Patent application number | Description | Published |
20100093084 | METHOD FOR CREATING INTRACELLULAR ARTIFICIAL NANOSTRUCTURES IN SITU - A method of creating intracellular artificial nanostructures in situ, which employees a chemical precursor. The precursor does not self-assemble due to the presence of a cleavable motif linked to it. When the precursor comes inside live cells by an uptaking mechanism on the cell membrane, the cleavable motif is then to be removed by an enzymatic action of a first enzyme. Without the cleavable motif, the precursor now engages in a self-assembling process to form nanostructures within the live cells, which may cause formation of a hydrogel. Furthermore, the self-assembling process can be made reversible by employing a second enzyme which puts the cleavable motif back to the precursor, whereby dissolving the nanostructures into solution. | 04-15-2010 |
20100297450 | Implementing self-assembly nanometer-sized structures within metal - polymer interface - An adhesion bond between a metallic surface layer and a second surface is formed by treating the layers with a material comprising sulphur-containing molecules. The sulphur-containing molecules are applied as a surface treatment of the surfaces, so that the sulphur-containing molecules act as a coupling agent to bond chemically to both substrates form nanometer-sized structures on the surfaces. The nanometer-sized structures are incorporated into a self-assembly interlayer in between the surfaces, with the interlayer forming a bond to both surfaces. | 11-25-2010 |
20120142616 | Antineoplastic Hydrogels, and Enzyme-Instructed Preparations Thereof - Disclosed is a general methodology to create nano fibers of therapeutic molecules that have a dual role, as both the delivery vehicle and the drug itself. It is shown that with proper molecular design, the integration of enzymatic reaction and self-assembly provides a powerful method to create molecular hydrogels of clinically-used therapeutics without compromising their bioactivities. In addition, the results disclosed herein demonstrate enzyme-instructed self-assembly as a facile strategy for generating the supramolecular hydrogels of molecules that inherently have poor solubility in water. For example, by covalently connecting paclitaxel with a motif that is prone to self-assemble, a hydrogel of paclitaxel can be formed without compromising the activity of the paclitaxel. | 06-07-2012 |
20140148410 | Supramolecular Nanofibers and Hydrogels Based on Nucleic Acids Functionalized with Nucleobases - Disclosed are nucleopeptide compounds that include a nucleobase, and an amino acid. Certain compounds further comprise a glycoside. The compounds may self-assemble to form supramolecular hydrogels. Also, the compounds may be used as a platform to examine specific biological functions (e.g., binding to DNA and RNA) of a dynamic supramolecular system that is able to interact with both proteins and nucleic acids. Other uses include: methods of growing cells and methods of delivering a substance to a cell. | 05-29-2014 |
20140235550 | Antineoplastic Hydrogels, and Enzyme-Instructed Preparations Thereof - Disclosed is a general methodology to create nanofibers of therapeutic molecules that have a dual role, as both the delivery vehicle and the drug itself. It is shown that with proper molecular design, the integration of enzymatic reaction and self-assembly provides a powerful method to create molecular hydrogels of clinically-used therapeutics without compromising their bioactivities. In addition, the results disclosed herein demonstrate enzyme-instructed self-assembly as a facile strategy for generating the supramolecular hydrogels of molecules that inherently have poor solubility in water. For example, by covalently connecting paclitaxel with a motif that is prone to self-assemble, a hydrogel of paclitaxel can be formed without compromising the activity of the paclitaxel. | 08-21-2014 |
20150306232 | HYDROGELATORS COMPRISING D-AMINO ACIDS - Described herein are compounds comprising an oligopeptide and a non-steroidal antiinflammatory agent. The compounds self-assemble into supramolecular hydrogels and can be used as topical treatments for inflammatory conditions, such as osteoarthritis. Also described herein are oligopeptides compounds made from D-amino acid residues that form supramolecular hydrogels. The compounds may be functionalized with active agents, such as anticancer therapeutic agents, antiinflammatory agents, or imaging agents, therefore providing new mechanisms for delivery of active agents. | 10-29-2015 |
Patent application number | Description | Published |
20090017441 | ASYMMETRIC CYANINE FLUORESCENT DYES - The present disclosure provides the asymmetric cyanine fluorescent dyes of formula I in which X, n, R | 01-15-2009 |
20090023129 | WHITE BLOOD CELL DIFFERENTIATION REAGENT AND METHOD OF USE THEREOF - The present disclosure provides a white blood cell differentiation reagent comprising a fluorescent dye compound of Formula I, wherein R | 01-22-2009 |
20100267080 | REAGENT FOR BLOOD ANALYSIS AND METHOD OF USE THEREOF - The present disclosure provides a reagent for blood analysis which may include: (1) a compound having the general formula I as a fluorescent dye, wherein n, X, R | 10-21-2010 |
20130321743 | BACKLIGHT MODULE AND LIQUID CRYSTAL DISPLAY - A backlight module includes a light guide plate and a light source. The light guide plate includes a light incident surface, a bottom surface adjacent to the light incident surface, and a light emitting surface opposite to the bottom surface. The light source is positioned adjacent to the light incident surface, and includes a reflective block and a first point light source. The reflective block includes a first reflective surface facing the light incident surface. An air gap is defined between the first reflective surface and the light incident surface. The first reflective surface includes a first end and a second end. A distance between the first reflective surface and the light incident surface increases gradually along a direction from the first end to the second end. | 12-05-2013 |
20130336473 | DISPLAY DEVICE - A display device on a supporting base utilizes the surface area of the support base to house a handset of a wireless telephone, a small touch screen, a microphone, a loudspeaker, and a switch. A communication module within the support base permits wireless communication between all components, incoming and outgoing calls may be managed on a hands-free basis, and the display of information relevant to external communications may be switched between the touch screen and a large upper screen of the display device. | 12-19-2013 |
20150123763 | METHOD FOR CONTROLLING TERMINAL DEVICE BY USING HEADSET WIRE AND THE TERMINAL DEVICE THEREOF - The present disclosure provides a method for controlling a terminal device by using a headset wire connected to the terminal device. The method includes: recognizing a user's gesture based on a current detected in a specific region of the headset wire; acquiring control instruction corresponding to the user's gesture; and executing the control instruction. According to the present disclosure, when a current is detected in the specific region of the headset wire, a user's gesture is recognized based on the current, control instruction corresponding to the user's gesture is acquired, and the control instruction is executed to control the terminal. In the whole procedure, the user only needs to touch the specific region of the headset wire without using pressure button to produce current signal, thereby the operation of controlling the terminal device is convenient and fast. | 05-07-2015 |
Patent application number | Description | Published |
20130208741 | Laser architectures - Disclosed herein are architectures for VCSEL systems. By using high power IR VCSEL element(s), a bulk doubling material can be used to double the IR light and generate visible light (red, green, blue, or UV light) in a cavity, in either continuous wave (CW) or pulsed mode. The reflectivity of the output distributed Bragg reflector (DBR) of these VCSELs can be designed to increase the power in the cavity, rather than the power in the VCSEL laser. By enabling the use of a bulk doubling material in the cavity and directly doubling the VCSEL the device can be inexpensive, simpler, high efficiency, better reliability, and vastly improved manufacturing and alignment tolerances. There are a number of cavity architectures that can be used to double the IR light from the VCSEL(s). The VCSEL(s) can be single elements, or arrays with high intensity elements. | 08-15-2013 |
20130208753 | Optical Pump for High Power Laser - Optical pump modules using VCSEL arrays are provided to pump optical gain media for achieving high power laser output in CW, QCW and pulse operation modes for operation. Low divergence and symmetric far-field emission from VCSELs are particularly suitable for compact arrays. VCSEL arrays configured as laser pump modules are operable at high temperatures with practically no degradation over a long period of time. VCSEL pump modules are adaptable for side- or end-pumping configurations to pump high power lasers in CW, QCW and pulse mode. Power output from VCSEL pump modules is scalable. Incorporating microlens arrays with the VCSEL arrays improve brightness of the pump modules. High power and high temperature operation of VCSEL modules make it suitable for making compact high power solid state lasers that are operable in small spaces such as, ignition of internal combustion engines, stationary power generation engines and pulsed detonation engines. | 08-15-2013 |
20130266032 | Laser architectures - Disclosed herein are architectures for an external cavity laser. In some embodiments, the external cavity laser includes vertical cavity surface emitting laser (VCSEL) elements, a Brewster plate, frequency doubling chips, and a microlens array. The Brewster plate is arranged at an angle relative to the light path, and is configured to polarize at least the light received from the VCSELs and propagating on the light path in a first direction, and extract, from the external cavity, frequency-doubled light propagating on the light path in a second direction opposite to the first direction. The doubling chips are operable to receive the light and double the frequency of a portion of the received light. The microlens array is aligned with the VCSEL elements. A mount may be employed to mount the side stack of doubling chips by either side mounting or end mounting. | 10-10-2013 |