Broude, US
Craig Broude, Los Angeles, CA US
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20090058126 | Glare reduction - The driver of a vehicle ( | 03-05-2009 |
20100065721 | Enhanced glare reduction - The driver of a vehicle ( | 03-18-2010 |
Eugenia Broude, Lexington, SC US
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20160000787 | INHIBITORS OF CDK8/19 FOR USE IN TREATING ESTROGEN RECEPTOR POSITIVE BREAST CANCER - The invention provides a selective inhibitor of CDK8/19 for use in a method of treating a patient having estrogen receptor positive (ER+) breast cancer, including breast cancer that is resistant to antiestrogen therapy. In some embodiments, the selective inhibitor of CDK8/19 is administered in combination with antiestrogen therapy. In some embodiments, the selective inhibitor of CDK8/19 is administered to ER+HER2+ breast cancer patients in combination with HER2-targeting drugs. | 01-07-2016 |
James Broude, Hastings On Hudson, NY US
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20140279102 | FRAUD DETECTION - A system and method of fraud detection is disclosed including identification of a group of employees and bills associated with each employee of the group. For each bill, at least two conditions of the following conditions are determined: whether a complimentary condition has been met, whether a transfer condition has been met, whether a void and promotion condition has been met, whether a gratuity inflation condition has been met, whether a point of sale authorization condition has been met, whether an automatic gratuity condition has been met, and whether a bill reuse condition has been met. A score corresponding to each of the determined conditions is calculated and a total score for each employee is established based on the score for the determined conditions for each of the bills. Each employee of the group is rated based on the employee's total score. | 09-18-2014 |
Natalia Broude, Natick, MA US
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20090220942 | ACTIVATED SPLIT-POLYPEPTIDES AND METHODS FOR THEIR PRODUCTION AND USE - The present invention relates to a method to produce activated split-polypeptide fragments that on reconstitution immediately forms an active protein. The method relate to real-time protein complementation. Also encompassed in the invention is a method to split and produce split-fluorescent proteins in an active state which produce a fluorescent signal immediately on reconstitution. The present application also provides methods to detect nucleic acids; non-nucleic acid analytes and nucleic acid hybridization in real-time using the novel activated split-polypeptide fragments of the invention. | 09-03-2009 |
20100047179 | TARGETED SPLIT BIOMOLECULAR CONJUGATES FOR THE TREATMENT OF DISEASES, MALIGNANCIES AND DISORDERS, AND METHODS OF THEIR PRODUCTION - The present invention is directed to compositions and methods for the production of split-biomolecular conjugates for the directed targeting of nucleic acids and polypeptides. More preferably, the compositions and methods allow for the use of the split biomolecular conjugates for the treatment of diseases, malignancies, disorders and screening. In some embodiments, the split biomolecular conjugates comprise split effector protein fragments conjugated to a probe, and interaction of both probes with a target nucleic acid or target polypeptide, such as a pathogenic nucleic acid sequence or pathogenic protein, brings a the split-effector fragments together to facilitate the reassembly of the effector molecule. Depending on the effector molecule, the protein complementation results in a cellular effect, in particular for the treatment of diseases, malignancies and disorders. | 02-25-2010 |
Natalia E. Broude, Natick, MA US
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20090029370 | REAL TIME NUCLEIC ACID DETECTION IN VIVO USING PROTEIN COMPLEMENTATION - The present invention relates to a method to detect nucleic acid molecules, such as RNA molecules in vivo using real time protein complementation methods. The invention further relates to methods for detecting nucleic acids, for example RNA in real-time in living cells with a high sensitivity, using a novel split biomolecular conjugate of the invention. | 01-29-2009 |
20100297629 | NUCLEIC ACID SUPPORTED PROTEIN COMPLEMENTATION - The present invention is directed to novel methods for in vitro and in vivo detection of target nucleic acid molecules, including DNA and RNA targets, as well as nucleic acid analogues. The present invention is based on protein complementation, in which two individual polypeptides are inactive. When the two inactive polypeptide fragment are brought in close proximity during hybridization to a target nucleic acid, they re-associate into an active, detectable protein. | 11-25-2010 |
Sergey Broude, Newton, MA US
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20080218817 | SYSTEM AND METHOD FOR MAKING SEAMLESS HOLOGRAMS, OPTICALLY VARIABLE DEVICES AND EMBOSSING SUBSTRATES - Apparatus and method for producing optically variable devices, optically variable media, dot matrix holograms or embossing substrates. The system includes: a laser beam generator, a laser beam shaper, a spatial light modulator, imaging optics and an image positioner. The laser beam generator generates a laser beam, which is shaped by the laser beam shaper to modify the laser beam to an optimized beam profile. The shaped laser beam is modulated by the spatial light modulator, which generates, at a place removed from the substrate surface, an optical pattern. The imaging optics causes the optical pattern to be imaged on the substrate surface. An image positioner allows for the optical pattern to be positioned to different areas of the substrate surface. The system can produce adapted optically variable devices, optically variable media, dot matrix holograms or embossing substrates | 09-11-2008 |
Sergey Broude, Newton Center, MA US
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20130193618 | Laser Machining System and Method for Machining Three-Dimensional Objects from a Plurality of Directions - Embodiments of the present disclosure are directed to systems ( | 08-01-2013 |
Sergey V. Broude, Newton, MA US
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20120000893 | Precision Laser Ablation - Methods and systems for precisely removing selected layers of materials from a multi-layer work piece using laser ablation are disclosed. Precise removal of one or more selected layers of materials of a work piece may be performed by irradiating at least one location on a multi-layer work piece with a laser beam, ablating material at the at least one location, detecting one or more characteristics of the material ablated at the at least one location and analyzing the one or more characteristics to identify a change in at least one of the one or more characteristics that indicates a change in the type of material being ablated. Related systems are also described. | 01-05-2012 |
Sergey V. Broude, Newton Center, MA US
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20110011839 | Method and apparatus for laser micromachining a conical surface - Embodiments of the present invention are directed to methods and systems for micromachining a conical surface. In one embodiment, such a system may include a rotating platform for receiving a long line of laser illumination, a mask having a predetermined pattern comprising a sector of a planar ring, the mask being positioned on the rotating platform, a workpiece stage having a rotational axis for rotating a removably-affixed workpiece comprising a conical surface, wherein the sector comprises the planar image of the conical surface, an excimer laser for producing a laser beam, a homogenizer for homogenizing the laser beam in at least a single direction, at least one condenser lens, a turning mirror and at least one projection lens. | 01-20-2011 |
20150343561 | Laser Machining System and Method for Machining Three-Dimensional Objects From A Plurality of Directions - A laser machining system for machining a work-piece includes a laser scanning head, external optical subsystems, and an image acquisition device. The external optical subsystems correspond to optical channels that include a first optical channel and a second optical channel. The laser scanning head controls an optical path so that a laser beam is directed and focused on the work-piece through the first optical channel and the second optical channel at different times. The first optical channel and the second optical channel correspond to respective specific portions of the work-piece to be machined by the laser beam. The image acquisition device is positioned to view the work-piece through the optical path. The image acquisition device acquires via the first optical channel one or more images of the work-piece to determine a displacement of the work-piece with reference to a best optical focus position of the second optical channel. | 12-03-2015 |