Barry, MA
Andrew Barry, Chelmsford, MA US
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20150198593 | METHOD AND SYSTEM OF MICROFLUIDIC IMMUNOASSAY USING MAGNETIC BEADS - A microfluidic Western blot method and system including a microfluidic western blot method for immunoassay of proteins, the method including introducing a sample including the proteins onto a chip; electrophoretically separating the proteins; binding the separated proteins to beads to form protein-attached beads, the beads being magnetic; flowing the protein-attached beads into a magnetic holding region; applying a magnetic field to the magnetic holding region to fix the protein-attached beads in place within the magnetic holding region; binding primary antibodies to target proteins on the protein-attached beads; binding secondary antibodies to the bound primary antibodies; and detecting the bound secondary antibodies. | 07-16-2015 |
Anthony Barry, Winchester, MA US
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20090324586 | LYOPHILIZATION CYCLE ROBUSTNESS STRATEGY - The present invention provides methods for assessing and optimizing lyophilization cycle robustness. In particular, the present invention provides rapid assessment of cycle robustness with respect to a variety of lyophilization process deviations by varying a relatively small number of parameters. | 12-31-2009 |
20110033464 | IMMUNOGLOBULIN FUSION PROTEIN FORMULATIONS - The present invention provides compositions of Ig fusion proteins, especially compositions including an Ig fusion protein, a bulking agent, a disaccharide, a surfactant, and a buffer. In one aspect, these compositions are stable under long-term storage or at least one freeze/thaw cycle. The invention also provides methods of preparation of the Ig fusion protein compositions. In one aspect, compositions of the invention are lyophilized. In a further aspect, the compositions are lyophilized by a process that includes an annealing step. | 02-10-2011 |
Anthony B. Barry, Winchester, MA US
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20090060906 | Anti-IL-13 antibody formulations and uses thereof - Formulations suitable for treatment of disorders associated with undesirable expression or activity of IL-13 are provided. | 03-05-2009 |
Carol Barry, Tyngsborough, MA US
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20120007277 | DEVICE AND METHOD FOR FORMING MULTILAYERED LAMINATES - Methods and devices for forming a vertically-oriented multilayer laminates, for example, a vertically-oriented multilayer laminates, are provided. The laminates may be fabricated by hardenable fluids, for example, polymers that are directed along flow paths to divide, repossession, and combine streams to provide the desired laminated structure. The flow divisions and recombination may be practiced repeatedly wherein laminates have tens or even tens of thousands of individual layers may be produced. The polymers used may have comparable viscosities, for example, having viscosity ratios of less than 3. Though aspects of the invention may be used packaging, aspects of the invention may be applied to any field where laminated structures are desired. | 01-12-2012 |
Carol M.f. Barry, Tyngsboro, MA US
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20090134033 | Directed assembly of a conducting polymer - The present invention provides a method for directed assembly of a conducting polymer. A method of the invention comprises providing a template such as an insulated template and electrophorectically assembling a conducting polymer thereon. Preferably, the template comprises a patterned electrode on which the conducting polymer is assembled. Moreover, the invention provides a method for transferring an assembled conducting polymer. For example, a method of the invention comprises providing a substrate such as a polymeric substrate and contacting a surface thereof with an assembled conducting polymer. The assembled conducting polymer can be disposed on a patterned electrode of a template, hi one embodiment, a method comprises removing the substrate. By removing the substrate, the assembled conducting polymer is transferred from the patterned electrode of the template to the substrate. The invention also provides a device with a template or substrate comprising an assembled conducting polymer. | 05-28-2009 |
Carol M.f. Barry, Tyngsborough, MA US
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20110123711 | METHODS FOR FORMING METAL-POLYMER HYBRID TOOLING FOR FORMING PARTS HAVING MICRO FEATURES - A method for forming metal-polymer hybrid tooling includes patterning a surface of a member such as a silicon wafer, stainless steel, nickel or nickel alloy, engaging a polymer layer with the patterned features of the surface of the silicon wafer to form the polymer layer having a reverse of the patterned surface the silicon wafer, removing the patterned polymer layer to expose a patterned polymer layer surface, depositing a metallic layer on the patterned polymer layer surface, and wherein the deposited metallic layer on the patterned polymer layer is operable to form parts with features having a width dimension between about 0.01 microns and about 100 microns and a height dimension of between about 0.01 micron and about 800 microns (e.g., up to aspect ratio of 8). | 05-26-2011 |
Daniel A. Barry, Berlin, MA US
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20080230640 | Shredder - A shredder including a shredding mechanism, a housing at least partially enclosing the shredding mechanism, and a receptacle that receives and contains shredded material is provided. The shredder may further includes a compactor including a ram that, when actuated, moves through the receptacle to compress shredded material in the receptacle. The shredder may further include a foot operated lever coupled to the compactor to actuate the ram. The compactor may also include a scissor mechanism that guides the ram through the receptacle. | 09-25-2008 |
20080283645 | SHREDDER - A shredder including a shredding mechanism, a housing at least partially enclosing the shredding mechanism, and a receptacle that receives and contains shredded material is provided. The shredder may further includes a compactor including a ram that, when actuated, moves through the receptacle to compress shredded material in the receptacle. The shredder may further include a foot operated lever coupled to the compactor to actuate the ram. The compactor may also include a scissor mechanism that guides the ram through the receptacle. | 11-20-2008 |
Daniel T. Barry, South Hadley, MA US
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20160114488 | CUSTOMER SERVICE ROBOT AND RELATED SYSTEMS AND METHODS - A robot for providing customer service within a facility includes a locomotion platform, an upper sensor for detecting objects within an upper field of view of the robot, a lower sensor for detecting objects within a lower field of view of the robot, a display and a robot computer in communication with the locomotion platform, the upper sensor and the lower sensor. The robot computer is configured to detect the presence of a customer within the facility based on information received from at least one of the upper sensor and lower sensor, and the robot computer is further configured to access one or more databases storing information associated with products available to customers within the facility and to provide customer service to the customer based on the accessed information. | 04-28-2016 |
Donald Barry, Norwood, MA US
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20090309308 | ROTATING SEALS FOR CELL PROCESSING SYSTEMS - The invention provides an improved rotating seal apparatus including a plurality of concentrically spaced annular rotating seals. The invention also provides a rotating seal apparatus including a pressurized annular chamber surrounding an annular rotating seal. | 12-17-2009 |
20140214042 | METHODS AND DEVICES FOR REMOVING ABNORMALITIES FROM BONE - Various exemplary methods and devices are provided for removing abnormalities from bone. In general, the methods and devices can be used to allow excess bone to be scraped from a bone surface. In an exemplary embodiment, a scraper tool is provided that includes an elongate shaft having a plurality of blades movably disposed therein. The blades can be configured to move as a unit between a retracted configuration, in which the blades can be entirely disposed within the elongate shaft, and an advanced configuration, in which at least a portion of the blades can extend distally from the elongate shaft and/or flare away from one another. A distal portion of each of the blades can have a radius of curvature corresponding to a radius of curvature of the bone to be scraped. | 07-31-2014 |
20150257771 | Methods and Devices for Removing Abnormalities from Bone - Various exemplary methods and devices are provided for removing abnormalities from bone. In general, the methods and devices can be used to allow excess bone to be scraped from a bone surface. In an exemplary embodiment, a scraper tool is provided that includes an elongate shaft having a plurality of blades movably disposed therein. The blades can be configured to move as a unit between a retracted configuration, in which the blades can be entirely disposed within the elongate shaft, and an advanced configuration, in which at least a portion of the blades can extend distally from the elongate shaft and/or flare away from one another. A distal portion of each of the blades can have a radius of curvature corresponding to a radius of curvature of the bone to be scraped. | 09-17-2015 |
Donald Barry, Raynham, MA US
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20130081697 | FLUIDIC MANIFOLD - A fluid management cassette system comprises a first and second opposed platen with first and second opposed films compressed between the platens. One or more channels formed one or both of the platens form pathways with the films through which fluids can be directed. Valves and other flow control mechanisms can be incorporated. | 04-04-2013 |
Francis P. Barry, Baltimore, MA US
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20090041730 | Joint Repair Using Mesenchymal Stem Cells - A method of repairing and/or stabilizing a joint by administering mesenchymal stem cells to the joint. Such a method provides for the regeneration of cartilaginous tissue in the joint, including meniscal tissue. | 02-12-2009 |
20120148548 | Joint Repair Using Mesenchymal Stem Cells - A method of repairing and/or stabilizing a joint by administering mesenchymal stem cells to the joint. Such a method provides for the regeneration of cartilaginous tissue in the joint, including meniscal tissue. | 06-14-2012 |
20130131804 | Joint Repair Using Mesenchymal Stem Cells - A method of repairing and/or stabilizing a joint by administering mesenchymal stem cells to the joint. Such a method provides for the regeneration of cartilaginous tissue in the joint, including meniscal tissue. | 05-23-2013 |
20150216904 | Joint Repair Using Mesenchymal Stem Cells - A method of repairing and/or stabilizing a joint by administering mesenchymal stem cells to the joint. Such a method provides for the regeneration of cartilaginous tissue in the joint, including meniscal tissue. | 08-06-2015 |
James J. Barry, Marlborough, MA US
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20100280522 | METHOD AND SYSTEM FOR DELIVERY OF COATED IMPLANTS - Method and system for delivery of coated implants is provided. One embodiment encompasses a coated implant delivery system. This system includes an implant delivery device having a first end, a second end, and an inner lumen, wherein the first end has a releasable implant retention region with an accessible surface having a coated implant adhesion-resistant treatment. In another embodiment a method of deploying a coated releasable implant at a target site of a vessel using an implant delivery system is provided. This method includes inserting a portion of an implant delivery device having a releasable implant into the vessel, advancing the implant delivery device to the target site, deploying the releasable implant from the delivery device, and withdrawing the inserted portion of the implant delivery device from the vessel. The implant delivery device in this embodiment has a releasable implant retention region with an accessible surface having a coated implant adhesion-resistant treatment and wherein the releasable implant has a first coating that faces the accessible surface of the releasable implant retention region. | 11-04-2010 |
20120203323 | METHOD AND SYSTEM FOR DELIVERY OF COATED IMPLANTS - An implant delivery system comprises an implant delivery device having a releasable implant retention region, with the releasable implant retention region having a delivery device coating including a therapeutic agent. The implant delivery device may be a balloon catheter. An implant is releasably positioned in physical communication with the releasable implant retention region. The implant may comprise an implant coating on its inner and/or outer surface, and the implant coating may include a therapeutic agent. The implant may be a stent. | 08-09-2012 |
20120239001 | LOADING AND RELEASE OF WATER-INSOLUBLE DRUGS - A medical device, polymer composition, and method for delivering substantially water-insoluble drugs to tissue at desired locations within the body. At least a portion of the exterior surface of the medical device is provided with a polymer coating. Incorporated in the polymer coating is a solution of at least one substantially water-insoluble drug in a volatile organic solvent. The medical device is positioned to a desired target location within the body, whereupon the drug diffuses out of the polymer coating. | 09-20-2012 |
20130304029 | LOADING AND RELEASE OF WATER-INSOLUBLE DRUGS - A medical device, polymer composition, and method for delivering substantially water-insoluble drugs to tissue at desired locations within the body. At least a portion of the exterior surface of the medical device is provided with a polymer coating. Incorporated in the polymer coating is a solution of at least one substantially water-insoluble drug in a volatile organic solvent. The medical device is positioned to a desired target location within the body, whereupon the drug diffuses out of the polymer coating. | 11-14-2013 |
James J. Barry, Marlboro, MA US
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20110196340 | LOADING AND RELEASE OF WATER-INSOLUBLE DRUGS - A medical device, polymer composition, and method for delivering substantially water-insoluble drugs to tissue at desired locations within the body. At least a portion of the exterior surface of the medical device is provided with a polymer coating. Incorporated in the polymer coating is a solution of at least one substantially water-insoluble drug in a volatile organic solvent. The medical device is positioned to a desired target location within the body, whereupon the drug diffuses out of the polymer coating. | 08-11-2011 |
James P. Barry, Charlton, MA US
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20080249355 | VIDEO ENDOSCOPIC DEVICE WITH DETACHABLE CONTROL CIRCUIT - An endoscopic device including a control circuit that is detachably connectable to a handle, where the control circuit functions and is compatible with a wide variety of displays. The handle of the endoscopic device is provided with a connector to transmit image data from a distal end to the detachable control circuit. The control circuit may be provided with a keyed outer surface to guide and maintain the control circuit in an engaged position relative to the handle and connector. | 10-09-2008 |
20080249370 | VIDEO BLADE LARYNGOSCOPE - A laryngoscope including a control circuit that is detachably connectable to a handle, where the control circuit functions and is compatible with a wide variety of displays. The laryngoscope may optionally be used in either the video mode where the user views a display presenting image data of the area ahead of the blade, or the user may use the laryngoscope in the direct visualization where the user uses the laryngoscope in a traditional manner directly viewing the area ahead of the blade during the intubation procedure. When used in the video mode, an LED is positioned adjacent to a window enclosing the digital image sensor to defog the window. | 10-09-2008 |
20080269557 | Surgical Method Utilizing Transluminal Endoscope and Instruments - A method of transluminal surgery is provided, which utilizes an endoscopic surgery apparatus having pivotable arms attached by hinges on its distal end. The arms are interchangeable with arms of various configurations. The method includes the steps of inserting an endoscopic surgery apparatus into a body cavity of a patient, making an incision in the body cavity wall to allow access to the patient's abdominal cavity, and further inserting the apparatus through the incision. Surgery is performed at the desired surgical site and the apparatus is withdrawn into the body cavity where the incision is closed. Finally, the apparatus is withdrawn from the patient's body. | 10-30-2008 |
20080269562 | ENDOSCOPE SYSTEM WITH PIVOTABLE ARMS - An endoscopic surgery apparatus is provided, including a tubular member, a handle located on a proximal end of the tubular member, and one or more pivotable arms detachably connected to a distal end of the tubular member. The tubular member has channels along its longitudinal axis, wherein at least one of the channels is an optical channel and at least one other channel is an illumination channel. The arms have guiding channels adapted to receive surgical tools, which direct the surgical tools. The arms are interchangeable with other arms of different configurations. Also, said arms have an open and a closed position, such that when the arms are in the closed position an opening is defined allowing viewing of a surgical site via the optical channel. | 10-30-2008 |
20090054733 | Articulating Endoscope Instrument - An endoscopic surgical instrument is provided that includes a handle portion, an elongated middle portion, an articulating portion and a tool portion. The tool portion is steerable by control mechanisms disposed on the handle portion which are accessible to a single hand of a user of the endoscopic surgical instrument. The endoscopic surgical instrument is advantageously employed in a variety of endoscopic surgical techniques, including transgastric or transluminal surgery. | 02-26-2009 |
20120078055 | Video stylet with directable tip - A video intubation system that provides for multiple image streams to be simultaneously presented to a user, the first image stream generated by a video laryngoscope and the second image stream generated by a video stylet. The video stylet is provided with a deflection section for ease of introducing an ETT into the trachea of a patient, the video stylet having a pistol-type grip and a control interface in the form of a trigger-type lever to facilitate comfortable griping and manipulation by the user. | 03-29-2012 |
20120296168 | Composite Flexible Endoscope Insertion Shaft With Tubular Substructure - An endoscope insertion shaft is disclosed comprising a tubular member having an axis and including at least one aperture for imparting desirable mechanical characteristics to the shaft. A composite, laminated or fused material comprises at least one layer encasing or jacketing the tubular member. | 11-22-2012 |
20130317300 | Simultaneous Display Video Laryngoscope And Video Stylet - A video intubation system that provides for multiple image streams to be simultaneously presented to a user on a touch screen display, the first image stream generated by a video laryngoscope and the second image stream generated by a video stylet. The video stylet is provided with a deflection section for ease of introducing an ETT into the trachea of a patient, the video stylet having a pistol-type grip and a control interface in the form of a trigger-type lever to facilitate comfortable griping and manipulation by the user. The first and second image streams may be saved and annotated by a user as desired. | 11-28-2013 |
20140046130 | Surgical Method Utilizing Transluminal Endoscope and Instruments - A method of transluminal surgery is provided, which utilizes an endoscopic surgery apparatus having pivotable arms attached by hinges on its distal end. The arms are interchangeable with arms of various configurations. The method includes the steps of inserting an endoscopic surgery apparatus into a body cavity of a patient, making an incision in the body cavity wall to allow access to the patient's abdominal cavity, and further inserting the apparatus through the incision. Surgery is performed at the desired surgical site and the apparatus is withdrawn into the body cavity where the incision is closed. Finally, the apparatus is withdrawn from the patient's body. | 02-13-2014 |
20160037027 | Durable Flexible Circuit Assembly - A flexible circuit assembly for an endoscope or borescope having an image sensor. The flexible circuit assembly has a flexible circuit with a first end, a second end, and a length between its first and second ends, the first end of the flexible circuit electrically connectable with the image sensor. A strengthening member is adjacent to the flexible circuit and along the length of the flexible circuit. An electrically insulated layer retains the strengthening member adjacent to the flexible circuit and encloses at least of portion of the strengthening member and the flexible circuit. The strengthening member may comprise a nitinol wire, and the nitinol wire may have a neutral position such that the nitinol wire returns to the neutral position after being articulated to a different position. | 02-04-2016 |
Jeffrey Barry, Longmeadow, MA US
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20140372913 | METHOD OF ORGANIZING AND ACCESSING INFORMATION - A method of organizing and accessing information on a website, comprising providing a plurality of primary category links associated with a plurality of primary categories, providing a plurality of topic links each associated with one or more art topics, each topic link having a topic name and a topic image, and providing a content region for presenting content for an art topic and having a content type associated with a primary category, wherein navigation around the website may be harmonized by art topic. | 12-18-2014 |
Joseph W. Barry, Walpole, MA US
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20100056236 | METHOD FOR DYNAMIC CONTENT GENERATION IN A ROLE-PLAYING GAME - The invention provides a role-playing game environment wherein the nature of various NPCs within the game may be varied over time within the game. The goals of various NPCs within the game may be dynamically and automatically changed within the game. At certain in-game time periods, the game server may dynamically assign one or more new goals for some or all of the NPCs based on the current status of each NPC. When a player later interacts with a given NPC assist (or impede) that NPC in reaching its currently assigned goal, the method may dynamically determine a steps that the player's avatar may perform to assist (or impede) the goal. Thus, players cannot predict what will happen when they move through the game and reach a location at which they can interact with a given NPC, making the game-playing experience ever fresh and challenging. | 03-04-2010 |
Katherine L. Barry, Belmont, MA US
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20160037970 | FOOD PROCESSING APPARATUS AND METHOD - Food processing apparatus and methods for processing food are disclosed. The apparatus may include stored sequences for operating a processing tool. The stored sequences may address various challenging aspects of blending solid foods and/or ice. In some embodiments, particular sequences are implemented with specific processing tools. | 02-11-2016 |
Kenneth J. Barry, Dracut, MA US
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20140209820 | CONTOURED SUPPORT GRID FOR HERMETICALLY SEALED THIN FILM APPLICATIONS - Systems and methods for manufacturing a vacuum device, such as an electron emitter, that includes a foil exit window palced over and joined to a support grid. In one particular method, the vacuum chamber of an electron emitter has a thin foil forming an exit window at one end. The thin foil may be titanium or any suitable material and the foil will typically enlarge during a bonding process that attaches the foil to the support grid. In one manufacturing process, the support grid is provided with a surface that has contours, typically being smooth recessed surfaces, that the foil once enlarged can lie against as the vacuum pulls the foil against the grid. | 07-31-2014 |
Ralph Barry, Hudson, MA US
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20140350463 | DUAL LUMEN PANCREATICOBILIARY CATHETER AND METHODS OF CANNULATING THE PANCREATICOBILIARY SYSTEM - Devices and methods for facilitating access to the pancreaticobiliary system are disclosed. In particular, the methods include bending a device having an elongate body with a first lumen, a second lumen, and respective first and second exit openings. The methods include inserting a first guidewire through the first lumen and out of the first exit opening to cannulate a pancreatic duct, and inserting a second guidewire through the second lumen and out of the second exit opening to cannulate a biliary duct. | 11-27-2014 |
Ralph J. Barry, Hudson, MA US
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20120160408 | Composite ePTFE- Silicone Covering for Stent - A medical device consists of a stent having a first surface and a second surface parallel to the first surface; a single expanded polytetrafluoroethylene (ePTFE) layer contacting the first surface of the stent; and an elastomeric layer applied to at least one surface of the stent. In at least one embodiment, the elastomeric layer is silicone. In at least one embodiment, the medical device is manufactured by positioning the ePTFE layer such that a first surface of the ePTFE layer contacts a first surface of the stent to form a stent-ePTFE assembly; and applying an elastomeric solution to the first surface of the ePTFE layer and at least one surface of the stent. | 06-28-2012 |
William D. Barry, Billerica, MA US
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20120119014 | TORSION SPRING WING DEPLOYMENT INITIATOR - A compact, purely mechanical wing deployment assisting mechanism uses torsion springs and lever arms to apply a deploying force to a guidance wing during its initial deployment through a wing slot in a rocket or missile, thereby assisting the wing to burst through a cover seal protecting the wing slot. The wings are then fully deployed by centrifugal force. Various embodiments include two “extreme duty” springs and two lever arms per wing, working in parallel. Embodiments provide a total of at least 24 pounds of force per wing at the end of a spring travel of 0.30 inches. In some embodiments, the entire mechanism weighs less than 0.5 pounds and/or occupies less than 2.5 cubic inches per wing. In embodiments, an assembled group, including two springs and two lever arms, is located between each pair of wings, whereby each assembled group applies one lever arm to each adjoining wing. | 05-17-2012 |
20140312575 | WING SLOT SEAL - A low cost, lightweight frangible wing slot seal can be applied to a guidance wing slot of a folding fin aerial rocket or missile, providing a barrier against exposure of internal missile components to external contaminants, while allowing unhindered deployment of missile guidance wings simply by bursting through the seals. The simple design is nearly foolproof, and has no impact the likelihood of weapon. failure. The seal is a flexible sheet which is sufficiently thin so as not to exceed the required volume envelope of the missile. The sheet includes a burst seam, which is breached when impacted by the leading edge of a deploying wing. No additional wing deployment force is required, and after deployment the seal has minimal impact on the aerodynamic performance of the wing. | 10-23-2014 |
Zoe Barry, Cambridge, MA US
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20130231945 | SYSTEMS AND METHODS FOR GENERATING, MANAGING, AND SHARING DIGITAL SCRIPTS - The present disclosure generally relates to improved systems and methods for generating, managing, and sharing digital scripts—which are accessible to patients and/or health care providers and may be accepted by any appropriate prescription dispensary—as well as a comprehensive, real-time source of patient prescription history in compliance with and furtherance of the Meaningful Use regulations. The systems and methods may support the multi-directional flow of script information to improve disease monitoring and treatment, to mitigate patient health risks like undesirable drug interactions, to identify social factors like patient ability to afford prescriptions, and to prevent prescription fraud like forged refills. | 09-05-2013 |