Barbieri, US
Christopher Barbieri, New York, NY US
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20130331279 | RECURRENT SPOP MUTATIONS IN PROSTATE CANCER - The invention relates generally to new prostate cancer markers, and particularly to a class of cancer marked by the presence of missense mutations in SPOP, an E3 ubiquitin ligase component. The invention provides methods and materials for detecting and diagnosing prostate cancer by detecting these mutations and may be useful in predicting disease progression and response to therapy. | 12-12-2013 |
Edward J. Barbieri, Willow Grove, PA US
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20130037709 | Method for Clinically Monitoring Niacin and Niacin Metabolites in Serum or Plasma - The present invention provides methods for determining the amount of nicotinic acid and its active metabolites in a biological sample using mass spectrometry. The methods involve specific sample collection processes necessary to stabilize and facilitate simultaneous analysis of nicotinic acid and active metabolites. Once in the laboratory, sample preparation is followed by solid phase extraction, liquid chromatographic separation of relevant moieties with detection by MS/MS whereby specific ion transitions are monitored. This invention has several clinical utilities, particularly those related to monitoring patients on antihyperlipidemic drug therapy. | 02-14-2013 |
Frank A. Barbieri, Boca Raton, FL US
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20080291662 | Lighting System - A lighting system includes a plurality of circular or disk-shaped lighting rings suitable for installation on a Christmas tree. The lighting rings include lights affixed to a webbing or net, and slits and trunk apertures to facilitate their placement around the Christmas tree trunk. For connection to an electrical power source, the lighting rings include electrical connectors including female electrical and male electrical connectors. | 11-27-2008 |
Jeff S. Barbieri, Sunrise, FL US
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20130038225 | Motion Activated Toilet Bowl Lighting Device - A motion activated toilet bowl lighting device includes a body member having inner, outer, top, and bottom walls that define an interior area. The inner wall includes an inwardly annular configuration complementary to a toilet bowl rim outer surface. The lighting device includes an attachment arm displaced from the inner wall. A bridge connects the top wall to the attachment arm such that the inner wall, attachment arm, and bridge sandwich the toilet rim. A motion detector is positioned on the outer wall and a light is positioned on the attachment arm. A light sensor is positioned on the body member. A battery and timer are situated in the interior area. The light is energized when the light sensor detects lower than a predetermined amount of ambient light and when the motion detector detects movement, the light being de-energized when the timer expires. | 02-14-2013 |
Joseph F. Barbieri, Richboro, PA US
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20090047533 | COMPOSITION AND METHOD FOR TREATING FIBROUS MATERIALS - Compositions useful in preventing fungal and bacterial growth in fibrous substrates, e.g., paper, are provided. These compositions also advantageously do not corrode metal substrates that are attached and/or adjacent to the fibrous substrate. The compositions contain didecyl dimethyl ammonium bicarbonate and didecyl dimethyl ammonium carbonate (DDABC), a water-soluble cationic salt of ethylene diamine tetraacetic acid, optionally water, and optionally an agent which complexes said water-soluble cationic salt of ethylene diamine tetraacetic acid. Also provided are products containing these compositions and methods of using the same. | 02-19-2009 |
Joseph T. Barbieri, New Berlin, WI US
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20090182123 | Method of Preparing Botulinum Neurotoxin Type E Light Chain - The present invention provides a preparation of botulinum toxin light chain type A or E, wherein the preparation is both catalytically active and soluble. Preferably, the preparation consists essentially of amino acid residues 1 through 425 of the botulinum toxin light chain type A. A method of screening inhibitors is also provided, wherein the method comprises exposing a test inhibitor to the preparation of botulinum toxin light chain type A and evaluating the biological activity of the preparation. In another embodiment, a method of providing a catalytically active, soluble preparation of botulinum toxin light chain, type A is provided, wherein the method comprises obtaining an expression vector comprising a DNA sequence encoding amino acid residues 1-425 and expressing a polypeptide. | 07-16-2009 |
Joseph T. Barbieri, Milwaukee, WI US
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20090017495 | ESCHERICHIA COLI-DERIVED VACCINE AND THERAPY AGAINST BOTULISM - A method of producing botulinum toxin C-terminal receptor binding domain (HCR) is disclosed. The one embodiment, the method comprises the steps of (a) preparing | 01-15-2009 |
20120039941 | ENGINEERED BOTULINUM NEUROTOXIN - The present invention provides a novel modified BoNT/E catalytic domain and methods of use thereof. In one embodiment, the light chain residue 224, or a residue corresponding to residue 224, of the modified BoNT/E catalytic domain has been altered to be aspartic acid or glutamic acid. The modified catalytic domain cleaves SNAP23 but does not cleave SNAP29 or SNAP47, providing novel methods of treating diseases including without limitation, asthma, CF, chronic obstructive pulmonary, gastric acid efflux and inflammation, immune disorders with a cytokine component or cancers with a cytokine component. | 02-16-2012 |
Laurel Rita Barbieri, Blauvelt, NY US
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20080306131 | Progesterone receptor modulator and uses thereof - Compounds of the structure: | 12-11-2008 |
20100041692 | PYRROLO[4,3,2-DE]QUINOLIN-8-AMINE COMPOUNDS AND METHODS OF THEIR PREPARATION AND USE - The present invention relates to compounds of formula I: | 02-18-2010 |
Mark D. Barbieri, Macomb Township, MI US
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20090048407 | RECIRCULATION LOOP REACTOR BULK POLYMERIZATION PROCESS - A process for producing polymer and more particularly adhesive using a recirculating loop reactor. In one embodiment the reactor includes one or more mixers to mix feed stock with the polymerized material recirculating in the reactor. In another embodiment a planetary roller extruder (PRE) may be used for this purpose. In still another embodiment, a combination of one or more static mixers and one or more PREs may be used. | 02-19-2009 |
20100105847 | PLUG FLOW BULK POLYMERIZATION OF VINYL MONOMERS - A process for continuous bulk polymerization is disclosed that includes providing a plug flow reactor comprising a primary loop reactor including a loop for recirculating a portion of a polymer-in-progress at a polymer flow rate back to a reactor in the primary loop reactor, introducing at least one monomer into the primary recirculation loop reactor at a monomer flow rate, polymerizing the monomer in the primary recirculation loop reactor in the presence of an initiator by way of a free-radical polymerization to form a polymer-in-progress, and recirculating a first portion of the polymer-in-progress through the loop into a reactor in the primary loop reactor to combine with the monomer at a ratio of polymer flow rate to monomer flow rate that is greater than 5. | 04-29-2010 |
Riccardo Barbieri, Boston, MA US
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20140303458 | SYSTEMS AND METHODS FOR INHIBITING APNEIC EVENTS - Systems and methods are disclosed to monitor physiological for the occurrence of life threatening events and to apply stimulation to prevent the occurrence of said life-threatening events. Systems and methods for applying the stimulation are also disclosed. These systems include applying the stimulation through via a mattress having a passive section and an active section, a plurality of focal stimulators, and/or an array to apply the stimulation are also disclosed. These devices include a mattress with an active region and a passive region, a stimulating array do deliver targeted stimulation, and a plurality of stimulators to apply focused stimulation. | 10-09-2014 |
Richard G. Barbieri, Morris, NY US
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20120000930 | ACU-SPRAY AEROSOL STRAW SYSTEMS - Acu-Spray Aerosol Straw is designed to allow the contents of a pressurized container to be dispensed at virtually any angle. Acu-Spray Aerosol Straw comprises a bendable, plastic straw. A wire is molded into the sidewall of the straw or molded integral to the straw tube as supporting means. The wire may be housed in a plastic casing and then molded onto the side of the original aerosol straw. The molding together of the wire that is encased and the straw-tube effectively prevents the separation of the two components due to bending. The bendable straw in combination with the wire is bendably-manipulatable such that a propelled fluid from a pressurized container is strategically dispensed onto a user-defined location. The device may be detachable from the nozzle to prevent breakage while the can is in storage. In certain embodiments the device may comprise a non-wire version wherein the bendable straw may be a non-bendable rigid structure. The rigid straw embodiment may comprise L-shaped, C-shaped, V-shaped configurations and/or other such shapes. | 01-05-2012 |
Robert S. Barbieri, Schnecksville, PA US
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20100076799 | System and method for using classification trees to predict rare events - Systems and methods are provided for predicting rare events, such as hospitalization events. A set of data records, each containing multiple attributes with one or more values (which may include an “unknown” value), may represent a root node of a decision tree. This root node may be partitioned based on one of the attributes, such that the concentration (e.g., “purity”) of a relevant outcome (e.g., the rare event) is increased in one node and decreased in another. This process may be repeated until a decision tree with sufficiently pure leaf nodes is created. This “purified” decision tree may then be used to predict one or more rare events. | 03-25-2010 |
20100082707 | Method and system for archiving biomedical data generated by a data collection device - A method for archiving biomedical data generated by a data collection device, includes the steps of automatically determining a data format in which the collection device is configured to store the biomedical data onto a computer-readable storage medium, based on the data format, extracting the biomedical data from the storage medium, and transmitting the extracted data to a database in which the extracted data is archived. | 04-01-2010 |
Thomas J. Barbieri, Hamden, CT US
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20090312795 | SUTURE ANCHORS - A suture anchor includes an outer sleeve having a longitudinal throughbore and defining leading and trailing ends and an insert positionable within the longitudinal throughbore of the outer sleeve. The insert defines at least one suture track for slidably supporting a suture whereby opposed free ends of the suture extend from the at least one suture track through the longitudinal throughbore to extend beyond the trailing end of the outer sleeve to be tensioned and secured relative to the tissue. The outer sleeve may include an external thread for threaded rotation and advancement into the tissue. | 12-17-2009 |
Travis A. Barbieri, Phoenix, AZ US
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20150349397 | RESONATING FILTER AND METHOD THEREOF - In general the embodiments described herein can provide alternating-current (AC) resonating filters. These resonating filters comprise a transmission line, a first resonator, and a second resonator. The first resonator is configured to block AC signals in a first frequency range, while the second resonator is configured to block AC signals in a second frequency range, where the second frequency range is higher than the first frequency range. The transmission line has a first node coupled to an AC source, and the first resonator is coupled to the transmission line a first distance from the first node, and the second resonator is coupled to the transmission line a second distance from the first node, where the second distance is greater than the first distance. When so configured the resonating filter can effectively block signals in multiple selected frequency bandwidths. | 12-03-2015 |