Patent application number | Description | Published |
20120076860 | COMPOSITIONS, METHODS, AND SYSTEMS RELATING TO CONTROLLED CRYSTALLIZATION AND/OR NUCLEATION OF MOLECULAR SPECIES - The present invention generally relates to compositions, methods, and systems relating to controlled crystallization and/or nucleation of a molecular species. In some embodiments, the crystallization and/or nucleation of the molecular species may be controlled by tuning the surface chemistry and/or the morphology of a crystallization substrate. In some embodiments, the molecular species is a small organic molecule (e.g., pharmaceutically active agent). | 03-29-2012 |
20120305174 | LAYER PROCESSING FOR PHARMACEUTICALS - Layer processing for pharmaceuticals, and related systems, methods, and articles are generally described. In some embodiments, ingestible pharmaceutical products (e.g., tablets) can be formed by processing one or more layers containing a pharmaceutically active composition. For example, at least one layer containing a pharmaceutically active composition can be manipulated (e.g., folded, rolled, stacked, etc.) such that the average thickness of the product formed by the manipulation is at least about two times the average thickness of the portions of the layer(s) used to form the product. In some embodiments, after the layer is manipulated, it can be processed (e.g., cut, coated, etc.) to form a final product such as, for example, a tablet. | 12-06-2012 |
20130118399 | METHODS AND SYSTEMS RELATING TO THE SELECTION OF SUBSTRATES COMPRISING CRYSTALLINE TEMPLATES FOR THE CONTROLLED CRYSTALLIZATION OF MOLECULAR SPECIES - The present invention generally relates to methods and systems relating to the selection of substrates comprising crystalline templates for the controlled crystallization of molecular species. In some embodiments, the methods and systems allow for the controlled crystallization of a molecular species in a selected polymorphic form. In some embodiments, the molecular species is a small organic molecule (e.g., pharmaceutically active agent). | 05-16-2013 |
20130295143 | ELECTROPROCESSING OF ACTIVE PHARMACEUTICAL INGREDIENTS - Electrospinning of crystalline particles comprising active pharmaceutical ingredients (API) from suspensions yields fibrous compositions comprising the API. The morphology and size of the crystalline particles may be preserved. The particles may be predominantly retained by fibers and distributed throughout the fibrous mesh. Tablet forms of the APIs prepared from the fibrous compositions demonstrate higher dissolution rates than tablets prepared from compacted powders of the APIs. | 11-07-2013 |
20150196489 | POLYMER MATRICES FOR CONTROLLING CRYSTALLIZATION - Compositions, methods, and systems for controlling crystallization of an agent are generally described. In some embodiments, an agent is crystallized in the presence of polymer matrices, such as polymer particles. The polymer matrix may influence at least a portion of the crystallization process and/or the resulting composition. In some such embodiments, the polymer matrix allows one or more aspect of the process and/or composition to be controlled and/or altered. For instance, the polymer matrix may act as a crystallization promoter and/or acceptable carriers of the crystallized agent. In certain embodiments, the polymer matrix described herein, can be used with any agent regardless of its chemical and/or physical properties. | 07-16-2015 |
20150239977 | CD20- AND EGFR-BINDING PROTEINS WITH ENHANCED STABILITY - The invention provides CD20-binding proteins and EGFR-binding proteins having a reduced tendency to aggregate. Compositions and methods of use are also provided. | 08-27-2015 |
20150259435 | HER2- AND VEGF-A-BINDING PROTEINS WITH ENHANCED STABILITY - The invention provides HER2-binding proteins and VEGF-A-binding proteins having a reduced tendency to aggregate. Compositions and methods of use are also provided. | 09-17-2015 |
20160129019 | COMPOSITIONS, METHODS, AND SYSTEMS RELATING TO CONTROLLED CRYSTALLIZATION AND/OR NUCLEATION OF MOLECULAR SPECIES - The present invention generally relates to compositions, methods, and systems relating to controlled crystallization and/or nucleation of a molecular species. In some embodiments, the crystallization and/or nucleation of the molecular species may be controlled by tuning the surface chemistry and/or the morphology of a crystallization substrate. In some embodiments, the molecular species is a small organic molecule (e.g., pharmaceutically active agent). | 05-12-2016 |
20160132634 | COMPUTER-IMPLEMENTED METHODS OF DETERMINING PROTEIN VISCOSITY - The invention provides computer-implemented methods for screening proteins such as antibodies based on viscosity properties. The methods involve making a spatial charge map (SCM) of the three-dimensional structure of the antibody or protein and determine a SCM score depending on a condition such as e.g. pH, which score correlates with the viscosity. Thus a quantitative measure of the viscosity is obtained. | 05-12-2016 |