Bell, MA
Audrey Bell, Acton, MA US
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20100120006 | Dynamic Minimally Invasive Training and Testing Environments - The disclosed invention contemplates a device and method related to training medical personnel (i.e., for example, surgeons) to perform endoscopic procedures. The disclosed technology solves two problems currently present in the art of using surgical simulators. The first improvement provides a dynamic training program, rather than a program that is the same for every training run. In one embodiment, the device provides a target array that can change position in three dimensions during the training session. In one embodiment, the target array can also change position at various velocities. Consequently, the present invention provides improved discrimination between evaluating innate skill of hand-eye coordination versus surgical skill. | 05-13-2010 |
Barbara Bell, Sudbury, MA US
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20110054312 | Reinforced Venous Access Catheter - A catheter for medical procedures comprises a shaft portion having a distal end insertable into a body lumen, the shaft portion having a wall defining a working lumen extending therewithin and a first strengthening element coupled to the wall to increase a burst pressure of the shaft portion, wherein the first strengthening element cooperates with a base material of the wall to define a flexible region of the shaft portion allowing the shaft portion to be atraumatically inserted into the body lumen. | 03-03-2011 |
Benjamin Bell, Shrewsbury, MA US
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20090292252 | Pressure Activated Valve for High Flow Rate and Pressure Venous Access Applications - A valve comprises a first housing including a first lumen extending therethrough and defining a first disk-facing surface and a second housing including a second lumen extending therethrough and defining a second disk-facing surface, the second housing being mated to the first housing so that the second disk-facing surface faces the first disk-facing surface in combination with a flexible disk gripped between gripping portions of the first and second disk-facing surfaces, the disk including a slit extending therethrough which, when acted upon by a fluid pressure of at least a predetermined threshold level opens to permit fluid flow between the first and second lumens and which, when acted upon by a fluid pressure less than the threshold level remains sealed preventing fluid flow between the first and second lumens and a relief well between opposing portions of the first and second housings radially outside the gripping portions, a width of the relief well exceeding a width of a radially outer portion of the flexible disk so that the radially outer portion of the disk is free to move therewithin. | 11-26-2009 |
20120232496 | High Flow Catheters - A catheter that comprises a hub, an elongated conduit, and at least one lumen therein. The lumen includes a proximal lumen section, a distal lumen section, and an intermediate lumen section extending between the proximal and distal lumen sections. The cross-sectional dimension of the intermediate lumen section is less than the cross-sectional dimension of the distal lumen section. In one embodiment, the cross-sectional dimension of the intermediate lumen section is less than the cross-sectional dimension of the proximal lumen section. In certain embodiments, the lumen tapers from the distal and/or proximal lumen sections to the intermediate lumen section. | 09-13-2012 |
20120245528 | CATHETER WITH POROUS CUFF - Disclosed is a catheter that includes a porous element. In one embodiment, the porous element comprises the same polymeric material as the catheter shaft. In another embodiment, the porous element comprises a porous polyurethane material. | 09-27-2012 |
20120245563 | HIGH FLOW CATHETERS - A catheter that comprises a hub, an elongated conduit, and at least one lumen therein. The lumen includes a proximal lumen section, a distal lumen section, and an intermediate lumen section extending between the proximal and distal lumen sections. The cross-sectional dimension of the intermediate lumen section is less than the cross-sectional dimension of the distal lumen section. In one embodiment, the cross-sectional dimension of the intermediate lumen section is less than the cross-sectional dimension of the proximal lumen section. In certain embodiments, the lumen tapers from the distal and/or proximal lumen sections to the intermediate lumen section. | 09-27-2012 |
20130220462 | Pressure Activated Valve for High Flow Rate and Pressure Venous Access Applications - A valve having a first housing including a first lumen extending therethrough and a first disk-facing surface, a second housing including a second lumen extending therethrough and a second disk-facing surface, where the second housing is coupled to the first housing so that the second disk-facing surface faces the first disk-facing surface. A flexible disk has at least a portion of an outer edge of the disk extending away from a plane of a central portion of the disk, the outer edge contacting the first disk-facing surface, the disk including a slit extending therethrough which, when acted upon by a fluid pressure of at least a threshold level opens to permit fluid flow between the first and second lumens and which, when acted upon by a fluid pressure less than the threshold level, prevents fluid flow between the first and second lumens. | 08-29-2013 |
20140276470 | Dialysis Catheters with Fluoropolymer Additives - A venous access catheter shaft and method of using and manufacturing such a catheter is provided. In one aspect of the invention, a catheter is provided comprising a base polymer having a Shore A durometer of 85A or lower, with 2.0% percent by weight of surface modifier, and a radiopaque filler comprising between 20-40 percentage by weight. In another aspect of the invention, a method reducing thrombus accumulation on a venous access catheter is provided wherein the catheter surface's resistance to thrombus formation is enhanced during indwell time by lowering the durometer rating of the base polymer of the catheter without increasing the amount of surface modifier additive. In another aspect of the invention, a method of manufacturing a catheter shaft is provided, wherein the shaft is formed comprising a base polymer having a Shore A durometer of 85A or lower, with 2.0% percent by weight of surface modifier, and a radiopaque filler comprising 30% by weight barium sulfate, and optionally a colorant of 0.2% weight. | 09-18-2014 |
20140276641 | CATHETERES WITH HIGH-PURITY FLUOROPOLYMER ADDITIVES - The present invention provides catheter compositions that provide anti-thrombogenic properties while not adversely impacting mechanical properties. All embodiments of the present invention comprise a catheter that comprises a fluoropolymer additive with specific compositions and/or purity levels. | 09-18-2014 |
20150038946 | CATHETERS WITH HIGH-PURITY FLUOROPOLYMER ADDITIVES - The present invention provides catheter compositions that provide anti-thrombogenic properties while not adversely impacting mechanical properties. All embodiments of the present invention comprise a catheter that comprises a fluoropolymer additive with specific compositions and/or purity levels. | 02-05-2015 |
20150057648 | Laser Device and Method of Use - It is an object and advantage of this invention to provide an improved device and method that uses targeted laser wavelength to treat a diseased vessel. An advantage of this invention is targeted ablation of diseased vessels without harming non-target tissue. This new technique allows for a controlled ablation, may not require injection of tumescent anesthesia prior to treatment and may decrease unwanted or unintended side effects. | 02-26-2015 |
20160038657 | MEDICAL DEVICES HAVING SURFACE MODIFIERS - Improved medical devices having anti-thrombogenic and anti-adherent surface modifiers for improved medical device performance and patient outcomes are provided. In certain embodiments, the medical devices are at least partially manufactured using an admixture of a base polymer and surface modifying fluoropolymer additives. In certain embodiments, the medical devices are vascular access devices, vascular access accessories, peripheral vascular devices, or components of these devices. | 02-11-2016 |
Benjamin D. Bell, Shrewsbury, MA US
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20130096514 | HIGH FLOW CATHETER VALVE - Valves for regulating fluid flows through medical devices are provided. In some embodiments, the valves are adapted for use in high flow applications and multiple valve elements disposed across a plurality of fluid flow paths branching from and into one or more inlets and outlets. | 04-18-2013 |
Christie L. Bell, Boston, MA US
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20130323226 | Compositions and Methods for Altering Tissue Specificity and Improving AAV9-Mediated Gene Transfer - A method of altering the targeting and/or cellular uptake efficiency of an adeno-associated virus (AAV) viral vector having a capsid containing an AAV9 cell surface binding domain is described. The method involves modifying a clade F cell surface receptor which comprises a glycan having a terminal sialic acid residue and a penultimate β-galactose residue. The modification may involve retargeting the vector by temporarily functionally ablate AAV9 binding in a subset of cells, thereby redirecting the vector to another subset of cells. Alternatively, the modification may involve increasing cellular update efficiency by treating the cells with a neuraminidase to expose cell surface β-galactose. Also provided are compositions containing the AAV9 vector and a neuraminidase. Also provided is a method for purifying AAV9 using β-galactose linked to solid support. Also provided are mutant vectors which have been modified to alter their targeting specificity, including mutant AAV9 in which the galactose binding domain is mutated and AAV in which an AAV9 galactose binding domain is engineered. | 12-05-2013 |
Daphne Winifred Bell, Arlington, MA US
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20080207615 | Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments - The present invention is directed to a method for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) treatment. In a preferred embodiment, the presence of at least one variance in the kinase domain of the erbB1 gene confers sensitivity to the tyrosine kinase inhibitor gefitinib. Thus, a diagnostic assay for these mutations will allow for the administration of gefitinib, erlotinib and other tyrosine kinase inhibitors to those patients most likely to respond to the drug. | 08-28-2008 |
20080234264 | Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments - The present invention is directed to a method for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) treatment. In a preferred embodiment, the presence of at least one variance in the kinase domain of the erbB1 gene confers sensitivity to the tyrosine kinase inhibitor gefitinib. Thus, a diagnostic assay for these mutations will allow for the administration of gefitinib, erlotinib and other tyrosine kinase inhibitors to those patients most likely to respond to the drug. | 09-25-2008 |
20130316935 | METHOD TO DETERMINE RESPONSIVENESS OF CANCER TO EPIDERMAL GROWTH FACTOR RECEPTOR TARGETING TREATMENTS - Disclosed herein are methods and reagents for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) targeting treatment. The detection of these mutations will allow for the administration of gefitinib, erlotinib and other tyrosine kinase inhibitors to those patients most likely to respond to the drug. | 11-28-2013 |
Edward W. Bell, Newbury, MA US
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20140042337 | INDUCTIVELY COUPLED PLASMA ION SOURCE WITH MULTIPLE ANTENNAS FOR WIDE ION BEAM - A wide ion beam source includes a plurality of RF windows arranged in a predetermined relationship, a single plasma chamber disposed on a first side of the plurality of RF windows, a plurality of RF antennas, each RF antenna of the plurality of RF antennas disposed on a second side of a respective RF window of the plurality of RF windows, the second side being opposite the first side, and a plurality of RF sources, each RF source coupled to a respective RF antenna of the plurality of RF antennas, wherein a difference in frequency of a first RF signal produced by a first RF source coupled to a first RF antenna from that of a second RF signal produced by a second RF source coupled to an RF antenna adjacent to the first RF antenna is greater than 10 kHz. | 02-13-2014 |
Eric Bell, Cambridge, MA US
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20150266946 | TREATMENT OF AGE-RELATED AND MITOCHONDRIAL DISEASES BY INHIBITION OF HIF-1 ALPHA FUNCTION - Disclosed herein are novel compositions and methods for the treatment of age-related diseases, mitochondrial diseases, the improvement of stress resistance, the improvement of resistance to hypoxia and the extension of life span. Also described herein are methods for the identification of agents useful in the foregoing methods. Methods and compositions are provided for the treatment of diseases or disorders associated with mitochondrial dysfunction. | 09-24-2015 |
Eugene Bell, Boston, MA US
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20080268054 | DERMAL DERIVED HUMAN STEM CELLS AND COMPOSITIONS AND METHODS THEREOF - This application discloses Dermal Derived Human Stem Cells (DDhSCs) and methods of making and using thereof. More specifically, the invention relates to DDhSCs derived from subsets of dedifferentiated dermal fibroblasts that can give rise to a series of cell lineages. The DDhSCs may be used, for example, in cell therapy and in the search for and development of novel medicaments. | 10-30-2008 |
20090162452 | EB Matrix Production From Animal Tissue And Its Use For Tissue Repair - A method of forming and preserving a bioremodelable, biopolymer scaffold material by subjecting animal tissue to chemical and mechanical processing. In addition to skin tissue, another source of EBM is a blood vessel. EBM may be used for hernia repair, colon, rectal, vaginal and or urethral prolapse treatment; pelvic floor reconstruction; muscle flap reinforcement; lung tissue support; rotator cuff repair or replacement; periosteum replacement; dura repair; pericardial membrane repair; soft tissue augmentation; intervertebral disk repair; and periodontal repair. EBM may also be used as a urethral sling, laminectomy barrier or spinal fusion device. | 06-25-2009 |
20150307836 | EB Matrix Production from Fetal Tissues and its Use for Tissue Repair - A method of performing and preserving a bioremodelable, biopolymer scaffold material by subjecting animal tissue to chemical and mechanical processing. In addition to skin tissue, another source of EBM is a blood vessel. EBM may be used for hernia repair, colon, rectal, vaginal and or urethral prolapse treatment; pelvic floor reconstruction; muscle flap reinforcement; lung tissue support; rotator cuff repair or replacement; periosteum replacement; dura repair; pericardial membrane repair; soft tissue augmentation; intervertebral disk repair; and periodontal repair. EBM may also be used as a urethral sling, laminectomy barrier or spinal fusion device. | 10-29-2015 |
Frances Bell, Somerville, MA US
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20160036231 | POWER LINE REACTANCE MODULE AND APPLICATIONS - The disclosure is generally directed to reactance modules or DSRs ( | 02-04-2016 |
Jeffrey Bell, Sudbury, MA US
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20140202116 | Self-Contained Devices for Treating Medical Waste and Methods if Their Use - Disclosed and claimed herein are devices for the treatment of medical waste using high temperature and pressure steam. The devices are designed to be self-contained and are movable by one person of average strength and ability. The devices are self-contained and require no special installation, connections, plumbing or permanent or semi-permanent electrical connections. Disclosed and claimed herein are methods using the disclosed and claimed devices. | 07-24-2014 |
Jeffrey Hamilton Bell, Sudbury, MA US
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20160051851 | Devices for Treating Medical Waste and Methods of their Use - Disclosed and claimed herein are devices for the treatment of medical waste using high temperature and pressure steam. The devices combine both the sterilization chamber and the steam generating component. The devices may be self-contained and may be movable by one person of average strength and ability. The devices which are self-contained require no special installation, connections, plumbing or permanent or semi-permanent electrical connections. Disclosed and claimed herein are methods using the disclosed and claimed devices. | 02-25-2016 |
Margaret Laureen Bell, Arlington, MA US
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20140278713 | ASSET FORECASTING IN ASSET INTENSIVE ENTERPRISES - A method, system, and computer program product for asset service and maintenance lifecycle management and supply chain planning. Some embodiments commence upon receiving a database record corresponding to an individually identified asset to be individually tracked through a corresponding asset lifecycle. Each individually identified asset has an asset-specific scheduled maintenance plan. During the performance of activities pertaining to the asset-specific scheduled maintenance plan, observations are made and events are recorded to generate a series of observations that are in turn collected into a learning model. The learning model and a predictor based on the learning model is used to predict a future demand or a forecast for items in quantities that are not given in the asset-specific scheduled maintenance plan. In exemplary cases, the forecast comprises items and/or quantities that are not given in the scheduled maintenance plan. | 09-18-2014 |
Michael A. Bell, Cambridge, MA US
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20150302964 | ELECTRICAL COMPONENT FOR ATTACHMENT TO PAPER AND OTHER SUBSTRATES AND MAGNETIC ATTACHMENT MECHANISM - An electrical component for attachment to paper and other substrates comprises, according to one embodiment, a functional electronic part including one or more support pillars on an underside thereof. Each of the support pillars comprises: a channel extending therethrough from a top opening to a bottom opening, where the top opening of the channel is adjacent to the functional electronic part; and a magnet moveably positioned in the channel in electrical contact with the functional electronic part, where the bottom opening of the channel has a width smaller than a maximum lateral dimension of the magnet. | 10-22-2015 |
Nuiliant Bell, Boston, MA US
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20080268054 | DERMAL DERIVED HUMAN STEM CELLS AND COMPOSITIONS AND METHODS THEREOF - This application discloses Dermal Derived Human Stem Cells (DDhSCs) and methods of making and using thereof. More specifically, the invention relates to DDhSCs derived from subsets of dedifferentiated dermal fibroblasts that can give rise to a series of cell lineages. The DDhSCs may be used, for example, in cell therapy and in the search for and development of novel medicaments. | 10-30-2008 |
Patrick J. Bell, Arlington, MA US
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20150014045 | Sleeved Coaxial Printed Circuit Board Vias - A printed circuit board, and a method of fabricating the printed circuit board is disclosed. The printed circuit board includes at least one coaxial via. A hollow via is disposed in the printed circuit board. A metal sleeve is formed around the circumference of said hollow via. An inner conductive path is disposed in the hollow via. Additionally, an insulating material is disposed in the hollow via, between the conducting path and the metal sleeve. The conductive path is used to connect signal traces disposed on two different layers of the printed circuit board. In some embodiments, these signal traces carry signals having a frequency above 1 GHz, although the disclosure is not limited to this embodiment. | 01-15-2015 |
Rosemary Bell, Wayland, MA US
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20090220888 | Dyed photoresists and methods and articles of manufacture comprising same - The present invention provides new photoresist compositions that comprise a resin binder, a photoactive component, particularly an acid generator, and a dye material that contains one or more chromophores that can reduce undesired reflections of exposure radiation. Preferred dye compounds are polymeric materials that include one or more chromophores such as anthracene and other polycyclic moieties that effectively absorb deep UV exposure radiation. | 09-03-2009 |
20110294069 | PHOTORESIST COMPOSITIONS AND METHODS OF FORMING PHOTOLITHOGRAPHIC PATTERNS - Provided are photoresist compositions useful in forming photolithographic patterns by a negative tone development process. Also provided are methods of forming photolithographic patterns by a negative tone development process and substrates coated with the photoresist compositions. The compositions, methods and coated substrates find particular applicability in the manufacture of semiconductor devices. | 12-01-2011 |
20120219901 | PHOTORESIST COMPOSITIONS AND METHODS OF FORMING PHOTOLITHOGRAPHIC PATTERNS - Provided are photoresist compositions useful in forming photolithographic patterns. Also provided are substrates coated with the photoresist compositions and methods of forming photolithographic patterns. The compositions, methods and coated substrates find particular applicability in the manufacture of semiconductor devices. | 08-30-2012 |
20120219902 | PHOTORESIST COMPOSITIONS AND METHODS OF FORMING PHOTOLITHOGRAPHIC PATTERNS - Provided are photoresist compositions useful in forming photolithographic patterns. Also provided are substrates coated with the photoresist compositions and methods of forming photolithographic patterns. The compositions, methods and coated substrates find particular applicability in the manufacture of semiconductor devices. | 08-30-2012 |
20130244180 | PHOTORESIST OVERCOAT COMPOSITIONS AND METHODS OF FORMING ELECTRONIC DEVICES - Provided are photoresist overcoat compositions, substrates coated with the overcoat compositions and methods of forming electronic devices by a negative tone development process. The compositions, coated substrates and methods find particular applicability in the manufacture of semiconductor devices. | 09-19-2013 |
20130244438 | PHOTOLITHOGRAPHIC METHODS - Provided are photoresist overcoat compositions, substrates coated with the overcoat compositions and methods of forming electronic devices by a negative tone development process. The compositions, coated substrates and methods find particular applicability in the manufacture of semiconductor devices. | 09-19-2013 |
20140212816 | PHOTOLITHOGRAPHIC METHODS - Provided are photoresist overcoat compositions, substrates coated with the overcoat compositions and methods of forming electronic devices by a negative tone development process. The compositions, coated substrates and methods find particular applicability in the manufacture of semiconductor devices. | 07-31-2014 |
20150159038 | PHOTORESIST OVERCOAT COMPOSITIONS AND METHODS OF FORMING ELECTRONIC DEVICES - Provided are photoresist overcoat compositions, substrates coated with the overcoat compositions and methods of forming electronic devices by a negative tone development process. The compositions, coated substrates and methods find particular applicability in the manufacture of semiconductor devices. | 06-11-2015 |
Rosemary Bell, Marlborough, MA US
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20160041467 | PHOTOLITHOGRAPHIC METHODS - Provided are photoresist overcoat compositions, substrates coated with the overcoat compositions and methods of forming electronic devices by a negative tone development process. The compositions, coated substrates and methods find particular applicability in the manufacture of semiconductor devices. | 02-11-2016 |
Stacey Jane Bell, Belmont, MA US
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20090099261 | Omega-3 mixtures - The present invention is directed to mixtures of omega- | 04-16-2009 |
William Bell, Brookline, MA US
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20140042094 | Filtering Blood - An independent blood filter device depends on flow geometry to deliver blood serum or plasma free of detrimental levels of hemoglobin. It depends critically on an upstream flow rate or pressure differential limiting control element or device that limits the rate of change of pressure differential across the filter element. Pre-evacuated versions can be used to simultaneously draw blood from a living being and provide pressure differential across the filter element between an evacuated collector and a supply end open to atmosphere. A unit pressurized by hand motion employs the external shape of a partially filled blood collection tube as a piston to produce pressure in advance of the control element or device to create the pressure differential across the filter element to a collector vented to atmosphere. The control element or device is disclosed in numerous forms, including specially sized flow constrictions and compliant arrangements. | 02-13-2014 |