Patent application number | Description | Published |
20080226645 | Methods and compositions for assessment and treatment of asthma - The present invention provides methods and compositions for the assessment and treatment of asthma and other inflammatory diseases, particularly those mediated by interleukin-13 (IL-13). The present invention also provides arrays comprising markers for asthma as well as IL-13 responsiveness. The markers of the present invention can be used in methods to diagnose a patient as having asthma or an IL-13-mediated condition, to evaluate the effectiveness of potential therapeutic agents, to identify or evaluate agents capable of modulating marker expression levels, and to select a treatment for a patient suffering from asthma or an IL-13-mediated condition. | 09-18-2008 |
20080280774 | Methods and Systems for Diagnosis, Prognosis and Selection of Treatment of Leukemia - The present invention provides methods, systems and equipment for the prognosis, diagnosis and selection of treatment of AML or other types of leukemia. Genes prognostic of clinical outcome of leukemia patients can be identified according to the present invention. Leukemia disease genes can also be identified according to the present invention. These genes are differentially expressed in PBMCs of AML patients relative to disease-free humans. These genes can be used for the diagnosis or monitoring the development, progression or treatment of AML. | 11-13-2008 |
20090061423 | PHARMACOGENOMIC MARKERS FOR PROGNOSIS OF SOLID TUMORS - The present invention provides methods, systems and equipment for prognosis or evaluation of treatment of solid tumors. Gene markers that are prognostic of solid tumors can be identified according to the present invention. Each gene marker has altered expression patterns in PBMCs of solid tumor patients following initiation of an anti-cancer treatment, and the magnitudes of these alterations are correlated with clinical outcomes of these patients. In one embodiment, a Cox proportional hazards model is used to determine the correlations between clinical outcomes of RCC patients and gene expression changes in PBMCs of these patients during the course of a CCI-779 treatment. Non-limiting examples of genes identified by the Cox model are depicted in Tables 4A3 4B, 5 A and 5B. These genes can be used as surrogate markers for prognosis of RCC. They can also be used as pharmacogenomic indicators for the efficacy of CCI-779 or other anti-cancer drugs. | 03-05-2009 |
Patent application number | Description | Published |
20120096754 | BREECH PLUG CLEANING TOOL - A cleaning tool set is used to clean carbon build-up from a breech plug. The cleaning tool set includes a first tool configured to remove the carbon buildup from the primer pocket and intermediate flash channel of the breech plug and a second tool configured to remove carbon buildup from the flash hole of the breech plug. | 04-26-2012 |
20130025490 | THREE COMPONENT BULLET WITH CORE RETENTION FEATURE AND METHOD OF MANUFACTURING THE BULLET - A three component bullet with an improved core retention feature and a method of manufacturing the bullet is described including a cylindrical jacket having an open end and a closed end containing a malleable metal core which is forced into a forming die having a bottleneck shaped interior resulting in a bottleneck shaped pre-form wherein the outside diameter of the open-ended forward portion of the jacket is smaller than the outside diameter of its closed rearward portion. The open end of the pre-form may be dropped through or forced through a malleable locking band of appropriate height, diameter and wall thickness. A relatively tight-fitting punch enters the open end of the pre-form generating sufficient axial force against the face of the metal core to radially swell the core and subsequently portions of the jacket fore and aft of the locking band, thereby securing the locking band in place while at the same time producing an inwardly-extending annular band of jacket material which embeds itself into the core material with the result that the core is permanently locked inside the jacket. | 01-31-2013 |
20140230683 | REDUCED FRICTION EXPANDING BULLET WITH IMPROVED CORE RETENTION FEATURE AND METHOD OF MANUFACTURING THE BULLET - A low-cost, reduced friction expanding bullet with an improved core retention feature and a method of manufacturing the bullet is described wherein a cylindrical jacket containing a compacted malleable metal core having an open end and a closed end is forced into a forming die having a bottleneck shaped interior resulting in a bottleneck shaped pre-form wherein the outside diameter of the open-ended forward portion of the jacket is smaller than the outside diameter of its closed rearward portion and wherein a transition shoulder separates the two diameters. The pre-form is then placed in a profile die wherein a base punch exerts an axial force against said pre-form which axially collapses a portion of the jacket wall forward of the transition shoulder subsequently forcing said portion of the jacket wall radially inwardly providing a reduction in bearing surface and forming an internal core-locking radius while at the same time forming an ogival bullet nose. The bullet thus formed provides reduced friction and ultimately higher muzzle velocity per any given chamber pressure level while also providing a core-locking feature comprising a wide-area, circumferential indentation which serves as a living hinge that ultimately expedites uniform bullet expansion. | 08-21-2014 |
20140311372 | MULTI-COMPONENT BULLET WITH CORE RETENTION FEATURE AND METHOD OF MANUFACTURING THE BULLET - A three component bullet with an improved core retention feature and a method of manufacturing the bullet includes a cylindrical jacket having an open end and a closed end containing a malleable metal core which is forced into a forming die having a bottleneck shaped interior, wherein the outside diameter of the open-ended forward portion of the jacket is smaller than the outside diameter of its closed rearward portion. The open end of the pre-form may be dropped through or forced through a malleable non-rigid locking band. A relatively tight-fitting punch enters the open end of the pre-form, to radially swell the core and subsequently portions of the jacket fore and aft of the non-rigid locking band, thereby securing the non-rigid locking band in place. An inwardly-extending annular band of jacket material embeds itself into the core material to lock the core inside the jacket. | 10-23-2014 |
20140331885 | THREE COMPONENT BULLET WITH CORE RETENTION FEATURE AND METHOD OF MANUFACTURING THE BULLET - A three component bullet with a core retention feature and a method of forming the bullet is described. The bullet can include a jacket surrounding a core and a locking band disposed around a circumference of the jacket and the core. The locking band can be received in a circumferential depression formed in the jacket and the core such as by compressing the core to cause the core and the jacket to expand radially fore and aft of the locking band. The circumferential depression can include shoulders that are in compressive engagement with the locking band to help secure the locking band in place. The circumferential depression can include an inwardly-extending annular band of jacket material which embeds itself into the core material with the result that the core is locked inside the jacket. | 11-13-2014 |