Baltazar
Baltazar Becerril, Morelos MX
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20090105086 | Methods of selecting internalizing antibodies - This invention provides methods of selecting antibodies that are internalized into target cells. The methods generally involve contacting target cells with one or more members of an antibody phage display library. The members of the phage display library are also contacted with cells of a subtractive cell line. The target cells are then washed to remove the subtractive cell line cells and members of the phage display library that are non-specifically bound or weakly bound to the target cells. The target cells are cultured under conditions where members of the phage display library can be internalized if bound to an internalizing marker and internalized members of the phage display library are then identified. | 04-23-2009 |
Baltazar Canete, Waiblingen DE
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20140355215 | Embedded Heat Slug to Enhance Substrate Thermal Conductivity - An electronic package is fabricated wherein a substrate is provided having three or more layers. A heat slug is embedded completely within the substrate. A die is attached above the substrate. Thermal paths to the heat slug are linked through the ground signal interconnects (traces, vias and planes). | 12-04-2014 |
Baltazar Deleon, Iii, Austin, TX US
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20100223419 | COPY CIRCUMVENTION IN A VIRTUAL NETWORK ENVIRONMENT - A method, system, and computer program product for circumventing data copy operations in a virtual network environment. The method includes copying a data packet from a user space to a first kernel space of a first logical partition (LPAR). Using a hypervisor, a mapped address of a receiving virtual Ethernet driver in a second LPAR is requested. The first mapped address is associated with a buffer of the receiving virtual Ethernet driver. The data packet is copied directly from the first kernel space of the first LPAR to a destination in a second kernel space of the second LPAR. The destination is determined utilizing the mapped address. The direct copying to the destination bypasses (i) a data packet copy operation from the first kernel space to a transmitting virtual Ethernet driver of the first LPAR, and (ii) a data packet copy operation via the hypervisor. The receiving virtual Ethernet driver is notified that the data packet has been successfully copied to the destination in the second LPAR. | 09-02-2010 |
Baltazar De Leon, Iii, Autin, TX US
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20100153974 | OBTAIN BUFFERS FOR AN INPUT/OUTPUT DRIVER - Disclosed is a computer implemented method, computer program product, and apparatus to obtain buffers in a multiprocessor system. A software component receives a call from an I/O device driver for a buffer, the call including at least one parameter, and walks a bucket data structure to a current bucket. The software component then determines whether the current bucket is free, and obtains a buffer list contained with the current bucket. Responsive to a determination that the current bucket is free, the software component determines whether sufficient buffers are obtained based on the parameter. Upon determining there are sufficient buffers obtained, the software component provides the current bucket and a second bucket as a single buffer list to the I/O device driver. | 06-17-2010 |
Baltazar Gomez-Mancilla, Portage, MI US
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20100035251 | BioMarkers for the Progression of Alzheimer's Disease - The genetic polymorphism LRRK2 (leucine-rich repeat kinase 2)-T1602S is significantly associated with conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD), with the patients with TT genotype being at greater risk to progress to Alzheimer's disease. The LRRK2-T2352 also showed a trend for conversion to Alzheimer's disease, with the patients with CC genotype tending to progress to Alzheimer's disease. Similar to the APOE-E4 allele, in the presence of a BuChE-K variant, LRRK2-T1602S and LRRK2-T2352 showed a greater association with the rate of conversion from mild cognitive impairment to Alzheimer's disease. In another study with placebo-treated Alzheimer's disease patients, LRRK2-T1602S and LRRK2-T2352 showed a same trend of association. The Alzheimer's disease patients with TT genotype of LRRK2-T1602S or CC genotype of LRRK2-T2352 tended to decline faster on cognitive performance over 6 months, especially in the presence of a BuChE-K variant. The association between the two common LRRK2 polymorphisms and Alzheimer's disease progression shows that LRRK2 may play a role in Alzheimer's disease pathogenesis, especially disease progression, and that polymorphisms of LRRK2 can be used as biomrkers of this progression. | 02-11-2010 |
Baltazar Gomez-Mancilla, Basel CH
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20100249136 | ORGANIC COMPOUNDS - The invention concerns the use an mGluR modulator, e.g. an mGluR5 modulator, for the treatment, prevention or delay of progression of Parkinson's Disease and associated disorders | 09-30-2010 |
20110212980 | COMBINATIONS FOR THE TREATMENT OF MIGRAINE - The present invention relates to novel combinations suitable for the treatment of migraine of various genesis or aetiology, which comprise, as active ingredients, at least one 5-HT | 09-01-2011 |
20120122878 | COMBINATION PRODUCTS - The invention concerns the combinations of an mGluR modulator, e.g. an mGluR5 modulator and at least one of L-dopa, a dopamine modulator, e.g. a dopamine agonist, a dopa decarboxylase inhibitor or a catechol-O-methyl transferase inhibitor. | 05-17-2012 |
20120157464 | USE OF AZABICYCLOALKYL DERIVATIVES OR PYRROLIDINE-2-ONE DERIVATIVES FOR THE TREATMENT OR PREVENTION OF ATAXIA - The invention concerns the use of azabicycloalkyl derivatives or pyrrolidine-2-one derivatives for the treatment, prevention or delay of progression of ataxia. | 06-21-2012 |
20120172346 | USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS - The invention concerns the use of a nicotinic acetylcholine receptor alpha 7 activators for the treatment, prevention or delay of progression of dyskinesia associated with dopamine agonist therapy in Parkinson's Disease. | 07-05-2012 |
20140171448 | USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS - The invention concerns the use of a nicotinic acetylcholine receptor alpha 7 activators for the treatment, prevention or delay of progression of a Movement Disorder selected from Dystonia, Dyskinesia, Chorea, Restless Legs Syndrome, Tics, Tremor, Myoclonus, Startle, Stiff Person Syndrome, Gait Disorder, Parkinson's Disease and Symptomatic Parkinsonism. | 06-19-2014 |
20140194423 | COMBINATION PRODUCTS - The invention concerns the combinations of an mGluR modulator, e.g. an mGluR5 modulator and at least one of L-dopa, a dopamine modulator, e.g. a dopamine agonist, a dopa decarboxylase inhibitor or a catechol-O-methyl transferase inhibitor. | 07-10-2014 |
Baltazar Siqueiros, San Dimas, CA US
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20140053475 | METHOD AND APPARATUS FOR LIFTING AND LEVELING A CONCRETE PANEL - A lifting apparatus to be embedded within a precast concrete panel or slab to enable the panel to be lifted, positioned atop a road bed, and elevated above the road bed. A lifting apparatus is located at each corner of the panel. Each lifting apparatus has a threaded sleeve extending through the panel to receive a removable threaded lifting bolt by which to establish a lifting point at which a lifting force is applied to lift and position the panel. When the threaded lifting bolt is rotated completely through the threaded sleeve, a pushing force is applied against a base plate, whereby to elevate the panel above the road bed as is necessary to make the panel level with adjacent panels during the construction or repair of a roadway. Grout is pumped through the panel to fill the space between the panel and the road bed. | 02-27-2014 |
20140369750 | GROUT CONTAINMENT SHEET AND METHOD - A water-impermeable grout containment sheet and a method for using the sheet, for example, during the construction of a roadway to support vehicular traffic. An excavation is first cut into a road bed, and a moisture (i.e., water) impermeable grout containment sheet is laid inside the excavation. A plurality of concrete panels are positioned adjacent one another to be coupled together within the excavation, such that at least one of the panels sits on top of the water-impermeable grout containment sheet. Grout is then pumped below the one panel to hold the panel in place within the excavation. The water-impermeable grout containment sheet lies between the grout and the road bed to establish a containment envelope to stop the grout from migrating away from the panel and prevent water from seeping outwardly from the grout into the road bed and into the grout from the excavation. | 12-18-2014 |
20150078822 | APPARATUS AND METHOD FOR JOINING ADJACENT CONCRETE PANELS - An apparatus and a method by which one end of a connecting rod is embedded in a first (e.g., precast) concrete panel and the opposite end of the connecting rod is moved inwardly of and affixed within an opposing rod receiving channel that is formed in an adjacent (e.g., precast) concrete panel so as to form a reliable joint for connecting the first and adjacent panels to one another. The apparatus and method have particular application in roadway construction and/or repair by creating a continuous flat driving surface to support vehicular traffic. Each of the connecting rod of the first concrete panel and the rod receiving channel of the adjacent concrete panel are axially aligned with one another and located so as to be separated from and spaced below the respective tops of the first and adjacent panels. | 03-19-2015 |