusable form, of rare earth minerals and zirconia from waste materials containing them. The method includes: mixing an ammonium sulfate powder and a powder containing the oxide waste material; heating the mixture to decompose the waste into a residue; dissolving the residue in water; separating rare earth constituents from the solution; and subsequently using the separated rare earth constituent (salt or solution) as a raw material. Moreover, the reactants used in the recovery may be recovered by appropriate precipitation and concentration operations. | 07-04-2013 |
20150313714 | Ceramic Manufactures - A ceramic body prosthetic implant or prosthetic implant component of a magnesium oxide stabilized transformation toughened zirconia (Mg-TTZ) ceramic can be made by providing a bisqued initial green body of ceramic by providing a powdered ceramic material, which substantially is a monoclinic zirconia having magnesium oxide for a stabilizer, and, without employing a binder additional to the powdered ceramic to do so, compressing the material in its powder form through a cold isostatic press operation to form a raw, pressed initial green body, and then heating the raw, pressed initial green body to a bisque stage to provide the bisqued initial green body. Then, the following further steps are carried out: without embedding the bisqued initial green body of ceramic in an embedding mass, machining the bisqued initial green body to provide a machined, bisqued green ceramic body such that the machined, bisqued green ceramic body has a shape, which is a precursor shape essentially analogous to, being of the same proportions as, the shape of, but larger than, the ceramic portion of a fired predetermined finished ceramic body prosthetic implant or prosthetic implant component; and then firing the machined, bisqued green ceramic body to provide a fired Mg-TTZ ceramic body product, which is the same size and shape or essentially the same size and shape as the ceramic portion of the fired predetermined finished ceramic body prosthetic implant or prosthetic implant component. | 11-05-2015 |
Richard Burlingame, Nocholasville, KY US
Patent application number | Description | Published |
---|---|---|
20140073020 | Sclareol and labdenediol diphosphate synthase polypeptides, encoding nucleic acid molecules and uses thereof - Provided are labdenediol diphosphate synthase polypeptides, sclareol synthase polypeptides, nucleic acid molecules encoding the labdenediol diphosphate synthase polypeptides and sclareol synthase polypeptides, and methods of using the labdenediol diphosphate synthase polypeptides, sclareol synthase polypeptides. Also provided are methods for producing labdenediol diphosphate, sclareol and (−)-ambroxide. | 03-13-2014 |
Richard Burlingame, Nicholasville, KY US
Patent application number | Description | Published |
---|---|---|
20100151519 | METHOD FOR PRODUCTION OF ISOPRENOIDS - The present invention is directed to variant squalene synthase enzymes, including | 06-17-2010 |
20100151555 | ISOPRENOID COMPOUNDS - The present invention is directed to variant squalene synthase enzymes, including | 06-17-2010 |
20130236943 | Method for production of isoprenoid compounds - The present invention is directed to variant squalene synthase enzymes, including | 09-12-2013 |
20140127754 | METHODS AND COMPOSITIONS FOR DEGRADATION OF LIGNOCELLULOSIC MATERIAL - Methods to convert lignocellulosic biomass to fermentable sugars with enzymes that degrade the lignocellulosic material are provided, as well as novel combinations of enzymes, including those that provide a synergistic release of sugars from plant biomass. | 05-08-2014 |
20140242658 | Method for production of isoprenoid compounds - The present invention is directed to variant squalene synthase enzymes, including | 08-28-2014 |
20140349352 | Sclareol and labdenediol diphosphate synthase polypeptides, encoding nucleic acid molecules and uses thereof - Provided are labdenediol diphosphate synthase polypeptides, sclareol synthase polypeptides, nucleic acid molecules encoding the labdenediol diphosphate synthase polypeptides and sclareol synthase polypeptides, and methods of using the labdenediol diphosphate synthase polypeptides, sclareol synthase polypeptides. Also provided are methods for producing labdenediol diphosphate, sclareol and (−)-ambroxide. | 11-27-2014 |
Richard P. Burlingame, Manitowoc, WI US
Patent application number | Description | Published |
---|---|---|
20090017520 | Process and Materials for Production of Glucosamine - The present invention relates to a method and materials for producing glucosamine by fermentation of a genetically modified microorganism. Included in the present invention are genetically modified microorganisms useful in the present method for producing glucosamine, as well as recombinant nucleic acid molecules and the proteins produces by such recombinant nucleic acid molecules. | 01-15-2009 |
20110237485 | Chrysosporium Cellulase and Methods of Use - The subject invention relates to novel compositions of neutral and/or alkaline cellulase and methods for obtaining neutral and/or alkaline cellulase compositions from | 09-29-2011 |
Richard P. Burlingame, Jupiter, FL US
Patent application number | Description | Published |
---|---|---|
20110045546 | Construction of Highly Efficient Cellulase Compositions for Enzymatic Hydrolysis of Cellulose - This invention provides novel enzyme compositions using newly identified and isolated | 02-24-2011 |
20110047656 | CONSTRUCTION OF HIGHLY EFFICIENT CELLULASE COMPOSITIONS FOR ENZYMATIC HYDROLYSIS OF CELLULOSE - This invention provides novel enzyme compositions using newly identified and isolated | 02-24-2011 |
20120030839 | Expression and High-Throughput Screening of Complex Expressed DNA Libraries in Filamentous Fungi - The invention provides a method for the expression and subsequent screening of DNA libraries, particularly synthetic, genomic, and cDNA libraries, in filamentous fungal hosts. In particular, the invention provides vectors, host strains, and a method for the expression and screening of complex DNA libraries, including, but not limited to, combinatory (combinatorial) libraries expressing one, two or more variable constituents and/or prepared from two or more sublibraries (e.g., for the expression and screening of immunoglobulin (including fragments and derivatives of whole immunoglobulin proteins) and other receptor or complex DNA libraries or libraries of libraries). The invention is useful for the expression and screening for a large variety of proteins and protein complexes, including human proteins. The present invention also relates to novel fungal protease sequences. | 02-02-2012 |
20150211013 | EXPRESSION AND HIGH-THROUGHPUT SCREENING OF COMPLEX EXPRESSED DNA LIBRARIES IN FILAMENTOUS FUNGI - The invention is generally directed to modified filamentous fungal host cells comprising one or more nucleic acids encoding one or more polypeptides under the control of one or more promoters that are functional in said cells. Methods of using the modified cells to express one or more polypeptides are also disclosed, including methods of screening cells transformed with one or more expression vectors comprising nucleic acids derived from synthetic or genomic nucleic acids including, cDNAs. Methods of purifying one or more polypeptides or complexes comprising one or more polypeptides expressed in the modified cells, intended for use as substrates in structure/function studies, as therapeutic agents, as diagnostic reagents, or as human or animal vaccines, are also disclosed. | 07-30-2015 |
Richard P. Burlingame, Nicholasville, KY US
Patent application number | Description | Published |
---|---|---|
20120246767 | Modified valencene synthase polypeptides, encoding nucleic acid molecules and uses thereof - Provided are modified valencene synthase polypeptides and methods of using the modified valencene synthase polypeptides. Also provided are methods for producing modified terpene synthases. | 09-27-2012 |
Richard Paul Burlingame, Nicholasville, KY US
Patent application number | Description | Published |
---|---|---|
20150376629 | FUNGAL PRODUCTION SYSTEM - The present invention provides a new fungal production system comprising a fungal host strain of | 12-31-2015 |
Richard Paul Burlingame, Jupiter, FL US
Patent application number | Description | Published |
---|---|---|
20120107856 | New Fungal Production System - The present invention provides a new fungal production system comprising a fungal host strain of | 05-03-2012 |
Richard Paul Burlingame, Manitowoc, WI US
Patent application number | Description | Published |
---|---|---|
20140127788 | TRANSFORMATION SYSTEM IN THE FIELD OF FILAMENTOUS FUNGAL HOSTS - A novel transformation system in the field of filamentous fungal hosts for expressing and secreting heterologous proteins or polypeptides is described. The invention also covers a process for producing large amounts of polypeptide or protein in an economical manner. The system comprises a transformed or transfected fungal strain of the genus | 05-08-2014 |
Robert Burlingame, Houston, TX US
Patent application number | Description | Published |
---|---|---|
20080202161 | METHOD FOR ADJUSTING HEATING VALUE OF LNG - Systems and methods for adjusting the heating value of liquefied natural gas (“LNG”) are provided. LNG can be apportioned into at least two portions. A first portion can be warmed to provide a vapor-liquid mixture which can be separated in a first separator to provide a first vapor and a first liquid. The first liquid can be separated to provide ANGL and a second vapor. The first vapor can be compressed and mixed with the second vapor to provide a first effluent. At least a portion of the first effluent can be used to heat the first portion. At least a portion of the first effluent can be used as a first reflux in the first separator. At least a portion of the first effluent can be mixed with a second portion of the LNG to provide an adjusted LNG. | 08-28-2008 |
20130099165 | Reforming Exchanger With Integrated Shift Conversion - Reforming exchangers for syngas production are provided. The reforming exchangers can have a shell-and-tube configuration and include a shift catalyst on the shell side of the exchanger to reduce a carbon monoxide concentration in a shell side product gas mixture. Processes for forming syngas using the reforming exchangers are also provided. | 04-25-2013 |
20130099166 | Reforming Exchanger System With Intermediate Shift Conversion - A reforming exchanger system for syngas production is provided. The reforming exchanger system can have a first and a second reforming exchanger, each with a shell-and-tube configuration, and a shift reactor located intermediate to the first and second reforming exchangers to reduce carbon monoxide concentration in the outlet gas. Processes for forming syngas using the reforming exchanger systems described herein are also provided. | 04-25-2013 |
20150224463 | REFORMING EXCHANGER WITH INTEGRATED SHIFT CONVERSION - Reforming exchangers for syngas production are provided. The reforming exchangers can have a shell-and-tube configuration and include a shift catalyst on the shell side of the exchanger to reduce a carbon monoxide concentration in a shell side product gas mixture. Processes for forming syngas using the reforming exchangers are also provided. | 08-13-2015 |
Robert G. Burlingame, Sherman, TX US
Patent application number | Description | Published |
---|---|---|
20090213282 | APPARATUS AND METHOD FOR ADJUSTABLE VARIABLE TRANSMISSIVITY POLARIZED EYEGLASSES - Adjustable variable transmissivity (AVT) eyeglasses for patients. In one embodiment, the eyeglasses include: (1) a frame having earpieces coupled thereto, (2) liquid crystal lenses coupled to the frame and configured to assume a transmissivity in response to a lens control signal, (3) a light sensor coupled to the frame and configured to sense light in a field of view and produce a sensor signal in response thereto, (4) a light plug coupled to the frame and configured to define a field of view and (5) an electronic circuit coupled to the frame and configured to employ the sensor signal to generate the lens control signal. | 08-27-2009 |
20090213283 | Apparatus and method for adjustable variable transmissivity polarized eye glasses - Adjustable variable transmissivity (AVT) eyewear for patients, the AVT eyewear having a liquid crystal lens driven by an electronics circuit so that light transmitted through the lens is detected, the transmitted light being driven to a setpoint by the electronics circuit according to feedback control on the liquid crystal lens drive voltage duty cycle. In another embodiment, light detected from the ambient is detected and the resulting photocurrent value processed by a microprocessor included in the electronics circuit, the microprocessor driving the liquid crystal lens to a desired transmissivity, the desired transmissivity given by a computed transmissivity curve. The computed transmissivity curve may be controlled by the physician or in an alternate embodiment controlled by the patient according to a set of electronic controls on the AVT eye glasses. | 08-27-2009 |
Robert Stevens Burlingame, Richmond, TX US
Patent application number | Description | Published |
---|---|---|
20100074812 | Low Pressure Drop Reforming Reactor - A syngas reforming reactor has a shell-and-tube configuration wherein the shell-side fluid flow path through the tube bundle has a longitudinal configuration. The reactor can include a shell-side inlet fluid distributor plate below the lower end of the tube bundle. The longitudinal flow configuration can provide a lower shell-side pressure drop and lower cost compared to a conventional cross-flow reforming exchanger | 03-25-2010 |
Rufus Burlingame, San Diego, CA US
Patent application number | Description | Published |
---|---|---|
20090176251 | Methods for Diagnosing Celiac Disease Based on the Level of Anti-Gliadin and Anti-tTG IgA and IgG Antibodies - The present invention is in the field of diagnosing celiac disease. More particularly, the present invention relates to a method to diagnose celiac disease based on the level of anti-gliadin and anti-tissue transglutaminase antibodies. | 07-09-2009 |
Samuel Burlingame, Belmont, NY US
Patent application number | Description | Published |
---|---|---|
20130171047 | METHOD FOR RECYCLING OF RARE EARTH AND ZIRCONIUM OXIDE MATERIALS - A method is presented for recovery, in reusable form, of rare earth minerals and zirconia from waste materials containing them. The method includes: mixing an ammonium sulfate powder and a powder containing the oxide waste material; heating the mixture to decompose the waste into a residue; dissolving the residue in water; separating rare earth constituents from the solution; and subsequently using the separated rare earth constituent (salt or solution) as a raw material. Moreover, the reactants used in the recovery may be recovered by appropriate precipitation and concentration operations. | 07-04-2013 |