Brock
Achim Brock, Basel CH
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20160067166 | COSMETIC COMPOSITION COMPRISING A NATURAL ORGANIC OIL AND POLYMETHYLMETHACRYLATE PARTICLES - The present invention relates to a topical composition comprising a natural organic oil and a porous cross-linked polymethylmethacrylate bead having a particle size D | 03-10-2016 |
20160081893 | COSMETIC COMPOSITION COMPRISING A COLLAGEN PROTECTING OR ENHANCING AGENT AND PARTICLES COMPRISING SILICA AND TITANIUM DIOXIDE TOPICAL COMPOSITIONS - The present invention relates to a topical composition comprising at least one collagen protecting and/or collagen enhancing agent and a silica-titanium dioxide composite particle having a particle size D | 03-24-2016 |
20160089310 | TOPICAL COMPOSITIONS - The present invention relates to a topical composition comprising at least one ingredient selected from the group consisting of a sebum control agent, a skin exfoliation agent and/or a collagen enhancing agent and a porous cross-linked polymethylmethacrylate bead having a particle size D | 03-31-2016 |
20160113859 | COSMETIC COMPOSITION COMPRISING A SILICONE OIL AND POLYMETHYLMETHACRYLATE PARTICLES - The present invention relates to a topical composition comprising a silicone oil and a porous cross-linked polymethylmethacrylate bead having a particle size D | 04-28-2016 |
Adrian Brock, Neuchatel CH
Patent application number | Description | Published |
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20110078659 | Java-Based Application Server that Supports Multiple Component Models - A Java-based application server supports runtime operations of components that belong to multiple component models. The components may cross-reference each other. A component of a source component model can be integrated into a target component model to form an integrated component. State transitions of the integrated component can be managed according to the target component model with reference to the libraries of the source component model. The integrated component can be installed in the application server for execution by a Java virtual machine. | 03-31-2011 |
20110078672 | Classloading Technique for an Application Server that Provides Dependency Enforcement - A Java-based application server, which supports multiple component models, includes a classloading module to enforce dependencies among classes and among the components that uses the classes. The classloading module determines whether a classloader created at deployment can share a version of a class with other classloaders. The classloading module also uses dependency information to determine which of the other classloaders on which the classloader depends. The classloading module uses pluggable classloading policies to determine the rules to be followed during classloading operations. The same state machine is used for classloading and for controlling the lifecycle of multiple component modules. The classloading module also utilizes abstraction of interfaces to communicate requirements and capabilities among the classloaders and with the system. | 03-31-2011 |
20110078673 | PERSISTING THE CHANGES FOR MANAGED COMPONENTS IN AN APPLICATION SERVER - A method and a system maintain a change to a component in an application server after the application server is re-started. The application server can be a Java-based application server that runs on a computer coupled to a management console. Through the management console, the application server receives an updated value of a component during runtime of the component. A profile service in the application server associates the component to a deployment descriptor that refers to an original value of the components. A representation of the component is then created and stored in a persistence data format in non-volatile data storage. The representation includes the updated value and indicates an association of the component with the deployment descriptor. When the application server is re-started, the representation is applied to the deployment descriptor to override the original value with the updated value. | 03-31-2011 |
Albert Brock, Gehrden DE
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20130276838 | DEVICE AND METHOD FOR CLEANING WALL OR GROUND SURFACES - A device for cleaning wall surfaces, ground surfaces, track superstructures or tunnel walls is configured to be arranged on a rail vehicle that moves along a direction of travel. The device includes an aspirator opening and at least two air nozzles arranged in rows of air nozzles disposed on either side of the aspirator opening such that the aspirator opening is disposed between the rows of air nozzles. The rows of air nozzles are supplied with compressed air such that the pressure of the row of air nozzles disposed in front of the aspiration opening in the direction of travel of the rail vehicle is lower than the pressure of the other row of air nozzles. | 10-24-2013 |
Allen Brock, Greenville, NC US
Patent application number | Description | Published |
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20140303867 | COAST CONTROL SYSTEMS AND METHODS - In one embodiment, a coast control system, or dead-man brake inhibitor, is associated with a tiller arm that is used for steering a vehicle. A spring acts upon the tiller arm when an operator releases a control handle attached to the tiller arm to move the tiller arm to a braking position which causes an electronically or mechanically actuated brake to be applied. Before releasing the control handle, the operator may actuate the coast control system to inhibit movement of the tiller arm towards the braking position when the control handle is released. The operator may vertically reposition the tiller arm while the coast control system remains actuated by overcoming the inhibiting force applied by the coast control system when the tiller arm is moved toward the braking position and by overcoming the spring acting on the tiller arm when the tiller arm is moved away from the braking position. | 10-09-2014 |
20160116587 | VEHICLE AND ENVIRONMENTAL DETECTION SYSTEM - A system includes a detection device configured to transmit and receive one or more signals in a generally vertical direction above a vehicle. Additionally, the system may include a processing device configured to measure a time of flight associated with the transmission and receipt of the one or more signals in the generally vertical direction. A distance travelled by the one or more signals may be determined based, at least in part, on the measured time of flight, and the distance travelled may be compared with a threshold distance to determine an overhead clearance of the vehicle. In response to determining the overhead clearance, a vehicle system may be activated. | 04-28-2016 |
Bishop Brock, Coupland, TX US
Patent application number | Description | Published |
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20140149750 | COMPUTING SYSTEM VOLTAGE CONTROL - An apparatus including a voltage safety verification unit (VSVU) configured to receive an indication of a first performance state, the first performance state being associated with a first voltage. The first performance state applies to at least one computing system component and the indication is received by a computing system component distinct from the requesting computing system component. The VSVU is configured to receive an indication of a second performance state. The second performance state is associated with a second voltage that is not equal to the first voltage. The VSVU is configured to determine whether the second performance state is within a range defined by a minimum and maximum performance state. Responsive to a determination that the second performance state is within the, the VSVU is configured to set the voltage of the at least one computing system component equal to the voltage associated with the second performance state. | 05-29-2014 |
20140149752 | ASSOCIATING ENERGY CONSUMPTION WITH A VIRTUAL MACHINE - Associating processor and processor core energy consumption with a task such as a virtual machine is disclosed. Various events cause a trace record to be written to a trace buffer for a processor. An identifier associated with a task using a processor core of the processor is read. In addition, one or more values associated with an energy consumption of the processor core are read. In response to the event, the one or more values associated with the energy consumption of the processor core and the identifier are written to the trace buffer memory. | 05-29-2014 |
20140149755 | DECOUPLED POWER AND PERFORMANCE ALLOCATION IN A MULTIPROCESSING SYSTEM - A performance supervisor computer program product is configured to set a maximum and a minimum performance operating limit for a plurality of processing units in accordance with a set of one or more rules enforced by the performance supervisor. Each of the plurality of processing units has logic configured to ensure a request for an operational setting complies with the maximum and minimum operating limits. Each of the plurality of processing units is configured to output a request for a limit compliant operational setting to a performance controller. The performance controller is configured to actuate the operational request. | 05-29-2014 |
20140149762 | DECOUPLED POWER AND PERFORMANCE ALLOCATION IN A MULTIPROCESSING SYSTEM - Embodiments of the inventive subject matter include setting minimum and maximum performance operating limits for each of a plurality of controllers. The operating limits are set in accordance with performance rules imposed on the system. In response to a request to change operation of a processing unit to a requested operational setting, it is determined whether the requested operational setting complies with the minimum and maximum performance operating limits. The minimum performance operating limit is sent to a performance controller if the requested operational setting does not comply with the minimum performance operating limit. The maximum performance operating limit is sent to a performance controller if the requested operational setting does not comply with the maximum performance operating limit. The requested operational setting is sent to a performance controller if the requested operational setting complies with the minimum and maximum performance operating limits. | 05-29-2014 |
20140149763 | COMPUTING SYSTEM VOLTAGE CONTROL - Computing system voltage control methods include receiving an indication of a first performance state. The first performance state is associated with a first voltage and applies to at least one computing system component. The indication of the first performance state is received by a first computing system component from a second computing system component. An indication of a second performance state is received, wherein the second performance state is associated with a second voltage that is not equal to the first voltage. It is determined whether the second performance state is within a range defined by a minimum performance state and a maximum performance state. Responsive to determining that the second performance state is within the range defined by the minimum performance state and the maximum performance state, the voltage of the at least one computing system component is set equal to the voltage associated with the second performance state. | 05-29-2014 |
20140149769 | COMPUTING SYSTEM FREQUENCY TARGET MONITOR - An apparatus includes memory, a processor coupled to the memory, and a set of one or more frequency target monitors. The processor includes a set of one or more processor cores, and the set of one or more frequency target monitors are coupled to the set of one or more processor cores. Each frequency target monitor is configured to determine a difference between an actual performance and an expected performance of a processor core from the set of one or more processor cores. Each frequency target monitor is also configured to, responsive to determining the difference between the actual performance and the expected performance of the processor core from the set of one or more processor cores, record an indication of a difference between the actual performance and the expected performance of the processor core from the set of one or more processor cores. | 05-29-2014 |
20140344823 | INTERRUPTION OF CHIP COMPONENT MANAGING TASKS - Embodiments include an apparatus comprising a processor and a computer readable storage medium having computer usable program code. The computer usable program code can be configured to determine whether priority of a requested task is higher than a priority of a currently executing task. The computer usable program code can be further configured to determine whether a value indicates that the currently executing task can be interrupted. The computer usable program code can be configured to trigger execution of the requested task on the processor, if the value indicates that the currently executed task can be interrupted. The computer usable program code can be further configured to wait for lapse of a time period and, interrupt the currently executing task upon detection of lapse of the time period or detection of a change to the value, if the value indicates that the currently executing task cannot be interrupted. | 11-20-2014 |
20140344824 | INTERRUPTION OF CHIP COMPONENT MANAGING TASKS - Embodiments include receiving, at a microcontroller of a chip, a request to execute a first task having a first priority. Embodiments further include determining that a second task having a second priority is currently executing. Embodiments further include determining that the first priority is higher than the second priority. Embodiments further include determining whether a value in a register indicates that the second task can be interrupted. If it is determined that the second task can be interrupted, embodiments further include triggering execution of the second task. If it is determined that the second task cannot be interrupted, embodiments further include waiting for lapse of a time period since receipt of the request to execute the first task, and interrupting the second task upon detecting lapse of the time period, or detecting, prior to the lapse of the time period, that the second task can be interrupted. | 11-20-2014 |
20150095009 | VIRTUAL POWER MANAGEMENT MULTIPROCESSOR SYSTEM SIMULATION - A model-based virtual power management driven multi-chip system simulator generates utilization data and performance data with a workload model that models one or more types of workloads based on parameters that characterize the one or more types of workloads. The simulator generates thermal data and power consumption data with a power model that models power consumption at a chip-level and a system-level. The simulator then generates performance counter information with a performance model that models change of performance counters over time and at least one of the generated utilization data and the generated performance data as input to the performance model. The simulator provides this generated data as input to a driver of the simulator. | 04-02-2015 |
20150095010 | VIRTUAL POWER MANAGEMENT MULTIPROCESSOR SYSTEM SIMULATION - A model-based virtual power management driven multi-chip system simulator generates utilization data and performance data with a workload model that models one or more types of workloads based on parameters that characterize the one or more types of workloads. The simulator generates thermal data and power consumption data with a power model that models power consumption at a chip-level and a system-level. The simulator then generates performance counter information with a performance model that models change of performance counters over time and at least one of the generated utilization data and the generated performance data as input to the performance model. The simulator provides this generated data as input to a driver of the simulator. | 04-02-2015 |
Bishop Brock, Austin, TX US
Patent application number | Description | Published |
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20140149779 | ASSOCIATING ENERGY CONSUMPTION WITH A VIRTUAL MACHINE - Associating processor and processor core energy consumption with a task such as a virtual machine is disclosed. Various events cause a trace record to be written to a trace buffer for a processor. An identifier associated with a task using a processor core of the processor is read. In addition, one or more values associated with an energy consumption of the processor core are read. In response to the event, the one or more values associated with the energy consumption of the processor core and the identifier are written to the trace buffer memory. | 05-29-2014 |
Carsten Brock, Montpellier FR
Patent application number | Description | Published |
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20120277230 | COMPOUNDS USEFUL FOR TREATING CANCER - The present invention relates to compound (I) wherein: means a pyridazine, a pyrimidine or a pyrazine group, R independently represent a hydrogen atom, a halogen atom or a group chosen among a CN group, a hydroxyl group, a COOR | 11-01-2012 |
20140080831 | COMPOUNDS USEFUL FOR TREATING CANCER - A method of preventing, inhibiting, or treating cancer that includes contacting a cell with at least one compound of formula (Ia) or a pharmaceutically acceptable salt thereof: | 03-20-2014 |
20150299129 | COMPOUNDS FOR TREATING CANCER - A method of preventing, inhibiting, or treating cancer that includes contacting a cell with at least one compound of formula (Ia) or a pharmaceutically acceptable salt thereof: | 10-22-2015 |
20150315173 | NEW ANTI-INVASIVE COMPOUNDS - The present invention relates to a compound of formula (I): | 11-05-2015 |
Christopher Brock, Auburn, WA US
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20150296808 | DEVICES, SYSTEMS, AND METHODS FOR FILLING DOUGHNUT HOLES - The present disclosure is directed towards systems, devices, and methods for filling doughnut holes. The system comprises a conveyor system that transports doughnut holes between at least a loading section, a culling section, and an injection section. The conveyor system includes a plurality of links coupled together to form a belt. The loading section includes a feeding device that feeds doughnut holes onto the conveyor system. The culling section includes a culling bar that culls excess doughnut holes from the conveyor. The injection section includes an injector system that injects feeds doughnut holes with a filling. | 10-22-2015 |
Colin Brock, Renton, WA US
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20150157299 | Sub-performing transducer element detection for medical ultrasound - Sub-performing elements of an ultrasound transducer array are detected. The power, such as current, used by or provided to the transmit driver is measured. By driving each element or group of elements separately, defective elements or groups of elements are detected from the amount of power used. | 06-11-2015 |
Daniela Brock, Mettmann DE
Patent application number | Description | Published |
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20130309302 | Process for manufacturing a pharmaceutical dosage form comprising nifedipine and candesartan cilexetil - The present invention relates to manufacturing processes for the preparation of a pharmaceutical dosage form comprising nifedipine and candesartan cilexetil and optionally at least one diuretic characterized in that nifedipine is released in the body in a controlled (modified) manner and the candesartan cilexetil is released rapidly (immediate release (IR)) and optionally the diuretic is released rapidly (immediate release (IR)) and the pharmaceutical dosage forms obtainable by these processes. | 11-21-2013 |
David Brock, Mitzpe Yericho IL
Patent application number | Description | Published |
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20080209311 | On-line digital image editing with wysiwyg transparency - A method for editing includes processing a page of markup-language code using a browser program running on a computer so as to display the page content in a browser window on a computer screen. An embedded application embedded as an object in the markup-language code and running in the browser program is used to overlay an image in a transparent editing window over the browser window so that at least some of the content behind the editing window remains visible. The image in the transparent editing window is edited in response to user input, while at least some of the content remains visible behind the editing window. A characteristic of the image is modified and a reference to the image with the modified characteristic is placed in the markup-language code. | 08-28-2008 |
David Brock, Cambridge GB
Patent application number | Description | Published |
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20150289223 | METHOD, APPARATUSES AND COMPUTER PROGRAM PRODUCT FOR ASSIGNING A UNIQUE LOCATION AREA CODE IN A NETWORK COMPRISING SMALL CELLS SERVED BY HOME NODE B'S UNDERLYING A MACROCELL - In a network comprising a cluster of small cells | 10-08-2015 |
20150319726 | NETWORK ELEMENTS, WIRELESS COMMUNICATION SYSTEM AND METHODS THEREFOR - A method and apparatus for periodically assigning new, unique Location Area Codes to each cell comprising a femto-cell network ( | 11-05-2015 |
Dovi Brock, Tel Aviv IL
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20110209281 | METHOD AND SYSTEM FOR RAPID AND CONTROLLED ELEVATION OF A RAISABLE FLOOR FOR POOLS - A rapid elevation floor system for a pool at least partially filled with pool water, including a raisable floor for disposing over the bottom of the pool. The raisable floor is combined of a plurality of modular floor elements, at least some of which include a ballasting receptacle. The ballasting receptacle is adapted to receive and discharge a volume of a flotation fluid lighter than the pool water, enabling the pool water to occupy any part of the volume when unoccupied by the flotation fluid. When the raisable floor is disposed beneath the surface of the pool water, the amount of the flotation fluid contained in the raisable floor is adjusted to render the specific weight of the raisable floor as equal to, or as slightly greater than the specific weight of the pool water, such that pumping of the flotation fluid into the ballasting receptacle(s) urges a rapid elevation of the raisable floor. | 09-01-2011 |
20150107014 | METHOD AND SYSTEM FOR RAPID AND CONTROLLED ELEVATION OF A RAISABLE FLOOR FOR POOLS - A method for assembling a rapid elevation floor system in a pool, the method comprising the stages of: assembling a raisable floor inside said pool and adding sensors to said raisable floor, and connecting said raisable floor platform to auxiliary units. The method further comprises laying flooring tiles on said raisable floor and sinking said raisable floor to a bottom of said pool. | 04-23-2015 |
Gene F. Brock, Conroe, TX US
Patent application number | Description | Published |
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20140272423 | ANTI-CORROSION COMPOSITIONS FOR NATURAL GAS RECOVERY OR CONVEYING EQUIPMEN - Improved anti-corrosion systems are provided for use with hydrocarbon recovery, treatment and distribution equipment, in order to inhibit corrosion on the metal surfaces thereof. The systems include an epoxy resin, a curing agent for the resin, and a surfactant, which is the reaction product of an alkyl benzene sulfonic acid at least partially neutralized of from about 6-11 with an ammonia or amine neutralizing agent. The systems provide improved anti-corrosion protection in the case of metal surfaces not continually wetted with liquid hydrocarbons, such as crude oil. | 09-18-2014 |
20140352965 | METHOD AND APPARATUS FOR DOWNHOLE APPLICATION OF TREATMENT CHEMICALS IN GAS WELLS - Improved methods are provided for the application of downhole oil or gas well treating agents, such as liquid corrosion inhibition agents. The methods involve first lowering a liquid retainer device into a well casing, preferably at or above the location of the well production zone, followed by introduction of a liquid treating agent. The presence of the liquid retainer device prevents substantial passage of the agent into the production zone, and forms a column of the liquid agent above the device. The retainer device is then withdrawn from the well so as to create a substantially uniform film of the agent along the inner surfaces of the well casing. In this manner, proper coating of the casing is achieved while preventing production losses owing to passage of the treating agent into the production zone. The liquid retainer is preferably one or more swab cups or oil field retainers. | 12-04-2014 |
Hans-Egon Brock, Oberhausen DE
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20090116964 | Turbine rotor and method for producing the rotor - A turbine rotor has a row of turbine blades associated with a circumferential groove in a disk, each turbine blade having foot received in the groove, a blade profile above the foot, and a shroud plate above the profile. Each blade foot and each shroud plate have end surfaces and side surfaces which form a rhomboid, the end surfaces of each shroud plate tapering toward each other along respective radii and abutting the end surfaces of adjacent shroud plates to form a closed ring. The blade profiles are torsionally stressed by applying a force to each plate in a direction parallel to the axis of the disk, thereby twisting the cover plates through an angle alpha so that the side surfaces of adjacent cover plates are circumferentially aligned in a plane perpendicular to the longitudinal axis. This force is maintained by clamping devices applied to the combs of adjacent blades. | 05-07-2009 |
Hansjorg Brock, Grenzach-Wyhlen DE
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20130019687 | Gauge Pressure Sensor - A gauge pressure sensor for determining the pressure of a medium by means of a housing and by means of a measuring element, which is positioned in the housing, wherein an outwards facing side of the measuring element is in contact with the medium and is exposed to the pressure, which is to be measured. A tube for a reference pressure is provided, which conducts ambient air to the measuring element, and by means of at least one dehumidifying chamber, positioned in the housing, for the collection of air moisture. The dehumidifying chamber contains a moisture adsorbing material or is primarily composed of a moisture adsorbing material, in that the moisture adsorbing material is at least, in sections, enclosed by a wall, which is composed of a first moisture permeable material, or is at least, in sections, free from a wall, and in that the reference pressure supply tube is at least, in sections, fabricated from a first or second moisture permeable material or in that the reference pressure supply tube has an aperture. | 01-24-2013 |
Hansjörg Brock, Grenzach-Wyhlen DE
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20110290033 | MEASURING APPARATUS AND METHOD FOR MANUFACTURING THE MEASURING APPARATUS - An apparatus for determining and/or monitoring a physical and/or chemical, measured variable of a medium, including a housing, especially an elongated housing, and a sensor arranged in the housing. The sensor serves for registering the measured variable, wherein the housing has at least one opening, through which the sensor comes in contact with the medium. The housing has a first housing section, in which the sensor and a sensor electronics are arranged. The sensor electronics is arranged on a first carrier element. The sensor electronics serves for changing the measured variable into an analog electrical signal. An insert is applied in the first housing section, in which the sensor electronics is arranged. The insert is tubular. | 12-01-2011 |
Jason Brock, Toronto CA
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20160031646 | TOOL FOR MANUALLY HANDLING HEAVY PLATES - A hand-operated tool is disclosed for handling a heavy plate while standing at a distance from the plate. The tool comprises a body with gripping members defining a notch for insertion of a plate. The gripping members have inner edges with stepped profiles, defining pairs of opposed gripping surfaces. The pairs of gripping surfaces are spaced apart at different widths for receiving plates of different thicknesses, a pairs close to the opening of the notch having a width greater than a pair farther from the opening of the notch. An elongate handle extends from the body, and a force may be applied to the handle to cause the opposed gripping surfaces frictionally and releasably retain the plate in the notch. | 02-04-2016 |
J. Don Brock, Chattanooga, TN US
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20150300738 | APPARATUS AND METHOD FOR TUBE DRYER - A dryer having an inlet end, a discharge end, an exterior shell, a discharge end manifold and an inlet end manifold. The preferred dryer also comprises a primary tube adapted to convey heat transfer oil to and from the dryer, a discharge end secondary tube which is in fluid communication with the primary tube and the discharge end manifold, and an inlet end secondary tube which is in fluid communication with the inlet end manifold. The preferred dryer further comprises a plurality of tertiary tubes which are in fluid communication with the discharge end manifold and the inlet end manifold, a heat source that is adapted to heat the heat transfer oil, and a sweep gas assembly. The preferred method comprises providing such a dryer, introducing heat transfer oil into the dryer, introducing wood materials into the dryer and drying the wood materials. | 10-22-2015 |
J. Donald Brock, Lookout Moutain, TN US
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20150029809 | METHOD AND APPARATUS FOR MAKING ASPHALT CONCRETE USING AGGREGATE MATERIAL FROM A PLURALITY OF MATERIAL STREAMS - A combination of components is provided for use in making asphalt concrete from a plurality of aggregate material streams. The combination includes an indirect dryer for heating aggregate material from a first material stream without directly exposing said first stream material to hot gases of combustion. The combination also includes a mixer for mixing aggregate material from the first material stream, aggregate material that has not been heated in the indirect dryer from a second material stream, and a binder component to produce asphalt concrete. | 01-29-2015 |
Jennifer M. Brock, Anchorage, AK US
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20140187875 | Mouth Guard For Determining physiological Conditions Of A Subject And Systems And Methods For Using Same - Mouth guards having electrodes, sensors, and/or accelerometers for determining one or more physiological conditions of a subject. Processing circuitry receives the outputs of the electrodes, sensors, and/or accelerometers. Optionally, at least a portion of the processing circuitry can be positioned within a helmet that is worn by a subject. The mouth guard can optionally be tethered to the helmet. | 07-03-2014 |
Johannes Brock, Ulm DE
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20150180503 | CONFIGURABLE MIXED-SIGNAL SYSTEMS - An electronic system includes a configurable processing device. The configurable processing device includes a processor that performs digital processing, a first input that receives digital signal, a first output that sends digital signal and a converter that converts between analog and digital signals. The converter includes a delta-sigma modulator. | 06-25-2015 |
20150234960 | DESIGN AUTOMATION FOR CONFIGURABLE MIXED-SIGNAL SYSTEMS - Configuration information is generated for a configurable mixed-signal system. Analog requirements for operating the configurable mixed-signal system are gathered. A simulation model of a delta-sigma modulator is received. A simulation based on the simulation model of the delta-sigma modulator is performed to obtain parameter settings for the delta-sigma modulator. The obtained parameter settings are used to build at least a portion of a description of the configurable mixed-signal system. The description of the configurable mixed signal system is synchronized to receive configuration information. | 08-20-2015 |
John Brock, Auburn, MI US
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20150300899 | PIEZOELECTRIC TRANSDUCER ASSEMBLY - A piezoelectric transducer assembly having improved impact resistance, stability, and higher quality pulse reproductions. The transducer assembly is not hard wired, but contains a spring contacting a piezoelectric disk with a cup operating as the electrical ground mechanism. | 10-22-2015 |
Johnny Brock, Brownsboro, AL US
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20150242577 | Medical Logistics Management Program - This invention are computer implementable programs and method designed as medical planning tool that (1) models the patient flow from the point of injury through more definitive care, and (2) supports operations research and systems analysis studies, operational risk assessment, and field medical services planning. The computer program of this invention comprises six individual modules, including the casualty generation module, which uses an exponential distribution to stochastically generate wounded in action, disease, and nonbattle injuries; a care providing module uses generic task sequences, simulated treatment times, and personnel, consumable supply, and equipment requirements to model patient treatment and queuing within a functional area; a network/transportation module simulates the evacuation (including queuing) and routing of patients through the network of care via transportation assets; a reporting module produces an database detailing various metrics, such as patient disposition, time-in-system data, and consumable, equipment, personnel, and transportation utilization rates, which can be filtered according to the user's needs. | 08-27-2015 |
Jonathan A. Brock, Syracuse, IN US
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20140150988 | CONDUIT MODULE COUPLED WITH HEATING OR COOLING MODULE - A heating and cooling system for use with hot, cold and source fluid circuits. A conduit module couples a heating/cooling module with the fluid circuits. The conduit module includes four three-way valves to communicated fluid from and to the fluid circuits to first and second heat exchangers in the heating/cooling module. The first heat exchanger is used to heat a fluid flow and the second one chills a second fluid flow. The conduit module simultaneously supplies a hot fluid flow to a hot fluid circuit and a cold fluid to a cold fluid circuit. The source fluid is routed by the conduit module to enhance efficiency. A method of circulating fluid is also disclosed. | 06-05-2014 |
Juergen Brock, Ottobrunn DE
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20140100837 | INTEGRATION VERIFICATION SYSTEM - A verification system for an integrated device includes a plurality of detailed subsystem virtual prototypes, a plurality of fast subsystem virtual prototypes, and a test controller. The plurality of detailed system virtual prototypes include simulation information for core functionality of subsystems of the device. The plurality of fast system level prototypes include simulation information to facilitate overall functionality of the combined subsystems of the device. | 04-10-2014 |
Kerry Brock, Forest City, NC US
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20150292499 | HYDRAULICALLY CONTROLLED HYDROSTATIC TRANSMISSION - A hydrostatic transmission system includes a pump including a rotatable swash plate, wherein rotation of the swashplate effects a change in volumetric displacement of the pump. An actuator is coupled to the swashplate, the actuator operative to effect rotation of the swashplate to change the volumetric displacement of the pump. An electronic controller is operatively coupled to the actuator, the electronic controller configured to command the actuator to effect rotation of the swashplate. | 10-15-2015 |
20150308569 | CONTROLLER AND SYSTEM FOR UTILITY VEHICLE - A vehicle includes a pump having a swash plate tiltable about a swashplate tilt axis, wherein rotation of the swashplate changes the title angle and effects a change in volumetric displacement of the pump. A controller is operatively coupled to the swashplate to effect rotation of the swashplate, the controller including a processor and memory, and logic stored in the memory and executable by the processor, the logic configured to automatically control at least one vehicle characteristic independent of a user input command. | 10-29-2015 |
Kerry Todd Brock, Forest City, NC US
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20150147191 | Pump Control System and Method - A zero turn mower vehicle | 05-28-2015 |
Linda G. Brock, Bethesda, MD US
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20150368622 | ATTENUATION OF HUMAN RESPIRATORY SYNCYTIAL VIRUS BY GENOME SCALE CODON-PAIR DEOPTIMIZATION - Described herein are RSV polynucleotide sequences that make use of multiple codons that are containing silent nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce a numerous synonymous codons into the genome. Due to the large number of defects involved, the attenuated viruses disclosed herein provide a means of producing attenuated, live vaccines against RSV. | 12-24-2015 |
Lindsay F. Brock, Orangeville CA
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20150284591 | COATING FOR ROOFTOPS AND METHOD OF MANUFACTURE FOR SAME - The disclosure is directed at a coating for rooftops or rooftop structures which is in a reflective state at a first temperature and in a non-reflective state at a second temperature. During colder months, the coating is in the non-reflective state while at warmer temperatures, the coating is in a reflective state. | 10-08-2015 |
Lori Brock, Ipswich, MA US
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20160123541 | SOLID-STATE LAMPS WITH ELECTRONICALLY ADJUSTABLE LIGHT BEAM DISTRIBUTION - Solid-state lamps having an electronically adjustable light beam distribution are disclosed. In accordance with some embodiments, a lamp configured as described herein includes a plurality of solid-state emitters (addressable individually and/or in groupings) mounted over a non-planar interior surface of the lamp. The interior mounting surface can be concave or convex, as desired, and may be of hemispherical or hyper-hemispherical geometry, among others, in accordance with some example embodiments. In some embodiments, the heat sink of the lamp may be configured to provide the interior mounting surface, whereas in some other embodiments, a separate mounting interface, such as a parabolic aluminized reflector (PAR), a bulged reflector (BR), or a multi-faceted reflector (MR), may be included to such end. Also, the lamp may include one or more focusing optics for modifying its output. In some cases, a lamp provided as described herein may be configured for retrofitting existing lighting structures. | 05-05-2016 |
20160123564 | SOLID-STATE LUMINAIRE WITH ELECTRONICALLY ADJUSTABLE LIGHT BEAM DISTRIBUTION - A luminaire having an electronically adjustable light beam distribution is disclosed. In accordance with some embodiments, the disclosed luminaire includes a housing, for example, of hemi-cylindrical, oblate hemi-cylindrical, oblong elliptical, or polyhedral shape. The disclosed luminaire also includes a plurality of solid-state light sources arranged over its housing, in accordance with some embodiments. The one or more solid-state emitters of a given solid-state light source may be addressable individually and/or in one or more groupings, in some embodiments. As such, the solid-state light sources can be electronically controlled individually and/or in conjunction with one another, providing for highly adjustable light emissions from the host luminaire, in accordance with some embodiments. One or more heat sinks may be mounted on the housing to assist with heat dissipation for the solid-state light sources. The luminaire can be configured, for example, to be mounted or as a free-standing lighting device, as desired. | 05-05-2016 |
20160128140 | LIGHTING TECHNIQUES UTILIZING SOLID-STATE LAMPS WITH ELECTRONICALLY ADJUSTABLE LIGHT BEAM DISTRIBUTION - Solid-state lamps having an electronically adjustable light beam distribution are disclosed. In accordance with some embodiments, a lamp configured as described herein includes a plurality of solid-state emitters (addressable individually and/or in groupings) mounted over a non-planar interior surface of the lamp. The interior mounting surface can be concave or convex, as desired, and may be of hemispherical or hyper-hemispherical geometry, among others, in accordance with some example embodiments. In some embodiments, the heat sink of the lamp may be configured to provide the interior mounting surface, whereas in some other embodiments, a separate mounting interface, such as a parabolic aluminized reflector (PAR), a bulged reflector (BR), or a multi-faceted reflector (MR), may be included to such end. Also, the lamp may include one or more focusing optics for modifying its output. In some cases, a lamp provided as described herein may be configured for retrofitting existing lighting structures. | 05-05-2016 |
Michael George Brock, London CA
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20110110819 | Sanitization process for objects and sanitization chamber - The present invention provides a process for sanitizing an object. The process comprises: (i) placing the object to be sanitized in a substantially enclosed environment, the environment being at atmospheric pressure when the object is placed therein, (ii) providing a gaseous chlorine dioxide vapour in the environment, and (iii) exposing the gaseous chlorine dioxide vapour to the object to sanitize the object. The process includes maintaining a pressure in the environment at substantially atmospheric pressure. | 05-12-2011 |
Neil A. Brock, Acton, MA US
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20150363196 | Systems And Methods For Software Corpora - Systems, methods, and computer program products are shown for providing a corpus. An example embodiment includes automatically obtaining a plurality of software files, determining a plurality of artifacts for each of the plurality of software files, and storing the plurality of artifacts for each of the plurality of software files in a database. Additional embodiments determine some of the artifacts for each of the software files by converting each of the software files into an intermediate representation and determining at least some of the artifacts from the intermediate representation for each of the software files. Certain example embodiments determine at least some of the artifacts for each of the software files by extracting a string of characters from each of the plurality of software files. The software files can be in a source code or a binary format. | 12-17-2015 |
20150363294 | Systems And Methods For Software Analysis - Systems, methods, and computer program products are provided for identifying software files, flaws in code, and program fragments by obtaining a software file, determining a plurality of artifacts, accessing a database which stores a plurality of reference artifacts for reference software files, comparing at least one of the artifacts to at least one of the reference artifacts stored in the database, and identifying the software file by identifying the reference software file having the reference artifacts that correspond to the plurality of artifacts. Certain embodiments can also automatically provide updated versions of files, patches to be applied, or repaired blocks of code to replace flawed blocks. Example embodiments can accept a wide variety of file types, including source code and binary files and can analyze source code or convert files to an intermediate representation (IR) and analyze the IR. | 12-17-2015 |
Nigel James Brock, Chapel Hill AU
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20120041732 | SYSTEM AND METHOD FOR ANALYZING DATA - A computer-implemented method, computer program product, and computing system for obtaining a simulation modeling file. One or more values is associated with one or more variables included within the simulation modeling file. The simulation modeling file is executed to generate at least one result set. The at least one result set is iteratively rendered while the at least one result set is generated. | 02-16-2012 |
20120041733 | SYSTEM AND METHOD FOR ANALYZING DATA - A computer-implemented method, computer program product, and computing system for generating one of more executions of a scenario concerning a simulation modeling file. One of the one or more executions of the scenario is defined as a child of the scenario, wherein one or more values are associated with one or more variables included within the child of the scenario. The scenario and the child of the scenario are graphically rendered. | 02-16-2012 |
20120041736 | SYSTEM AND METHOD FOR ANALYZING DATA - A computer-implemented method, computer program product, and computing system for obtaining an oil field modeling file. One or more values are associated with one or more variables included within the oil field modeling file. The oil field modeling file is executed to generate one or more result sets. A portion of each of the one or more result sets is compared with empirically-derived data related to the portion. | 02-16-2012 |
20120041924 | SYSTEM AND METHOD FOR ANALYZING DATA - A computer-implemented method, computer program product, and computing system for defining at least a portion within a simulation modeling file for copying from an original location, thus defining an identified portion. A destination location is defined for the identified portion. A multi-threaded copying procedure is effectuated to copy the identified portion from the original location to the destination location, thus generating a copied portion of the simulation modeling file. The multi-threaded copying procedure utilizes at least two processing threads. | 02-16-2012 |
20120041987 | SYSTEM AND METHOD FOR ANALYZING DATA - A computer-implemented method, computer program product, and computing system for identifying one or more variables included within at least a portion of a simulation modeling file. Comment data is inserted into the at least a portion of the simulation modeling file to define one or more values for each of one or more variables. | 02-16-2012 |
20120042209 | SYSTEM AND METHOD FOR ANALYZING DATA - A computer-implemented method, computer program product, and computing system for defining one or more failure conditions. Two of more executions are selected from a plurality of available executions based upon a simulation modeling file, thus defining two or more selected executions. A first of the two or more selected executions is executed while monitoring for the occurrence of the one or more failure conditions. | 02-16-2012 |
Raymond G. Brock, Beaverton, OR US
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20140373424 | PROJECTILE-WEAPON RETICLE WITH HOLDOVER AIMING FEATURES FOR MULTIPLE PROJECTILE VELOCITIES - A reticle of a projectile-weapon aiming system such as a riflescope includes first and second series of secondary aiming marks spaced apart below a primary aiming point, the first and second series providing holdover aiming points for regularly incrementing target distances for respective subsonic and supersonic .300 AAC Blackout ammunition, or other differing types of ammunition, without requiring adjustment of the optics or settings of the aiming system. | 12-25-2014 |
20150354921 | PROJECTILE-WEAPON RETICLE WITH HOLDOVER AIMING FEATURES FOR MULTIPLE PROJECTILE VELOCITIES - A reticle of a projectile-weapon aiming system such as a riflescope includes first and second series of secondary aiming marks spaced apart below a primary aiming point, the first and second series providing holdover aiming points for regularly incrementing target distances for respective subsonic and supersonic .300 AAC Blackout ammunition, or other differing types of ammunition, without requiring adjustment of the optics or settings of the aiming system. | 12-10-2015 |
Richard Thomas Brock, Scottsdale, AZ US
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20150149237 | Systems and methods to improve sales effectiveness utilizing a moving, contextually relevant navigator to guide sales representatives in prospect communications based on prospect's digital and conversational behavior and organization's best sales practices - Systems and methods to optimize sales performance operating in the manner a sales rep works: capturing prospect interactions real-time, providing a navigation tool and talking points to facilitate timely and relevant communications, and automatically updating Customer Relationship Management (CRM) and other systems—enabling users to effectively execute sales strategies. Prospect interactions are time-stamped and tracked to create a story-so-far record for each prospect. A customized, key-word searchable database of talking points provides intelligent, consistent knowledge to the user during prospect communications. Unlimited, unique moving navigators categorize talking points according to the organization's database of information and are customized to optimize data retrieval. Drag-and-drop emails are created by selecting pre-defined, best practice talking points or can be personalized in one-to-one campaigns, and include automated embedded tracking of prospect's email opens and clicks. All activities are timed and tracked from beginning to close of sale providing sales process analyses. | 05-28-2015 |
Robert Brock, Sw 18 5jj GB
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20130226633 | Flexible Booking Of A Shared Vehicle - A method, apparatus and computer program product for providing flexible booking of a shared vehicle is presented. An application for a mobile device is provided having an interface to allow a user of the mobile device to make a reservation of a shared vehicle by selecting a date the user desires to reserve the shared vehicle. The user is further able to select a location to locate at least one shared vehicle on the date. The user receives a list of vehicles proximate the location selected by the user, and an indication of available times for each of the vehicles. The user can then make a reservation of a particular shared vehicle for a particular time period on the date. | 08-29-2013 |
Roland Brock, Uleve DE
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20100061932 | PEPTIDES USEFUL AS CELL-PENETRATING PEPTIDES - The present invention is related to a peptide having an amino acid sequence comprising at least 8 consecutive amino acids of the human lactoferrin protein or of the bovine lactoferrin protein, whereby the peptide is suitable to act as a cell-penetrating peptide. | 03-11-2010 |
Roland Brock, Kleve DE
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20130108662 | PEPTIDES USEFUL AS CELL-PENETRATING PEPTIDES | 05-02-2013 |
Ronald Brock, Oxford, MI US
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20140366833 | Connecting Rod with Bearing-less Large End - A connecting rod of an internal combustion engine, that includes a large bore, and an interior bore surface. The current art uses soft metal bearing surfaces to reduce wear, and friction between the connecting rod inner diameter and the crankshaft journal surface. The soft metal bearing surface is a separate component of the engine. In this invention the large bore end interior diameter is coated with a hard material to reduce, or eliminate wear. The hard material is a metal or metal alloy applied to the inner diameter by a thermal spray method. A relatively soft polymer material can also be applied to the interior diameter surface of the con-rod bore. The relatively softer polymer acts as a first and sometimes a consumable layer, and applied over the thermal sprayed hard layer. The polymer layer is often used in conjunction with the sprayed metal layer. The polymer coating may be worn off the inner diameter surface; this delay in surface to surface contact to the sprayed metal layer has beneficial effects on the sprayed metal layer. The delay of surface to surface contact will usually result in a longer service life of the sprayed metal coating. | 12-18-2014 |
Ryan Brock, Cary, IL US
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20140240753 | Methods, Apparatuses, And Computer Program Products For Implementing Cloud Connected Printers And An Adaptive Printer-Based Application Framework - Methods, apparatuses, and computer program products are provided to facilitate connections between devices, such as a printer and a cloud-based server, and to implement an adaptive application framework. In the context of an apparatus, a printer is provided comprising communications circuitry configured to facilitate communications with a network; and processing circuitry configured to transmit a connection request to the network; receive requested connection parameters from the network; transmit printer connection parameters to the network; and establish a first secure connection between the printer and the network. The printer comprising processing circuitry further configured to receive requested connection parameters comprising at least a signed security certificate and a DNS name for a server on the network and to verify the signed security certificate and the DNS name for the server. The printer comprising processing circuitry further configured to transmit printer connection parameters comprising at least a signed security certificate for the printer. The printer comprising processing circuitry further configured to receive a request from the network to establish one or more communication channels over the first secure connection. | 08-28-2014 |
Simon Thomas Henry Brock, Portishead GB
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20100213143 | Apparatus for Inhibiting Fines Carryover - Apparatus for inhibiting fines carryover in the form of a settlement tank comprising: a filter which divides the tank into upper and lower portions; a fluid inlet in the lower portion for admitting into the tank a fluid with entrained solids; and a fluid outlet in the upper portion through which filtered fluid can leave the tank. The filter comprises filter media supported on a permeable wall, the wall including a filter media outlet which is normally closed, and opening means for opening the filter media outlet to allow the filter media to discharge into the lower portion of the tank. The invention also relates to a method of refilling the filter with filter media. | 08-26-2010 |
Stephan Brock, Heidelberg DE
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20130179091 | SYSTEMS AND METHODS FOR IDENTIFYING UNKNOWN DRUG TARGETS VIA ADVERSE EVENT DATA - The present disclosure is directed to systems and methods for identifying unknown drug targets via adverse event data. An analyzer receives an identification of a first drug having one or more unknown target proteins and identifies a second drug related to the first drug. The analyzer retrieves, from an adverse event database, a first side effect profile associated with the first drug, and a second side effect profile associated with the second drug. The analyzer generates a third side effect profile comprising a subset of the first side effect profile not shared by the second side effect profile, and identifies a third drug having a fourth side effect profile comprising the third side effect profile. The analyzer retrieves a list of one or more target proteins of the third drug not targeted by the second drug, and presents the retrieved list as potential target proteins of the first drug. | 07-11-2013 |
20130179138 | SYSTEMS AND METHODS FOR USING ADVERSE EVENT DATA TO PREDICT POTENTIAL SIDE EFFECTS - The present disclosure describes systems and methods for predicting a likely side effect profile for even new, untested medications. A predicted side effect profile may be generated based on intersections of side effect profiles of other medications that affect the same or related molecular entities, such as the nearby target proteins, involve the same pathways, or are otherwise similarly related. To generate a predicted side effect profile for a new drug targeting a novel or previously un-targeted protein target, an analyzer may query an adverse event database for records pertaining to patients who have taken drugs or combinations of drugs that target or affect molecular entities in the vicinity of the novel target within a global molecular entity graph, and, in some embodiments, may retrieve a plurality of adverse event records and generate an intersection of side effects associated with related targets to predict likely side effects for the novel target. | 07-11-2013 |
20130179181 | SYSTEMS AND METHODS FOR PERSONALIZED DE-RISKING BASED ON PATIENT GENOME DATA - The present disclosure describes systems and methods for using patient-specific genomic information to optimize or de-risk therapy for the patient. A user may identify a medication for consideration for prescription to a patient, and a genetic variant of the patient affecting a first protein. An analyzer may identify a second medication targeting the first protein, and may retrieve adverse event data from an adverse event database for patients co-medicated with both the first medication and second medication. The analyzer may determine, based on rates of adverse events, the likelihood of an adverse event occurring through co-medication of the first medication and second medication. Based on the likelihood, and based on a correspondence or non-correspondence between a protein activation characteristic of the first medication and the effect of the genetic variant of the patient, the analyzer may indicate or contra-indicate the first medication for the patient. | 07-11-2013 |
20130179187 | SYSTEMS AND METHODS FOR DE-RISKING PATIENT TREATMENT - The present disclosure describes systems and methods for de-risking patient treatment by identifying medications or combinations of medications to be contraindicated for a specific indication. An analyzer executed by a processor of a computing device from a user may receive an identification of an indication (e.g. the subject of a clinical trial, or the diagnosis of a patient visiting a physician's office). The analyzer may retrieve, from an adverse event database, medication and co-medication information of patients that experienced a side effect corresponding to the indication. The analyzer may sort the retrieved medication and co-medication information to generate an ordered list of medications consumed by patients that experienced the side effect, and identify a first medication of the ordered list. A display module executed by the computing device may display, to the user, the first medication of the ordered list for contraindication from the clinical trial. | 07-11-2013 |
20150106112 | SYSTEMS AND METHODS FOR MULTIVARIATE ANALYSIS OF ADVERSE EVENT DATA - The present disclosure describes systems and methods for multivarlate analysis of adverse event data. According to a first aspect, patient-specific genomic Information is used to optimize or de-risk therapy for the patient. According to other aspects of the invention, unknown drug targets are identified via adverse event data. According to still other espects, a medication is identified to exclude from use for an indication or from a clinical trial of another medication. According to another aspect, a predicted side effect profile is generated for a medication targeting a novel target. According to still another aspect, combination therapies are identified via adverse event data. According to another aspect, molecular interactions between a plurality of molecular entities are displayed in an intuitive format. According to still another aspect, molecular entities responsible for adverse event differences between similar indications are identified. According to still another aspect, genetic variants associated with adverse events in a clinical trial are identified. | 04-16-2015 |
Stephan Brock, Weinheim DE
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20090306186 | NOVEL TISSUE PROTECTIVE ERYTHROPOIETIN RECEPTOR (NEPOR) AND METHODS OF USE - There is disclosed a molecular composition(s) of a novel tissue protective erythropoietin (EPO) binding receptor protein complex, termed NEPOR. Presence of NEPOR components on a tumour allows EPO to impinge on the survival of associated cells thereby enhancing tumour progression and negatively effecting patient survival. Presence of NEPOR represents a prognostic biomarker for poorer patient outcome. Thus, methods are provided for stratifying patients having a tumour as suitable (i.e. NEPOR not present) or non-suitable (i.e., NEPOR present) for EPO treatment, comprising: (a) isolating a tissue sample from an individual who is receiving or is a candidate for receiving erythropoietin, (b) determining the level of expression of the NEPOR gene(s) (mRNA) and/or the presence of the NEPOR gene product (protein) from the isolated tissue, and (c) correlating the presence of an NEPOR gene expression product or the presence of NEPOR protein to a physiological response to the treatment with erythropoietin. Furthermore, by disclosing the molecular compositions of NEPOR species, there are disclosed methods for rationally identifying/designing NEPOR modulating therapeutics. Methods also are provided for treating neurological insults such as stroke (via enhancement of NEPOR activity) and cancer (via down-regulation of cyto-protective signaling from NEPOR). | 12-10-2009 |
20120245087 | NOVEL TISSUE PROTECTIVE ERYTHROPOIETIN RECEPTOR (NEPOR) AND METHODS OF USE - There is disclosed a molecular composition(s) of a novel tissue protective erythropoietin (EPO) binding receptor protein complex, termed NEPOR. Presence of NEPOR components on a tumour allows EPO to impinge on the survival of associated cells thereby enhancing tumour progression and negatively effecting patient survival. Presence of NEPOR represents a prognostic biomarker for poorer patient outcome. Thus, methods are provided for stratifying patients having a tumour as suitable (i.e. NEPOR not present) or non-suitable (i.e., NEPOR present) for EPO treatment, comprising: (a) isolating a tissue sample from an individual who is receiving or is a candidate for receiving erythropoietin, (b) determining the level of expression of the NEPOR gene(s) (mRNA) and/or the presence of the NEPOR gene product (protein) from the isolated tissue, and (c) correlating the presence of an NEPOR gene expression product or the presence of NEPOR protein to a physiological response to the treatment with erythropoietin. Furthermore, by disclosing the molecular compositions of NEPOR species, there are disclosed methods for rationally identifying/designing NEPOR modulating therapeutics. Methods also are provided for treating neurological insults such as stroke (via enhancement of NEPOR activity) and cancer (via down-regulation of cyto-protective signaling from NEPOR). | 09-27-2012 |
20130268290 | SYSTEMS AND METHODS FOR DISEASE KNOWLEDGE MODELING - Systems and methods are described herein for disease knowledge modeling and clinical treatment decision support, and the prioritization of possible treatment options based on tumor or other disease biomarkers. Disease or indication information, including identification of biomolecular entities associated with the indication may be culled through text data mining to create a knowledge model of the indication. In some embodiments, the knowledge model may comprise a network of associations between molecular entities, including such drug targets and biomakers, genes, pathways. The model may be combined with patient-specific variant information and historical treatment records to identify and prioritize treatment decisions and allow for the prediction of disease drivers and provide treatment options tailored to a patient's genetic data. | 10-10-2013 |
20140296318 | NOVEL TISSUE PROTECTIVE ERYTHROPOIETIN RECEPTOR (NEPOR) AND METHODS OF USE - Methods of determining whether a patient is suitable for erythropoietin (EPO) therapy, including (A) isolating a tissue sample from said patient; (B) determining the level of expression of EPH-B4 in said sample; and (C) correlating a presence of EPH-B4 expression to a negative physiological response to EPO therapy). In addition, methods of enhancing the effectiveness of EPO therapy in a patient by administering to said patient, in conjunction with EPO therapy, an siRNA specific for EPH-B4. | 10-02-2014 |
20150081323 | SYSTEMS AND METHODS FOR DISEASE KNOWLEDGE MODELING AND CLINICAL DECISION SUPPORT - Systems and methods are described herein for disease knowledge modeling and clinical treatment decision support. Disease or indication information, including identification of biomolecular entities associated with the indication may be culled through data mining to create a knowledge model of the indication. In some embodiments, the knowledge model may comprise a network of associations between molecular entities, including drug targets and biomarkers, genes, pathways. The model is used for prioritizing treatment decisions, for treatments comprising one or more medications associated with one or more molecular entities in the model. The priority of a suggested treatment depends on at least one property of one or more medications of the suggested treatment. | 03-19-2015 |
20150363559 | SYSTEMS AND METHODS FOR CLINICAL DECISION SUPPORT - Systems and methods are described herein for the prioritization of possible treatment options based on biomarkers, such as (but not limited to) tumor and germline-based genomic variants. The system and methods may thereby identify patient and the status of a biomarker in the treatment options tailored to a patient, in particular to his/her clinical, molecular, and/or genetic condition. Furthermore, the system and method provides a means for prioritizing the possible treatment options based on the extraction and contextualization of clinical and molecular knowledge. The system gathers and/or accesses biomarker information and transforms the information into prioritized, clinically actionable options identified for a specific patient case. | 12-17-2015 |
20150370982 | SYSTEMS AND METHODS FOR CLINICAL DECISION SUPPORT - The present disclosure relates to systems and methods for bioinformatics and data processing. In particular, in a first aspect, the present disclosure relates to methods and systems for generating a personalized treatment guideline for a patient and for selecting a treatment for a patient. In another aspect, the present disclosure relates to methods and systems for selecting patients for a clinical trial of a treatment. The invention resolves cases in which patients have more than one “actionable” aberration by combining the patient-specific molecular information and the treatment-specific molecular information further with a clinico-molecular disease model, specifically a scoring of genes and/or proteins that represents several aspects of their involvement into the disease. In this way, treatments and patients can be prioritized that are most likely to impact or impacted by the disease mechanism, respectively. | 12-24-2015 |
20150379219 | SYSTEMS AND METHODS FOR IDENTIFYING UNKNOWN DRUG TARGETS VIA ADVERSE EVENT DATA - The present disclosure is directed to systems and methods for identifying unknown drug targets via adverse event data. An analyzer receives an identification of a first drug having one or more unknown target proteins and identifies a second drug related to the first drug. The analyzer retrieves, from an adverse event database, a first side effect profile associated with the first drug, and a second side effect profile associated with the second drug. The analyzer generates a third side effect profile comprising a subset of the first side effect profile not shared by the second side effect profile, and identifies a third drug having a fourth side effect profile comprising the third side effect profile. The analyzer retrieves a list of one or more target proteins of the third drug not targeted by the second drug, and presents the retrieved list as potential target proteins of the first drug. | 12-31-2015 |
Steven Brock, Westhill GB
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20140374114 | Subsea Intervention System - A subsea intervention system including at least one control station, at least one programmable logic controller system in each control station, at least one supervisory control and data acquisition system, at least one safety system capable of interacting with each control station, wherein the safety system is capable of controlling a process shutdown process, an emergency shutdown process, and an emergency quick-disconnect process. The system may also include subsea distribution units, safety manifold subsea control modules, system hydraulic power units, client hydraulic power units, grease skids, flushing and chemical injection units, or umbilical reelers. | 12-25-2014 |
Tracy Brock, Waupun, WI US
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20150375891 | CONTAINER WITH SECURE AUDIBLE CLOSURE - A re-closeable folded container includes a hexahedral base including a front panel and a rear panel, a cover pivotally connected with an upper edge of a rear panel for movement between an open position and a closed position, and a locking panel hingedly connected with an upper edge of the front panel. The front panel includes a tear-away portion defined by a score line. The locking panel includes a first tab, a second tab, and a tear-away portion defined by score lines. The tear-away portion of the locking panel is fixedly attached to both the front portion of the cover and the tear-away portion of the front panel such that initial movement of the cover from the closed position toward the open position causes the locking panel and the front panel to tear along the score lines and causes both tear-away portions to pivotally move with the cover. | 12-31-2015 |
Victoria Brock, Renfrew GB
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20140257927 | COMPUTER SYSTEM FOR PROCESSING DATA ON RETURNED GOODS - One aspect provides a computer system for processing data on returned products, by receiving returns data on purchased products returned for a refund; and determining predicted return data for a product sold in the future based on the returns data for the product purchased in the past. Another aspect provides a computer system for receiving customer selection data for a product that the customer proposes to one of purchase and refund, the customer selection data including data identifying the customer and the product; accessing returns data using at least one of the data identifying the customer and the data identifying the product, the returns data indicating at least one of a customer's propensity to return products and a propensity of the product to be returned; and generating a customer interface dependent upon on the returns data for one of the proposed purchase and the proposed refund. | 09-11-2014 |
William Brock, Chattanooga, TN US
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20150294047 | System for Continuous Modeling and Dissemination of Threat Zones Associated with Hazardous Release Materials - A computer cloud implemented method and system for manually or electronically inputting real time geophysical location data, physical properties of the substance, associated release parameters of the physical substance into the open earth atmosphere, and weather data (historical, current or future forecasted data) on the assumption the release of the substance occurred at the same instantaneous time the weather data was entered and repeatedly calculating the results with new updated data for any of the above data parameters using algorithmic modeling of toxic substance releases to compute a model of the predicted toxic threat zone (Gaussian model) or a model of the predicted toxic plume pathway and associated exposure levels (CFD) and rendering the results electronically for visual display in, on or over any multi-coordinate display system in any medium and distributed or distributable to users electronically or manually when input parameters are updated, and displaying other related information associated with toxic substance release, are provided. | 10-15-2015 |