Bigwood
Bob Bigwood, Hillsboro, OR US
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20100025858 | WINGED VIAS TO INCREASE OVERLAY MARGIN - Winged via structures to increase overlay margin are generally described. In one example, a method comprises depositing a sacrificial layer to an interlayer dielectric, the interlayer dielectric being coupled with a semiconductor substrate, forming at least one trench structure in the sacrificial layer wherein the trench structure comprises a first direction along a length of the trench structure and a second direction along a width of the trench structure wherein the second direction is substantially perpendicular to the first direction, depositing a light sensitive material to the trench structure and the sacrificial layer, and patterning at least one winged via structure in the light sensitive material to overlay the trench structure wherein the winged via structure extends in the second direction beyond the width of the trench structure onto the sacrificial layer. | 02-04-2010 |
David Bigwood, Lexington, MA US
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20130212128 | METHODS AND APPARATUS FOR QUERYING A RELATIONAL DATA STORE USING SCHEMA-LESS QUERIES - The invention provides, in one aspect, a method of searching an RDF triples data store of the type in which the triples are maintained in accord with a first storage schema. The method includes inputting a first query specifying RDF triples that are to be identified in the data store. That first query assumes either (i) that the triples are stored in a schema-less manner (i.e., with no storage schema) or (ii) that the triples are maintained in accord with a second storage schema that differs from the first. The method further includes generating, from the first query, a second query that specifies those same RDF triples, yet, that reflects the first storage schema. That second query can be applied to the RDF triples data store in order to identify and/or retrieve the desired data. | 08-15-2013 |
Douglas Bigwood, Madison, CT US
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20080311601 | Methods for Prediction and Prognosis of Cancer, and Monitoring Cancer Therapy - The present invention relates to biomarkers and the use of biomarkers for the prediction and prognosis of cancer as well as the use of biomarkers to monitor the efficacy of cancer treatment. Specifically, this invention relates to the use of VEGF as a biomarker for multi-kinase inhibitors. | 12-18-2008 |
20080311604 | Methods for Prediction and Prognosis of Cancer, and Monitoring Cancer Therapy - The present invention relates to biomarkers and the use of biomarkers for the prediction and prognosis of cancer as well as the use of biomarkers to monitor the efficacy of cancer treatment. Specifically, this invention relates to the use of soluble VEGF-R2 as a biomarker for multi-kinase inhibitors. | 12-18-2008 |
20100233680 | Gene Expression Profiles and Methods of Use - The present invention relates to gene expression profiles, microarrays comprising nucleic acid sequences representing gene expression profiles, and methods of using expression profiles and microarrays. The invention also provides methods and compositions for diagnostic assays for detecting cancer and therapeutic methods and compositions for treating cancer. The invention also provides methods for designing, identifying, and optimizing therapeutics for cancer. | 09-16-2010 |
Douglas Bigwood, Medison, CT US
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20100209914 | METHODS, SYSTEMS, AND KITS FOR EVALUATING MULTIPLE SCLEROSIS - The present invention provides a method for evaluating multiple sclerosis (MS), or excluding MS as a diagnosis for a patient The method comprises determining a gene expression profile for a sample from such a patient. The gene expression profile, which contains gene expression values for a plurality of genes that are differentially expressed in white blood cells of MS patients, is compared to an MS-profile and/or a non-MS profile, and classified. The invention also provides a method for monitoring treatment of an MS patient Pre-treatment and post-treatment gene expression profiles contain gene expression values for a plurality of genes that are differentially expressed upon treatment of MS patients. The expression profiles may then be compared, to identify differences between pre-treatment and post-treatment gene expression. These differences are indicative of the patient's response to treatment The invention further provides kits and systems for performing the methods of the invention. | 08-19-2010 |
Douglas Bigwood, Gaithersburg, MD US
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20130143762 | Gene expression profiles and methods of use - The present invention relates to gene expression profiles, microarrays comprising nucleic acid sequences representing gene expression profiles, and methods of using expression profiles and microarrays. The invention also provides methods and compositions for diagnostic assays for detecting cancer and therapeutic methods and compositions for treating cancer. The invention also provides methods for designing, identifying, and optimizing therapeutics for cancer. | 06-06-2013 |
Douglas W. Bigwood, Madison, CT US
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20120015830 | MICRORNA PROFILES FOR EVALUATING MULTIPLE SCLEROSIS - The present invention provides methods, systems, and kits for evaluating multiple sclerosis (MS) in a patient. Particularly, the invention provides convenient miRNA-based tests for evaluating a patient for MS, including for diagnosing MS, for excluding MS as a diagnosis, for determining the presence of disease activity associated with MS, and for monitoring the course of disease or efficacy of treatment for MS. | 01-19-2012 |
20120214682 | MICRORNA SIGNATURES INDICATIVE OF IMMUNOMODULATING THERAPY FOR MULTIPLE SCLEROSIS - The present invention provides methods, systems, and kits for evaluating multiple sclerosis (MS) in a patient. Particularly, the invention provides convenient miRNA-based tests for evaluating a patient for MS, including for diagnosing MS, for excluding MS as a diagnosis, and for monitoring the course of disease or efficacy of treatment, including evaluation of immunomodulating therapy. | 08-23-2012 |
20140371103 | METHODS AND REAGENTS FOR EVALUATING AUTOIMMUNE DISEASE AND DETERMINING ANTIBODY REPERTOIRE - The invention provides methods and kits for determining an antibody or T-cell receptor repertoire in a sample containing B-cells and/or T-cells, and provides a method for evaluating a patient for the presence of an autoimmune disorder. | 12-18-2014 |
20150057181 | MICRORNA SIGNATURES INDICATIVE OF IMMUNOMODULATING THERAPY FOR MULTIPLE SCLEROSIS - The present invention provides methods, systems, and kits for evaluating multiple sclerosis (MS) in a patient. Particularly, the invention provides convenient miRNA-based tests for evaluating a patient for MS, including for diagnosing MS, for excluding MS as a diagnosis, and for monitoring the course of disease or efficacy of treatment, including evaluation of immunomodulating therapy. | 02-26-2015 |
George T. Bigwood, Southfield, MI US
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20150106790 | DETECTING MERGE CONFLICTS AND COMPILATION ERRORS IN A COLLABORATIVE INTEGRATED DEVELOPMENT ENVIRONMENT - A method, system, and computer program product for detecting merge conflicts and compilation errors in a collaborative integrated development environment are provided in the illustrative embodiments. Prior to at least one user committing a set of uncommitted changes associated with a source code to a repository, the computer receives the set of uncommitted changes associated with the source code. The computer creates at least one temporary branch corresponding to the set of uncommitted changes associated with the source code. The computer device merges the at least one temporary branch to corresponding portions of the source code. The computer determines whether a merge conflict has occurred. If the merge conflict occurred, the computer communicates a first notification to the at least one user, the first notification indicating the merge conflict. | 04-16-2015 |
Michael C. Bigwood, Oreland, PA US
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20110224323 | POLYESTERS, METHODS OF THEIR PREPARATION AND USE - Crosslinked polycondensation products of: (a) polyols selected from the group consisting of: (1) polyols with three or more hydroxyl groups, (2) acetal forms of (1), and (3) mixtures thereof, and (b) polyacids selected from the group consisting of: (1) polyacids with two or more carboxylic groups, (2) anhydrides of (1), (3) esters of (1), and (4) mixtures thereof are disclosed. The resulting polyesters have a molar ratio of polyol to polyacid from about 1:3 to about 3:1 and are highly-crosslinked. Preferred monomers are sustainable monomers such as glycerol, citric acid, fumaric acid, and sebacic acid. Two-step heating processes for preparing the high molecular weight polyesters are also provided. | 09-15-2011 |
Michael P. Bigwood, Yukon, OK US
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20140107246 | ULTRAVIOLET CURED POLYESTERS FROM SUSTAINABLE MATERIALS - Crosslinked, ultraviolet cured polycondensation products of either a saturated or unsaturated polyol and an unsaturated polyacid are disclosed. The preferred monomers used in the present invention are sustainable monomers, such as glycerol, castor oil, fumaric acid, sebacic acid, and citric acid. Other monomers, including maleic acid, may also be used. The monomers are cured using a photoinitiator. Processes for preparing the polycondensation products are also provided. | 04-17-2014 |
Michael P. Bigwood, Oreland, PA US
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20110224323 | POLYESTERS, METHODS OF THEIR PREPARATION AND USE - Crosslinked polycondensation products of: (a) polyols selected from the group consisting of: (1) polyols with three or more hydroxyl groups, (2) acetal forms of (1), and (3) mixtures thereof, and (b) polyacids selected from the group consisting of: (1) polyacids with two or more carboxylic groups, (2) anhydrides of (1), (3) esters of (1), and (4) mixtures thereof are disclosed. The resulting polyesters have a molar ratio of polyol to polyacid from about 1:3 to about 3:1 and are highly-crosslinked. Preferred monomers are sustainable monomers such as glycerol, citric acid, fumaric acid, and sebacic acid. Two-step heating processes for preparing the high molecular weight polyesters are also provided. | 09-15-2011 |
Robert M. Bigwood, Hillsboro, OR US
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20140117488 | PATTERN DECOMPOSITION LITHOGRAPHY TECHNIQUES - Techniques are disclosed for realizing a two-dimensional target lithography feature/pattern by decomposing (splitting) it into multiple unidirectional target features that, when aggregated, substantially (e.g., fully) represent the original target feature without leaving an unrepresented remainder (e.g., a whole-number quantity of unidirectional target features). The unidirectional target features may he arbitrarily grouped such that, within a grouping, all unidirectional target features share a common target width value. Where multiple such groupings are provided, individual groupings may or may not have the same common target width value. In some cases, a series of reticles is provided, each reticle having a mask pattern correlating to a grouping of unidirectional target features. Exposure of a photoresist material via the aggregated series of reticles substantially (e.g., fully) produces the original target feature/pattern. The pattern decomposition techniques may be integrated into any number of patterning processes, such as litho-freeze-litho-etch and litho-etch-litho-etch patterning processes. | 05-01-2014 |