Patent application number | Description | Published |
20090125092 | METHODS FOR MAKING AN ENCAPSULATED STENT AND INTRALUMINAL DELIVERY THEREOF - A method for making an encapsulated stent includes providing a first seamless unsintered ePTFE tube, providing a second seamless sintered ePTFE tube, positioning a self-expanding stent between the first and second ePTFE tubes to form an assembly, and joining the first ePTFE tube to the second ePTFE tube through openings in a wall of the stent by applying first pressure, and then heat, to the assembly. | 05-14-2009 |
20090311132 | METHODS FOR MAKING A SUPPORTED GRAFT - A method for forming a self-expanding stent-graft, including coupling a shape memory member to a polymer cladding to form a polymer clad member, winding a length of the polymer clad member about a mandrel so that adjacent windings include regions of polymer cladding that overlap, heating the wound polymer clad member to join and seal the overlapping regions to one another, manipulating the stent-graft from a first diameter to a second diameter smaller than the first diameter, and loading the stent-graft into a restraining sheath, wherein the restraining sheath prevents the stent-graft from reverting to the first diameter. | 12-17-2009 |
20110196473 | METHODS FOR MAKING AN ENCAPSULATED STENT AND INTRALUMINAL DELIVERY THEREOF - A method for making an encapsulated stent includes providing a first seamless unsintered ePTFE tube, providing a second seamless sintered ePTFE tube, positioning a self-expanding stent between the first and second ePTFE tubes to form an assembly, disposing an ePTFE interlayer member between the first and second ePTFE tubes, and joining the first ePTFE tube to the second ePTFE tube through openings in a wall of the stent by applying first pressure, and then heat, to the assembly. | 08-11-2011 |
20110315305 | SELECTIVE ADHERENCE OF STENT-GRAFT COVERINGS - A method for making a radially expandable stent-graft, including positioning a radially expandable stent member concentrically over a first polymeric member, locating a second polymeric member concentrically over the stent member and first polymeric member, and joining the first polymeric member to the second polymeric member through interstices of the stent member at selective locations to form slip planes between the first and second polymeric members. The slip planes accommodate movement of the stent between the polymeric members to facilitate compression of the stent graft to a low profile. | 12-29-2011 |
20120145318 | METHODS FOR MAKING AN ENCAPSULATED STENT AND INTRALUMINAL DELIVERY THEREOF - A method for making an encapsulated stent includes providing a first seamless unsintered ePTFE tube, providing a second seamless unsintered ePTFE tube, positioning a balloon-expandable stent between the first and second ePTFE tubes to form an assembly, disposing an ePTFE interlayer member between the first and second ePTFE tubes, and joining the first ePTFE tube to the second ePTFE tube through openings in a wall of the stent by applying first pressure, and then heat, to the assembly. | 06-14-2012 |
20120193018 | Methods for Making a Supported Graft - A method for forming a self-expanding stent-graft, including coupling a shape memory member to a polymer cladding to form a polymer clad member, disposing a length of the polymer clad member in an overlapping helical manner about a longitudinal axis, joining and sealing adjacent overlapping regions of the polymer clad member to form a stent-graft, manipulating the stent-graft from a first diameter to a second diameter smaller than the first diameter, and loading the stent-graft into a restraining sheath at the second diameter, the restraining sheath preventing expansion of the stent-graft from the second diameter to the first diameter. | 08-02-2012 |
20130102839 | Methods for Making a Supported Graft - A method for preparing a stent-graft for intraluminal delivery, including positioning an expanded polytetrafluoroethylene (ePTFE) substrate over a support mandrel, coupling a shape memory member to a polymer cladding to form a polymer clad member, winding the polymer clad member in an overlapping helical manner onto a surface of the ePTFE substrate, joining and sealing adjacent overlapping regions of the polymer clad member together and to the surface of the ePTFE substrate to form a stent-graft, manipulating the stent-graft from a larger first diameter to a smaller second diameter, and loading the stent-graft into a restraining sheath at the smaller second diameter. | 04-25-2013 |
Patent application number | Description | Published |
20100191317 | ENDOLUMINAL IMPLANTABLE STENT-GRAFTS - An implantable endoluminal device that is fabricated from materials that present a blood or body fluid and tissue contact surface that has controlled heterogeneities in material constitution. An endoluminal stent-graft and web-stent that is made of an monolithic material deposited into a monolayer and etched into regions of structural members and web regions subtending interstitial regions between the structural members. An endoluminal graft is also provided which is made of a biocompatible metal or metal-like material. The endoluminal stent-graft is characterized by having controlled heterogeneities in the stent material along the blood flow surface of the stent and the method of fabricating the stent using vacuum deposition methods. | 07-29-2010 |
20100217373 | IMPLANTABLE GRAFT AND METHODS OF MAKING SAME - The present invention relates to an implantable endoluminal graft comprised of a microporous thin-film covering having a plurality of openings and a structural support element underlying and physically attached to the microporous thin-film covering, the microporous thin-film covering having shape memory properties. | 08-26-2010 |
20110056909 | METHODS OF MAKING MEDICAL DEVICES - Scaffold-supported metal or pseudometallic film covers suitable for use as medical devices are disclosed together with methods of fabricating the devices. Methods for making the medical devices consist of either providing or forming a scaffold, then depositing a metallic or pseudometallic film cover onto the scaffold in such a manner as to form an integral, substantially monolithic junction between the deposited cover material and the scaffold. | 03-10-2011 |
20110077528 | METHOD AND APPARATUS FOR SIMULTANEOUS HEMOGLOBIN REFLECTIVITY MEASUREMENT AND OCT MEASUREMENT, THROMBUS DETECTION AND TREATMENT, AND OCT FLUSHING - A method and apparatus for simultaneous hemoglobin reflectivity measurement and OCT measurement, thrombus detection and treatment, and OCT flushing. A first optical energy for OCT and a second optical energy for hemoglobin may be used. | 03-31-2011 |
20120132612 | METHOD FOR MAKING GROOVES ON A LUMINAL SURFACE OF AN INTRAVASCULAR STENT - The invention relates to methods and apparatus for manufacturing intravascular stents wherein the intravascular stent has its inner surface treated to promote the migration of endothelial cells onto the inner surface of the intravascular stent. In particular, the inner surface of the intravascular stent has at least one groove formed therein. | 05-31-2012 |
20120135130 | METHOD OF MAKING IMPLANTABLE MEDICAL DEVICES HAVING CONTROLLED SURFACE PROPERTIES - An implantable medical device that is fabricated from materials that present a blood or body fluid or tissue contact surface that has controlled heterogeneities in material constitution. An endoluminal stent-graft and web-stent that is made of a monolithic material formed into differentiated regions defining structural members and web regions extending across interstitial spaces between the structural members. The endoluminal stent-graft is characterized by having controlled heterogeneities at the blood flow surface of the stent. | 05-31-2012 |
20120223056 | METHOD FOR MAKING GROOVES ON A LUMINAL SURFACE OF AN INTRAVASCULAR STENT - The invention relates to methods and apparatus for manufacturing intravascular stents wherein the intravascular stent has its inner surface treated to promote the migration of endothelial cells onto the inner surface of the intravascular stent. In particular, the inner surface of the intravascular stent has at least one groove formed therein. | 09-06-2012 |
20120310158 | BALLOON CATHETER HAVING METAL BALLOON AND METHOD OF MAKING SAME - A metal balloon catheter having a main tubular body, a metal balloon proximate a distal end of the main tubular body, a central annulus extending along an entire longitudinal aspect of the catheter for accommodating a guidewire therethrough and an inflation annulus adjacent the central annulus which extends along the longitudinal axis of the main tubular body and terminates in fluid flow communication with an inflation chamber of the metal balloon. The metal balloon catheter may be either unitary integral metal catheter in which the main tubular body and the balloon are fabricated of metal, or it may consist of a polymeric main tubular body and a metal balloon. | 12-06-2012 |
20120325774 | METHODS OF MAKING MEDICAL DEVICES - Scaffold-supported metal or pseudometallic film covers suitable for use as medical devices are disclosed together with methods of fabricating the devices. Methods for making the medical devices consist of either providing or forming a scaffold, then depositing a metallic or pseudometallic film cover onto the scaffold in such a manner as to form an integral, substantially monolithic junction between the deposited cover material and the scaffold. | 12-27-2012 |
20130041251 | IN VIVO SENSOR AND METHOD OF MAKING SAME - Implantable in vivo sensors used to monitor physical, chemical or electrical parameters within a body. The in vivo sensors are integral with an implantable medical device and are responsive to externally or internally applied energy. Upon application of energy, the sensors undergo a phase change in at least part of the material of the device which is then detected external to the body by conventional techniques such as radiography, ultrasound imaging, magnetic resonance imaging, radio frequency imaging or the like. The in vivo sensors of the present invention may be employed to provide volumetric measurements, flow rate measurements, pressure measurements, electrical measurements, biochemical measurements, temperature, measurements, or measure the degree and type of deposits within the lumen of an endoluminal implant, such as a stent or other type of endoluminal conduit. The in vivo sensors may also be used therapeutically to modulate mechanical and/or physical properties of the endoluminal implant in response to the sensed or monitored parameter. | 02-14-2013 |
20130131784 | METALLIC IMPLANTABLE GRAFTS AND METHOD OF MAKING SAME - Implantable medical grafts fabricated of metallic or pseudometallic films of biocompatible materials having a plurality of microperforations passing through the film in a pattern that imparts fabric-like qualities to the graft or permits the geometric deformation of the graft. The implantable graft is preferably fabricated by vacuum deposition of metallic and/or pseudometallic materials into either single or multi-layered structures with the plurality of microperforations either being formed during deposition or after deposition by selective removal of sections of the deposited film. The implantable medical grafts are suitable for use as endoluminal or surgical grafts and may be used as vascular grafts, stent-grafts, skin grafts, shunts, bone grafts, surgical patches, non-vascular conduits, valvular leaflets, filters, occlusion membranes, artificial sphincters, tendons and ligaments. | 05-23-2013 |
20130166018 | DEVICE FOR IN VIVO DELIVERY OF BIOACTIVE AGENTS AND METHOD OF MANUFACTURE THEREOF - The implantable structural element for in vivo controlled delivery of bioactive active agents to a situs in a body. The implantable structural element may be configured as an implantable prosthesis, such as an endoluminal stent, cardiac valve, osteal implant or the like, which serves a dual function of being prosthetic and a carrier for a bioactive agent. Control over elution of the bioactive agents occurs through a plurality of cantilever-like cover members which prevent drug elution until an endogenous or exogenous stimulus causes the cover members to open and permit drug elution. | 06-27-2013 |
20130287931 | METHODS OF MAKING DEVICES - The method of making devices is disclosed herein. More particularly, a method of manufacturing a device, comprises: vacuum depositing a device-forming metal onto an unpatterned, exterior surface of a generally cylindrical substrate to form a generally tubular, unpatterned crystalline metal film under at least one vacuum deposition process condition selected from at least one of chamber pressure, deposition pressure, and partial pressure of a process gas, said at least one process condition optimized to substantially eliminate formation of chemical and intra- and intergranular precipitates in the bulk material; and removing the deposited generally tubular, unpatterned crystalline metal film from the generally cylindrical substrate. | 10-31-2013 |
20140054258 | METHOD FOR MAKING GROOVES ON A LUMINAL SURFACE OF AN INTRAVASCULAR STENT - Methods for manufacturing intravascular stents are disclosed wherein the intravascular stent has its inner surface treated to promote the migration of endothelial cells onto the inner surface of the intravascular stent. In particular, the inner surface of the intravascular stent has at least one groove formed therein. | 02-27-2014 |
20140067043 | IMPLANTABLE EXPANDABLE MEDICAL DEVICES HAVING REGIONS OF DIFFERENTIAL MECHANICAL PROPERTIES AND METHODS OF MAKING SAME - An implantable expandable medical device in which selected regions of the device are in a martensite phase and selected regions are in an austenite phase. The martensitic regions exhibit pseudoplastic behavior in vivo and may be deformed without recovery under in vivo body conditions. In contrast the austenitic regions exhibit superelastic behavior in vivo and will recover their pre-programmed configuration upon deformation or release of an applied strain. | 03-06-2014 |
20140096906 | Methods for Making an Encapsulated Stent - A method for making an encapsulated stent includes providing first and second ePTFE layers and a stent positioned therebetween. The first ePTFE layer may be unsintered and have a node-fibril microstructure in which the fibrils are oriented perpendicular to the longitudinal axis. The second ePTFE layer may be unsintered and have a node-fibril microstructure in which the fibrils are oriented parallel to the longitudinal axis. The method includes joining the first ePTFE layer to the second ePTFE layer through openings in a wall of the stent. | 04-10-2014 |
20140107766 | Methods for Making a Supported Graft - A device includes a tubular substrate and a support member. The support member includes a component that is elastically deformable and elastically recoverable. The support member wraps around and adheres to an abluminal surface of the tubular substrate. The device is adapted for use in an anatomical conduit. For example, the device may be adapted for bypassing an anatomical conduit, for creating an arteriovenous shunt, or as a support structure for maintaining an opening in an anatomical conduit. | 04-17-2014 |
20140216637 | METHODS OF MAKING MEDICAL DEVICES - Scaffold-supported metal or pseudometallic film covers suitable for use as medical devices are disclosed together with methods of fabricating the devices. Methods for making the medical devices consist of either providing or forming a scaffold, then depositing a metallic or pseudometallic film cover onto the scaffold in such a manner as to form an integral, substantially monolithic junction between the deposited cover material and the scaffold. | 08-07-2014 |
20140303714 | Selective Adherence of Stent-Graft Coverings - An endoluminal prosthesis including a radially expandable support member having interior and exterior surfaces and a wall with openings, a first covering member including a biocompatible polymer material at least partially positioned against the interior surface, and a second covering member including a biocompatible polymer material at least partially positioned against the exterior surface. The first covering member attaches to the second covering member at predetermined bonding locations within less than all of the openings thereby leaving unbonded regions. | 10-09-2014 |
Patent application number | Description | Published |
20090031967 | INTEGRAL WATERWALL EXTERNAL HEAT EXCHANGERS - A combustion system having a combustor that includes tubing for carrying boiler water, a cyclone to recover solids from exhaust of the combustor and an external heat exchanger to recover heat from the solids, includes: a bypass for providing boiler water from the combustor to tube bundles of the external heat exchanger and a boiler water return for providing boiler water from the tube bundles to waterwall tubing of the combustor. A method and an external heat exchanger are also provided. | 02-05-2009 |
20100089061 | START-UP SYSTEM MIXING SPHERE - A start-up system mixing element including; a body defining a cavity, a first inlet port disposed in the body and configured to provide a first fluid to the cavity, a second inlet port disposed in the body and configured to provide a second fluid to the cavity, an outlet port disposed in the body and configured to remove the first and second fluids from the cavity and an internal distribution pipe disposed in the first inlet port, wherein the internal distribution pipe is configured to provide the first fluid to the cavity via a plurality of holes directed toward a center of the cavity. | 04-15-2010 |
20100251976 | EJECTOR DRIVEN STEAM GENERATOR START UP SYSTEM - A generating system is presented that includes a steam generator, a separator coupled to the generator, a supply providing feed water, a start-up system coupled to and receiving the feed water, and a recirculation system coupled to the start-up system. The steam generator operates in a plurality of operating modes. In one mode the steam generator generates a flow of steam and fluid. The separator separates the flow into components of steam and fluid. The recirculation system receives the feed water from the start-up system and provides a required flow to the steam generator during at least one mode. The recirculation system includes an ejector. The ejector induces a portion of the fluid from the separator into the recirculation system, mixes the induced fluid with the feed water to provide a recirculation flow, and the recirculation system provides the required flow to the steam generator including the recirculation flow. | 10-07-2010 |
20110239782 | METHOD AND SYSTEM FOR MEASUREMENT OF A FLOW RATE OF A FLUID - A system for measuring a flow rate of a fluid through a plurality of tubes sharing a common flow orifice, the system includes an ultrasonic transducer having a plurality of sensors in communication with a plurality of tubes sharing a common flow orifice. The system includes an electronic module coupled to the ultrasonic transducer, the electronic module connecting selected sensors to a flow rate analyzer for determining a flow rate of fluid through the plurality of tubes on which the sensors are in communication with. | 10-06-2011 |
Patent application number | Description | Published |
20090075381 | Amnion-derived cell compositions, methods of making and uses thereof - The invention is directed to substantially purified amnion-derived cell populations, compositions comprising the substantially purified amnion-derived cell populations, and to methods of creating such substantially purified amnion-derived cell populations, as well as methods of use. The invention is further directed to antibodies, in particular, monoclonal antibodies, that bind to amnion-derived cells or, alternatively, to one or more amnion-derived cell surface protein markers. The invention is further directed to methods for producing the antibodies, methods for using the antibodies, and kits comprising the antibodies. | 03-19-2009 |
20100028306 | Amnion-Derived Cell Compositions, Methods of Making and Uses Thereof - The invention is directed to substantially purified amnion-derived cell populations, compositions comprising the substantially purified amnion-derived cell populations, and to methods of creating such substantially purified amnion-derived cell populations, as well as methods of use. The invention is further directed to antibodies, in particular, monoclonal antibodies, that bind to amnion-derived cells or, alternatively, to one or more amnion-derived cell surface protein markers. The invention is further directed to methods for producing the antibodies, methods for using the antibodies, and kits comprising the antibodies. | 02-04-2010 |
20100068180 | NOVEL METHODS FOR MODULATING INFLAMMATORY AND/OR IMMUNE RESPONSES - The invention is directed to novel methods for modulating inflammatory and/or immune responses. Such methods utilize compositions comprising extraembryonic cells (herein referred to as EE cells) including but not limited to extraembryonic HLA-G positive cells (herein referred to as EHP cells) and amnion-derived multipotent progenitor cells (herein referred to as AMP cells); compositions comprising expanded EE cell populations, and/or cell lysates and/or conditioned media derived therefrom, alone or in combination with each other and/or in combination with various extracellular matrices and/or devices and/or other suitable active agents. | 03-18-2010 |
20120263684 | Novel methods for modulating inflammatory and/or immune responses - The invention is directed to novel methods for modulating inflammatory and/or immune responses. Such methods utilize compositions comprising extraembryonic cells (herein referred to as EE cells) including but not limited to extraembryonic HLA-G positive cells (herein referred to as EHP cells) and amnion-derived multipotent progenitor cells (herein referred to as AMP cells); compositions comprising expanded EE cell populations, and/or cell lysates and/or conditioned media derived therefrom, alone or in combination with each other and/or in combination with various extracellular matrices and/or devices and/or other suitable active agents. | 10-18-2012 |
20120264106 | Novel methods for modulating inflammatory and/or immune responses - The invention is directed to novel methods for modulating inflammatory and/or immune responses. Such methods utilize compositions comprising extraembryonic cells (herein referred to as EE cells) including but not limited to extraembryonic HLA-G positive cells (herein referred to as EHP cells) and amnion-derived multipotent progenitor cells (herein referred to as AMP cells); compositions comprising expanded EE cell populations, and/or cell lysates and/or conditioned media derived therefrom, alone or in combination with each other and/or in combination with various extracellular matrices and/or devices and/or other suitable active agents. | 10-18-2012 |
20120270319 | Amnion-derived cell compositions, methods of making and uses thereof - The invention is directed to substantially purified amnion-derived cell populations, compositions comprising the substantially purified amnion-derived cell populations, and to methods of creating such substantially purified amnion-derived cell populations, as well as methods of use. The invention is further directed to antibodies, in particular, monoclonal antibodies, that bind to amnion-derived cells or, alternatively, to one or more amnion-derived cell surface protein markers. The invention is further directed to methods for producing the antibodies, methods for using the antibodies, and kits comprising the antibodies. | 10-25-2012 |
20120301444 | Amnion-derived cell compositions, methods of making and uses thereof - The invention is directed to substantially purified amnion-derived cell populations, compositions comprising the substantially purified amnion-derived cell populations, and to methods of creating such substantially purified amnion-derived cell populations, as well as methods of use. The invention is further directed to antibodies, in particular, monoclonal antibodies, that bind to amnion-derived cells or, alternatively, to one or more amnion-derived cell surface protein markers. The invention is further directed to methods for producing the antibodies, methods for using the antibodies, and kits comprising the antibodies. | 11-29-2012 |
20120315246 | Compositions and methods for modulating inflammatory and/or immune responses - The invention is directed to novel compositions and methods for modulating inflammatory and/or immune responses. Such novel compositions are derived from extraembryonic cells (herein referred to as EE cells) including but not limited to extraembryonic HLA-G positive cells (herein referred to as extraembryonic HLA-G positive or “EHP” cells) and Amnion-derived Multipotent Progenitor cells (herein referred to as AMP cells), alone or in combination with each other and/or in combination with various matrices and/or devices and/or other suitable active agents. The novel methods of modulating inflammatory and/or immune responses utilize such novel compositions. | 12-13-2012 |
20130071364 | Amnion-derived cells, methods of making and uses thereof - The invention is directed to substantially purified amnion-derived cell populations, compositions comprising the substantially purified amnion-derived cell populations, and to methods of creating such substantially purified amnion-derived cell populations, as well as methods of use. The invention is further directed to antibodies, in particular, monoclonal antibodies, that bind to amnion-derived cells or, alternatively, to one or more amnion-derived cell surface protein markers. The invention is further directed to methods for producing the antibodies, methods for using the antibodies, and kits comprising the antibodies. | 03-21-2013 |
20130183654 | Compositions and methods for modulating ischemic injury - The invention is directed to methods of modulating ischemic injury in tissues and organs. The invention is further directed to methods of increasing time to ischemic injury in tissues and organs. Such methods utilize compositions comprising cells capable of modulating inflammatory responses, referred to herein as Inflammatory Response Modulating Cells (IRMCs). The IRMCs any be used directly or cell membranes derived from them may be used in practicing the methods of the invention. In addition, the IRMCs and IRMC membranes may be used alone or in combination with each other and/or in combination with various suitable active agents. | 07-18-2013 |
20130251675 | Methods for Modulating Inflammatory Responses - The invention is directed to novel methods for modulating inflammatory and/or immune responses. Such methods utilize compositions comprising extraembryonic cells (herein referred to as EE cells) including but not limited to extraembryonic HLA-G positive cells (herein referred to as EHP cells) and amnion-derived multipotent progenitor cells (herein referred to as AMP cells); compositions comprising expanded EE cell populations, and/or cell lysates and/or conditioned media derived therefrom, alone or in combination with each other and/or in combination with various extracellular matrices and/or devices and/or other suitable active agents. | 09-26-2013 |
20130302289 | Methods for Modulating Immune Responses - The invention is directed to novel methods for modulating inflammatory and/or immune responses. Such methods utilize compositions comprising extraembryonic cells (herein referred to as EE cells) including but not limited to extraembryonic HLA-G positive cells (herein referred to as EHP cells) and amnion-derived multipotent progenitor cells (herein referred to as AMP cells); compositions comprising expanded EE cell populations, and/or cell lysates and/or conditioned media derived therefrom, alone or in combination with each other and/or in combination with various extracellular matrices and/or devices and/or other suitable active agents. | 11-14-2013 |
20140037591 | Methods for reducing and/or preventing excessive cellular apoptosis - The invention is directed to novel methods for reducing the number of apoptotic cell deaths in a population of cells undergoing excessive cellular apoptosis. The invention is also directed to novel methods for preventing apoptotic cell death in a population of cells at risk for developing excessive cellular apoptosis. In particular, the invention is directed to novel methods for reducing or preventing excessive cellular apoptosis comprising exposing cells exhibiting or at risk for developing excessive cellular apoptosis to a novel cellular factor-containing composition called Amnion-derived Cellular Cytokine Solution (referred to herein as ACCS), which is obtained from the culturing of Amnion-derived Multipotent Progenitor (AMP) cells, or AMP cells. | 02-06-2014 |
20140255904 | Modulating ischemic injury and preserving/storing tissue - The invention is directed to methods of modulating ischemic injury in tissues and organs, including donor tissue and organs and intact tissue and organs. The invention is further directed to methods of increasing time to ischemic injury in such tissues and organs. The invention is further directed to storing and preserving donor tissues and organs. Such methods utilize compositions comprising Amnion-derived Cellular Cytokine Solution (herein referred to as ACCS). The ACCS compositions may be formulated for sustained-release, targeted-release, timed-release, extended-release, etc. and may be used alone or in combination with various suitable active agents. | 09-11-2014 |