Bradbury, US
Adam Wyatt Bradbury, Gaithersburg, MD US
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20150138357 | Integrated Automotive System, Pop Up Nozzle Assembly and Remote Control Method for Cleaning a Wide Angle Image Sensors Exterior Surface - A pop-up external lens washing system has an extendable aiming fixture configured to aim a lens cleaning spray at an external lens which is exposed to the elements and apt to become soiled with debris. The extendable nozzle assembly is configured to be aimed toward the external lens by the extended aiming fixture during the washing operation only and has at least one laterally offset washing nozzle projecting from the aiming fixture to a spray washing fluid toward the external lens surface, spraying at a shallow, glancing spray aiming angle to impinge upon and wash the lens external surface. | 05-21-2015 |
Andrew M. Bradbury, Sante Fe, NM US
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20120077960 | FLUOROBODIES: INTRINSICALLY FLUORESCENT BINDING LIGANDS - Binding ligands with intrinsic fluorescence (“fluorobodies”), fluorobody libraries, and methods of preparing fluorobodies are provided. In one aspect, the invention provides fluorobodies generated from a highly stable, artificial fluorescent protein, eCGP123 and derivatives thereof. | 03-29-2012 |
Andrew M. Bradbury, Santa Fe, NM US
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20090142820 | Directed evolution methods for improving polypeptide folding, solubility and stability - The invention provides directed evolution methods for improving the folding, solubility and stability (including thermostability) characteristics of polypeptides. In one aspect, the invention provides a method for generating folding and stability-enhanced variants of proteins, including but not limited to fluorescent proteins, chromophoric proteins and enzymes. In another aspect, the invention provides methods for generating thermostable variants of a target protein or polypeptide via an internal destabilization baiting strategy. Internally destabilization a protein of interest is achieved by inserting a heterologous, folding-destabilizing sequence (folding interference domain) within DNA encoding the protein of interest, evolving the protein sequences adjacent to the heterologous insertion to overcome the destabilization (using any number of mutagenesis methods), thereby creating a library of variants. The variants in the library are expressed, and those with enhanced folding characteristics selected. | 06-04-2009 |
20100009441 | POLYNUCLEOTIDES ENCODING ANTI-SULFOTYROSINE ANTIBODIES - The invention provides anti-sulfotyrosine specific antibodies capable of detecting and isolating polypeptides that are tyrosine-sulfated. The sulfotyrosine antibodies and antibody fragments of the invention may be used to discriminate between the non-sulfated and sulfated forms of such proteins, using any number of immunological assays, such ELISAs, immunoblots, Western Blots, immunoprecipitations, and the like. Using a phage-display system, single chain antibodies (scFvs) were generated and screened against tyrosine-sulfated synthetic peptide antigens, resulting in the isolation of scFvs that specifically recognize sulfotyrosine-containing peptides and/or demonstrate sulfotyrosine-specific binding in tyrosine sulfated proteins. The VH and VL genes from one such sulfotyrosine-specific scFv were employed to generate a full length, sulfotyrosine-specific immunoglobulin. | 01-14-2010 |
20100215662 | Anti-influenza M2e antibody - Humanized recombinant and monoclonal antibodies specific for the ectodomain of the influenza virus M2 ion channel protein are disclosed. The antibodies of the invention have anti-viral activity and may be useful as anti-viral therapeutics and/or prophylactic/vaccine agents for inhibiting influenza virus replication and for treating individuals infected with influenza. | 08-26-2010 |
20100222551 | Highly thermostable fluorescent proteins - Thermostable fluorescent proteins (TSFPs), methods for generating these and other stability-enhanced proteins, polynucleotides encoding such proteins, and assays and method for using the TSFPs and TSFP-encoding nucleic acid molecules are provided. The TSFPs of the invention show extremely enhanced levels of stability and thermotolerance. In one case, for example, a TSFP of the invention is so stable it can be heated to 99° C. for short periods of time without denaturing, and retains 85% of its fluorescence when heated to 80° C. for several minutes. The invention also provides a method for generating stability-enhanced variants of a protein, including but not limited to fluorescent proteins. | 09-02-2010 |
20110245464 | HIGHLY THERMOSTABLE FLUORESCENT PROTEINS - Thermostable fluorescent proteins (TSFPs), methods for generating these and other stability-enhanced proteins, polynucleotides encoding such proteins, and assays and method for using the TSFPs and TSFP-encoding nucleic acid molecules are provided. The TSFPs of the invention show extremely enhanced levels of stability and thermotolerance. In one case, for example, a TSFP of the invention is so stable it can be heated to 99° C. for short periods of time without denaturing, and retains 85% of its fluorescence when heated to 80° C. for several minutes. The invention also provides a method for generating stability-enhanced variants of a protein, including but not limited to fluorescent proteins. | 10-06-2011 |
20120064085 | ANTI-INFLUENZA M2e ANTIBODY - Humanized recombinant and monoclonal antibodies specific for the ectodomain of the influenza virus M2 ion channel protein are disclosed. The antibodies of the invention have anti-viral activity and may be useful as anti-viral therapeutics and/or prophylactic/vaccine agents for inhibiting influenza virus replication and for treating individuals infected with influenza. | 03-15-2012 |
20120077266 | HIGHLY THERMOSTABLE FLUORESCENT PROTEINS - Thermostable fluorescent proteins (TSFPs), methods for generating these and other stability-enhanced proteins, polynucleotides encoding such proteins, and assays and method for using the TSFPs and TSFP-encoding nucleic acid molecules are provided. The TSFPs of the invention show extremely enhanced levels of stability and thermotolerance. In one case, for example, a TSFP of the invention is so stable it can be heated to 99° C. for short periods of time without denaturing, and retains 85% of its fluorescence when heated to 80° C. for several minutes. The invention also provides a method for generating stability-enhanced variants of a protein, including but not limited to fluorescent proteins. | 03-29-2012 |
20130085072 | RECOMBINANT RENEWABLE POLYCLONAL ANTIBODIES - Described herein are methods that combine phage and yeast display to create polyclonal antibodies that are renewable, and when amplified over 100 million fold, maintain diversity without loss of representation of any of the antibodies present. The antibody representation remains essentially constant, as confirmed by deep sequencing. The provided methods allow generation, use and propagation of polyclonal antibodies, without concern that representation is lost. Furthermore, because the derivation of the polyclonal pool is carried out in vitro using phage and yeast display, it is possible in various embodiments to eliminate reactivities that are considered undesirable. Additionally, the polyclonal pool can be enriched for higher affinity antibodies. | 04-04-2013 |
Barton James Bradbury, Wallingford, CT US
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20090012071 | 4-SUBSTITUTED-1H-ISOTHIAZOLO[5,4-B][1,4]OXAZINO[2,3,4-IJ]QUINOLINE-7,8(2H,9H)-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS - The present invention provides compounds of the formula that possess antimicrobial activity. Certain compounds provided herein possess potent antibacterial, antiprotozoal, or antifungal activity. Particular compounds provided herein are also potent and/or selective inhibitors of microbial DNA synthesis and reproduction. The invention provides anti-microbial compositions, including pharmaceutical compositions, containing a compound of the invention and one or more or more carriers. The invention provides pharmaceutical compositions containing a 4-substituted- | 01-08-2009 |
20110213152 | METHOD FOR SYNTHESIS OF 8-ALKOXY-9H-ISOTHIAZOLO[5,4-B]QUINOLINE-3,4-DIONES - The present invention provides process for synthesis of 8-methoxy-9H-isothiazolo[5,4-b]quinoline-3,4-diones and 8A,9-dihydro-4aH-isothiazolo[5,4-b]quinoline-3,4-diones of the Formula A. | 09-01-2011 |
20110223132 | ISOTHIAZOLOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS - The invention provides compounds and salts of Formula I and Formula | 09-15-2011 |
20120040959 | 8-METHOXY-9H-ISOTHIAZOLO[5,4-B]QUINOLINE-3,4-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS - The invention provides compound and salts of Formula I and II, disclosed herein, which includes compounds of Formula A and Formula B: | 02-16-2012 |
20120114601 | NEW ISOTHIAZOLOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS - The invention provides certain compounds and salts of Formula I and Formula II: | 05-10-2012 |
Carly Bradbury, Philadelphia, PA US
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20120005053 | BEHAVIORAL-BASED CUSTOMER SEGMENTATION APPLICATION - Embodiments of the invention relate to systems, methods, and computer program products for comprehensive and holistic behavior-based customer segmentation and customer profiling based on the segmentation. In specific embodiments of the invention, the segmentation includes internal credit behavior segmentation and external credit segmentation. In other embodiments, the segmentation includes internal credit behavior segmentation and external credit segmentation, and spend preference segmentation. In still further embodiments any combination of behavior algorithms may be implemented to segment the customer base and determine a related customer profile. The application additionally provides for new behavior algorithms to be added as needed in the future and the ability to interface with existing/legacy segmentation applications. | 01-05-2012 |
20150228014 | AUTOMATED CUSTOMER CHARACTERIZATION - A comprehensive and holistic behavior-based customer characterization scheme is presented. Specifically, the characterization scheme includes internal credit behavior segmentation and external credit segmentation. In other embodiments, the characterization includes internal credit behavior segmentation and external credit segmentation, and spend preference segmentation. In still further embodiments any combination of behavior algorithms may be implemented to characterize the customer base and determine a related customer profile. The application additionally provides for new behavior algorithms to be added as needed in the future and the ability to interface with existing/legacy segmentation applications. | 08-13-2015 |
Christopher Matthew Bradbury, Essex Junction, VT US
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20100305043 | CCL18 AND CCL3 METHODS AND COMPOSITIONS FOR DETECTING AND TREATING CANCER - The invention relates to methods of treating cancer by administering one or more chemokines that are downregulated in cancerous cells. More specifically, the invention provides methods for treating or preventing cancers such as malignant melanoma by administering a chemokine such as CCL18 and/or CCL3. The invention further provides methods for diagnosing cancer such as melanoma. | 12-02-2010 |
Colin Bradbury, San Diego, CA US
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20090262138 | ENHANCED POWER DISTRIBUTION UNIT WITH SELF-ORIENTING DISPLAY - An enhanced power distribution unit (PDU) with self-orienting display uses an orientation sensor in conjunction with a microprocessor to properly orient visual display of information by one or more displays of the enhanced PDU. Information displayed can relate to electrical current furnished to one or more power outlets of the enhanced PDU and/or information related to temperature, humidity or other conditions of the enhanced PDU. | 10-22-2009 |
Daniel P. Bradbury, Cumming, GA US
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20120236509 | Lightweight Unitary Display - A lightweight display includes a plurality of display modules having a plurality of pixels carried by a display mounting frame. A support frame integral with the display mounting frame provides support. An electronic support member carries electrical components electrically communicating with the plurality of display modules for controlling the display of an image. Wherein the depth of the plurality of display modules, display mounting frame, support frame and electronic support member is less than four inches when defining a display assembly. Also wherein the display assembly has a screen size measured diagonally in a range of 114 inches to 224 inches and a weight in the range of 90 pounds to 120 pounds and wherein the display assembly has an aspect ratio ranging from 1.67 to 1.82. | 09-20-2012 |
20150247627 | Lightweight Unitary Display - A lightweight display includes a plurality of display modules having a plurality of pixels carried by a display mounting frame. A support frame integral with the display mounting frame provides support. An electronic support member carries electrical components electrically communicating with the plurality of display modules for controlling the display of an image. Wherein the depth of the plurality of display modules, display mounting frame, support frame and electronic support member is less than four inches when defining a display assembly. Also wherein the display assembly has a screen size measured diagonally in a range of 114 inches to 224 inches and a weight in the range of 90 pounds to 120 pounds and wherein the display assembly has an aspect ratio ranging from 1.67 to 1.82. | 09-03-2015 |
Dave Bradbury, Center Barnstead, NH US
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20090101175 | CONTINUAL FLOW PIN WASHER - A multi-chambered deposition pin wash station is provided. The wash station includes a lower chamber and an upper drain basin connected by a plurality of wash tubes. Cleaning fluid is provided to the lower chamber and passes through the cleaning tubes into the upper drain basin. The cleaning tubes are adapted to clean a single deposition pin with a single tube per wash cycle. | 04-23-2009 |
20130061880 | Continual Flow Pin Washer - A multi-chambered deposition pin wash station is provided. The wash station includes a lower chamber and an upper drain basin connected by a plurality of wash tubes. Cleaning fluid is provided to the lower chamber and passes through the cleaning tubes into the upper drain basin. The cleaning tubes are adapted to clean a single deposition pin with a single tube per wash cycle. | 03-14-2013 |
Dave Bradbury, Center Bamstead, NH US
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20120000493 | CONTINUAL FLOW PIN WASHER - A multi-chambered deposition pin wash station is provided. The wash station includes a lower chamber and an upper drain basin connected by a plurality of wash tubes. Cleaning fluid is provided to the lower chamber and passes through the cleaning tubes into the upper drain basin. The cleaning tubes are adapted to clean a single deposition pin with a single tube per wash cycle. | 01-05-2012 |
David Bradbury, Ipswich, MA US
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20100142850 | System, method, and product for scanning of biological materials - An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values. | 06-10-2010 |
20110243411 | System, method, and product for scanning of biological materials - An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values. | 10-06-2011 |
20120235016 | System, Method, and Product for Scanning of Biological Materials - An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values. | 09-20-2012 |
Dennis Scott Bradbury, Laneville, TX US
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20160003559 | Gas-Fired Tube Swaged Joint - A heat exchange system for heating, ventilation, and air conditioning (HVAC) may comprise a burner box, a hot collector box, and a heat exchanger tube. The heat exchanger tube may be disposed between, and in fluid communication with, the hot collector box and the burner box. The heat exchanger tube may be rigidly connected to at least one of the hot collector box or burner box by a swaged joint. | 01-07-2016 |
Frank K. Bradbury, Saugus, MA US
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20100067373 | REDUNDANCY IN VOICE AND DATA COMMUNICATIONS SYSTEM - Apparatus is used in communicating in a data and voice communication system. The apparatus includes a line card and a crosspoint switch in communication with the line card. The apparatus also includes an accelerator card in communication with the line card and the crosspoint switch. The crosspoint switch is configured to provide a redundant communications path between the line card and the accelerator card. | 03-18-2010 |
20110096661 | REDUNDANCY IN VOICE AND DATA COMMUNICATIONS SYSTEMS - A method includes receiving information at an interface circuit and providing the information from the interface circuit to a processing circuit through a direct communications path between the interface circuit and a processing circuit, which processes the information received from the interface circuit. The method further includes providing the information from the interface circuit to the processing circuit via a crosspoint switch in response to a failure of the direct communications path, wherein the direct communication does not pass through the crosspoint switch. | 04-28-2011 |
Glenn Allen Bradbury, Mason, OH US
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20100043167 | Plural nozzle cleaning implement - A plural nozzle cleaning implement. The nozzles are oriented inwardly, to provide a converging spray pattern. The converging spray pattern provides more coverage of the target surface, which increases residence time of fluid sprayed onto debris. | 02-25-2010 |
20110146011 | APPARATUS FOR COLLECTING DEBRIS FROM A TARGET SURFACE - An apparatus for removing debris from a target surface. The apparatus comprises a hollow roller with a supply roll and take-up roll axially rotatably disposed within the volume of the hollow roller. A sheet material, such as adhesive tape, extends from the supply roll through a slot, around the periphery of the roller at least 180°, back into the slot and onto be take-up roll. A partition separates the supply roll and take-up roll, reducing contamination of tape on the supply roll. An index mechanism may be provided to advance the tape one path length from the supply roll to take-up roll, the user does not overuse or underuse fresh tape. | 06-23-2011 |
20120084933 | CLEANING HEAD FOR A TARGET SURFACE - A unit dose for cleaning an unsanitary surface, such as a toilet bowl. The unit dose comprises a water dispersible shell containing granules defining a core. The granules obviate the need for sheet material in the unit dose and provide cleaning efficacy when submerged. | 04-12-2012 |
20120096662 | CLEANING DEVICE HAVING PLURAL AND CUSTOMIZABLE CLEANING SURFACES - A device for cleaning debris from a target surface. The device has a sole plate with permanent bristles and a removable/replaceable pad. The device also has a replaceable, on-board supply of cleanser. The pad/cleanser may be replaced when depleted and replaced with a new pad/cleanser or may simply be replaced with a new pad/cleanser when that pad/cleanser is more suitable for a particular cleaning task. | 04-26-2012 |
20120246853 | Starch Head Having a Stiffening Member - A head for cleaning a target surface, such as a toilet bowl. The head has a longitudinal axis and comprises a starch based material. The material may be provided as a sheet, and formed to make a generally round head or a head of laminae. The head may optionally contain granules, which optionally define a core and improve the stiffness of the head. The starch based material may be extruded to have a machine direction oriented in the longitudinal direction of the cleaning device. | 10-04-2012 |
20120246854 | Water Disposable Head Comprising Plural Water Disposable Materials - A head for cleaning a target surface, such as a toilet bowl. The head has a longitudinal axis and comprises a starch based material. The material may be provided as a sheet, and formed to make a generally round head or a head of laminae. The head may optionally contain granules, which optionally define a core and improve the stiffness of the head. The starch based material may be extruded to have a machine direction oriented in the longitudinal direction of the cleaning device. | 10-04-2012 |
20130043329 | SPRAY DEVICE - A device for spraying contents from a pressurized container. The device has an anti-pre-spray mechanism which prevents inadvertent actuation or spray when a new container is loaded into the device. The anti-pre-spray mechanism provides a dead band between a valve assembly in the pressurized container and an actuation mechanism. The dead band may comprise a gap, spring, etc. The actuation mechanism may be activated by the consumer at the point of use. | 02-21-2013 |
20130333129 | FLOOR CLEANING DEVICE HAVING DISPOSABLE FLOOR SHEETS AND ROTATABLE BEATER BAR AND METHOD OF CLEANING A FLOOR THEREWITH - A cleaning system. The system has a floor cleaning device, disposable floor sheet removably attachable to the device and a rotatable beater bar. The device has a single wheel, and moves on the target surface by rolling action of the wheel and gliding of the floor sheet. This arrangement, not having multiple wheels, provides enhanced maneuverability, and improves cleaning performance. The cleaning system may be used to clean hard surfaces, such as a floor. | 12-19-2013 |
20130340186 | CLEANING DEVICE HAVING PLURAL AND CUSTOMIZABLE CLEANING SURFACES - A device for cleaning debris from a target surface. The device has a sole plate with permanent bristles and a removable/replaceable pad. The device also has a replaceable, on-board supply of cleanser. The pad/cleanser may be replaced when depleted and replaced with a new pad/cleanser or may simply be replaced with a new pad/cleanser when that pad/cleanser is more suitable for a particular cleaning task. | 12-26-2013 |
20140026344 | RETAINERS FOR A DEVICE HAVING REMOVABLE FLOOR SHEETS - A retainer for removably attaching a sheet to a cleaning device. The retainer has at least one cantilevered finger extending inwardly from the periphery of a cavity towards the inside of that cavity. Behind the retainer is a flexible barrier, at least partially covering the back of the cavity. The barrier prevents the user's finger from going too far into the cavity and becoming pinched, and allows the thickness of the device to which the sheet is attached to be reduced compared to a device having a conventional sheet retainer. The barrier may provide visual and/or tactile barrier cues to a user, qualitatively signaling the user which direction is proper for insertion of the sheet into the retainer and quantitatively signally the user how far the sheet should be inserted into the retainer. Strands and/or a membrane panel which are elastic or inelastic may be used for the barrier. | 01-30-2014 |
20140250619 | FLOOR CLEANING DEVICE HAVING A SOLE PLATE TO REMOVABLY RECEIVE A CLEANING SHEET THEREON - An implement for a cleaning system. The system has a floor cleaning device, which can accept a cleaning sheet removably attachable to the device. The device has a foot which comprises a housing and a panel movable in relationship to each other. The sheet is removably attachable to the panel, without requiring attachment to the housing. This arrangement provides ergonomic benefit and ease of sheet replacement. The cleaning system may be used to clean hard surfaces, such as a floor. | 09-11-2014 |
20150033491 | FLOOR CLEANING DEVICE HAVING A DUST BIN AND A PANEL FOR HOLDING A CLEANING SHEET PROXIMATE THERETO - A foot for a device and a related device for cleaning a target surface and which can accept a sheet for contact with the target surface. The device also has a rotatable beater bar. The beater bar and sheet provide two cleaning modes for the device. The device has a foot which comprises a housing and forward lip for the beater bar and further has a sole plate for accepting the cleaning sheet. The lip and proximate edge of the sole plate are in spaced in relationship to each other. The proper spacing between the portion of the housing with the beater and sole plate holding the sheet, provides for improved dual mode cleaning performance. The cleaning system may be used to clean hard surfaces, such as a floor. | 02-05-2015 |
20150059121 | FLOOR CLEANING DEVICE HAVING DISPOSABLE FLOOR SHEETS AND ROTATABLE BEATER BAR AND METHOD OF CLEANING A FLOOR THEREWITH - A cleaning system. The system has a floor cleaning device, disposable floor sheet removably attachable to the device pad, and a rotatable beater bar. The device has a single wheel, and moves on the target surface by rolling action of the wheel and gliding of the floor sheet. This arrangement, not having multiple wheels, provides enhanced maneuverability, and improves cleaning performance. The cleaning system may be used to clean hard surfaces, such as a floor. | 03-05-2015 |
James R. Bradbury, Littleton, CO US
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20090212184 | Articulated Mounting Systems And Bearings For Joints Thereof - An articulated mounting system ( | 08-27-2009 |
James S. Bradbury, Bothell, WA US
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20110307780 | CLOUD-BASED APPLICATION HELP - A cloud help system is described herein that is a confederation of both internet and product help content that gives the user of a software application a rich web-based user interface for searching the internet in conjunction with and in the context of the software application. An application developer associates identifiers with various features and areas within an application. Upon detecting a user request for product help, the system receives the identifier and identifies instructional material related to the received identifier. The instructional material combines traditional local and online help information with dynamic content from an online data source. The online data source includes an association between each identifier and one or more searches for online content. An administrator can update the online searches over time so that new material can be incorporated. | 12-15-2011 |
Jason Bradbury, Jasonville, IN US
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20160081864 | PORTABLE EXTRICATION DEVICE AND METHOD OF USE - A patient transport conveyor for conveying a patient on a liner between a first elevation and a second elevation includes a rail containing conveyor having a first end for placement at the first elevation and a second end for placement at the second elevation. The rail containing conveyor includes first and second spaced generally parallel rail members extending generally between the first and second ends. The first and second rail members define a litter receiving space for receiving the litter and maintaining the litter on the conveyor. A guide member extends generally between the first and second ends. The guide member configured for being engaged with the litter to help maintain the litter in the litter receiving space. A coupler is disposed at the first end and is configured for coupling the transport conveyor to an anchoring at the first elevation for maintaining the position of the transport conveyor. | 03-24-2016 |
Jonathan Bradbury, Inglewood, CA US
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20090203446 | Methods of Playing Video Games - Video game systems for executing instructions according to a video game contained on an item of first media including: an item of second media containing data defining an aspect of the video game; and a video game console including a housing, a first media device supported by the housing, a second media device supported by the housing, and a control unit supported by the housing and configured to control the first media device to read the item of first media and to control the second media device to read the item of second media. | 08-13-2009 |
20110092286 | Video Game System and Methods of Operating a Video Game - Video game systems for executing instructions according to a video game contained on an item of first media including: an item of second media containing data defining an aspect of the video game; and a video game console including a housing, a first media device supported by the housing, a second media device supported by the housing, and a control unit supported by the housing and configured to control the first media device to read the item of first media and to control the second media device to read the item of second media. | 04-21-2011 |
Keith Bradbury, Blauvelt, NY US
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20150039325 | Assessing Pharmaceuticals - Among other things, data is stored for each of several pharmaceuticals that are associated with a given indication. The data is representative of elements of value of the pharmaceutical including elements within the domains of clinical efficacy, safety and use, and economics. A computer is used to calculate a drug score for each of the pharmaceuticals based on the data that is representative of the elements of value. Through a user interface, the relative scores and the basis on which they were calculated are displayed to enable decisions about the pharmaceuticals. | 02-05-2015 |
20150039331 | ASSESSING PHARMACEUTICALS - Among other things, data is stored for each of several pharmaceuticals that are associated with a given indication. The data is representative of elements of value of the pharmaceutical including elements within the domains of clinical efficacy, safety and use, and economics. A computer is used to calculate a drug score for each of the pharmaceuticals based on the data that is representative of the elements of value. Through a user interface, the relative scores and the basis on which they were calculated are displayed to enable decisions about the pharmaceuticals. | 02-05-2015 |
Keith J. Bradbury, Blauvelt, NY US
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20100228570 | COMPUTER SYSTEM AND METHOD FOR GENERATING HEALTHCARE RISK INDICES USING MEDICATION COMPLIANCE INFORMATION - A healthcare risk index is generated using a patient or individual's pharmacy claims. The index may be used to explain and predict variation in pharmacy-related costs and variation in total healthcare costs or utilization. In particular, the index is generated by first examining the individual's pharmacy claims to identify any chronic conditions possessed by the individual. Similarly, the individual's pharmacy claims are examined to identify any compliance medications prescribed to the individual. The chronic condition information is used to generate a chronic condition score by summing regression coefficients for each chronic condition possessed by the individual. Likewise, the compliance medication information is used to generate a compliance medication score by summing products of regression coefficients for each compliance medication prescribed to the individual with associated medication supply weights. From there, a modified chronic condition score is generated by multiplying the chronic condition score by an overall chronic condition regression coefficient. The modified chronic condition score may then be further modified by subtracting a no-claims weight from the chronic condition score in cases where the individual has no pharmacy claims. Finally, the risk index may be determined by summing the modified chronic condition score and the compliance medication score. | 09-09-2010 |
20100235193 | COMPUTER SYSTEM AND METHOD FOR GENERATING HEALTHCARE RISK INDICES USING MEDICATION COMPLIANCE INFORMATION - A healthcare risk index is generated using a patient or individual's pharmacy claims. The index may be used to explain and predict variation in pharmacy-related costs and variation in total healthcare costs or utilization. In particular, the index is generated by first examining the individual's pharmacy claims to identify any chronic conditions possessed by the individual. Similarly, the individual's pharmacy claims are examined to identify any compliance medications prescribed to the individual. The chronic condition information is used to generate a chronic condition score by summing regression coefficients for each chronic condition possessed by the individual. Likewise, the compliance medication information is used to generate a compliance medication score by summing products of regression coefficients for each compliance medication prescribed to the individual with associated medication supply weights. From there, a modified chronic condition score is generated by multiplying the chronic condition score by an overall chronic condition regression coefficient. The modified chronic condition score may then be further modified by subtracting a no-claims weight from the chronic condition score in cases where the individual has no pharmacy claims. Finally, the risk index may be determined by summing the modified chronic condition score and the compliance medication score. | 09-16-2010 |
Laura Bradbury, Newton, MA US
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20090209737 | USE OF DENATURING AGENTS DURING AFFINITY CAPTURE - A method for affinity capturing target molecules is disclosed, comprising obtaining a sample comprising a target molecule; and, in the presence of a denaturing agent; affinity capturing the target molecule with a single chain affinity molecule or antigen binding portion thereof that specifically binds the target molecule, wherein the affinity molecule or antigen binding portion thereof is immobilized on a support. | 08-20-2009 |
Louis Bradbury, New York, NY US
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20160060711 | CruP Protects Against ROS in Oxygenic Photosynthetic Organisms - The herein invention provides methods for selecting a plant that is cold and anoxia tolerant by detecting the expression of CruP in said plant, selecting a plant that overexpresses CruP as being cold and anoxia tolerant. Also provided are methods for providing cold tolerance, anoxia tolerance and protection against reactive oxygen species in a plant by introducing a gene that encodes CruP with higher than wild type expression in said plant. | 03-03-2016 |
Margaret Bradbury, Vista, CA US
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20140336386 | FORMULATIONS PHARMACOKINETICS OF DEUTERATED BENZOQUINOLINE INHIBITORS OF VESICULAR MONOAMINE TRANSPORTER 2 - The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2 (VMAT2) activity in a subject for the treatment of chronic hyperkinetic movement disorders. | 11-13-2014 |
20140341994 | FORMULATIONS AND PHARMACOKINETICS OF DEUTERATED BENZOQUINOLINE INHIBITORS OF VESICULAR MONOAMINE TRANSPORTER 2 - The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2 (VMAT2) activity in a subject for the treatment of chronic hyperkinetic movement disorders. | 11-20-2014 |
Michael S. Bradbury, Eagle, CO US
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20130099073 | Retractable Hanging Assembly for Cookware and Utensils - An apparatus for storing and retrieving cookware and utensils utilizing an assembly attached to the interior of a kitchen cabinet. The assembly is accessible by slides attached to the cabinet and incorporates hanger assembling and hanging guard assemblies whose positions are adjustable along the length of the assembly. The hanger assemblies utilize hooks that hang in a downward vertical position and are capable of rotating and pivoting around their vertical axes. The hanging guards are constructed of material that protects and separates the cookware hanging from the hanging assemblies. | 04-25-2013 |
Michelle Bradbury, New York, NY US
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20130039848 | FLUORESCENT SILICA-BASED NANOPARTICLES - The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer The nanoparticle has a fluorescent compound positioned within the nanoparticle, and has greater brightness and fluorescent quantum yield than the free fluorescent compound To facilitate efficient urinary excretion of the nanoparticle, it may be coated with an organic polymer, such as polyethylene glycol) (PEG) The small size of the nanoparticle, the silica base and the organic polymer coating minimizes the toxicity of the nanoparticle when administered in vivo The nanoparticle may further be conjugated to a ligand capable of binding to a cellular component associated with the specific cell type, such as a tumor marker A therapeutic agent may be attached to the nanoparticle Radionuclides/radiometals or paramagnetic ions may be conjugated to the nanoparticle to permit the nanoparticle to be detectable by various imaging techniques. | 02-14-2013 |
20140248210 | MULTIMODAL SILICA-BASED NANOPARTICLES - The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer. The nanoparticle has a range of diameters including between about 0.1 nm and about 100 nm, between about 0.5 nm and about 50 nm, between about 1 nm and about 25 nm, between about 1 nm and about 15 nm, or between about 1 nm and about 8 nm. The nanoparticle has a fluorescent compound positioned within the nanoparticle, and has greater brightness and fluorescent quantum yield than the free fluorescent compound. The nanoparticle also exhibits high biostability and biocompatibility. To facilitate efficient urinary excretion of the nanoparticle, it may be coated with an organic polymer, such as poly(ethylene glycol) (PEG). The small size of the nanoparticle, the silica base and the organic polymer coating minimizes the toxicity of the nanoparticle when administered in vivo. In order to target a specific cell type, the nanoparticle may further be conjugated to a ligand, which is capable of binding to a cellular component associated with the specific cell type, such as a tumor marker. In one embodiment, a therapeutic agent may be attached to the nanoparticle. To permit the nanoparticle to be detectable by not only optical fluorescence imaging, but also other imaging techniques, such as positron emission tomography (PET), single photon emission computed tomography (SPECT), computerized tomography (CT), bioluminescence imaging, and magnetic resonance imaging (MRI), radionuclides/radiometals or paramagnetic ions may be conjugated to the nanoparticle. | 09-04-2014 |
20150343091 | NANOPARTICLE DRUG CONJUGATES - Described herein are nanoparticle drug conjugates (NDCs), which, in certain embodiments, comprise a non-toxic, multi-modality, clinically proven silica-based nanoparticle platform with covalently attached drug molecules/moieties. The nanoparticle drug conjugates (NDCs) demonstrate imaging capability and targeting ligands which efficiently clear through the kidneys. Furthermore, the conjugates incorporate therapeutic agents for cancer detection, prevention, and/or treatment. | 12-03-2015 |
Michelle S. Bradbury, New York, NY US
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20150182118 | SYSTEMS, METHODS, AND APPARATUS FOR MULTICHANNEL IMAGING OF FLUORESCENT SOURCES IN REAL TIME - Presented herein is a multichannel imaging system capable of detecting and distinguishing multiple fluorescent light sources simultaneously. Also described herein are methods of using the system to image disease or cellular abnormalities, e.g., for diagnostic and/or intraoperative purposes. | 07-02-2015 |
Neal Bradbury, Hillsdale, NJ US
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20140317459 | BACKUP SYSTEM DEFECT DETECTION - A backup defect detection system includes a backend and an agent. The backend includes a plurality of file servers backed by a database. The database contains data associated with one or more users. The agent is installed on a user's computing device and in communication with the backend to scan a user's selected folders to determine new or changed files and upload the new or changed files to the backend. The agent is configured to generate one or more logs recording the success or failure type of a file backup and transmit the logs to the backend. The backend is configured to generate a report from the logs, filter and prioritize the report based on a set of user defined importance for each error type and provide the filtered and prioritized report for further action. Related apparatus, systems, techniques and articles are also described. | 10-23-2014 |
Robert Bradbury, Saugus, MA US
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20090305905 | COMPOSITIONS AND METHODS RELATING TO CHARACTERIZATION AND THERAPEUTIC APPLICATION OF PRISTINE STEM CELLS - “Pristine” stem cells are provided by a process of precise selection wherein stem cells exhibiting ideal behavior, good morphology and proper gene expression are selected. Stem cells are divided into pools and observed for optimum speed of growth, proper gene expression levels, and other tests indicative of healthy cell function due to lack of mutation or misrepair of genes. Autologous pools of such “pristine” stem cells provide a source of stem cells having the genome least affected by mutation, and therefore in a more pristine state. | 12-10-2009 |
Rurik Bradbury, New York, NY US
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20140108959 | Collaboration Network Platform Providing Virtual Rooms with Indication of Number and Identity of Users in the Virtual Rooms - The present invention extends to methods, systems, and computer program products for implementing a collaboration network platform that provides virtual rooms with an indication of which users of the collaboration network are working within the virtual rooms. A virtual room comprises an organizational unit for grouping users of a collaboration network with respect to a particular subject. For each virtual room within the collaboration network, a count of the number of users and/or a representation of each of the users that are currently working in the virtual room can be maintained and displayed as appropriate. The virtual room can also provide an option to transmit audio and/or video communications in real-time to some or all of the users that are in the virtual room. | 04-17-2014 |
Sarah Elizabeth Bradbury, Dallas, TX US
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20150278775 | Systems and Methods for Utilizing Social Media with Money Transfer Transactions - Systems and methods which utilize one or more social networking systems when creating, funding, and/or notifying a party of a transaction are provided. In accordance with one aspect, a money transfer transaction may be staged by a user whereupon a link corresponding to the staged transaction may be posted to one or more social networking services in order to allow for multiple users to access and fund the staged transaction. Additionally, in some aspects a user of a social networking service may generate a comment or post which then automatically triggers the staging of a money transfer transaction. Moreover, social networking services may be utilized to provide various notifications regarding money transfer transactions. | 10-01-2015 |
Stanley Jay Bradbury, San Francisco, CA US
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20090203390 | METHOD AND SYSTEMS FOR DYNAMIC ASSIGNMENT OF COMMON SHORT CODES FOR SHARED USE TEXT MESSAGE ROUTING - A computer-readable medium encoded with executable instructions for a text messaging service for dynamically associating a first user to a first business via a shared common short code is provided. The instructions are for receiving a first text message from a first user via a first shared common short code, determining a user history associated with the first user based on an identification of the first user, and determining an association of the first shared common short code with a first business based on the user history associated with the first user. The instructions are further for storing the association of the first shared common short code with the first business for the first user in the user history associated with the first user and routing the first text message to the first business. | 08-13-2009 |
Steve Bradbury, Hastings-On-Hudson, NY US
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20140068437 | COMPUTERIZED SYSTEM AND METHOD OF COMMUNICATING ABOUT DIGITAL CONTENT - A computerized system and method for communicating about digital content. In one embodiment, the system allows users to view and post video comments about source digital content. Typically, the source digital content and associated videos comments are assigned unique identifications so the relationships among videos can be stored in a central database. This means that video comments about source digital content can be decentralized since the source digital content has unique identifiers throughout websites and the relationship with any associated videos can be determined based on relationships stored in the database. | 03-06-2014 |
Thomas Albert Bradbury, Peoria, AZ US
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20090057497 | Innovative Duct Bank Spacer - An Innovative Duct Bank Spacer allows the manipulation of the duct bank spacer to accommodate multiple conduit sizes in a single ready-made duct bank spacer. The inventive device includes PVC Pipe that is fitted thru drilled High Density Polyethylene (HDPE) slats. PVC pipe spacers are placed in between the HDPE slats to accommodate the conduit size and spacing needed and/or required. The PVC Pipe is glued into PVC couplings at each end of the Innovative Duct Bank Spacer to secure the placement of the PVC pipes. Two or more Innovative Duct Bank Spacers may be easily joined together with a piece of PVC pipe at either end to create an even larger duct bank spacer. | 03-05-2009 |
Thomas J. Bradbury, Yardley, PA US
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20140065194 | Three-dimensional Printing System and Equipment Assembly - A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non-pharmaceutical/non-medical objects. It can be used to prepare single or multiple articles. | 03-06-2014 |
20150183166 | Three-dimensional Printing System and Equipment Assembly - A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non-pharmaceutical/non-medical objects. It can be used to prepare single or multiple articles. | 07-02-2015 |
William L. Bradbury, San Diego, CA US
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20130319762 | Transient liquid phase, pressureless joining of aluminum nitride components - A monolithic, substantially hermetic joining or bonding of two or more aluminum nitride (“AlN”) ceramic components is made by promoting transient liquid phase sintering near the contact areas between the components. In a first approach, AlN particles are combined with a rare earth oxide sintering additive such as yttrium oxide (Y2O3) in a joining paste can be applied between the joining surfaces of fired ceramic preformed components prior to final firing to weld the components together. In a second approach, the additive is added to green mixture, and the components having different shrinkage aspect ratios are mated and cofired in an atmosphere containing a partial pressure of the additive. The additive encourages wetting and diffusion of the liquid phases present on the surfaces of ceramic interface particles in the contact areas during final firing. Such processes can be used to form complex ceramic structures such as a ceramic susceptor used in integrated circuit fabrication. The components can have a plurality of embedded metallized electronic traces which can be electrically interconnected across the interface between the components. | 12-05-2013 |
20150016083 | Thermocompression bonding apparatus and method - A multi-layer aluminum nitride ceramic, multi-heating element substrate is provided for forming electrical bonds between integrated circuits and an interposer structure using a thermocompression bonding process. The individually energizable heater element traces can be run through common regions of the heater surface platform. A network of cooling vias can be run through other parts of the substrate. The traces are then separately controlled and energized during a predetermined routine resulting in a temperature profile that maintains a substantially constant temperature plateau phase near a reflow temperature, and a more uniform temperature across the spaced apart surface regions of the heater substrate, thus imparting a more precisely uniform heating to the parts being bonded. | 01-15-2015 |