Patent application number | Description | Published |
20090005356 | SUBSTITUTED PYRROLOPYRIDINES AND PYRAZOLOPYRIDINES AS KINASE MODULATORS - Provided herein are substituted pyrrolopyridine heterocycles and substituted pyrazolopyridine heterocycles, pharmaceutical compositions comprising said heterocycles and methods of using said heterocycles in the treatment of disease. The heterocycles disclosed herein function as kinase modulators and have utility in the treatment of diseases such as cancer, allergy, asthma, inflammation, obstructive airway disease, autoimmune diseases, metabolic disease, infection, CNS disease, brain tumor, obesity, asthma, hematological disorder, degenerative neural disease, cardiovascular disease, or disease associated with angiogenesis, neovascularization, or vasculogenesis. | 01-01-2009 |
Patent application number | Description | Published |
20100104598 | DEVELOPMENT OF DENGUE VIRUS VACCINE COMPONENTS - The invention is related to a dengue virus or chimeric dengue virus that contains a mutation in the 3′ untranslated region (3′-UTR) comprising a Δ30 mutation that removes the TL-2 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, and nucleotides additional to the Δ30 mutation deleted from the 3′-UTR that removes sequence in the 5′ direction as far as the 5′ boundary of the TL-3 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, or a replacement of the 3′-UTR of a dengue virus of a first serotype with the 3′-UTR of a dengue virus of a second serotype, optionally containing the Δ30 mutation and nucleotides additional to the Δ30 mutation deleted from the 3′-UTR; and immunogenic compositions, methods of inducing an immune response, and methods of producing a dengue virus or chimeric dengue virus. | 04-29-2010 |
20100316670 | CHIMERIC SLE/DENGUE TYPE 4 ANTIGENIC VIRUSES - Embodiments described herein concern attenuated, St. Louis Encephalitis Virus/dengue virus type 4 antigenic chimeric viruses, which can be used to prepare immunogenic compositions, vaccines, and diagnostic reagents. Methods of making and using the foregoing are provided. | 12-16-2010 |
20120114694 | DEVELOPMENT OF MUTATIONS USEFUL FOR ATTENUATING DENGUE VIRUSES AND CHIMERIC DENGUE VIRUSES - A menu of mutations was developed that is useful in fine-tuning the attenuation and growth characteristics of dengue virus vaccines. | 05-10-2012 |
20130089567 | DEVELOPMENT OF DENGUE VIRUS VACCINE COMPONENTS - The invention is related to a dengue virus or chimeric dengue virus that contains a mutation in the 3′ untranslated region (3′-UTR) comprising a Δ30 mutation that removes the TL-2 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, and nucleotides additional to the Δ30 mutation deleted from the 3′-UTR that removes sequence in the 5′ direction as far as the 5′ boundary of the TL-3 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, or a replacement of the 3′-UTR of a dengue virus of a first serotype with the 3′-UTR of a dengue virus of a second serotype, optionally containing the Δ30 mutation and nucleotides additional to the Δ30 mutation deleted from the 3′-UTR; and immunogenic compositions, methods of inducing an immune response, and methods of producing a dengue virus or chimeric dengue virus. | 04-11-2013 |
20140212434 | MULTIVALENT VACCINES FOR RABIES VIRUS AND FILOVIRUSES - The present invention provides methods and compositions for inducing an immune response that confers dual protection against infections by either or both of a rabies virus and a filovirus, and/or which can be used therapeutically for an existing infection with rabies virus and/or a filovirus to treat at least one symptom thereof and/or to neutralize or clear the infecting agents. In particular, the present invention provides a recombinant rabies virus vector omprising a nucleotide sequence encoding at least one filovirus glycoprotein or an immunogenic fragment thereof, as well as pharmaceutical compostions comprising the vaccine vectors. | 07-31-2014 |
20140294892 | CONSTRUCTION OF WEST NILE VIRUS AND DENGUE VIRUS CHIMERAS FOR USE IN A LIVE VIRUS VACCINE TO PREVENT DISEASE CAUSED BY WEST NILE VIRUS - The present invention relates to attenuated, immunogenic West Nile virus chimeras built on a dengue virus backbone for the production of immunogenic, live, attenuated West Nile virus vaccines. | 10-02-2014 |
20150064214 | DEVELOPMENT OF MUTATIONS USEFUL FOR ATTENUATING DENGUE VIRUSES AND CHIMERIC DENGUE VIRUSES - A menu of mutations was developed that is useful in fine-tuning the attenuation and growth characteristics of dengue virus vaccines. | 03-05-2015 |
Patent application number | Description | Published |
20120319360 | PLUG ASSEMBLY FOR BLADE OUTER AIR SEAL - A plug assembly includes a cup which defines a cup portion and a cup anti-liberation portion along an axis, a wedge is mountable within the cup portion to at least partially radially expand the cup anti-liberation portion. | 12-20-2012 |
20130216363 | SURFACE AREA AUGMENTATION OF HOT-SECTION TURBOMACHINE COMPONENT - An example turbomachine hot-section component protrusion extends away from a base surface of a hot-section component along a longitudinal axis. A radial cross-section of the protrusion has a profile that is non-circular. | 08-22-2013 |
20130323033 | BLADE OUTER AIR SEAL WITH CORED PASSAGES - A blade outer air seal for a gas turbine engine includes a wall, a forward hook, and an aft hook. The wall extends between the forward hook and the aft hook, which are adapted to mount the blade outer air seal to a casing of the gas turbine engine. The wall includes a cored passage extending along at least a portion of the wall. The cored passage extends radially and axially through a portion of the aft hook to communicate with one or more apertures along a trailing edge of the aft hook. | 12-05-2013 |
20140083099 | MULTI-STAGE HIGH PRESSURE COMPRESSOR CASE - A compressor case assembly according to an exemplary embodiment of this disclosure, among other possible things, includes a case. A plurality of vane stages circumscribe an interior of the case. Each of the plurality of vane stages include a vane guide and at least one window for inserting a respective at least one vane there through. The at least one window is axially aligned with each of the vane guides The at least one window extends from an outer surface of the case into each of the vane guides. | 03-27-2014 |
20140248115 | Active Clearance Control System with Zone Controls - An ACC system and method of using such for changing a turbine blade to BOAS gap on an aircraft engine is disclosed. The ACC system may comprise a first ring, a first supply line and a first flow control assembly. The first ring may be configured to substantially encircle a portion of a case assembly that is disposed around an aircraft engine turbine. The first ring may include a plurality of segments that each define a chamber, an inlet port and a plurality of outlet ports. At least a portion of the outlet ports may be configured to be disposed adjacent to the case. The first supply line may be operatively connected to a first segment of the plurality of segments. The first flow control assembly may be operatively connected to the first supply line and configured to meter the flow of cool air into the first segment. | 09-04-2014 |
20140298788 | GAS TURBINE ENGINE INCLUDING PNEUMATIC ACTUATOR SYSTEM - A gas turbine engine that includes a compressor section and a pneumatic actuator system is delivered. The pneumatic actuator system includes a bleed air duct that receives bleed air from the compressor section and delivers the bleed air through an accumulator and to an actuator. The accumulator includes a chamber that attenuates a fluctuation in a pressure of the bleed air. | 10-09-2014 |
20150068214 | LOW THERMAL MASS JOINT - A gas turbine engine includes a tangential on-board injector (TOBI) fluidly connected to a compressor section. A diffuser case structurally supports a combustor section and the tangential on-board injector via at least one low thermal mass joint. | 03-12-2015 |
Patent application number | Description | Published |
20120001816 | THREE-AXIS PEDESTAL HAVING MOTION PLATFORM AND PIGGY BACK ASSEMBLIES - A rotationally-stabilizing tracking antenna system suitable for mounting on a moving structure includes a three-axis pedestal for supporting an antenna about a first azimuth axis, a second cross-level axis, and a third elevation axis, a three-axis drive assembly for rotating a vertical support assembly relative to a base assembly about the first azimuth axis, a cross-level driver for pivoting a cross-level frame assembly relative to the vertical support assembly about the second cross-level axis, and an elevation driver for pivoting an elevation frame assembly relative to the cross-level frame assembly about the third elevation axis, a motion platform assembly affixed to and movable with the elevation frame assembly, three orthogonally mounted angular rate sensors disposed on the motion platform assembly for sensing motion about predetermined X, Y and Z axis of the elevation frame assembly, a three-axis gravity accelerometer mounted on the motion platform assembly and configured to determine a. true-gravity zero reference, and a control unit for determining the actual position of elevation frame assembly based upon the sensed motion about said predetermined X, Y, and Z axes and said true-gravity zero reference, and for controlling the azimuth, cross-level and elevation drivers to position the elevation frame assembly in a desired position. Instead of or in addition to the motion platform assembly, the antenna system may include primary and secondary antenna affixed relative to the cross-level frame assembly and a control unit for selecting operation of a selected on of the primary and secondary antennas, determining the actual position of elevation frame assembly based upon the sensed motion about said predetermined X, Y, and Z axes, and for controlling the azimuth, cross-level and elevation drivers to position the selected one of the primary and secondary antennas in a desired position for tracking a communications satellite. Methods of using the three-axis pedestal having motion platform assembly is also described. | 01-05-2012 |