Patent application number | Description | Published |
20090247462 | FGF VARIANTS AND METHODS FOR USE THEREOF - The present invention provides fibroblast growth factor variants demonstrating enhanced receptor subtype specificity and/or affinity. Preferred embodiments include both variants having enhanced activity that act as improved agonists and variants having reduced activity that act as antagonists. Methods of utilizing preferred FGF variants in preparation of medicaments for the treatment of skeletal disorders including skeletal dysplasia, osteoporosis and enhancing bone fracture healing and cartilage healing processes are provided. | 10-01-2009 |
20120214739 | FGF VARIANTS AND METHODS FOR USE THEREOF - The present invention provides fibroblast growth factor variants demonstrating enhanced receptor subtype specificity and/or affinity. Preferred embodiments include both variants having enhanced activity that act as improved agonists and variants having reduced activity that act as antagonists. Methods of utilizing preferred FGF variants in preparation of medicaments for the treatment of skeletal disorders including skeletal dysplasia, osteoporosis and enhancing bone fracture healing and cartilage healing processes are provided. | 08-23-2012 |
20150072426 | FGF-2 Variants and Methods of Use Thereof - A method of treating an individual (i) having abnormal bone; or (ii) afflicted with a disease or disorder related to normal or abnormal FGF receptors or a skeletal disorder; or (iii) having dysplasic bone. The method includes administering to the individual a pharmaceutical composition comprising a therapeutically effective amount of a fibroblast growth factor 9 (FGF-9) variant comprising at least one amino acid substitution in the beta 8-beta 9 loop, wherein said FGF-9 variant incorporates one of the amino acid sequences set forth in SEQ ID NO: 11, 13, 14, 15, 16 or 17. | 03-12-2015 |
Patent application number | Description | Published |
20080250183 | STREAM UNDER-RUN/OVER-RUN RECOVERY - Machine-readable media, methods, and apparatus are described to recover from stream under-run and/or over-run conditions. In some embodiments, an audio controller may discard any partial sample block of the stream. | 10-09-2008 |
20100169883 | PROVIDING MULTIPLE VIRTUAL DEVICE CONTROLLERS BY REDIRECTING AN INTERRUPT FROM A PHYSICAL DEVICE CONTROLLER - Embodiments of apparatuses, methods, and systems for providing multiple virtual device controllers by redirecting an interrupt from a physical device controller are disclosed. In one embodiment, an apparatus includes a processor, a physical device controller, and virtualization logic. The virtualization logic is to receive a first interrupt from the physical device controller, and in response, send a second interrupt to the processor from one of a plurality of virtual device controllers. | 07-01-2010 |
20100169884 | INJECTING TRANSACTIONS TO SUPPORT THE VIRTUALIZATION OF A PHYSICAL DEVICE CONTROLLER - Embodiments of apparatuses, methods, and systems for injecting transactions to support the virtualization of a physical device controller are disclosed. In one embodiment, an apparatus includes a processor, system memory, a physical device controller, and a virtualization agent. The physical device controller is to be shared by a plurality of virtual machines created by a virtual machine monitor installed on a processor. The virtualization agent is coupled to the system memory through a first interface and coupled to the physical device controller through a second interface, to represent the physical device controller as a plurality of virtual device controllers available to be allocated to the plurality of virtual machines, and to inject transactions onto the first interface and the second interface on behalf of the plurality of virtual device controllers. | 07-01-2010 |
20100169885 | Paging instruction for a virtualization engine to local storage - Embodiments of apparatuses, methods, and systems for paging instructions for a virtualization engine to local storage are disclosed. In one embodiment, an apparatus includes a processor, a physical device controller, a virtualization engine, system memory, and local storage. The physical device controller is to be shared by a plurality of virtual machines created by a virtual machine monitor installed on a processor. The virtualization engine is to represent the physical device controller as a plurality of virtual device controllers available to be allocated to the plurality of virtual machines. The local storage is separate from the physical memory to store instructions transferred from the system memory for execution by the virtualization engine. | 07-01-2010 |
20100174841 | PROVIDING MULTIPLE VIRTUAL DEVICE CONTROLLERS BY REDIRECTING AN INTERRUPT FROM A PHYSICAL DEVICE CONTROLLER - Embodiments of apparatuses, methods, and systems for providing multiple virtual device controllers by redirecting an interrupt from a physical device controller are disclosed. In one embodiment, an apparatus includes a processor, a physical device controller, and virtualization logic. The virtualization logic is to receive a first interrupt from the physical device controller, and in response, send a second interrupt to the processor from one of a plurality of virtual device controllers. | 07-08-2010 |
20110299680 | Methods and Apparatuses for Securing Playback Content - An apparatus for secured playback is presented. In one embodiment, the apparatus includes a controller that includes a key derivation module to manage authentication and key derivation. In one embodiment, the apparatus provides a video decryption key to a graphics engine if video data portions in a data stream are retrievable without having to decrypt the data stream. In one embodiment, the apparatus also includes a decryption module to decrypt a part of data in conjunction with an encryption key to generate video information and video data. The controller then writes an encrypted version of the video data to a video buffer of a graphics engine. | 12-08-2011 |