Brough, US
Andrew Winslow Brough, Redmond, WA US
Patent application number | Description | Published |
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20140171129 | LOCATION CONTEXT, SUPPLEMENTAL INFORMATION, AND SUGGESTIONS FOR MEETING LOCATIONS - Enhanced input field features and techniques for displaying and resolving location information in meeting items are provided. In response to a user's interaction with a place name displayed in the location field of a user interface for a meeting item, up to date information is retrieved about the location associated with the place name from a web service and displayed. The display can include a map image tile. In addition to enabling the displaying of up to date information, during creation of the meeting item, the location input field of a meeting item can present location suggestions from within the location input field, for example, as a drop-down listing of possible locations. The suggestions for completing a user's input text string to the location input field can be obtained from sources such as a web service, a mailbox, a managed database/directory service, a history cache/database or a combination thereof. | 06-19-2014 |
Chris Brough, Temple, TX US
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20100084787 | Composite Load Bearing Structure - A composite load bearing member is provided comprising an elongated inner structural member and a thick polymeric composite outer member. An apparatus for producing the composite load bearing member is provided including devices for suspending the inner structural member within a mold cavity prior to and during injection of the polymeric composite outer member. A method of using the apparatus to produce the composite load bearing member is provided. | 04-08-2010 |
Chris Brough, Austin, TX US
Patent application number | Description | Published |
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20090053315 | Thermo-Kinetic Mixing for Pharmaceutical Applications - Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding. | 02-26-2009 |
20130303630 | Thermo-Kinetic Mixing for Pharmaceutical Applications - Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding. | 11-14-2013 |
20140039031 | PHARMACEUTICAL FORMULATIONS OF ACETYL-11-KETO-B-BOSWELLIC ACID, DIINDOLYLMETHANE, AND CURCUMIN FOR PHARMACEUTICAL APPLICATIONS - The present disclosure is directed to compositions and methods for formulating a pharmaceutical dosage form by forming a composition comprising acetyl-11-keto-β-boswellic acid, diindolylmethane, or curcumin with one or more pharmaceutically acceptable excipients for enhanced solubility to increase bioavailability and improve therapeutic efficacy. The composition can be processed by thermo-kinetic compounding along with conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding. | 02-06-2014 |
David B. Brough, Las Vegas, NV US
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20160047097 | SNOW FLIPPER - A snow flipper for clearing snow. The snow flipper includes a blade. The snow flipper also includes a handle attached the blade. The handle includes a first portion, a second portion attached to the second portion and a bend creating a vertical portion of the handle. The snow flipper further includes a handgrip. The handgrip is movably secured to the handle, telescopes relative to the handle and provides a gripping surface for the user. The snow flipper additionally includes a flat spring attached to the vertical portion of the handle. The flat spring includes a curved piece of rigid material configured to deform under a force, return to its initial shape upon removal of the force and cause downward motion of the handgrip to result in motion that is upward and away from the user. The snow flipper moreover includes a wheel attached near one end of the flat spring. | 02-18-2016 |
Douglas Brough, Gaithersburg, MD US
Patent application number | Description | Published |
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20120225470 | METHODS OF PROPAGATING MONKEY ADENOVIRAL VECTORS - The invention provides methods for propagating a monkey adenovirus in a cell including a human cell, comprising one or more gene products isolated from a human adenovirus. Also provided are methods for propagating wherein the monkey adenovirus comprises a nucleic acid sequence encoding a human adenovirus gene product. The invention further provides a monkey adenovirus. including a replication-deficient monkey adenovirus, obtained by such propagation methods. | 09-06-2012 |
20150297699 | MALARIA ANTIGENS AND METHODS OF USE - The invention is directed to a composition comprising one or more polypeptides or one or more nucleic acid sequences that can induce a protective immune response against | 10-22-2015 |
20150329834 | METHODS OF PROPAGATING MONKEY ADENOVIRAL VECTORS - The invention provides methods for propagating a monkey adenovirus in a cell, including a human cell, comprising one or more gene products isolated from a human adenovirus. Also provided are methods for propagating wherein the monkey adenovirus comprises a nucleic acid sequence encoding a human adenovirus gene product. The invention further provides a monkey adenovirus, including a replication-deficient monkey adenovirus, obtained by such propagation methods. | 11-19-2015 |
Douglas E. Brough, Gaithersburg, MD US
Patent application number | Description | Published |
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20080233650 | Method for propagating adenoviral vectors encoding inhibitory gene products - The invention provides a method of propagating an adenoviral vector. The method comprises (a) providing a cell comprising a cellular genome comprising a nucleic acid sequence encoding a tetracycline operon repressor protein (tetR), and (b) contacting the cell with an adenoviral vector comprising a heterologous nucleic acid sequence encoding a toxic protein. The heterologous nucleic acid sequence is operably linked to a promoter and one or more tetracycline operon operator sequences (tetO), and expression of the heterologous nucleic acid sequence is inhibited in the presence of tetR, such that the adenoviral vector is propagated. The invention also provides a system comprising the aforementioned cell and adenoviral vector. | 09-25-2008 |
20090018100 | MATERIALS AND METHODS FOR TREATING OCULAR-RELATED DISORDERS - The present invention is directed to a method of prophylactically or therapeutically treating an animal for at least one ocular-related disorder, e.g., ocular neovascularization or age-related macular degeneration. The method comprises contacting an ocular cell with an expression vector comprising a nucleic acid sequence encoding an inhibitor of angiogenesis and the same or different nucleic acid sequence encoding a neurotrophic agent. The method also can comprise contacting an ocular cell with different expression vectors, each comprising a nucleic acid sequence encoding an inhibitor of angiogenesis and/or a nucleic acid sequence encoding a neurotrophic agent. In addition, the present invention provides a viral vector comprising a nucleic acid sequence encoding pigment epithelium-derived factor (PEDF) or a therapeutic fragment thereof. | 01-15-2009 |
20090041759 | Materials and methods for treating ocular-related disorders - The invention is directed to a method of delivering a gene product to an animal. The method comprises administering an expression vector comprising a nucleic acid sequence operably linked to a promoter and encoding a gene product, and upregulating transcription of the nucleic acid sequence in the ocular cell. The expression vector can be an adenoviral vector. The invention further provides a method of prophylactically or therapeutically treating an animal for at least one ocular-related disorder. The method comprises contacting an ocular cell with an expression vector comprising a nucleic acid sequence encoding an inhibitor of angiogenesis and/or a neurotrophic agent. In one aspect, the method further comprises upregulating transcription of the nucleic acid sequence. Preferably, if 2×10 | 02-12-2009 |
20090264509 | Adenoviral vector-based foot-and-mouth disease vaccine - The invention is directed to an adenoviral vector comprising at least one nucleic acid sequence encoding an | 10-22-2009 |
20100222234 | Malaria antigen screening method - The invention provides a method of identifying an antigen from a pathogen or a disease antigen comprising the use of an adenoviral vector array comprising two or more different adenoviral vectors, wherein each adenoviral vector comprises a nucleic acid sequence encoding a different antigen of a pathogen. The adenoviral vectors are administered to antigen presenting cells (APCs) in vitro or to an animal in vivo. The immunogenicity of the antigen is measured by screening for an immune response from effector T lymphocytes in vitro and by screening for the absence of pathogen-induced disease onset in vivo. | 09-02-2010 |
20120316226 | METHODS OF GENE THERAPY FOR TREATING DISORDERS OF THE EAR BY ADMINISTERING A VECTOR ENCODING AN ATONAL-ASSOCIATED FACTOR - The invention is directed to a method of changing the sensory perception of an animal. The method comprises administering an expression vector comprising a nucleic acid sequence encoding an atonal-associated factor, which is expressed to produce the atonal-associated factor resulting in generation of hair cells that allow perception of stimuli in the inner ear. Also provided is a method of generating a hair cell in differentiated sensory epithelia in vivo. The method comprises contacting differentiated sensory epithelial cells with an adenoviral vector (a) deficient in one or more replication-essential gene functions of the E1 region and E4 region, (b) comprising a spacer in the E4 region, and (c) comprising a nucleic acid sequence encoding an atonal-associated factor. The nucleic acid sequence is expressed to produce the atonal-associated factor such that a hair cell is generated. An adenoviral vector encoding an atonal-associated factor also is provided. | 12-13-2012 |
20130337008 | ADENOVIRAL VECTOR-BASED DENGUE FEVER VACCINE - The invention relates to a replication-deficient adenoviral vector comprising two or more nucleic acid sequences encoding Dengue virus antigens and a chimeric hexon protein. The chimeric hexon protein comprises a first portion and a second portion. The first portion comprises at least 10 contiguous amino acid residues from a first adenovirus serotype (e.g., serotype 5 adenovirus hexon protein), optionally with one amino acid substitution. The second portion comprises (a) at least one hypervariable region (HVR) of a hexon protein of an adenovirus of a second adenovirus serotype, or (b) at least one synthetic hypervariable region (HVR) that is not present in the hexon protein of the wild-type adenovirus of the first adenovirus serotype. | 12-19-2013 |
20140005257 | METHODS OF GENE THERAPY FOR TREATING DISORDERS OF THE EAR BY ADMINISTERING A VECTOR ENCODING AN ATONAL-ASSOCIATED FACTOR | 01-02-2014 |
20140248307 | AFFENADENOVIRUS (GORILLA) OR ADENOVIRAL VECTORS AND METHODS OF USE - The invention provides an adenovirus or adenoviral vector characterized by comprising one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pIX protein, DNA polymerase protein, penton protein, hexon protein, and/or fiber protein. | 09-04-2014 |
20140248308 | AFFENADENOVIRUS (GORILLA) OR ADENOVIRAL VECTORS AND METHODS OF USE - The invention provides an adenovirus or adenoviral vector characterized by comprising one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pIX protein, DNA polymerase protein, penton protein, hexon protein, and/or fiber protein. | 09-04-2014 |
20140271711 | ADENOVIRAL VECTOR-BASED RESPIRATORY SYNCYTIAL VIRUS (RSV) VACCINE - The invention provides an adenovirus or adenoviral vector characterized by comprising a nucleic acid sequence encoding one or more Respiratory Syncytial Virus (RSV) antigens and one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pIX protein, DNA polymerase protein, penton protein, hexon protein, and/or fiber protein, as well as a method of inducing an immune response against RSV in a mammal by administering the adenovirus or adenoviral vector to the mammal. | 09-18-2014 |
20140273228 | METHOD FOR PROPAGATING ADENOVIRAL VECTORS ENCODING INHIBITORY GENE PRODUCTS - The invention provides a method of propagating an adenoviral vector. The method comprises (a) providing a cell comprising a cellular genome comprising a nucleic acid sequence encoding a tetracycline operon repressor protein (tetR), and (b) contacting the cell with an adenoviral vector comprising a heterologous nucleic acid sequence encoding a toxic protein. The heterologous nucleic acid sequence is operably linked to a promoter and one or more tetracycline operon operator sequences (tetO), and expression of the heterologous nucleic acid sequence is inhibited in the presence of tetR, such that the adenoviral vector is propagated. The invention also provides a system comprising the aforementioned cell and adenoviral vector. | 09-18-2014 |
20140314717 | SIMIAN (GORILLA) ADENOVIRUS OR ADENOVIRAL VECTORS AND METHODS OF USE - The invention provides an adenovirus or adenoviral vector characterized by comprising one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pIX protein, DNA polymerase protein, penton protein, hexon protein, and/or fiber protein. | 10-23-2014 |
20140314809 | MALARIA ANTIGEN SCREENING METHOD - The invention provides a method of identifying an antigen from a pathogen or a disease antigen comprising the use of an adenoviral vector array comprising two or more different adenoviral vectors, wherein each adenoviral vector comprises a nucleic acid sequence encoding a different antigen of a pathogen. The adenoviral vectors are administered to antigen presenting cells (APCs) in vitro or to an animal in vivo. The immunogenicity of the antigen is measured by screening for an immune response from effector T lymphocytes in vitro and by screening for the absence of pathogen-induced disease onset in vivo. | 10-23-2014 |
20150140025 | HERPES SIMPLEX VIRUS VACCINE - Herpes Simplex Virus (HSV) antigens that elicit an HSV-specific immune response and can be used to treat or prevent HSV infection are provided. Nucleic acid sequences, polypeptides, vectors, and compositions, as well as methods to induce an immune response against HSV, treat or prevent HSV disease, induce a T cell response against HSV, and induce an antibody response against HSV also are provided. | 05-21-2015 |
20150157700 | ADENOVIRAL VECTOR-BASED MALARIA VACCINE - The invention provides an adenovirus or adenoviral vector characterized by comprising a nucleic acid sequence encoding one or more | 06-11-2015 |
20160102320 | ADENOVIRAL VECTOR ENCODING HUMAN ATONAL HOMOLOG-1 (HATH1) - The invention is directed to a replication-deficient adenoviral vector comprising a nucleic acid sequence encoding a human atonal homolog-1 (Hath1) protein operably linked to a human glial fibrillary acidic protein (GFAP) promoter. The invention also is directed to a composition and method utilizing the adenoviral vector to generate sensory cells in the inner ear of a human. | 04-14-2016 |
Farrell Lynn Brough, West Jordan, UT US
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20110208778 | MANAGING DIGITAL IDENTITY INFORMATION - A basic architecture for managing digital identity information in a network such as the World Wide Web is provided. A user of the architecture can organize his or her information into one or more profiles which reflect the nature of different relationships between the user and other entities, and grant or deny each entity access to a given profile. Various enhancements which may be provided through the architecture are also described, including tools for filtering email, controlling access to user web pages, locating other users and making one's own location known, browsing or mailing anonymously, filling in web forms automatically with information already provided once by hand, logging in automatically, securely logging in to multiple sites with a single password and doing so from any machine on the network, and other enhancements. | 08-25-2011 |
George Brough, Wake Forest, NC US
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20120141502 | ANTIBODIES SPECIFIC TO E6 PROTEINS OF HPV AND USE THEREOF - The subject invention provides an antibody composition for detecting E6 protein of at least one HPV strain in a sample. The subject antibodies may be used to detect oncogenic HPV E6 proteins in a sample, and the antibodies find use in a variety of diagnostic and therapeutic applications, including methods of diagnosing and treating cancer. Kits for performing the subject methods and containing the subject antibodies are also provided. Also disclosed in the present invention is a method of generating an antibody that specifically binds to amino-terminus of E6 proteins of at least two HPV strains. | 06-07-2012 |
20150153345 | ANTIBODIES SPECIFIC TO E6 PROTEINS OF HPV AND USE THEREOF - The subject invention provides an antibody composition for detecting E6 protein of at least one HPV strain in a sample. The subject antibodies may be used to detect oncogenic HPV E6 proteins in a sample, and the antibodies find use in a variety of diagnostic and therapeutic applications, including methods of diagnosing and treating cancer. Kits for performing the subject methods and containing the subject antibodies are also provided. Also disclosed in the present invention is a method of generating an antibody that specifically binds to amino-terminus of E6 proteins of at least two HPV strains. | 06-04-2015 |
Hans Brough, San Carlos, CA US
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20120066618 | CAROUSEL OF THE NEW - In a method of ranking or filtering new content items for presentation to members of a group of users of a social-networking service, content items that are candidates for presentation to the members are received. A user of the social-networking service is enabled to serve as a curator of the candidates, with the enabling including enabling the user to scroll through subsets of the candidates in a carousel user interface to indicate an opinion of the user with respect to an importance to the group of each of one or more candidates. One or more of the candidates are presented to the members of the group based on the opinion of the user with respect to the candidates. | 03-15-2012 |
20150082200 | PRESENTING CONTENT ITEMS RELEVANT TO A GROUP OF USERS - In a method of ranking or filtering new content items for presentation to members of a group of users of a social-networking service, content items that are candidates for presentation to the members are received. A user of the social-networking service is enabled to serve as a curator of the candidates, with the enabling including enabling the user to scroll through subsets of the candidates in a carousel user interface to indicate an opinion of the user with respect to an importance to the group of each of one or more candidates. One or more of the candidates are presented to the members of the group based on the opinion of the user with respect to the candidates. | 03-19-2015 |
Mala Brough, Fort Worth, TX US
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20130318579 | Method of Initiating Randomized Communication Links among Persons Belonging To an Organization by Executing Computer-Executable Instructions Stored On a Non-Transitory Computer-Readable Medium - A method of initiating randomized communication links among persons belonging to an organization by executing computer-executable instructions stored on a non-transitory computer-readable medium allows members within an organization to submit requests to be engaged with other organization members for various activities such as eating or exercising. Engagement requests specify a time frame and a location to meet with other users. Engagement requests are time dependent and confined to a particular location. Engagements may be randomized, or prioritized for members who have not previously engaged with each other and filtered based on various other criteria. | 11-28-2013 |
Michael Brough, Aliso Viejo, CA US
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20150071619 | METHOD FOR EDITING MULTIPLE VIDEO FILES AND MATCHING THEM TO AUDIO FILES - A software application for mobile devices enables users to easily create a fully-edited short video by combining video clips of various lengths to form a final video that resembles a Hollywood-style, professionally edited video clip. The videos are automatically edited to the music cuts using pre-programmed storyboards and transitions that align with the user's thematic selection. There are few steps involved in the process making for a user-friendly experience. The professional style video clip is produced on a user's phone in only 45 seconds and can then be shared with friends via email, YouTube, Facebook and other forms of social media. | 03-12-2015 |
20150133076 | Mobile device application monitoring software - A software application for monitoring the performance of other software applications on mobile devices using efficient crowd sourced data and efficient proxies for performance of the applications. | 05-14-2015 |
20150363289 | Mobile device application monitoring software - A software application for monitoring the performance of other software applications on mobile devices using efficient crowd sourced data and recommending third party software apps based on a user's demographics and mobile device data. | 12-17-2015 |
Paul B. Brough, Marlborough, MA US
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20130041690 | HEALTH CARD REWARD SYSTEM - A system for the management of the interaction between the patient and health care providers and of the patient's medical records. The patient receives reward points for using the program that involves selecting health-care providers from a preferred list. The system employs a smartcard that securely identifies the patient, securely carries the patient's medical records in memory, and carries the records of the patient's reward points. Each healthcare provider has highly-secure equipment that allows the reading from and writing to the smartcard. The system is managed by a remote central computer system that operates over a global communication network. | 02-14-2013 |
Richard Brough, Henderson, NV US
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20130331148 | Image Modifying Assembly for Smart Devices - An image modifying assembly for connection to a smart device, such as a smartphone or smartpad, is disclosed. The assembly includes an adapter case for receiving the smart device, a connector attached to the adapter case, a locking collar operably associated with the connector for removable attachment thereto, and a clamping device having a first clamping portion for connection to the locking collar, a second clamping portion spaced from the first clamping portion, and a bore extending between the first and second clamping portions. The bore together with the locking collar and opening provide an optical path for the camera associated with the smart device. The second clamping portion is adapted for connection to an image modifying device, such as a spotting scope, lens, night vision monocular, and so on, to thereby modify an image before it is received by the camera. | 12-12-2013 |
Richard A. Brough, Wingdale, NY US
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20080230154 | ABSORBER LAYER FOR DSA PROCESSING - A method of processing a substrate comprising depositing a layer comprising amorphous carbon on the substrate and then laser annealing the substrate is provided. Optionally, the layer further comprises a dopant selected from the group consisting of nitrogen, boron, phosphorus, fluorine, and combinations thereof. In one aspect, the layer comprising amorphous carbon is an anti-reflective coating and an absorber layer that absorbs electromagnetic radiation emitted by the laser and anneals a top surface layer of the substrate. | 09-25-2008 |
Thomas Charles Brough, High Point, NC US
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20090221408 | RAPID FILM BONDING USING PATTERN PRINTED ADHESIVE - Various processes for the creation of a film to film bond using printed patterns of adhesive traces. In some implementations of the process, control of the process including control of the temperature of the adhesive and film to a temperature approaching the heat distortion temperature for the film will vary the strength of the bond from a frangible bond to a bond the tears the film, (a film-tearing bond). Some implementations of the process may be used to produce bonded films at web speed rates that are significantly higher than commercial rates for heat seal processes. | 09-03-2009 |