Patent application number | Description | Published |
20080221077 | Ansamycin formulations and methods of use thereof - Provided herein, inter alia, are solid forms of geldanamycin analogs, pharmaceutical compositions comprising a geldanamycin analog and a crystallization inhibitor, methods of making and using such compositions. Additionally, provided are methods for the treatment of cancer, a neoplastic disease state and/or a hyperproliferative disorder, and methods of inhibiting Heat Shock Protein 90 (“Hsp90”). | 09-11-2008 |
20090062528 | Ansamycin formulations and methods of use thereof - Provided herein, inter alia, are solid forms of geldanamycin analogs, pharmaceutical compositions comprising a geldanamycin analog and a crystallization inhibitor, methods of making and using such compositions. Additionally, provided are methods for the treatment of cancer, a neoplastic disease state and/or a hyperproliferative disorder, and methods of inhibiting Heat Shock Protein 90 (“Hsp90”). | 03-05-2009 |
20090069281 | Ansamycin formulations and methods of use thereof - Provided herein, inter alia, are solid forms of geldanamycin analogs, pharmaceutical compositions comprising a geldanamycin analog and a crystallization inhibitor, methods of making and using such compositions. Additionally, provided are methods for the treatment of cancer, a neoplastic disease state and/or a hyperproliferative disorder, and methods of inhibiting Heat Shock Protein 90 (“Hsp90”). | 03-12-2009 |
20110009442 | METHODS FOR STEREOSELECTIVE REDUCTION - The invention is directed to a method to reduce a C—C double bond of an enone of a steroidal compound to produce a mixture of β ketone product and α ketone product, comprising treating a solution or suspension of the steroidal compound in a solvent with hydrogen gas in the presence of a catalyst and a substituted pyridine. | 01-13-2011 |
20110201574 | FATTY ACID AMIDE HYDROLASE INHIBITORS - The present invention provides fatty acid amide hydrolase inhibitors, solid forms thereof, compositions thereof, and methods of making and using the same. | 08-18-2011 |
20120065399 | Transfer Hydrogenation of Cyclopamine Analogs - Provided herein is a process for the transfer-hydrogenation of ketone analogs of members of the jervine type of | 03-15-2012 |
20120065400 | Transfer Hydrogenation of Cyclopamine Analogs - Provided herein is a process for the transfer-hydrogenation of ketone analogs of members of the jervine type of | 03-15-2012 |
20120083607 | Enzymatic Transamination of Cyclopamine Analogs - Provided are processes for the synthesis of amino analogues from ketone starting materials. | 04-05-2012 |
20140357868 | METHODS FOR STEREOSELECTIVE REDUCTION - The invention is directed to a method to reduce a C—C double bond of an enone of a steroidal compound to produce a mixture of β ketone product and α ketone product, comprising treating a solution or suspension of the steroidal compound in a solvent with hydrogen gas in the presence of a catalyst and a substituted pyridine. | 12-04-2014 |
20140371456 | Enzymatic Transamination of Cyclopamine Analogs - Provided are processes for the synthesis of amino analogues from ketone starting materials. | 12-18-2014 |