Patent application number | Description | Published |
20110319352 | Compounds That Bind Oxysterol Binding Proteins, and Methods of Use Thereof - The invention relates in part to the discovery that certain CRAMs, such as schweinfurthin A, target OSBPs (a family of oxysterol binding proteins). Because OSBPs have been shown to be integral to atherosclerosis and Alzheimer's disease (AD), one aspect of the invention relates to the use of CRAMs, or a pharmaceutically acceptable salt, biologically active metabolite, solvate, hydrate, prodrug, enantiomer or stereoisomer thereof, in the treatment and/or prevention of atherosclerosis, Alzheimer's disease and related disorders. Another aspect of the invention relates to novel derivatives of CRAMs, or a pharmaceutically acceptable salt, biologically active metabolite, solvate, hydrate, prodrug, enantiomer or stereoisomer thereof, for the treatment and/or prevention of atherosclerosis, Alzheimer's disease and related disorders. Another aspect of the invention relates to the use of an immobilized CRAMs, such as OSW-I, to aid in screening of compounds to identify additional OSBP binders. Other aspects of the invention relate to the use of CRAMs to treat cancer, such as p21-deficient cancers. | 12-29-2011 |
Patent application number | Description | Published |
20130167952 | APPARATUS TO VISUALLY INDICATE A LEAK FROM A RELIEF VALVE - Apparatus to visually indicate a leak from a relief valve are disclosed. In one example, an apparatus is disclosed that includes a pipe plug having a head and a shaft. The pipe plug is to attach to a relief valve. An opening is to extend through the head and shaft. The apparatus also includes a first flexible membrane to cover an end of the opening. In some examples, the first flexible membrane is to expand when fluid is released via the relief valve into the opening of the pipe plug. | 07-04-2013 |
20130168580 | FAIL-SAFE APPARATUS FOR USE WITH FLUID VALVES - Fail-safe apparatus for use with fluid valves are disclosed herein. An example fail-safe apparatus includes a first piston, a second piston movably coupled relative to the first piston, and a fluid chamber between the first and second pistons to receive a control fluid. The control fluid is to operatively couple the first and second pistons when the control fluid is provided in the fluid chamber. The first piston is operatively decoupled from the second piston when at least some of the control fluid is removed from the fluid chamber. | 07-04-2013 |
20130168587 | MOUNTING ASSEMBLIES FOR USE WITH FLUID CONTROL DEVICES - Mounting assemblies for use with fluid control devices are disclosed. An example apparatus includes a bonnet to be coupled to a valve and a mounting assembly including a first side to be coupled to an actuator and a second side to be rotatably coupled at an end of the bonnet to enable a rotational position of the mounting assembly to change relative to the bonnet. | 07-04-2013 |
20150211552 | ELECTRONIC CONTROLLER WITH INTEGRAL VENT VALVE - An electronic regulator includes an inlet valve coupled to an inlet port, the inlet port configured to receive a supply pressure, and an exhaust valve coupled to an exhaust port, the exhaust port configured to release a pilot pressure when the exhaust valve is open. The electronic regulator also includes a pilot pressure output pneumatically coupled to the inlet valve and exhaust valve and configured to be coupled to an external process control device to provide the pilot pressure to the external process control device. A setpoint input coupled to both the inlet valve and the exhaust valve receives a setpoint signal indicative of a setpoint value, and the electronic regulator operates the inlet valve and the exhaust valve to control the pilot pressure according to the setpoint value. Further, the electronic regulator includes a vent valve coupled to a venting port and pneumatically coupled to the pilot pressure output. The venting port is configured to release the pilot pressure according to the safety control signal. | 07-30-2015 |
Patent application number | Description | Published |
20090071550 | IN-LINE ADJUSTABLE REGULATORS - Adjustable in-line fluid regulators are described. One described example fluid regulator includes a body having a fluid inlet and a fluid outlet. The example regulator also includes a first fluid regulator having a valve to control the flow of fluid from the inlet to the outlet, a piston coupled to the valve via a stem, wherein the piston is to receive a pressure associated with the outlet. The first fluid valve also includes a spring plate movable along a longitudinal axis of the stem, a spring disposed between the piston and the spring plate, and an adjuster engaged with the body to move the spring plate to change a compression of the spring and a regulated outlet pressure of the fluid regulator. | 03-19-2009 |
20100180959 | TEMPERATURE-CONTROLLED PRESSURE REGULATORS - Temperature-controlled pressure regulators are described. An example temperature-controlled pressure regulator described herein includes a regulator body having an inlet fluidly coupled to an outlet via a first passageway. A heat block is disposed within the regulator body and receives at least a portion of the first passageway. The heat block is to provide heat to the process fluid as the process fluid flows through the heat block via the first passageway, which separates the process fluid from the heat block. | 07-22-2010 |
20100180960 | TEMPERATURE-CONTROLLED PRESSURE REGULATORS - Temperature-controlled pressure regulators are described. An example temperature-controlled pressure regulator described herein includes a regulator body having a process fluid inlet fluidly coupled to a process fluid outlet via a first passageway and a heat transfer medium inlet to be fluidly coupled to a heat transfer medium outlet via a second passageway, where the heat transfer medium inlet is integrally formed with the regulator body. A heat chamber body is removably coupled to the regulator body to form a chamber between the heat transfer medium inlet and the heat transfer medium outlet. At least a portion of the first passageway is disposed within the chamber, and the chamber is to receive a heat transfer medium via the heat transfer medium inlet to provide heat to the process fluid as the process fluid flows through the chamber via the first passageway, which separates the process fluid from the heat transfer medium. | 07-22-2010 |
20100212757 | IN-LINE PRESSURE REGULATORS - In-line pressure regulators are described. An example in-line pressure regulator includes a body having threads to threadingly engage a port of another pressure regulator. The body defines an inlet, an aperture, and a seating surface. Additionally, the example in-line pressure regulator includes a piston assembly operatively coupled to a valve plug. The piston assembly is slidably movable relative to the body to move the valve plug relative to the aperture and the seating surface to control a flow of fluid between the inlet and the other regulator. Additionally, the piston assembly is to slidably and sealingly engage a surface of the port of the other pressure regulator. | 08-26-2010 |
Patent application number | Description | Published |
20080307943 | UNIVERSAL GRAND PIANO PIANO ACTION WITH SIMULTANEOUS HALF STROKE KEYBOARD DESIGN CAPABILITY - A universal grand piano piano action that has adjustable connections between the repetition base, heel, and rest cushion bracket of the piano action to provide a one-size-fits-all after-market replacement piano action for any grand piano. Other components of the grand piano piano action, such as the jack and flanges, may require specific design and manufacture for each brand of grand piano. This invention is the first piano action to allow for true simultaneous half stroke keyboard design for both the white and sharp keys of a piano and includes the method for installing such. | 12-18-2008 |
20090007750 | LOW INERTIA GRAND PIANO PIANO ACTION - Composite or plastic molded articles used in a grand piano piano action. The articles make up a piano action with less dynamic mass which is, thus, more responsive to the piano player. In addition, the new action provides the extremely valuable collateral benefits of increased efficiency of manufacture and maintenance. | 01-08-2009 |
20090178534 | HAMMER SHANK AND SHANK BUTT FOR PIANO - A hammer shank and shank butt for a grand piano with greatly improved rigidity and the collateral benefits of increased efficiency of manufacture and maintenance. Hammer shank comprises a long cylindrical member that is connected at one end to a traditional grand piano hammer and at the other end to a novel shank butt. Shank butt comprises: a hammer shank hole, a knuckle slot, a set of two flange attachment holes, and a void area. A traditional grand piano knuckle is attached to the knuckle slot. The shank butt is connected to the repetition flange of the piano. Thus, hammer shank is not directly connected to these members and thus can remain an integral cylindrical member without holes, notches, or voids, thereby allowing for a lighter, more rigid sub-member yielding hammer assembly with less mass. The invention provides the capability for a piano to be played with less touch weight on the keys and therefore provides a more responsive piano keyboard. The invention also allows for full “retrofitability” of hammer assembly into all existing grand piano brands. Embodiments include a composite shank butt that is a molded article and a composite hammer shank that is an extruded or molded article. | 07-16-2009 |
20090235804 | HAMMER ASSEMBLY FOR GRAND PIANO - A hammer assembly for a grand piano comprising: a hammer, a hammer shank, a tubular lever interface, and a moveable knuckle. A grand piano tubular lever interface comprises: a deep socket; a set of two hinge pin attachment holes; a void area; and a moveable knuckle visual location system. A moveable knuckle comprises: a spline; a resilient core; a synthetic buckskin wear surface, and a moveable knuckle visual location system. Novel hammer assembly allows for a direct lever relationship between hammer shank and knuckle without requirement of a forked end hammer shank with knuckle slot. Best mode spline comprises: an upright rectangular portion and a wide base portion, wherein wide base portion includes an intricate shape. Intricate shape comprises: at least one recess area and at least one protrusion area. The inverse of intricate shape is included on the bottom of the tubular lever interface. Moveable knuckle visual location system further comprises at least one pointer located on the moveable knuckle which fits snuggly into one of several notches on the tubular lever interface. Moveable knuckle can be visually located onto tubular lever interface at any one of multiple distinct locations along a range that runs parallel to the length of the hammer shank and the length of tubular lever interface. The moveable knuckle visual location system allows for custom configuration of a specifically dimensioned hammer assembly with custom “tubular lever interface center-to center” dimension to refurbish any brand of grand piano from one stock-set of hammer assembly components. | 09-24-2009 |
20130186250 | PIANO ACTION FLANGE WITH OPEN-SLOTTED RAIL ATTACHMENT FEATURE - A piano action flange with an open-slotted rail attachment feature that is a slot-shaped void completely through the piano action flange, running in the longitudinal direction of the piano action flange, with width slightly larger than the outer diameter of the thread end the flange screw but smaller that the head diameter of the flange screw, where the slot-shaped void is open on one end, breaking through the end of said piano action flange, to leave the slot-shaped void open and accessible from the end of the piano action flange. | 07-25-2013 |
20130186251 | MAIN ACTION RAIL FOR UPRIGHT PIANO WITH FRONT-ACCESSIBLE WHIPPEN FLANGE SCREW - An upright piano main action rail with a thinner cross section and relocated lower front surface so that when the main action rail is installed an the upright piano, the lower front surface of upright piano main action rail resides in the same location as the lower rear surface of prior art upright piano main action rails. An upright piano main action rail also has all whippen mounting holes located on the lower front surface instead of the lower rear surface as is traditional. | 07-25-2013 |
20130186252 | HAMMER BUTT FOR UPRIGHT PIANO ACTION WITH HALF-CONICAL HAMMER SHANK HOLE - A hammer butt for an upright piano with a half-conical hammer shank hole located on the top of said hammer butt which has a cylindrical-shaped cross section as viewed from the side of said hammer butt flange and a trapezoidal-shaped cross section as viewed from the front of said hammer butt, with the bottom of said half-conical hammer shank hole representing the short side of said trapezoidal-shaped front cross section. | 07-25-2013 |
20130247740 | DAMPER ACTION FOR UPRIGHT PIANO WITH SOSTENUTO SPRING TAB USING TENSION FROM THE DAMPER SPRING - A damper action for an upright piano that comprises a springed tab on the damper lever that “ratchets” or gives way or folds away in one direction and does not in the other, to provide retention when the spring tab passes by the longitudinal ridge on the sostenuto rod in one direction and non-retention when the spring tab passes by the longitudinal ridge on the sostenuto rod the other direction. The ratchet aspect of the spring tab uses tension from the damper spring and does not require a separate spring to apply tension to yield the ratchet effect. | 09-26-2013 |
20130247741 | LOST MOTION COMPENSATION DEVICE FOR AN UPRIGHT PIANO ACTION - Lost motion compensation device is a mechanical device that rigidly and pivotally connects the rest rail of an upright piano to the front end of the whippen of an upright piano to cause the two member to rotate in unison as the rest rail is rotated by depressing and releasing the soft pedal on an upright piano. | 09-26-2013 |
Patent application number | Description | Published |
20100094198 | SYSTEMS AND METHODS FOR TIGHTENING OPHTHALMIC SURGICAL NEEDLES - An ophthalmic surgery system includes a pump for generating fluid flow during ophthalmic surgery, a handpiece interface for providing control of a surgical handpiece, and a power wrench assembly for coupling to an ophthalmic surgical needle. The power wrench assembly is configured to rotate the ophthalmic surgical needle relative to the surgical handpiece until torque applied to the ophthalmic surgical needle is within a desired torque range. | 04-15-2010 |
20100296664 | EARPIECE SYSTEM - A system and method for providing earpieces includes an inventory of earpieces having a plurality of parameters and a device for making a non-contact ear measurement. An earpiece is selected from the inventory based on the non-contact measurement. | 11-25-2010 |
20130188804 | EARBUDS AND EARPHONES FOR PERSONAL SOUND SYSTEM - A personal sound system includes a portable electronic device that provides an analog audio signal to an audio output; an earphone system, connected by wire to the audio output, the portable electronic device, the earphone system including at least one earphone speaker; at least one control associated with the earphone system, the at least one control wirelessly linked to the portable electronic device so that operation of the at least control adjusts the balance between two or more frequency components of the analog audio signal provided to the at least one earphone. | 07-25-2013 |
20130336495 | EARPHONES AND EARBUDS WITH PHYSIOLOGIC SENSORS - An earphone with a physiologic sensor includes a housing; a speaker in the housing; an enhancer comprising a body mounted on the housing and adapted to be secured in the ear to acoustically couple the speaker to the user's ear; and an optical physiologic sensor disposed inside the enhancer, the enhancer having an aperture or window aligned with the optical physiologic sensor, so that the sensor can optically couple with the user's ear when the enhancer is secured in the user's ear. | 12-19-2013 |
20140119590 | SPLITTER FOR EARPHONES AND HEADPHONES - A set of earphones includes a splitter having a splitter body, having first and second ends. A signal wire extends from the first end of the splitter. Left and right earphone wires extending from the second end of the splitter. A sleeve projecting from the second end of the splitter, surrounding the left and right earphone wires. A cinch is slidably mounted on the left and right earphone wires, a portion of the cinch is adapted to fit in the sleeve projecting from the second end of the elongate body, for stowing the cinch when not in use. | 05-01-2014 |
20140270315 | EARPHONES - An earphone is provided that includes a generally conical housing having generally circular front face adapted to be seated in the concha of the user's ear. The housing tapers away from the front face toward the rear of the housing. A wire guide extends from the rear of the housing, generally transversely to the axis of the housing. A speaker is disposed in the housing. A first resilient portion is disposed on the sidewall of the housing, opposite from the wire guide forming a first contact surface. A second resilient portion is disposed on the sidewall of the housing, opposite from the first resilient portion. The second resilient portion extends sufficiently circumferentially around the housing to form first and second contact surfaces disposed on opposite sides of the wire guide. The first, second, and third contact surfaces allowing the housing to be grasped between the thumb and two fingers of the user to facilitate insertion of the front portion of the housing into the user's ear. | 09-18-2014 |
20140270317 | BEHIND THE EAR EARPHONE - A behind-the-ear mountable earphone includes a generally C-shaped ear support. The support has a first section extending between a first end and the top of the “C”, adapted to fit behind the user's ear, and a second section extending from the top of the “C” to a second end. The second section is in a plane different from the first section, so that when the first section is behind the user's ear, the second section extends over the front of the user's ear. An earphone is telescopingly mounted on the second end of the C-shaped support. The earphone comprising a generally circular face adapted to be received in the concha of the user's ear, the generally circular face disposed at an angle with respect to the first section of the generally C-shaped support. | 09-18-2014 |
20140273925 | CLOSED LOOP ATHLETE TRAINING SYSTEM - An athletic training system includes a personal electronic device having a processor, a memory, and a GPS sensor. The processor runs an application that calculates at least one of distance traveled, elevation change, and speed, of the user carrying the personal electronic device, and based upon location information obtained from the GPS sensor provides a training-related message to the user based upon at least one of the calculated distance traveled, elevation change, and speed. | 09-18-2014 |
20140307891 | WIRELESS HEADPHONES - Wireless headphones include left and right earphones connected by a cable. Each of the left and right earphones comprising a generally C-shaped body adapted to fit behind the user's ear, with a concave inner edge, a convex outer edge, a first end that is positioned generally adjacent the top of the user's ear and a second end positioned generally adjacent the bottom of the user's ear when the body is positioned behind the user's ear. A speaker having a sound tunnel associated therewith adapted to fit in the ear canal of the wearer; a resilient support extending forwardly and downwardly from the top end of the C-shaped body, the support normally supporting the speaker in a position which, when the C-shaped body behind the user's ear, is misaligned with the user's ear canal, but resiliently deflects to allow the sound tunnel to align with and be inserted into the user's ear canal, thereby resiliently biasing the C-shaped body against the user's head. | 10-16-2014 |
20150030194 | EARPIECE SYSTEM - An earbud adapter or in-ear monitor includes an Ear Interface that fits the human ear and further permits the wearer of these devices to adjust parameters of the fit. In additional aspects, the Ear Interface portion of these devices permits the user to adjust the transmission of ambient sound. The Ear Interface portion also allows the user to change ornamentation. | 01-29-2015 |
20150230016 | CINCH - A cable cinch for an earphone cable includes first and second cinch elements. The first element has a top and a bottom with a sidewall therebetween, front and rear openings in the sidewall, and first and second posts extending between the top and bottom walls, intermediate the front and rear openings. The second element has a top and a bottom with a sidewall therebetween, front and rear openings in the sidewall, and first and second posts extending between the top and bottom walls, intermediate the front and rear openings. The first and second elements are arranged with their rear openings facing toward each other to define a generally S-shaped cable path between the front openings of the first and second elements, the cable path extending from the front opening of the first element between a post and the sidewall of the first element and out the rear opening of the first element, through the rear opening of the second element, around a post in the second cinch element and back out the rear opening of the second cinch element, into rear opening of the first element, around a post in the first element, and out the rear opening of the first element, into the rear opening of the second element, between a post and the sidewall of the second element, and out the front opening of the second cinch element, the cable extending through the generally S-shaped cable path. | 08-13-2015 |
20150281827 | VARIABLE OCCLUSION HEADPHONES - An adjustable occlusion headphone includes a housing having a face, a resilient seal member on the housing, adapted to surround the user's ear, and with the face of the housing form a chamber enclosing the user's ear. A speaker communicates through the face of the housing to provide sound to the user's ear. There is at least one port in the face of the housing. A passage extends from each port to the exterior of the housing. A valve member associated with each passage, is operable between an open position and a closed position, and an operator for operating each valve member between its open and closed position to control sound communication from outside the housing to the chamber. | 10-01-2015 |