Patent application number | Description | Published |
20100009845 | Pipette Tip Containing Particle-Filled Polymer Monolith - The present invention relates to a pipette tip which is fitted with a porous organic monolith which is doped with active particles. Due to a unique polymerization method, the extraction tips stay highly permeable which allows sample to pass through the monolithic bed. The extraction tip represents an ideal tool for solid phase extraction, especially for desalting, isolating and purifying biomolecules such as peptides and proteins. | 01-14-2010 |
20100078572 | ANALYSIS OF LOW MOLECULAR WEIGHT MOLECULES BY MALDI-MS - The invention relates to a process for the analysis of molecules having a molecular weight of <1500 Da by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS), wherein an analyte containing low molecular weight molecules is applied to a matrix material, which is characterized in that the matrix material comprises fullerene-derivatised silica. This process allows clear identification of small molecules through intensive signals without matrix -related background disturbances. | 04-01-2010 |
20100323013 | HYDROLYSATES MADE OF PLANT EXTRACTS AND ANTIBACTERIAL AGENT CONTAINING THE SAME - The present invention relates to an antibacterial agent and a hydrolysate made of at least one extract that has been produced by extraction using ethanol/water from dried plant material of: a) at least one of the plants selected from the group consisting of: | 12-23-2010 |
20120088906 | Isolation of Phosphoproteins, Glycoproteins and Fragments thereof - The invention provides methods and apparatus for the selective isolation of phosphorylated and glycosylated proteins and their fragments. Metal cation is used to precipitate proteins or protein fragments containing phospho groups and/or glyco groups. The sample preparation method can be used for several types of biological samples, including HeLa cells, food, and human cerebrospinal fluid. The proteins are isolated, recovered and ready for analysis by mass spectrometry or other analytical methods allowing detection limits down to the femtomole level. The method and apparatus are valuable tools in the field of protein analysis and diagnostics. | 04-12-2012 |
20120255894 | METHOD FOR COVALENTLY ATTACHING POLYMERIC MONOLITHS TO POLYETHER ETHER KETONE (PEEK) SURFACES - Method for covalently attaching polymeric monoliths to polyether ether ketone (PEEK) surfaces The present invention provides a method of covalently attaching a polymeric monolith to the internal surface of polyether ether ketone (PEEK) tubing and column housings, comprising the steps of: (a) reducing the ketone group of the PEEK to a hydroxyl group to obtain a modified PEEK, (b) optionally reacting the hydroxyl group obtained in step (a) with a compound having an active vinyl group to form a modified PEEK selected from the group of acrylate modified PEEK, methacrylate modified PEEK, styrene modified PEEK and epoxy modified PEEK, and (c) reacting the modified PEEK obtained in step (a) or (b) with a polymer or polymerization mixture for forming the polymeric monolith. Hereby, the mechanical stability and solvent durability of larger diameter monolithic columns as well as their overall performance are improved. | 10-11-2012 |
20140147502 | HYDROLYSATES MADE OF PLANT EXTRACTS AND ANTIBACTERIAL AGENT CONTAINING THE SAME - The present invention relates to an antibacterial agent and a hydrolysate made of at least one extract that has been produced by extraction using ethanol/water from dried plant material of: a) at least one of the plants selected from the group consisting of: | 05-29-2014 |
20140200330 | Isolation of Phosphoproteins, Glycoproteins and Fragments thereof - The invention provides methods and apparatus for the selective isolation of phosphorylated and glycosylated proteins and their fragments. A lanthanide metal cation is used to precipitate proteins or protein fragments containing phospho groups and/or glyco groups. The sample preparation method can be used for many types of biological samples, including HeLa cells, food, and human cerebrospinal fluid. The proteins are isolated, recovered and ready for analysis by mass spectrometry or other analytical methods allowing detection limits down to the femtomole level. The method and apparatus are valuable tools in the field of protein analysis and diagnostics. | 07-17-2014 |
20140251918 | Dissolvable Bed Chromatographic Column and Methods of Use - An automated or semi-automated method was developed for the isolation of proteins using lanthanide metals. Phosphoproteins and glycoproteins can be isolated from complex biological samples using filtration with novel column configurations. | 09-11-2014 |
20140329991 | Isolation of Phosphoproteins, Glycoproteins and Fragments thereof - The invention provides methods and apparatus for the selective isolation of phosphorylated and glycosylated proteins and their fragments. A lanthanide metal cation is used to precipitate proteins or protein fragments containing phospho groups and/or glyco groups. The sample preparation method can be used for many types of biological samples, including HeLa cells, food, and human cerebrospinal fluid. The proteins are isolated, recovered and ready for analysis by mass spectrometry or other analytical methods allowing detection limits down to the femtomole level. The method and apparatus are valuable tools in the field of protein analysis and diagnostics. | 11-06-2014 |
Patent application number | Description | Published |
20120042506 | Method for Constructing a Dipole Antenna - A method of fabricating a microwave antenna assembly is disclosed. The fabrication method includes providing a proximal portion having an inner conductor and an outer conductor, the inner conductor extending at least partially therein. The method further includes providing a distal portion disposed distally of the proximal portion, with the inner conductor extending at least partially therein. A high strength material may be injected from an inflow slot to an outflow slot of the distal portion such that the material is disposed in-between the inner conductor and a ceramic layer. The material bonds the distal portion and the ceramic layer to the proximal portion while providing mechanical strength to the distal portion. | 02-23-2012 |
20120325516 | Thermally Tuned Coaxial Cable For Microwave Antennas - A coaxial cable, including an inner conductor and an outer conductor surrounding the inner conductor and a thermally responsive material positioned between the outer conductor and the inner conductor. The outer conductor is in a generally concentric relationship to the inner conductor and the inner and outer conductors are adapted to connect to an energy source. A thermal change in the thermally responsive material alters the generally concentric relationship between the outer conductor and the inner conductor. | 12-27-2012 |
20130085488 | NARROW GAUGE HIGH STRENGTH CHOKED WET TIP MICROWAVE ABLATION ANTENNA - An electromagnetic surgical ablation probe having a coaxial feedline and cooling chamber is disclosed. The disclosed probe includes a dipole antenna arrangement having a radiating section, a distal tip coupled to a distal end of the radiating section, and a ring-like balun short, or choke, which may control a radiation pattern of the probe. A conductive tube disposed coaxially around the balun short includes at least one fluid conduit which provides coolant, such as dionized water, to a cooling chamber defined within the probe. A radiofrequency transparent catheter forms an outer surface of the probe and may include a lubricious coating. | 04-04-2013 |
20130123772 | Perfused Core Dielectrically Loaded Dipole Microwave Antenna Probe - A microwave surgical ablation probe having an arrangement of coolant channels in fluid communication with a cooling chamber disposed within the distal end of the probe is disclosed. A hypotube having one or more longitudinal ribs extending radially inward from an inner surface thereof is coaxially disposed around a coaxial feedline. The longitudinal ribs of the hypotube engage an outer sheath of the feedline to define a fluid inflow channel to deliver coolant to the cooling chamber, and a fluid outflow channel to receive fluid from the cooling chamber. The cooling chamber may be formed from porous ceramic or porous metallic material that provides structural support to the probe while permitting coolant to circulate therethrough. The probe includes dielectric and choke members that are adapted to control the microwave radiation pattern (e.g., ablation shape), and which may provide improved coupling of the probe to tissue. | 05-16-2013 |
20130178843 | System and Method For Treating Tissue Using An Expandable Antenna - A method of repairing an inner vessel wall includes the step of inserting at least a portion of a microwave ablation device into a vessel. The microwave ablation device includes an inner conductor disposed within an outer conductor and defines a longitudinal axis. The method also includes the steps of inserting a repairing sealant into the vessel such that the repairing sealant is disposed between an inner vessel wall and the outer conductor and expanding at least a portion of the outer conductor relative to the longitudinal axis to force at least a portion of the repairing sealant into the inner vessel wall. The method also includes the step of delivering energy to at least one of the inner conductor and the outer conductor to activate the repairing sealant to repair the inner vessel wall. | 07-11-2013 |
20130178844 | System and Method For Treating Tissue Using An Expandable Antenna - An ablation device includes an antenna assembly having a radiating portion configured to deliver energy from a power source to tissue of a patient. The radiating portion has an outer conductor and an inner conductor extending therethrough. The inner conductor is disposed within the outer conductor and defines a longitudinal axis. One of the inner conductor and the outer conductor is movable relative to the other to cause at least a portion of the outer conductor to expand radially relative to the longitudinal axis. | 07-11-2013 |
20130231653 | ABLATION DEVICES WITH ADJUSTABLE RADIATING SECTION LENGTHS, ELECTROSURGICAL SYSTEMS INCLUDING SAME, AND METHODS OF ADJUSTING ABLATION FIELDS USING SAME - An energy applicator for directing energy to tissue includes a feedline and a radiating section operably coupled to the feedline, wherein the radiating section has a length. The energy applicator also includes a length adjustment member adapted to allow for selective adjustment of the length of the radiating section. | 09-05-2013 |
20130261620 | Microwave-Shielded Tissue Sensor Probe - A tissue sensor probe and corresponding electromagnetic surgical ablation system are disclosed. The system includes an ablation probe operatively coupled to a generator, a controller operatively coupled to the generator, and a tissue sensor probe operatively coupled to the controller. The tissue sensor probe includes an electrically-conductive enclosure configured to shield a temperature sensor from electromagnetic radiation produced by the ablation probe. At least a portion of the electrically-conductive enclosure is made of a high thermal-conductivity material. A material of high thermal-conductivity is disposed in the electrically-conductive enclosure in thermal association with the thermally-conductive material of the electrically-conductive enclosure. The temperature sensor is disposed in the material of high thermal conductivity so as to electrically isolate the temperature sensor from the enclosure. The temperature sensor provides tissue temperature to the controller, which monitors tissue temperature to determine tissue status and to activate and deactivate the generator based on the tissue status. | 10-03-2013 |
20140000098 | MICROWAVE ANTENNA PROBES AND METHODS OF MANUFACTURING MICROWAVE ANTENNA PROBES | 01-02-2014 |
20140005657 | MICROWAVE ANTENNA PROBES | 01-02-2014 |
20140114302 | TUNABLE MICROWAVE ABLATION PROBE - An electromagnetic surgical ablation probe having a tunable helical antenna element is disclosed. The probe includes a coaxial feedline having an inner conductor coaxially disposed within a dielectric, and an outer conductor coaxially disposed around the dielectric. The inner conductor and dielectric extend distally beyond a distal end of the outer conductor. A helical antenna element is operably coupled to a distal end of the inner conductor. During use, the antenna may be tuned by changing at least one dimension of the helical antenna element. Embodiments are presented wherein a dimensions of the helical antenna element is changed by state change of a shape memory alloy, by a change in temperature, by activation of a piston by fluidic pressure, by linear motion of a conical tip, and by a manual screw-type adjustment. | 04-24-2014 |
20140257267 | ADJUSTABLE TUNING OF A DIELECTRICALLY LOADED LOOP ANTENNA - A microwave antenna assembly is disclosed. The antenna assembly includes an elongated member defining a longitudinal axis and having proximal and distal ends. The antenna assembly also includes an outer conductor and an inner conductor each disposed within the elongated member and extending along the longitudinal axis. A portion of the inner conductor is deployable relative to the outer conductor such that the antenna assembly may transition from a first configuration to a second configuration. The antenna assembly also includes an expandable sheath at least partially disposed about a distal portion of the inner conductor and defining at one or more lumens configured to couple to a supply of dielectric material used to regulate the expansion of the expandable sheath. | 09-11-2014 |
20140290045 | METHOD FOR CONSTRUCTING A DIPOLE ANTENNA - A method of fabricating a microwave antenna assembly is disclosed. The fabrication method includes providing a proximal portion having an inner conductor and an outer conductor, the inner conductor extending at least partially therein. The method further includes providing a distal portion disposed distally of the proximal portion, with the inner conductor extending at least partially therein. A high strength material may be injected from an inflow slot to an outflow slot of the distal portion such that the material is disposed in-between the inner conductor and a ceramic layer. The material bonds the distal portion and the ceramic layer to the proximal portion while providing mechanical strength to the distal portion. | 10-02-2014 |
20150038957 | MICROWAVE ANTENNA HAVING A COAXIAL CABLE WITH AN ADJUSTABLE OUTER CONDUCTOR CONFIGURATION - A microwave ablation system includes a power source. A microwave antenna is adapted to connect to the power source via a coaxial cable that includes inner and outer conductors having a compressible dielectric operably disposed therebetween. The inner conductor in operative communication with a radiating section associated with the microwave antenna. The outer conductor includes a distal end transitionable with respect to each of the inner conductor, compressible dielectric and radiating section from an initial condition wherein the distal end has a first diameter to a subsequent condition wherein the distal end has second diameter. Transition of the distal end from the initial condition to the subsequent condition enhances the delivery of microwave energy from the power source to the inner conductor and radiating section such that a desired effect to tissue is achieved. | 02-05-2015 |
20150057651 | FLUID COOLED CHOKE DIELECTRIC AND COAXIAL CABLE DIELECTRIC - The microwave antenna assembly includes a feedline electrically connected to an elongated shaft by a choke electrical connector. The feedline includes an inner conductor, an outer conductor, an elongated shaft and a choke electrical connector. The inner conductor is disposed in coaxial arrangement with the inner conductor and forms a dielectric supply lumen therebetween. The elongated shaft at least partially surrounding the feedline and form a dielectric return lumen therebetween. The choke electrical connector surrounds at least a portion of the feedline and electrically connects the feedline outer conductor to the elongated shaft. A low-loss dielectric fluid is supplied between the inner conductor and the outer conductor of the feedline and forms a dielectric barrier therebetween. The low-loss dielectric fluid also forms a dielectric barrier between the outer conductor of the feedline and the elongated shaft and the choke electrical connector forms a plurality of apertures extending therethrough, the apertures forming at least a portion of the dielectric return lumen. | 02-26-2015 |
20150100051 | ELECTROSURGICAL DEVICES, DIRECTIONAL REFLECTOR ASSEMBLIES COUPLEABLE THERETO, AND ELECTROSURGICAL SYSTEMS INCLUDING SAME - A directional reflector assembly includes a tubular shaft having a proximal end and a distal end and adapted to operably engage an electrosurgical ablation probe, and a conical aperture having a proximal open apex joined to a distal end of the tubular shaft, and a distal open base, wherein an interior volume of the tubular shaft is open to the conical aperture. | 04-09-2015 |
20150129302 | THERMALLY TUNED COAXIAL CABLE FOR MICROWAVE ANTENNAS - A coaxial cable, including an inner conductor and an outer conductor surrounding the inner conductor and a thermally responsive material positioned between the outer conductor and the inner conductor. The outer conductor is in a generally concentric relationship to the inner conductor and the inner and outer conductors are adapted to connect to an energy source. A thermal change in the thermally responsive material alters the generally concentric relationship between the outer conductor and the inner conductor. | 05-14-2015 |
20150202004 | MODIFIED WET TIP ANTENNA DESIGN - A microwave antenna including a feedline, a radiating section, an inflow hypotube, a puck, a transition collar and a sleeve. The feedline includes a coaxial cable including an inner and outer conductor, and a dielectric disposed therebetween. The radiating section includes a dipole antenna coupled to the feedline and a trocar coupled to the distal end of the dipole antenna. The inflow hypotube is disposed around the outer conductor and configured to supply fluid to the radiating portion. The puck includes at least two ribs with inflow slots defined between two adjacent ribs. The transition collar is coupled to the distal end of the inflow hypotube and the first end of the puck. The transition collar includes at least two outflow slots configured to receive fluid from a distal end of the inflow hypotube and to transition the fluid from the outflow slots to a distal end of the radiating section. The sleeve overlays the two outflow slots of the transition collar, the puck and at least the distal portion of the radiating section. The sleeve forms a fluid-tight seal with the transition collar proximal the outflow slots and defines a first gap for transitioning the fluid to exit the outflow slots of the transition collar to the distal end of the radiating section. | 07-23-2015 |
20150223888 | DUAL ANTENNA MICROWAVE RESECTION AND ABLATION DEVICE, SYSTEM AND METHOD OF USE - A system for generating microwave energy includes a microwave generator that generates first and second microwave signals, a transmission line and a dual antenna microwave device. The transmission line transmits the first and second microwave signals to the microwave device. The microwave device includes a first antenna proximal a second antenna and a dual-sided choke positioned therebetween. The first antenna receives the first microwave signal from the transmission line between a first conductor and a second conductor and the second antenna receives the second microwave signal between the second conductor and a third conductor. The dual-sided choke includes a first and a second antenna choke circuit. The first antenna choke circuit limits the propagation of electromagnetic fields generated by the first antenna toward the second antenna and the second antenna choke circuit limits the propagation of electromagnetic fields generated by the second antenna toward the first antenna. | 08-13-2015 |
20150320489 | ABLATION PROBE FIXATION - An ablation probe fixation apparatus for securing an ablation probe to tissue includes a base having a top surface and a skin-contacting bottom surface, wherein the base includes an adhesive layer disposed on the skin-contacting bottom surface. The fixation apparatus also includes a fixation member coupled to the top surface of the base. The base and the fixation member include an aperture defined therein for insertion of the ablation probe therethrough. | 11-12-2015 |
20150320495 | MANAGEMENT OF VOLTAGE STANDING WAVE RATIO AT SKIN SURFACE DURING MICROWAVE ABLATION - A dielectric spacer for use during microwave ablation of tissue is disclosed. The dielectric spacer includes a housing having a predetermined thickness and a skin-contacting bottom surface. The housing is configured to be filled with a dielectric material having a predetermined dielectric permittivity. The housing is further configured to be placed on the tissue in proximity with at least one microwave antenna assembly, wherein the thickness and the dielectric permittivity are configured to shift a maximum voltage standing wave ratio of the at least one microwave antenna assembly. | 11-12-2015 |
20150320496 | SYSTEM AND METHOD FOR TREATING TISSUE USING AN EXPANDABLE ANTENNA - An ablation device includes an antenna assembly having a radiating portion configured to deliver energy from a power source to tissue of a patient. The radiating portion has an outer conductor and an inner conductor extending therethrough. The inner conductor is disposed within the outer conductor and defines a longitudinal axis. One of the inner conductor and the outer conductor is movable relative to the other to cause at least a portion of the outer conductor to expand radially relative to the longitudinal axis. | 11-12-2015 |
20150320497 | SYSTEM AND METHOD FOR TREATING TISSUE USING AN EXPANDABLE ANTENNA - A method of repairing an inner vessel wall includes the step of inserting at least a portion of a microwave ablation device into a vessel. The microwave ablation device includes an inner conductor disposed within an outer conductor and defines a longitudinal axis. The method also includes the steps of inserting a repairing sealant into the vessel such that the repairing sealant is disposed between an inner vessel wall and the outer conductor and expanding at least a portion of the outer conductor relative to the longitudinal axis to force at least a portion of the repairing sealant into the inner vessel wall. The method also includes the step of delivering energy to at least one of the inner conductor and the outer conductor to activate the repairing sealant to repair the inner vessel wall. | 11-12-2015 |
20150327928 | SYSTEM AND METHOD FOR PERFORMING AN ABLATION PROCEDURE - A method of performing an ablation procedure includes the initial step of supplying a fluid to a cooling chamber defined within an antenna assembly. The method also includes the steps of decreasing the temperature of the fluid to form a solid material and inserting the antenna assembly into tissue. The method also includes the step of supplying energy to the antenna assembly to treat tissue. Residual heat from the antenna assembly transitions the solid material back to the fluid. The method also includes the step of circulating the fluid within the antenna assembly to dissipate heat emanating from the antenna assembly. | 11-19-2015 |
20160030112 | CHOKED DIELECTRIC LOADED TIP DIPOLE MICROWAVE ANTENNA - A microwave antenna assembly is disclosed. The antenna assembly includes a feedline having an inner conductor, an outer conductor and an inner insulator disposed therebetween and a radiating section coupled to the feedline, the radiating section including a dipole antenna and a tubular dielectric loading disposed about the dipole antenna. | 02-04-2016 |
20160045259 | MICROWAVE-SHIELDED TISSUE SENSOR PROBE - A tissue sensor probe and corresponding electromagnetic surgical ablation system are disclosed. The system includes an ablation probe coupled to a generator, a controller coupled to the generator, and a tissue sensor probe coupled to the controller. The tissue sensor probe includes an electrically-conductive enclosure configured to shield a temperature sensor from electromagnetic radiation produced by the ablation probe. At least a portion of the electrically-conductive enclosure is made of a high thermal-conductivity material. A material of high thermal-conductivity is disposed in the electrically-conductive enclosure in thermal association with the thermally-conductive material of the electrically-conductive enclosure. The temperature sensor is disposed in the material of high thermal conductivity so as to electrically isolate the temperature sensor from the enclosure. The temperature sensor provides tissue temperature to the controller, which monitors tissue temperature to determine tissue status and activates and deactivates the generator based on the tissue status. | 02-18-2016 |
20160045264 | MICROWAVE ANTENNA PROBES AND METHODS OF MANUFACTURING MICROWAVE ANTENNA PROBES - A method of manufacturing a surgical instrument includes charging a first component to a first voltage, charging a second component to a second voltage such that a pre-determined voltage differential is established between the first and second components, axially moving at least one of the first and second components relative to the other, monitoring an electrical characteristic to determine whether an axial distance between the first and second components is equal to a target axial distance, and retaining the first and second components in fixed position relative to one another once the axial distance between the first and second components is equal to the target axial distance. | 02-18-2016 |
20160058508 | NARROW GAUGE HIGH STRENGTH CHOKED WET TIP MICROWAVE ABLATION ANTENNA - An electromagnetic surgical ablation probe having a coaxial feedline and cooling chamber is disclosed. The disclosed probe includes a dipole antenna arrangement having a radiating section, a distal tip coupled to a distal end of the radiating section, and a ring-like balun short, or choke, which may control a radiation pattern of the probe. A conductive tube disposed coaxially around the balun short includes at least one fluid conduit which provides coolant, such as dionized water, to a cooling chamber defined within the probe. A radiofrequency transparent catheter forms an outer surface of the probe and may include a lubricious coating. | 03-03-2016 |